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P20674

- COX5A_HUMAN

UniProt

P20674 - COX5A_HUMAN

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Protein
Cytochrome c oxidase subunit 5A, mitochondrial
Gene
COX5A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: ProtInc
  2. electron carrier activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. hydrogen ion transmembrane transport Source: GOC
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:COX5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:2267. COX5A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrial inner membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4141Mitochondrion1 Publication
Add
BLAST
Chaini42 – 150109Cytochrome c oxidase subunit 5A, mitochondrial
PRO_0000006100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871N6-acetyllysine By similarity
Modified residuei113 – 1131N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP20674.
PaxDbiP20674.
PRIDEiP20674.

2D gel databases

DOSAC-COBS-2DPAGEP20674.
OGPiP20674.
SWISS-2DPAGEP20674.
UCD-2DPAGEP20674.

PTM databases

PhosphoSiteiP20674.

Expressioni

Gene expression databases

ArrayExpressiP20674.
BgeeiP20674.
CleanExiHS_COX5A.
GenevestigatoriP20674.

Organism-specific databases

HPAiHPA027526.

Interactioni

Protein-protein interaction databases

BioGridi114778. 12 interactions.
IntActiP20674. 9 interactions.
MINTiMINT-1386385.
STRINGi9606.ENSP00000317780.

Structurei

3D structure databases

ProteinModelPortaliP20674.
SMRiP20674. Positions 47-150.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG284808.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP20674.
KOiK02264.
OMAiARDHSSG.
OrthoDBiEOG74J99R.
PhylomeDBiP20674.
TreeFamiTF105062.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20674-1 [UniParc]FASTAAdd to Basket

« Hide

MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE    50
EFDARWVTYF NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN 100
DFASTVRILE VVKDKAGPHK EIYPYVIQEL RPTLNELGIS TPEELGLDKV 150
Length:150
Mass (Da):16,762
Last modified:December 16, 2008 - v2
Checksum:i104DAF468BD302FC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051T → L in AAA99220. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22760 mRNA. Translation: AAA99220.1.
DQ987236 mRNA. Translation: ABK92283.1.
DQ987237 mRNA. Translation: ABK92284.1.
CR407649 mRNA. Translation: CAG28577.1.
AC125435 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99288.1.
BC024240 mRNA. Translation: AAH24240.1.
CCDSiCCDS10273.1.
PIRiJT0342. OTHU5A.
RefSeqiNP_004246.2. NM_004255.3.
UniGeneiHs.401903.

Genome annotation databases

EnsembliENST00000322347; ENSP00000317780; ENSG00000178741.
ENST00000564811; ENSP00000456386; ENSG00000178741.
GeneIDi9377.
KEGGihsa:9377.
UCSCiuc002azi.4. human.

Polymorphism databases

DMDMi218511986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22760 mRNA. Translation: AAA99220.1 .
DQ987236 mRNA. Translation: ABK92283.1 .
DQ987237 mRNA. Translation: ABK92284.1 .
CR407649 mRNA. Translation: CAG28577.1 .
AC125435 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99288.1 .
BC024240 mRNA. Translation: AAH24240.1 .
CCDSi CCDS10273.1.
PIRi JT0342. OTHU5A.
RefSeqi NP_004246.2. NM_004255.3.
UniGenei Hs.401903.

3D structure databases

ProteinModelPortali P20674.
SMRi P20674. Positions 47-150.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114778. 12 interactions.
IntActi P20674. 9 interactions.
MINTi MINT-1386385.
STRINGi 9606.ENSP00000317780.

Protein family/group databases

TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSitei P20674.

Polymorphism databases

DMDMi 218511986.

2D gel databases

DOSAC-COBS-2DPAGE P20674.
OGPi P20674.
SWISS-2DPAGE P20674.
UCD-2DPAGE P20674.

Proteomic databases

MaxQBi P20674.
PaxDbi P20674.
PRIDEi P20674.

Protocols and materials databases

DNASUi 9377.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322347 ; ENSP00000317780 ; ENSG00000178741 .
ENST00000564811 ; ENSP00000456386 ; ENSG00000178741 .
GeneIDi 9377.
KEGGi hsa:9377.
UCSCi uc002azi.4. human.

Organism-specific databases

CTDi 9377.
GeneCardsi GC15M075212.
HGNCi HGNC:2267. COX5A.
HPAi HPA027526.
MIMi 603773. gene.
neXtProti NX_P20674.
PharmGKBi PA26784.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284808.
HOGENOMi HOG000160656.
HOVERGENi HBG051088.
InParanoidi P20674.
KOi K02264.
OMAi ARDHSSG.
OrthoDBi EOG74J99R.
PhylomeDBi P20674.
TreeFami TF105062.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi COX5A. human.
GenomeRNAii 9377.
NextBioi 35130.
PROi P20674.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20674.
Bgeei P20674.
CleanExi HS_COX5A.
Genevestigatori P20674.

Family and domain databases

Gene3Di 1.25.40.40. 1 hit.
InterProi IPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view ]
PANTHERi PTHR14200. PTHR14200. 1 hit.
Pfami PF02284. COX5A. 1 hit.
[Graphical view ]
SUPFAMi SSF48479. SSF48479. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subunit Va of human and bovine cytochrome c oxidase is highly conserved."
    Rizzuto R., Nakase H., Zeviani M., Dimauro S., Schon E.A.
    Gene 69:245-256(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates."
    Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R., Goodman M., Grossman L.I.
    BMC Evol. Biol. 8:8-8(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: PROTEIN SEQUENCE OF 42-52.
    Tissue: Liver.
  8. "The major protein expression profile and two-dimensional protein database of human heart."
    Kovalyov L.I., Shishkin S.S., Efimochkin A.S., Kovalyova M.A., Ershova E.S., Egorov T.A., Musalyamov A.K.
    Electrophoresis 16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 56-64 AND 73-80.
    Tissue: Heart.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX5A_HUMAN
AccessioniPrimary (citable) accession number: P20674
Secondary accession number(s): P30045, Q8TB65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 16, 2008
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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