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P20659

- TRX_DROME

UniProt

P20659 - TRX_DROME

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Protein
Histone-lysine N-methyltransferase trithorax
Gene
trx, KMT2A, CG8651
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo.3 Publications

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei3598 – 35981S-adenosyl-L-methionine By similarity
Binding sitei3600 – 36001S-adenosyl-L-methionine By similarity
Binding sitei3642 – 36421S-adenosyl-L-methionine By similarity
Metal bindingi3668 – 36681Zinc By similarity
Metal bindingi3714 – 37141Zinc By similarity
Metal bindingi3716 – 37161Zinc By similarity
Metal bindingi3721 – 37211Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi759 – 884126Nuclear receptor
Add
BLAST
Zinc fingeri1266 – 134782PHD-type 1
Add
BLAST
Zinc fingeri1348 – 139346PHD-type 2
Add
BLAST
Zinc fingeri1421 – 148262PHD-type 3
Add
BLAST
Zinc fingeri1734 – 179360PHD-type 4; atypical
Add
BLAST
Zinc fingeri1794 – 184451PHD-type 5; atypical
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: FlyBase
  2. histone methyltransferase activity (H3-K4 specific) Source: InterPro
  3. identical protein binding Source: IntAct
  4. protein binding Source: IntAct
  5. protein homodimerization activity Source: UniProtKB
  6. protein phosphatase 1 binding Source: FlyBase
  7. sequence-specific DNA binding Source: InterPro
  8. sequence-specific DNA binding transcription factor activity Source: InterPro
  9. transcription regulatory region DNA binding Source: FlyBase
  10. zinc ion binding Source: InterPro

GO - Biological processi

  1. axon guidance Source: FlyBase
  2. germ cell migration Source: FlyBase
  3. histone H3 acetylation Source: FlyBase
  4. histone H3-K4 methylation Source: FlyBase
  5. histone methylation Source: FlyBase
  6. positive regulation of transcription elongation from RNA polymerase II promoter Source: FlyBase
  7. regulation of response to DNA damage stimulus Source: FlyBase
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

SignaLinkiP20659.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase trithorax (EC:2.1.1.43)
Alternative name(s):
Lysine N-methyltransferase 2A
Gene namesi
Name:trx
Synonyms:KMT2A
ORF Names:CG8651
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003862. trx.

Subcellular locationi

Nucleus. Chromosome
Note: Binds to 16 discrete sites on larval salivary gland polytene chromosomes.1 Publication

GO - Cellular componenti

  1. MLL1/2 complex Source: FlyBase
  2. histone methyltransferase complex Source: FlyBase
  3. microtubule associated complex Source: FlyBase
  4. nucleus Source: FlyBase
  5. polytene chromosome Source: FlyBase
  6. transcription elongation factor complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 37263726Histone-lysine N-methyltransferase trithorax
PRO_0000124874Add
BLAST

Proteomic databases

PaxDbiP20659.
PRIDEiP20659.

Expressioni

Tissue specificityi

Maternal isoforms are expressed in syncytial blastoderm, confined to the ventral region fated to become mesoderm. An additional broad domain of expression arises during cellularization and is quickly resolved into four pair-rule-like stripes in the posterior half of the embryo.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiP20659.

Interactioni

Subunit structurei

Interacts with ash1 via its SET domain.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-591327,EBI-591327
cyp33Q9V3G32EBI-591327,EBI-128445

Protein-protein interaction databases

BioGridi66813. 36 interactions.
IntActiP20659. 6 interactions.
MINTiMINT-907260.

