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Protein

Cytochrome P450 2H2

Gene

CYP2H2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2H2 (EC:1.14.14.1)
Alternative name(s):
CYPIIH2
Cytochrome P450 PCHP7
Gene namesi
Name:CYP2H2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2H2PRO_0000051767Add
BLAST

Expressioni

Inductioni

By phenobarbital.

Structurei

3D structure databases

ProteinModelPortaliP20678.
SMRiP20678. Positions 33-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP20678.
KOiK17853.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLGLPTIL LLVCISCFLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP
60 70 80 90 100
WDLMESFKEL SKKYGPIFTI HLGPKKVVVL YGYDVVKEAL IDNGEAFSGR
110 120 130 140 150
GNLPLFEKVF KGTGIVTSNG ESWRQMRRFA LTTLRDFGMG KKSIEERIQE
160 170 180 190 200
EARFLVERIR NTHEKPFNPT VFLMHAVSNI ICSTVFGDRF DYEDKKFLDL
210 220 230 240 250
IEMLDENERY QNRIQTQLYN FFPTILDYLP GPHKTLIKSI ETVDDFITEI
260 270 280 290 300
IRAHQESFDA SCPRDFIDAF INKMQQEKEN SYFTVESLTR TTLDLFLAGT
310 320 330 340 350
GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD
360 370 380 390 400
AVIHEIQRFI DFLPVNLPRA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK
410 420 430 440 450
EFPNPEKFDP GHFLNANGTF RKSNYFMPFS AGKRICAGEG LARMELFLFL
460 470 480 490
TSILQNFSLK PVKDRKDIDI SPIVTSAANI PRPYEVSFIP R
Length:491
Mass (Da):56,485
Last modified:February 1, 1991 - v1
Checksum:i63F906362FDC8722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25469 mRNA. Translation: AAA48743.1.
PIRiA31418.
RefSeqiNP_001001757.1. NM_001001757.1.
UniGeneiGga.802.

Genome annotation databases

GeneIDi414841.
KEGGigga:414841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25469 mRNA. Translation: AAA48743.1.
PIRiA31418.
RefSeqiNP_001001757.1. NM_001001757.1.
UniGeneiGga.802.

3D structure databases

ProteinModelPortaliP20678.
SMRiP20678. Positions 33-491.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414841.
KEGGigga:414841.

Organism-specific databases

CTDi1562.

Phylogenomic databases

HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP20678.
KOiK17853.

Miscellaneous databases

NextBioi20818737.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: regulation of two P450 mRNAs transcribed from different genes."
    Hansen A.J., May B.K.
    DNA 8:179-191(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase."
    Nakai K., Ward A.M., Gannon M., Rifkind A.B.
    J. Biol. Chem. 267:19503-19512(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-25.
  3. "Isolation of four forms of acetone-induced cytochrome P-450 in chicken liver by HPLC and their enzymic characterization."
    Sinclair J.F., Wood S., Lambrecht L., Gorman N., Mende-Mueller L., Smith L., Hunt J., Sinclair P.
    Biochem. J. 269:85-91(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-21.

Entry informationi

Entry nameiCP2H2_CHICK
AccessioniPrimary (citable) accession number: P20678
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.