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Protein

Serine/threonine-protein phosphatase PP1

Gene

bimG

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the control of mitosis by reversing the action of the nimA kinase.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Manganese 1By similarity1
Metal bindingi65Manganese 1By similarity1
Metal bindingi91Manganese 1By similarity1
Metal bindingi91Manganese 2By similarity1
Metal bindingi123Manganese 2By similarity1
Active sitei124Proton donorBy similarity1
Metal bindingi172Manganese 2By similarity1
Metal bindingi247Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • anisotropic cell growth Source: ASPGD
  • attachment of mitotic spindle microtubules to kinetochore Source: EnsemblFungi
  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: ASPGD
  • establishment of cell polarity Source: ASPGD
  • mitotic DNA damage checkpoint Source: EnsemblFungi
  • mitotic spindle elongation Source: ASPGD
  • negative regulation of chromosome condensation Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 (EC:3.1.3.16)
Gene namesi
Name:bimG
ORF Names:AN0410
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588161 – 323Serine/threonine-protein phosphatase PP1Add BLAST323

Proteomic databases

PRIDEiP20654.

Structurei

3D structure databases

ProteinModelPortaliP20654.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172697.
InParanoidiP20654.
KOiK06269.
OMAiKKPRYPP.
OrthoDBiEOG092C37EX.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQDVDLDS IIDRLLEVRG SRPGKQVQLL ESEIRYLCTK AREIFISQPI
60 70 80 90 100
LLELEAPIKI CGDIHGQYYD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL
110 120 130 140 150
ETICLLLAYK IKYPENFFVL RGNHECASIN RIYGFYDECK RRYNIKLWKT
160 170 180 190 200
FTDCFNCLPI AAIIDEKIFT MHGGLSPDLN SMEQIRRVMR PTDIPDCGLL
210 220 230 240 250
CDLLWSDPDK DITGWSENDR GVSFTFGPDV VSRFLQKHDM DLICRAHQVV
260 270 280 290 300
EDGYEFFSKR QLVTLFSAPN YCGEFDNAGA MMSVDESLLC SFQILKPAEK
310 320
KQKYVYGAMS SGRPITPPRK QKK
Length:323
Mass (Da):37,176
Last modified:February 1, 1991 - v1
Checksum:i9CED43E15C5AA5BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27067 mRNA. Translation: AAA33299.1.
AACD01000007 Genomic DNA. Translation: EAA66509.1.
BN001308 Genomic DNA. Translation: CBF89542.1.
PIRiA32549.
RefSeqiXP_658014.1. XM_652922.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002289; CADANIAP00002289; CADANIAG00002289.
EAA66509; EAA66509; AN0410.2.
GeneIDi2876189.
KEGGiani:AN0410.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27067 mRNA. Translation: AAA33299.1.
AACD01000007 Genomic DNA. Translation: EAA66509.1.
BN001308 Genomic DNA. Translation: CBF89542.1.
PIRiA32549.
RefSeqiXP_658014.1. XM_652922.1.

3D structure databases

ProteinModelPortaliP20654.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP20654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002289; CADANIAP00002289; CADANIAG00002289.
EAA66509; EAA66509; AN0410.2.
GeneIDi2876189.
KEGGiani:AN0410.2.

Phylogenomic databases

HOGENOMiHOG000172697.
InParanoidiP20654.
KOiK06269.
OMAiKKPRYPP.
OrthoDBiEOG092C37EX.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP1_EMENI
AccessioniPrimary (citable) accession number: P20654
Secondary accession number(s): C8VTH6, Q5BGC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.