Structurei

3D structure databases

ProteinModelPortaliP20659.
SMRiP20659. Positions 1267-1296, 1343-1403, 1420-1523, 1737-1842, 3566-3726.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1884 – 194158FYR N-terminal
Add
BLAST
Domaini3386 – 347085FYR C-terminal
Add
BLAST
Domaini3588 – 3704117SET
Add
BLAST
Domaini3710 – 372617Post-SET
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3665 – 36662S-adenosyl-L-methionine binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi512 – 5165Poly-Ser
Compositional biasi565 – 5706Poly-Asp
Compositional biasi661 – 6644Poly-Ser
Compositional biasi905 – 9106Poly-Ser
Compositional biasi1576 – 15827Poly-Gln
Compositional biasi2298 – 3027730Gln-rich
Add
BLAST
Compositional biasi3032 – 30409Poly-Ser
Compositional biasi3181 – 31844Poly-Gln
Compositional biasi3220 – 32256Poly-Glu

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00740000115089.
InParanoidiP20659.
KOiK09186.
OMAiARCEPYS.
OrthoDBiEOG75XGJZ.
PhylomeDBiP20659.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR016569. MeTrfase_trithorax.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF010354. Methyltransferase_trithorax. 1 hit.
SMARTiSM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 2 hits.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 4 hits.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P20659-1) [UniParc]FASTAAdd to Basket

