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Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

COX5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc
  • electron carrier activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
REACT_355377. TP53 Regulates Metabolic Genes.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:COX5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:2267. COX5A.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial inner membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26784.

Chemistry

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX5A.
DMDMi218511986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4141Mitochondrion1 PublicationAdd
BLAST
Chaini42 – 150109Cytochrome c oxidase subunit 5A, mitochondrialPRO_0000006100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871N6-acetyllysineBy similarity
Modified residuei113 – 1131N6-acetyllysineBy similarity
Modified residuei141 – 1411Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP20674.
PaxDbiP20674.
PRIDEiP20674.

2D gel databases

DOSAC-COBS-2DPAGEP20674.
OGPiP20674.
SWISS-2DPAGEP20674.
UCD-2DPAGEP20674.

PTM databases

PhosphoSiteiP20674.

Expressioni

Gene expression databases

BgeeiP20674.
CleanExiHS_COX5A.
ExpressionAtlasiP20674. baseline and differential.
GenevisibleiP20674. HS.

Organism-specific databases

HPAiHPA027526.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOSC8Q96B263EBI-715032,EBI-371922
KRT31Q153233EBI-715032,EBI-948001
KRT40Q6A1623EBI-715032,EBI-10171697

Protein-protein interaction databases

BioGridi114778. 16 interactions.
IntActiP20674. 12 interactions.
MINTiMINT-1386385.
STRINGi9606.ENSP00000317780.

Structurei

3D structure databases

ProteinModelPortaliP20674.
SMRiP20674. Positions 47-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG284808.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP20674.
KOiK02264.
OMAiSIRCYSH.
OrthoDBiEOG74J99R.
PhylomeDBiP20674.
TreeFamiTF105062.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE
60 70 80 90 100
EFDARWVTYF NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN
110 120 130 140 150
DFASTVRILE VVKDKAGPHK EIYPYVIQEL RPTLNELGIS TPEELGLDKV
Length:150
Mass (Da):16,762
Last modified:December 16, 2008 - v2
Checksum:i104DAF468BD302FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051T → L in AAA99220 (PubMed:2853101).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22760 mRNA. Translation: AAA99220.1.
DQ987236 mRNA. Translation: ABK92283.1.
DQ987237 mRNA. Translation: ABK92284.1.
CR407649 mRNA. Translation: CAG28577.1.
AC125435 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99288.1.
BC024240 mRNA. Translation: AAH24240.1.
CCDSiCCDS10273.1.
PIRiJT0342. OTHU5A.
RefSeqiNP_004246.2. NM_004255.3.
UniGeneiHs.401903.

Genome annotation databases

EnsembliENST00000322347; ENSP00000317780; ENSG00000178741.
ENST00000564811; ENSP00000456386; ENSG00000178741.
GeneIDi9377.
KEGGihsa:9377.
UCSCiuc002azi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22760 mRNA. Translation: AAA99220.1.
DQ987236 mRNA. Translation: ABK92283.1.
DQ987237 mRNA. Translation: ABK92284.1.
CR407649 mRNA. Translation: CAG28577.1.
AC125435 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99288.1.
BC024240 mRNA. Translation: AAH24240.1.
CCDSiCCDS10273.1.
PIRiJT0342. OTHU5A.
RefSeqiNP_004246.2. NM_004255.3.
UniGeneiHs.401903.

3D structure databases

ProteinModelPortaliP20674.
SMRiP20674. Positions 47-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114778. 16 interactions.
IntActiP20674. 12 interactions.
MINTiMINT-1386385.
STRINGi9606.ENSP00000317780.

Chemistry

DrugBankiDB02659. Cholic Acid.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteiP20674.

Polymorphism and mutation databases

BioMutaiCOX5A.
DMDMi218511986.

2D gel databases

DOSAC-COBS-2DPAGEP20674.
OGPiP20674.
SWISS-2DPAGEP20674.
UCD-2DPAGEP20674.

Proteomic databases

MaxQBiP20674.
PaxDbiP20674.
PRIDEiP20674.

Protocols and materials databases

DNASUi9377.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322347; ENSP00000317780; ENSG00000178741.
ENST00000564811; ENSP00000456386; ENSG00000178741.
GeneIDi9377.
KEGGihsa:9377.
UCSCiuc002azi.4. human.

Organism-specific databases

CTDi9377.
GeneCardsiGC15M075212.
HGNCiHGNC:2267. COX5A.
HPAiHPA027526.
MIMi603773. gene.
neXtProtiNX_P20674.
PharmGKBiPA26784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284808.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP20674.
KOiK02264.
OMAiSIRCYSH.
OrthoDBiEOG74J99R.
PhylomeDBiP20674.
TreeFamiTF105062.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
REACT_355377. TP53 Regulates Metabolic Genes.

Miscellaneous databases

ChiTaRSiCOX5A. human.
GenomeRNAii9377.
NextBioi35130.
PROiP20674.
SOURCEiSearch...

Gene expression databases

BgeeiP20674.
CleanExiHS_COX5A.
ExpressionAtlasiP20674. baseline and differential.
GenevisibleiP20674. HS.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Subunit Va of human and bovine cytochrome c oxidase is highly conserved."
    Rizzuto R., Nakase H., Zeviani M., Dimauro S., Schon E.A.
    Gene 69:245-256(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates."
    Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R., Goodman M., Grossman L.I.
    BMC Evol. Biol. 8:8-8(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: PROTEIN SEQUENCE OF 42-52.
    Tissue: Liver.
  8. "The major protein expression profile and two-dimensional protein database of human heart."
    Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A., Ershova E.S., Egorov T.A., Musalyamov A.K.
    Electrophoresis 16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 56-64 AND 73-80.
    Tissue: Heart.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCOX5A_HUMAN
AccessioniPrimary (citable) accession number: P20674
Secondary accession number(s): P30045, Q8TB65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 16, 2008
Last modified: June 24, 2015
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.