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P20654

- PP1_EMENI

UniProt

P20654 - PP1_EMENI

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Protein
Serine/threonine-protein phosphatase PP1
Gene
bimG, AN0410
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays an important role in the control of mitosis by reversing the action of the nimA kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Manganese 1 By similarity
Metal bindingi65 – 651Manganese 1 By similarity
Metal bindingi91 – 911Manganese 1 By similarity
Metal bindingi91 – 911Manganese 2 By similarity
Metal bindingi123 – 1231Manganese 2 By similarity
Active sitei124 – 1241Proton donor By similarity
Metal bindingi172 – 1721Manganese 2 By similarity
Metal bindingi247 – 2471Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. anisotropic cell growth Source: ASPGD
  2. chromosome segregation Source: ASPGD
  3. establishment of cell polarity Source: ASPGD
  4. mitotic nuclear division Source: UniProtKB-KW
  5. mitotic spindle elongation Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 (EC:3.1.3.16)
Gene namesi
Name:bimG
ORF Names:AN0410
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

GO - Cellular componenti

  1. cell septum Source: ASPGD
  2. nucleolus Source: ASPGD
  3. spindle pole body Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Serine/threonine-protein phosphatase PP1
PRO_0000058816Add
BLAST

Proteomic databases

PRIDEiP20654.

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00002289.

Structurei

3D structure databases

ProteinModelPortaliP20654.
SMRiP20654. Positions 1-308.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
KOiK06269.
OMAiMGDVMNI.
OrthoDBiEOG79KPQ9.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20654-1 [UniParc]FASTAAdd to Basket

« Hide

MADQDVDLDS IIDRLLEVRG SRPGKQVQLL ESEIRYLCTK AREIFISQPI    50
LLELEAPIKI CGDIHGQYYD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL 100
ETICLLLAYK IKYPENFFVL RGNHECASIN RIYGFYDECK RRYNIKLWKT 150
FTDCFNCLPI AAIIDEKIFT MHGGLSPDLN SMEQIRRVMR PTDIPDCGLL 200
CDLLWSDPDK DITGWSENDR GVSFTFGPDV VSRFLQKHDM DLICRAHQVV 250
EDGYEFFSKR QLVTLFSAPN YCGEFDNAGA MMSVDESLLC SFQILKPAEK 300
KQKYVYGAMS SGRPITPPRK QKK 323
Length:323
Mass (Da):37,176
Last modified:February 1, 1991 - v1
Checksum:i9CED43E15C5AA5BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27067 mRNA. Translation: AAA33299.1.
AACD01000007 Genomic DNA. Translation: EAA66509.1.
BN001308 Genomic DNA. Translation: CBF89542.1.
PIRiA32549.
RefSeqiXP_658014.1. XM_652922.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002289; CADANIAP00002289; CADANIAG00002289.
GeneIDi2876189.
KEGGiani:AN0410.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27067 mRNA. Translation: AAA33299.1 .
AACD01000007 Genomic DNA. Translation: EAA66509.1 .
BN001308 Genomic DNA. Translation: CBF89542.1 .
PIRi A32549.
RefSeqi XP_658014.1. XM_652922.1.

3D structure databases

ProteinModelPortali P20654.
SMRi P20654. Positions 1-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00002289.

Proteomic databases

PRIDEi P20654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00002289 ; CADANIAP00002289 ; CADANIAG00002289 .
GeneIDi 2876189.
KEGGi ani:AN0410.2.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172697.
KOi K06269.
OMAi MGDVMNI.
OrthoDBi EOG79KPQ9.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1."
    Doonan J.H., Morris N.R.
    Cell 57:987-996(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiPP1_EMENI
AccessioniPrimary (citable) accession number: P20654
Secondary accession number(s): C8VTH6, Q5BGC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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