Also known as: D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGRSKFPGKP SKSINRKRIS VLQLEDDAAN PAEPQQPAPE SQQPSGSGSG     50
SSAAREKGNN CDNDEDDNAP GGASISGNTA SSSAGSGNSG NGSSSGSSTG 100
SGSSGSGSTN GGSVNGGTHH KSAANLDKEA VTKDQNGDGD KTRGNVSSAP 150
SGKLSAAASG KALSKSSRTF SASTSVTSSG RSSGSSPDGN SGASSDGASS 200
GISCGKSTAK STEASSGKLA KTTGAGTCSS AKSSKASSGT TSEATTSGLS 250
GACLKALFVA TPATSTGLAC ALVSPGGSSQ GGTFPISAAL LRARKNSNKK 300
FKNLNLARGE VMLPSTSKLK QLNSPVVDNP SPSPPIASGS TPSVEGGIGV 350
GGVVSPGEDA ALKRVLTEMP NEVARDPSPS SCTAAANGAA SGKGSASNGP 400
PAMASSGDGS SPKSGADTGP STSSTTAKQK KTVTFRNVLE TSDDKSVVKR 450
FYNPDIRIPI VSIMKKDSLN RPLNYSRGGE CIVRPSILSK ILNKNSNIDK 500
LNSLKFRSAG ASSSSSNQES GSSSNVFGLS RAFGAPMDED DEGGVTFRRN 550
DSPEDQNNAE DDEMDDDDDD EEAEEDDENE DDNDEAVSEK SAETEKSAGA 600
DERDPDEKQL VMDSHFVLPK RSTRSSRIIK PNKRLLEEGA ISTKKPLSLG 650
DSKGKNVFGT SSSSAGSTAS TFSASTNLKL GKETFFNFGT LKPNSSAAGN 700
FVLRQPRLQF QADNQQATFT APKACPTSPS AIPKPANSLA TSSFGSLAST 750
NSSTVTPTPS ACSICSAVVS SKEVTQARKY GVVACDVCRK FFSKMTKKSI 800
SANSSTANTS SGSQQYLQCK GNEGSPCSIH SAKSQLKNFK KFYKDRCTAC 850
WLKKCMISFQ LPAAHRSRLS AILPPGMRGE AAAREEKSAE LLSPTGSLRF 900
TSTASSSSPS VVASTSVKWK SSGDSTSALT SIKPNPLAEN NVTFGSTPLL 950
RPAILENPLF LKISNAADQK LAAAEAISPS LTKKNSKQEK EKVKESEQSE 1000
KLLSPTQAGT KKSGAAEAQV EEVQPQKEEA PQTSTTTQPS ASNGASHGVP 1050
QAELAGETNA TGDTLKRQRI DLKGPRVKHV CRSASIVLGQ PLATFGEDQQ 1100
PEDAADMQQE IAAPVPSAIM EPSPEKPTHI VTDENDNCAS CKTSPVGDES 1150
KPSKSSGSAQ AEVKKATALG KEGTASAAGG SSAKVTTRNA AVASNLIVAA 1200
SKKQRNGDIA TSSSVTQSSN QTQGRKTKEH RQQRTLISID FWENYDPAEV 1250
CQTGFGLIVT ETVAQRALCF LCGSTGLDPL IFCACCCEPY HQYCVQDEYN 1300
LKHGSFEDTT LMGSLLETTV NASTGPSSSL NQLTQRLNWL CPRCTVCYTC 1350
NMSSGSKVKC QKCQKNYHST CLGTSKRLLG ADRPLICVNC LKCKSCSTTK 1400
VSKFVGNLPM CTGCFKLRKK GNFCPICQRC YDDNDFDLKM MECGDCGQWV 1450
HSKCEGLSDE QYNLLSTLPE SIEFICKKCA RRNESSKIKA EEWRQAVMEE 1500
FKASLYSVLK LLSKSRQACA LLKLSPRKKL RCTCGASSNQ GKLQPKALQF 1550
SSGSDNGLGS DGESQNSDDV YEFKDQQQQQ QQRNANMNKP RVKSLPCSCQ 1600
QHISHSQSFS LVDIKQKIAG NSYVSLAEFN YDMSQVIQQS NCDELDIAYK 1650
ELLSEQFPWF QNETKACTDA LEEDMFESCS GGNYEDLQDT GGVSASVYNE 1700
HSTSQAESRS GVLDIPLEEV DDFGSCGIKM RLDTRMCLFC RKSGEGLSGE 1750
EARLLYCGHD CWVHTNCAMW SAEVFEEIDG SLQNVHSAVA RGRMIKCTVC 1800
GNRGATVGCN VRSCGEHYHY PCARSIDCAF LTDKSMYCPA HAKNGNALKA 1850
NGSPSVTYES NFEVSRPVYV ELDRKRKKLI EPARVQFHIG SLEVRQLGAI 1900
