P20655 (RIPS_MOMCO) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 31, 2011.
Version 55.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ribosome-inactivating protein momorcochin-S EC=3.2.2.22 Alternative name(s): rRNA N-glycosidase |
| Organism | Momordica cochinchinensis (Spiny bitter cucumber) |
| Taxonomic identifier | 3674 [NCBI] |
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Cucurbitales › Cucurbitaceae › Momordiceae › Momordica |
Protein attributes
| Sequence length | 30 AA. |
| Sequence status | Fragment. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Inactivates eukaryotic 60S ribosomal subunits. |
| Catalytic activity | Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. |
| Post-translational modification | Glycosylated. Ref.1 |
| Sequence similarities | Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Plant defense |
| Molecular function | Hydrolase Protein synthesis inhibitor Toxin |
| PTM | Glycoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | defense response Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of translationInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | rRNA N-glycosylase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Purification and properties of a new ribosome-inactivating protein with RNA N-glycosidase activity suitable for immunotoxin preparation from the seeds of Momordica cochinchinensis." Bolognesi A., Barbieri L., Carnicelli D., Abbondanza A., Cenini P., Falasca A.I., Dinota A., Stirpe F. Biochim. Biophys. Acta 993:287-292(1989) [PubMed: 2597699] [Abstract] Cited for: PROTEIN SEQUENCE, GLYCOSYLATION. Tissue: Seed. |
Cross-references
Sequence databases | |
|---|---|
| PIR | S07065. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR016138. Ribosome_inactivat_prot_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.420.10. Ribosome_inactivat_prot_sub1. 1 hit. |
| PROSITE | PS00275. SHIGA_RICIN. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIPS_MOMCO | ||||||||
| Accession | Primary (citable) accession number: P20655 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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