P20674 (COX5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide Va

Gene names

Name:

COX5A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 5A family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	respiratory electron transport chain Traceable author statement. Source: Reactome
Cellular component	mitochondrial inner membrane Traceable author statement. Source: Reactome
Molecular function	cytochrome-c oxidase activity Traceable author statement. Source: ProtInc electron carrier activity Traceable author statement Ref.1. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 41	41	Mitochondrion Ref.7
	Chain	42 – 150	109	Cytochrome c oxidase subunit 5A, mitochondrial		PRO_0000006100
Experimental info
	Sequence conflict	105	1	T → L in AAA99220. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P20674 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 104DAF468BD302FC	FASTA	150	16,762
	10 20 30 40 50 60 MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF 70 80 90 100 110 120 NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK 130 140 150 EIYPYVIQEL RPTLNELGIS TPEELGLDKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subunit Va of human and bovine cytochrome c oxidase is highly conserved." Rizzuto R., Nakase H., Zeviani M., Dimauro S., Schon E.A. Gene 69:245-256(1988) [PubMed: 2853101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates." Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R., Goodman M., Grossman L.I. BMC Evol. Biol. 8:8-8(2008) [PubMed: 18197981] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Human liver protein map: update 1993." Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F. Electrophoresis 14:1216-1222(1993) [PubMed: 8313870] [Abstract] Cited for: PROTEIN SEQUENCE OF 42-52. Tissue: Liver.
[8]	"The major protein expression profile and two-dimensional protein database of human heart." Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A., Ershova E.S., Egorov T.A., Musalyamov A.K. Electrophoresis 16:1160-1169(1995) [PubMed: 7498159] [Abstract] Cited for: PROTEIN SEQUENCE OF 56-64 AND 73-80. Tissue: Heart.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M22760 mRNA. Translation: AAA99220.1. DQ987236 mRNA. Translation: ABK92283.1. DQ987237 mRNA. Translation: ABK92284.1. CR407649 mRNA. Translation: CAG28577.1. AC125435 Genomic DNA. No translation available. CH471136 Genomic DNA. Translation: EAW99288.1. BC024240 mRNA. Translation: AAH24240.1.
IPI	IPI00025086.
PIR	OTHU5A. JT0342.
RefSeq	NP_004246.2. NM_004255.3.
UniGene	Hs.401903.
3D structure databases
ProteinModelPortal	P20674.
SMR	P20674. Positions 47-150.
ModBase	Search...
Protein-protein interaction databases
IntAct	P20674. 2 interactions.
MINT	MINT-1386385.
STRING	P20674.
Protein family/group databases
TCDB	3.D.4.11.1. proton-translocating cytochrome oxidase (COX) superfamily.
PTM databases
PhosphoSite	P20674.
Polymorphism databases
DMDM	218511986.
2D gel databases
SWISS-2DPAGE	P20674.
DOSAC-COBS-2DPAGE	P20674.
OGP	P20674.
Siena-2DPAGE	P20674.
UCD-2DPAGE	P20674.
Proteomic databases
PRIDE	P20674.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322347; ENSP00000317780; ENSG00000178741.
GeneID	9377.
KEGG	hsa:9377.
Organism-specific databases
CTD	9377.
GeneCards	GC15M075212.
H-InvDB	HIX0202152.
HGNC	HGNC:2267. COX5A.
HPA	HPA027526.
MIM	603773. gene.
neXtProt	NX_P20674.
PharmGKB	PA26784.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20525.
HOGENOM	HBG381551.
HOVERGEN	HBG051088.
InParanoid	P20674.
OMA	HHEETFE.
OrthoDB	EOG4D7Z71.
PhylomeDB	P20674.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	P20674.
Bgee	P20674.
CleanEx	HS_COX5A.
Genevestigator	P20674.
GermOnline	ENSG00000178741. Homo sapiens.
Family and domain databases
InterPro	IPR003204. Cyt_c_oxidase_su5A. [Graphical view]
Gene3D	G3DSA:1.25.40.40. Cyt_c_ox5A. 1 hit.
KO	K02264.
PANTHER	PTHR14200. Cyt_c_ox5A. 1 hit.
Pfam	PF02284. COX5A. 1 hit. [Graphical view]
SUPFAM	SSF48479. Cyt_c_ox5A. 1 hit.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

COX5A_HUMAN

Accession

Primary (citable) accession number: P20674
Secondary accession number(s): P30045, Q8TB65

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	December 16, 2008
Last modified:	January 25, 2012
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.