VPRFSDSYEA VVPINFLCSR LYWSSKEPWK IVEYTVRTTI QNSSSTLTAL 1950
DVGRNYTVDH TNPNSKEVQL GMAQIARWHT SLARSEFLEN GGTDWSGEFP 2000
NPNSCVPPDE NTEEEPQQQA DLLPPELKDA IFEDLPHELL DGISMLDIFL 2050
YDDKTDLFAI SEQSKDGTQA MTSNQAQNQN QQAGGANSVS ICDEDTRNSN 2100
TSLGNGWPAS NPVEDAMLSA ARNSSQVQML KTLAWPKLDG NSAMATAIKR 2150
RKLSKNLAEG VFLTLSSQQR NKKEMATVAG VSRRQSISET SVEGVATTSG 2200
SVRSKSFTWS AAKRYFEKSE GREEAAKMRI MQMDGVDDSI TEFRIISGDG 2250
NLSTAQFSGQ VKCDRCQCTY RNYDAFQRHL PSCSPTMSSN ETESDVSGQG 2300
MTNNATQISA ESLNELQKQL LANAGGLNYL QSATSFPQVQ SLGSLGQFGL 2350
QGLQQLQLQP QSLGSGFFLS QPNPATQANT DDLQIYANSL QSLAANLGGG 2400
FTLAQPTVTA PAQPQLIAVS TNPDGTQQFI QIPQTMQATT TPTATYQTLQ 2450
ATNTDKKIML PLTAAGKPLK TVATKAAQQA AVKQRQLKSG HQVKPIQAKL 2500
QPHPQQHQQQ QQTQVQQPIT VMGQNLLQPQ LLFQSSTQTQ APQIILPQAQ 2550
PQNIISFVTG DGSQGQPLQY ISIPTAGEYK PQPQPTATPT FLTTAPGAGA 2600
TYLQTDASGN LVLTTTPSNS GLQMLTAQSL QAQPQVIGTL IQPQTIQLGG 2650
GADGNQPGSN QQPLILGGTG GGSSGLEFAT TSPQVILATQ PMYYGLETIV 2700
QNTVMSSQQF VSTAMPGMLS QNASFSATTT QVFQASKIEP IVDLPAGYVV 2750
LNNTGDASSA GTFLNAASVL QQQTQDDTTT QILQNANFQF QSVPTSSGAS 2800
TSMDYTSPVM VTAKIPPVTQ IKRTNAQAKA AGISGVGKVP PQPQVVNKVL 2850
PTSIVTQQSQ VQVKNSNLKQ SQVKGKAASG TGTTCGAPPS IASKPLQKKT 2900
NMIRPIHKLE VKPKVMKPTP KVQNQNHSLL QQQQQQQPQL QQQIPAVVVN 2950
QVPKVTISQQ RIPAQTQQQQ LQQAQMIHIP QQQQPLQQQQ VQVQPSMPII 3000
TLAEAPVVQS QFVMEPQALE QQELANRVQH FSTSSSSSSS NCSLPTNVVN 3050
PMQQQAPSTT SSSTTRPTNR VLPMQQRQEP APLSNECPVV SSPTPPKPVE 3100
QPIIHQMTSA SVSKCYAQKS TLPSPVYEAE LKVSSVLESI VPDVTMDAIL 3150
EEQPVTESIY TEGLYEKNSP GESKTEQLLL QQQQREQLNQ QLVNNGYLLD 3200
KHTFQVEPMD TDVYREEDLE EEEDEDDDFS LKMATSACND HEMSDSEEPA 3250
VKDKISKILD NLTNDDCADS IATATTMEVD ASAGYQQMVE DVLATTAAQS 3300
APTEEFEGAL ETAAVEAAAT YINEMADAHV LDLKQLQNGV ELELRRRKEE 3350
QRTVSQEQEQ SKAAIVPTAA APEPPQPIQE PKKMTGPHLL YEIQSEDGFT 3400
YKSSSITEIW EKVFEAVQVA RRAHGLTPLP EGPLADMGGI QMIGLKTNAL 3450
KYLIEQLPGV EKCSKYTPKY HKRNGNVSTA ANGAHGGNLG GSSASAALSV 3500
SGGDSHGLLD YGSDQDELEE NAYDCARCEP YSNRSEYDMF SWLASRHRKQ 3550
PIQVFVQPSD NELVPRRGTG SNLPMAMKYR TLKETYKDYV GVFRSHIHGR 3600
GLYCTKDIEA GEMVIEYAGE LIRSTLTDKR ERYYDSRGIG CYMFKIDDNL 3650
VVDATMRGNA ARFINHCCEP NCYSKVVDIL GHKHIIIFAL RRIVQGEELT 3700
YDYKFPFEDE KIPCSCGSKR CRKYLN 3726
Length:3,726
Mass (Da):400,098
Last modified:March 2, 2010 - v4
Checksum:iE3DDB8F062BD7796
GO
Isoform B (identifier: P20659-2) [UniParc]FASTAAdd to Basket

