P20651 (PP2BB_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 106.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform EC=3.1.3.16 Alternative name(s): CAM-PRP catalytic subunit Calmodulin-dependent calcineurin A subunit beta isoform | ||
| Gene names |
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| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus![]() |
Protein attributes
| Sequence length | 525 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. |
| Catalytic activity | A phosphoprotein + H2O = a protein + phosphate. |
| Cofactor | Binds 1 Fe3+ ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity. |
| Subunit structure | Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. |
| Sequence similarities | Belongs to the PPP phosphatase family. PP-2B subfamily. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 525 | 525 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | PRO_0000058827 | |||||
Regions | |||||||||
| Region | 1 – 310 | 310 | Catalytic | ||||||
| Region | 256 – 262 | 7 | Calcineurin B binding-site 1 Potential | ||||||
| Region | 305 – 310 | 6 | Calcineurin B binding-site 2 Potential | ||||||
| Region | 402 – 424 | 23 | Calmodulin-binding Potential | ||||||
| Region | 475 – 497 | 23 | Inhibitory domain | ||||||
| Compositional bias | 11 – 20 | 10 | Poly-Pro | ||||||
Sites | |||||||||
| Active site | 160 | 1 | Proton donor By similarity | ||||||
| Metal binding | 99 | 1 | Iron By similarity | ||||||
| Metal binding | 101 | 1 | Iron By similarity | ||||||
| Metal binding | 127 | 1 | Iron By similarity | ||||||
| Metal binding | 127 | 1 | Zinc By similarity | ||||||
| Metal binding | 159 | 1 | Zinc By similarity | ||||||
| Metal binding | 208 | 1 | Zinc By similarity | ||||||
| Metal binding | 290 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)." Kuno T., Takeda T., Hirai M., Ito A., Mukai H., Tanaka C. Biochem. Biophys. Res. Commun. 165:1352-1358(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells." Wadzinski B.E., Heasley L.E., Johnson G.L. J. Biol. Chem. 265:21504-21508(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 245-315. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M31809 mRNA. Translation: AAA40848.1. D90036 mRNA. Translation: BAA14084.1. M58441 mRNA. Translation: AAA41915.1. |
| IPI | IPI00201407. |
| PIR | A33794. |
| RefSeq | NP_058738.1. NM_017042.2. |
| UniGene | Rn.11063. Rn.136394. |
3D structure databases | |
| ProteinModelPortal | P20651. |
| SMR | P20651. Positions 24-381. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-66N. |
| STRING | 10116.ENSRNOP00000010476. |
PTM databases | |
| PhosphoSite | P20651. |
Proteomic databases | |
| PaxDb | P20651. |
| PRIDE | P20651. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 24675. |
| KEGG | rno:24675. |
| UCSC | RGD:3383. rat. |
Organism-specific databases | |
| CTD | 5532. |
| RGD | 3383. Ppp3cb. |
Phylogenomic databases | |
| eggNOG | COG0639. |
| HOGENOM | HOG000172699. |
| HOVERGEN | HBG002819. |
| InParanoid | P20651. |
| KO | K04348. |
| OrthoDB | EOG4PVNZK. |
Enzyme and pathway databases | |
| Reactome | REACT_111984. Signal Transduction. |
Gene expression databases | |
| ArrayExpress | P20651. |
| Genevestigator | P20651. |
| GermOnline | ENSRNOG00000007757. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view] |
| Pfam | PF00149. Metallophos. 1 hit. [Graphical view] |
| PRINTS | PR00114. STPHPHTASE. |
| SMART | SM00156. PP2Ac. 1 hit. [Graphical view] |
| PROSITE | PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 604059. |
Entry information
| Entry name | PP2BB_RAT | ||||||||
| Accession | Primary (citable) accession number: P20651 Secondary accession number(s): Q6LDJ7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
