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P20674

- COX5A_HUMAN

UniProt

P20674 - COX5A_HUMAN

Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

COX5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: ProtInc
    2. electron carrier activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. hydrogen ion transmembrane transport Source: GOC
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Protein family/group databases

    TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 5A, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide Va
    Gene namesi
    Name:COX5A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:2267. COX5A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial inner membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26784.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4141Mitochondrion1 PublicationAdd
    BLAST
    Chaini42 – 150109Cytochrome c oxidase subunit 5A, mitochondrialPRO_0000006100Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei87 – 871N6-acetyllysineBy similarity
    Modified residuei113 – 1131N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP20674.
    PaxDbiP20674.
    PRIDEiP20674.

    2D gel databases

    DOSAC-COBS-2DPAGEP20674.
    OGPiP20674.
    SWISS-2DPAGEP20674.
    UCD-2DPAGEP20674.

    PTM databases

    PhosphoSiteiP20674.

    Expressioni

    Gene expression databases

    ArrayExpressiP20674.
    BgeeiP20674.
    CleanExiHS_COX5A.
    GenevestigatoriP20674.

    Organism-specific databases

    HPAiHPA027526.

    Interactioni

    Protein-protein interaction databases

    BioGridi114778. 12 interactions.
    IntActiP20674. 9 interactions.
    MINTiMINT-1386385.
    STRINGi9606.ENSP00000317780.

    Structurei

    3D structure databases

    ProteinModelPortaliP20674.
    SMRiP20674. Positions 47-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG284808.
    HOGENOMiHOG000160656.
    HOVERGENiHBG051088.
    InParanoidiP20674.
    KOiK02264.
    OMAiARDHSSG.
    OrthoDBiEOG74J99R.
    PhylomeDBiP20674.
    TreeFamiTF105062.

    Family and domain databases

    Gene3Di1.25.40.40. 1 hit.
    InterProiIPR003204. Cyt_c_oxidase_su5A/6.
    [Graphical view]
    PANTHERiPTHR14200. PTHR14200. 1 hit.
    PfamiPF02284. COX5A. 1 hit.
    [Graphical view]
    SUPFAMiSSF48479. SSF48479. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20674-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE    50
    EFDARWVTYF NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN 100
    DFASTVRILE VVKDKAGPHK EIYPYVIQEL RPTLNELGIS TPEELGLDKV 150
    Length:150
    Mass (Da):16,762
    Last modified:December 16, 2008 - v2
    Checksum:i104DAF468BD302FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051T → L in AAA99220. (PubMed:2853101)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22760 mRNA. Translation: AAA99220.1.
    DQ987236 mRNA. Translation: ABK92283.1.
    DQ987237 mRNA. Translation: ABK92284.1.
    CR407649 mRNA. Translation: CAG28577.1.
    AC125435 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99288.1.
    BC024240 mRNA. Translation: AAH24240.1.
    CCDSiCCDS10273.1.
    PIRiJT0342. OTHU5A.
    RefSeqiNP_004246.2. NM_004255.3.
    UniGeneiHs.401903.

    Genome annotation databases

    EnsembliENST00000322347; ENSP00000317780; ENSG00000178741.
    ENST00000564811; ENSP00000456386; ENSG00000178741.
    GeneIDi9377.
    KEGGihsa:9377.
    UCSCiuc002azi.4. human.

    Polymorphism databases

    DMDMi218511986.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22760 mRNA. Translation: AAA99220.1 .
    DQ987236 mRNA. Translation: ABK92283.1 .
    DQ987237 mRNA. Translation: ABK92284.1 .
    CR407649 mRNA. Translation: CAG28577.1 .
    AC125435 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99288.1 .
    BC024240 mRNA. Translation: AAH24240.1 .
    CCDSi CCDS10273.1.
    PIRi JT0342. OTHU5A.
    RefSeqi NP_004246.2. NM_004255.3.
    UniGenei Hs.401903.

    3D structure databases

    ProteinModelPortali P20674.
    SMRi P20674. Positions 47-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114778. 12 interactions.
    IntActi P20674. 9 interactions.
    MINTi MINT-1386385.
    STRINGi 9606.ENSP00000317780.

    Protein family/group databases

    TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    PTM databases

    PhosphoSitei P20674.

    Polymorphism databases

    DMDMi 218511986.

    2D gel databases

    DOSAC-COBS-2DPAGE P20674.
    OGPi P20674.
    SWISS-2DPAGE P20674.
    UCD-2DPAGE P20674.

    Proteomic databases

    MaxQBi P20674.
    PaxDbi P20674.
    PRIDEi P20674.

    Protocols and materials databases

    DNASUi 9377.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322347 ; ENSP00000317780 ; ENSG00000178741 .
    ENST00000564811 ; ENSP00000456386 ; ENSG00000178741 .
    GeneIDi 9377.
    KEGGi hsa:9377.
    UCSCi uc002azi.4. human.

    Organism-specific databases

    CTDi 9377.
    GeneCardsi GC15M075212.
    HGNCi HGNC:2267. COX5A.
    HPAi HPA027526.
    MIMi 603773. gene.
    neXtProti NX_P20674.
    PharmGKBi PA26784.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284808.
    HOGENOMi HOG000160656.
    HOVERGENi HBG051088.
    InParanoidi P20674.
    KOi K02264.
    OMAi ARDHSSG.
    OrthoDBi EOG74J99R.
    PhylomeDBi P20674.
    TreeFami TF105062.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi COX5A. human.
    GenomeRNAii 9377.
    NextBioi 35130.
    PROi P20674.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20674.
    Bgeei P20674.
    CleanExi HS_COX5A.
    Genevestigatori P20674.

    Family and domain databases

    Gene3Di 1.25.40.40. 1 hit.
    InterProi IPR003204. Cyt_c_oxidase_su5A/6.
    [Graphical view ]
    PANTHERi PTHR14200. PTHR14200. 1 hit.
    Pfami PF02284. COX5A. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48479. SSF48479. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Subunit Va of human and bovine cytochrome c oxidase is highly conserved."
      Rizzuto R., Nakase H., Zeviani M., Dimauro S., Schon E.A.
      Gene 69:245-256(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates."
      Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R., Goodman M., Grossman L.I.
      BMC Evol. Biol. 8:8-8(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. Cited for: PROTEIN SEQUENCE OF 42-52.
      Tissue: Liver.
    8. "The major protein expression profile and two-dimensional protein database of human heart."
      Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A., Ershova E.S., Egorov T.A., Musalyamov A.K.
      Electrophoresis 16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 56-64 AND 73-80.
      Tissue: Heart.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX5A_HUMAN
    AccessioniPrimary (citable) accession number: P20674
    Secondary accession number(s): P30045, Q8TB65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3