Also known as: C, E

The sequence of this isoform differs from the canonical sequence as follows:
     1-368: Missing.

Show »
Length:3,358
Mass (Da):364,664
Checksum:i1382F25255A47E5B
GO

Sequence cautioni

The sequence AAK93328.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 368368Missing in isoform B.
VSP_006665Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 24911GTTSEATTSGL → LEQLVKQQPLV in AAA29025. 1 Publication
Add
BLAST
Sequence conflicti239 – 24911GTTSEATTSGL → LEQLVKQQPLV in CAA90513. 1 Publication
Add
BLAST
Sequence conflicti239 – 24911GTTSEATTSGL → LEQLVKQQPLV in CAA83516. 1 Publication
Add
BLAST
Sequence conflicti303 – 3031N → K in AAA29025. 1 Publication
Sequence conflicti303 – 3031N → K in CAA90513. 1 Publication
Sequence conflicti303 – 3031N → K in CAA83516. 1 Publication
Sequence conflicti337 – 3371A → L in AAA29025. 1 Publication
Sequence conflicti337 – 3371A → L in CAA90513. 1 Publication
Sequence conflicti337 – 3371A → L in CAA83516. 1 Publication
Sequence conflicti521 – 5211G → R in AAA29025. 1 Publication
Sequence conflicti521 – 5211G → R in CAA90513. 1 Publication
Sequence conflicti521 – 5211G → R in CAA90514. 1 Publication
Sequence conflicti521 – 5211G → R in CAA83515. 1 Publication
Sequence conflicti521 – 5211G → R in CAA83516. 1 Publication
Sequence conflicti578 – 5781E → Q in AAA29025. 1 Publication
Sequence conflicti578 – 5781E → Q in CAA90513. 1 Publication
Sequence conflicti578 – 5781E → Q in CAA90514. 1 Publication
Sequence conflicti578 – 5781E → Q in CAA83515. 1 Publication
Sequence conflicti578 – 5781E → Q in CAA83516. 1 Publication
Sequence conflicti587 – 5871V → A in AAA29025. 1 Publication
Sequence conflicti587 – 5871V → A in CAA90513. 1 Publication
Sequence conflicti587 – 5871V → A in CAA90514. 1 Publication
Sequence conflicti587 – 5871V → A in CAA83515. 1 Publication
Sequence conflicti587 – 5871V → A in CAA83516. 1 Publication
Sequence conflicti700 – 7001N → I in AAA29025. 1 Publication
Sequence conflicti700 – 7001N → I in CAA90513. 1 Publication
Sequence conflicti700 – 7001N → I in CAA90514. 1 Publication
Sequence conflicti700 – 7001N → I in CAA83515. 1 Publication
Sequence conflicti700 – 7001N → I in CAA83516. 1 Publication
Sequence conflicti720 – 7201T → A in AAA29025. 1 Publication
Sequence conflicti720 – 7201T → A in CAA90513. 1 Publication
Sequence conflicti720 – 7201T → A in CAA90514. 1 Publication
Sequence conflicti720 – 7201T → A in CAA83515. 1 Publication
Sequence conflicti720 – 7201T → A in CAA83516. 1 Publication
Sequence conflicti1073 – 10731K → P in AAA29025. 1 Publication
Sequence conflicti1073 – 10731K → P in CAA90513. 1 Publication
Sequence conflicti1073 – 10731K → P in CAA90514. 1 Publication
Sequence conflicti1073 – 10731K → P in CAA83515. 1 Publication
Sequence conflicti1073 – 10731K → P in CAA83516. 1 Publication
Sequence conflicti1529 – 15302KL → NV in AAA29025. 1 Publication
Sequence conflicti1529 – 15302KL → NV in CAA90513. 1 Publication
Sequence conflicti1529 – 15302KL → NV in CAA90514. 1 Publication
Sequence conflicti1529 – 15302KL → NV in CAA83515. 1 Publication
Sequence conflicti1529 – 15302KL → NV in CAA83516. 1 Publication
Sequence conflicti1594 – 15941S → P in AAA29025. 1 Publication
Sequence conflicti1594 – 15941S → P in CAA90513. 1 Publication
Sequence conflicti1594 – 15941S → P in CAA90514. 1 Publication
Sequence conflicti1594 – 15941S → P in CAA83515. 1 Publication
Sequence conflicti1594 – 15941S → P in CAA83516. 1 Publication
Sequence conflicti1627 – 16271A → E in AAA29025. 1 Publication
Sequence conflicti1627 – 16271A → E in CAA90513. 1 Publication
Sequence conflicti1627 – 16271A → E in CAA90514. 1 Publication
Sequence conflicti1627 – 16271A → E in CAA83515. 1 Publication
Sequence conflicti1627 – 16271A → E in CAA83516. 1 Publication
Sequence conflicti1690 – 16901T → A in AAA29025. 1 Publication
Sequence conflicti1690 – 16901T → A in CAA90513. 1 Publication
Sequence conflicti1690 – 16901T → A in CAA90514. 1 Publication
Sequence conflicti1690 – 16901T → A in CAA83515. 1 Publication
Sequence conflicti1690 – 16901T → A in CAA83516. 1 Publication
Sequence conflicti2010 – 20101E → Q in AAA29025. 1 Publication
Sequence conflicti2010 – 20101E → Q in CAA90513. 1 Publication
Sequence conflicti2010 – 20101E → Q in CAA90514. 1 Publication
Sequence conflicti2010 – 20101E → Q in CAA83515. 1 Publication
Sequence conflicti2010 – 20101E → Q in CAA83516. 1 Publication
Sequence conflicti2025 – 20251P → PWLTSPLKFLGLSTHGGLLL WLLLGVVVRLKQGG in AAA29025. 1 Publication
Sequence conflicti2341 – 23411S → R in CAA90513. 1 Publication
Sequence conflicti2341 – 23411S → R in CAA90514. 1 Publication
Sequence conflicti2341 – 23411S → R in CAA83515. 1 Publication
Sequence conflicti2341 – 23411S → R in CAA83516. 1 Publication
Sequence conflicti2365 – 23651S → N in AAA29025. 1 Publication
Sequence conflicti2365 – 23651S → N in CAA90513. 1 Publication
Sequence conflicti2365 – 23651S → N in CAA90514. 1 Publication
Sequence conflicti2365 – 23651S → N in CAA83515. 1 Publication
Sequence conflicti2365 – 23651S → N in CAA83516. 1 Publication
Sequence conflicti2392 – 23921S → G in CAA90513. 1 Publication
Sequence conflicti2392 – 23921S → G in CAA90514. 1 Publication
Sequence conflicti2392 – 23921S → G in CAA83515. 1 Publication
Sequence conflicti2392 – 23921S → G in CAA83516. 1 Publication
Sequence conflicti3157 – 31571E → Q in AAA29025. 1 Publication
Sequence conflicti3157 – 31571E → Q in CAA90513. 1 Publication
Sequence conflicti3157 – 31571E → Q in CAA90514. 1 Publication
Sequence conflicti3157 – 31571E → Q in CAA83515. 1 Publication
Sequence conflicti3157 – 31571E → Q in CAA83516. 1 Publication
Sequence conflicti3234 – 32341A → R in AAA29025. 1 Publication
Sequence conflicti3234 – 32341A → R in CAA90513. 1 Publication
Sequence conflicti3234 – 32341A → R in CAA90514. 1 Publication
Sequence conflicti3234 – 32341A → R in CAA83515. 1 Publication
Sequence conflicti3234 – 32341A → R in CAA83516. 1 Publication
Sequence conflicti3690 – 36901L → V in AAA29025. 1 Publication
Sequence conflicti3690 – 36901L → V in CAA90513. 1 Publication
Sequence conflicti3690 – 36901L → V in CAA90514. 1 Publication
Sequence conflicti3690 – 36901L → V in CAA83515. 1 Publication
Sequence conflicti3690 – 36901L → V in CAA83516. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31617 mRNA. Translation: AAA29025.1.
Z50152 Genomic DNA. Translation: CAA90514.1.
Z50152 Genomic DNA. Translation: CAA90513.1.
Z31725 Genomic DNA. Translation: CAA83516.1.
Z31725 Genomic DNA. Translation: CAA83515.1.
AE014297 Genomic DNA. Translation: AAF55041.2.
AE014297 Genomic DNA. Translation: AAN13599.1.
AE014297 Genomic DNA. Translation: AAN13600.1.
AE014297 Genomic DNA. Translation: AAN13601.1.
AE014297 Genomic DNA. Translation: AAX52951.1.
AY051904 mRNA. Translation: AAK93328.1. Different initiation.
PIRiA35085.
RefSeqiNP_001014621.1. NM_001014621.2. [P20659-2]
NP_476769.1. NM_057421.3. [P20659-1]
NP_476770.1. NM_057422.3. [P20659-2]
NP_599108.1. NM_134281.2. [P20659-2]
NP_599109.1. NM_134282.2. [P20659-1]
UniGeneiDm.6437.

Genome annotation databases

EnsemblMetazoaiFBtr0082947; FBpp0082406; FBgn0003862. [P20659-1]
FBtr0082950; FBpp0082409; FBgn0003862. [P20659-1]
GeneIDi41737.
KEGGidme:Dmel_CG8651.
UCSCiCG8651-RC. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31617 mRNA. Translation: AAA29025.1 .
Z50152 Genomic DNA. Translation: CAA90514.1 .
Z50152 Genomic DNA. Translation: CAA90513.1 .
Z31725 Genomic DNA. Translation: CAA83516.1 .
Z31725 Genomic DNA. Translation: CAA83515.1 .
AE014297 Genomic DNA. Translation: AAF55041.2 .
AE014297 Genomic DNA. Translation: AAN13599.1 .
AE014297 Genomic DNA. Translation: AAN13600.1 .
AE014297 Genomic DNA. Translation: AAN13601.1 .
AE014297 Genomic DNA. Translation: AAX52951.1 .
AY051904 mRNA. Translation: AAK93328.1 . Different initiation.
PIRi A35085.
RefSeqi NP_001014621.1. NM_001014621.2. [P20659-2 ]
NP_476769.1. NM_057421.3. [P20659-1 ]
NP_476770.1. NM_057422.3. [P20659-2 ]
NP_599108.1. NM_134281.2. [P20659-2 ]
NP_599109.1. NM_134282.2. [P20659-1 ]
UniGenei Dm.6437.

