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P20674 (COX5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene names
Name:COX5A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 5A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4141Mitochondrion Ref.7
Chain42 – 150109Cytochrome c oxidase subunit 5A, mitochondrial
PRO_0000006100

Amino acid modifications

Modified residue871N6-acetyllysine By similarity
Modified residue1131N6-acetyllysine By similarity

Experimental info

Sequence conflict1051T → L in AAA99220. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P20674 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 104DAF468BD302FC

FASTA15016,762
        10         20         30         40         50         60 
MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF 

        70         80         90        100        110        120 
NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK 

       130        140        150 
EIYPYVIQEL RPTLNELGIS TPEELGLDKV 

« Hide

References

« Hide 'large scale' references
[1]"Subunit Va of human and bovine cytochrome c oxidase is highly conserved."
Rizzuto R., Nakase H., Zeviani M., Dimauro S., Schon E.A.
Gene 69:245-256(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates."
Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R., Goodman M., Grossman L.I.
BMC Evol. Biol. 8:8-8(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Human liver protein map: update 1993."
Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.
Electrophoresis 14:1216-1222(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 42-52.
Tissue: Liver.
[8]"The major protein expression profile and two-dimensional protein database of human heart."
Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A., Ershova E.S., Egorov T.A., Musalyamov A.K.
Electrophoresis 16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 56-64 AND 73-80.
Tissue: Heart.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M22760 mRNA. Translation: AAA99220.1.
DQ987236 mRNA. Translation: ABK92283.1.
DQ987237 mRNA. Translation: ABK92284.1.
CR407649 mRNA. Translation: CAG28577.1.
AC125435 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99288.1.
BC024240 mRNA. Translation: AAH24240.1.
PIROTHU5A. JT0342.
RefSeqNP_004246.2. NM_004255.3.
UniGeneHs.401903.

3D structure databases

ProteinModelPortalP20674.
SMRP20674. Positions 47-150.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114778. 11 interactions.
IntActP20674. 9 interactions.
MINTMINT-1386385.
STRING9606.ENSP00000317780.

Protein family/group databases

TCDB3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteP20674.

Polymorphism databases

DMDM218511986.

2D gel databases

DOSAC-COBS-2DPAGEP20674.
OGPP20674.
SWISS-2DPAGEP20674.
UCD-2DPAGEP20674.

Proteomic databases

PaxDbP20674.
PRIDEP20674.

Protocols and materials databases

DNASU9377.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322347; ENSP00000317780; ENSG00000178741.
ENST00000564811; ENSP00000456386; ENSG00000178741.
GeneID9377.
KEGGhsa:9377.
UCSCuc002azi.4. human.

Organism-specific databases

CTD9377.
GeneCardsGC15M075212.
HGNCHGNC:2267. COX5A.
HPAHPA027526.
MIM603773. gene.
neXtProtNX_P20674.
PharmGKBPA26784.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284808.
HOGENOMHOG000160656.
HOVERGENHBG051088.
InParanoidP20674.
KOK02264.
OMASIRCYSH.
OrthoDBEOG74J99R.
PhylomeDBP20674.
TreeFamTF105062.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP20674.
BgeeP20674.
CleanExHS_COX5A.
GenevestigatorP20674.

Family and domain databases

Gene3D1.25.40.40. 1 hit.
InterProIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERPTHR14200. PTHR14200. 1 hit.
PfamPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMSSF48479. SSF48479. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCOX5A. human.
GenomeRNAi9377.
NextBio35130.
PROP20674.
SOURCESearch...

Entry information

Entry nameCOX5A_HUMAN
AccessionPrimary (citable) accession number: P20674
Secondary accession number(s): P30045, Q8TB65
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM