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P20678

- CP2H2_CHICK

UniProt

P20678 - CP2H2_CHICK

Protein

Cytochrome P450 2H2

Gene

CYP2H2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2H2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIH2
    Cytochrome P450 PCHP7
    Gene namesi
    Name:CYP2H2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Cytochrome P450 2H2PRO_0000051767Add
    BLAST

    Expressioni

    Inductioni

    By phenobarbital.

    Structurei

    3D structure databases

    ProteinModelPortaliP20678.
    SMRiP20678. Positions 33-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP20678.
    KOiK17853.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20678-1 [UniParc]FASTAAdd to Basket

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    MDFLGLPTIL LLVCISCFLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP    50
    WDLMESFKEL SKKYGPIFTI HLGPKKVVVL YGYDVVKEAL IDNGEAFSGR 100
    GNLPLFEKVF KGTGIVTSNG ESWRQMRRFA LTTLRDFGMG KKSIEERIQE 150
    EARFLVERIR NTHEKPFNPT VFLMHAVSNI ICSTVFGDRF DYEDKKFLDL 200
    IEMLDENERY QNRIQTQLYN FFPTILDYLP GPHKTLIKSI ETVDDFITEI 250
    IRAHQESFDA SCPRDFIDAF INKMQQEKEN SYFTVESLTR TTLDLFLAGT 300
    GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD 350
    AVIHEIQRFI DFLPVNLPRA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK 400
    EFPNPEKFDP GHFLNANGTF RKSNYFMPFS AGKRICAGEG LARMELFLFL 450
    TSILQNFSLK PVKDRKDIDI SPIVTSAANI PRPYEVSFIP R 491
    Length:491
    Mass (Da):56,485
    Last modified:February 1, 1991 - v1
    Checksum:i63F906362FDC8722
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25469 mRNA. Translation: AAA48743.1.
    PIRiA31418.
    RefSeqiNP_001001757.1. NM_001001757.1.
    UniGeneiGga.802.

    Genome annotation databases

    GeneIDi414841.
    KEGGigga:414841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25469 mRNA. Translation: AAA48743.1 .
    PIRi A31418.
    RefSeqi NP_001001757.1. NM_001001757.1.
    UniGenei Gga.802.

    3D structure databases

    ProteinModelPortali P20678.
    SMRi P20678. Positions 33-491.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414841.
    KEGGi gga:414841.

    Organism-specific databases

    CTDi 1562.

    Phylogenomic databases

    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P20678.
    KOi K17853.

    Miscellaneous databases

    NextBioi 20818737.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: regulation of two P450 mRNAs transcribed from different genes."
      Hansen A.J., May B.K.
      DNA 8:179-191(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase."
      Nakai K., Ward A.M., Gannon M., Rifkind A.B.
      J. Biol. Chem. 267:19503-19512(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-25.
    3. "Isolation of four forms of acetone-induced cytochrome P-450 in chicken liver by HPLC and their enzymic characterization."
      Sinclair J.F., Wood S., Lambrecht L., Gorman N., Mende-Mueller L., Smith L., Hunt J., Sinclair P.
      Biochem. J. 269:85-91(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-21.

    Entry informationi

    Entry nameiCP2H2_CHICK
    AccessioniPrimary (citable) accession number: P20678
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3