3D structure databases

ProteinModelPortali P20659.
SMRi P20659. Positions 1267-1296, 1343-1403, 1420-1523, 1737-1842, 3566-3726.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66813. 36 interactions.
IntActi P20659. 6 interactions.
MINTi MINT-907260.

Proteomic databases

PaxDbi P20659.
PRIDEi P20659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082947 ; FBpp0082406 ; FBgn0003862 . [P20659-1 ]
FBtr0082950 ; FBpp0082409 ; FBgn0003862 . [P20659-1 ]
GeneIDi 41737.
KEGGi dme:Dmel_CG8651.
UCSCi CG8651-RC. d. melanogaster.

Organism-specific databases

CTDi 41737.
FlyBasei FBgn0003862. trx.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00740000115089.
InParanoidi P20659.
KOi K09186.
OMAi ARCEPYS.
OrthoDBi EOG75XGJZ.
PhylomeDBi P20659.

Enzyme and pathway databases

SignaLinki P20659.

Miscellaneous databases

GenomeRNAii 41737.
NextBioi 825306.
PROi P20659.

Gene expression databases

Bgeei P20659.

Family and domain databases

Gene3Di 3.30.40.10. 3 hits.
InterProi IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR016569. MeTrfase_trithorax.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF010354. Methyltransferase_trithorax. 1 hit.
SMARTi SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 2 hits.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 2 hits.
PROSITEi PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 4 hits.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains."
    Mazo A.M., Huang D.-H., Mozer B.A., Dawid I.B.
    Proc. Natl. Acad. Sci. U.S.A. 87:2112-2116(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION.
  2. "The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts."
    Sedkov Y., Tillib S., Mizrokhi L., Mazo A.
    Development 120:1907-1917(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  3. "Conservation of structure and expression of the trithorax gene between Drosophila virilis and Drosophila melanogaster."
    Tillib S., Sedkov Y., Mizrokhi L., Mazo A.
    Mech. Dev. 53:113-122(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Oregon-R.
    Tissue: Embryo.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2970-3726 (ISOFORMS A/B).
    Strain: Berkeley.
    Tissue: Embryo.
  7. "Trithorax and ASH1 interact directly and associate with the trithorax group-responsive bxd region of the Ultrabithorax promoter."
    Rozovskaia T., Tillib S., Smith S., Sedkov Y., Rozenblatt-Rosen O., Petruk S., Yano T., Nakamura T., Ben-Simchon L., Gildea J., Croce C.M., Shearn A., Canaani E., Mazo A.
    Mol. Cell. Biol. 19:6441-6447(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ASH1.
  8. "Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins."
    Rozovskaia T., Rozenblatt-Rosen O., Sedkov Y., Burakov D., Yano T., Nakamura T., Petruck S., Ben-Simchon L., Croce C.M., Mazo A., Canaani E.
    Oncogene 19:351-357(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ASH1.
  9. "The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head."
    Kuzin B., Tillib S., Sedkov Y., Mizrokhi L., Mazo A.
    Genes Dev. 8:2478-2490(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. "Drosophila Enhancer of zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites."
    Czermin B., Melfi R., McCabe D., Seitz V., Imhof A., Pirrotta V.
    Cell 111:185-196(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYMATIC ACTIVITY.

Entry informationi

Entry nameiTRX_DROME
AccessioniPrimary (citable) accession number: P20659
Secondary accession number(s): A4V2V9
, A4V2W0, Q27255, Q27327, Q8INF9, Q960R2, Q9VFL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 2, 2010
Last modified: July 9, 2014
This is version 160 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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