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P20678 (CP2H2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2H2

EC=1.14.14.1
Alternative name(s):
CYPIIH2
Cytochrome P450 PCHP7
Gene names
Name:CYP2H2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2H2
PRO_0000051767

Sites

Metal binding4361Iron (heme axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P20678 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 63F906362FDC8722

FASTA49156,485
        10         20         30         40         50         60 
MDFLGLPTIL LLVCISCFLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP WDLMESFKEL 

        70         80         90        100        110        120 
SKKYGPIFTI HLGPKKVVVL YGYDVVKEAL IDNGEAFSGR GNLPLFEKVF KGTGIVTSNG 

       130        140        150        160        170        180 
ESWRQMRRFA LTTLRDFGMG KKSIEERIQE EARFLVERIR NTHEKPFNPT VFLMHAVSNI 

       190        200        210        220        230        240 
ICSTVFGDRF DYEDKKFLDL IEMLDENERY QNRIQTQLYN FFPTILDYLP GPHKTLIKSI 

       250        260        270        280        290        300 
ETVDDFITEI IRAHQESFDA SCPRDFIDAF INKMQQEKEN SYFTVESLTR TTLDLFLAGT 

       310        320        330        340        350        360 
GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD AVIHEIQRFI 

       370        380        390        400        410        420 
DFLPVNLPRA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK EFPNPEKFDP GHFLNANGTF 

       430        440        450        460        470        480 
RKSNYFMPFS AGKRICAGEG LARMELFLFL TSILQNFSLK PVKDRKDIDI SPIVTSAANI 

       490 
PRPYEVSFIP R 

« Hide

References

[1]"Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: regulation of two P450 mRNAs transcribed from different genes."
Hansen A.J., May B.K.
DNA 8:179-191(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase."
Nakai K., Ward A.M., Gannon M., Rifkind A.B.
J. Biol. Chem. 267:19503-19512(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-25.
[3]"Isolation of four forms of acetone-induced cytochrome P-450 in chicken liver by HPLC and their enzymic characterization."
Sinclair J.F., Wood S., Lambrecht L., Gorman N., Mende-Mueller L., Smith L., Hunt J., Sinclair P.
Biochem. J. 269:85-91(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-21.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25469 mRNA. Translation: AAA48743.1.
PIRA31418.
RefSeqNP_001001757.1. NM_001001757.1.
UniGeneGga.802.

3D structure databases

ProteinModelPortalP20678.
SMRP20678. Positions 33-491.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414841.
KEGGgga:414841.

Organism-specific databases

CTD1562.

Phylogenomic databases

HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidP20678.
KOK17853.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818737.

Entry information

Entry nameCP2H2_CHICK
AccessionPrimary (citable) accession number: P20678
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families