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Protein

Potassium-transporting ATPase alpha chain 1

Gene

ATP4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3874-aspartylphosphate intermediateBy similarity1
Metal bindingi728MagnesiumBy similarity1
Metal bindingi732MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • ion transmembrane transport Source: Reactome
  • transport Source: ProtInc

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciMetaCyc:HS02790-MONOMER.
BRENDAi3.6.3.10. 2681.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105675.8.
HGNCiHGNC:819. ATP4A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 142LumenalSequence analysisAdd BLAST23
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 299CytoplasmicSequence analysisAdd BLAST136
Transmembranei300 – 319HelicalSequence analysisAdd BLAST20
Topological domaini320 – 331LumenalSequence analysisAdd BLAST12
Transmembranei332 – 349HelicalSequence analysisAdd BLAST18
Topological domaini350 – 783CytoplasmicSequence analysisAdd BLAST434
Transmembranei784 – 803HelicalSequence analysisAdd BLAST20
Topological domaini804 – 813LumenalSequence analysis10
Transmembranei814 – 834HelicalSequence analysisAdd BLAST21
Topological domaini835 – 854CytoplasmicSequence analysisAdd BLAST20
Transmembranei855 – 877HelicalSequence analysisAdd BLAST23
Topological domaini878 – 929LumenalSequence analysisAdd BLAST52
Transmembranei930 – 949HelicalSequence analysisAdd BLAST20
Topological domaini950 – 963CytoplasmicSequence analysisAdd BLAST14
Transmembranei964 – 982HelicalSequence analysisAdd BLAST19
Topological domaini983 – 997LumenalSequence analysisAdd BLAST15
Transmembranei998 – 1018HelicalSequence analysisAdd BLAST21
Topological domaini1019 – 1035CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi495.
MalaCardsiATP4A.
OpenTargetsiENSG00000105675.
PharmGKBiPA25113.

Chemistry databases

ChEMBLiCHEMBL2095173.
DrugBankiDB00736. Esomeprazole.
DB00448. Lansoprazole.
DB00338. Omeprazole.
DB00213. Pantoprazole.
DB01129. Rabeprazole.
DB05351. TAK-390MR.

Polymorphism and mutation databases

BioMutaiATP4A.
DMDMi148877240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462531 – 1035Potassium-transporting ATPase alpha chain 1Add BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphotyrosineBy similarity1
Modified residuei10PhosphotyrosineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei840PhosphoserineBy similarity1
Modified residuei954Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP20648.
MaxQBiP20648.
PaxDbiP20648.
PeptideAtlasiP20648.
PRIDEiP20648.

PTM databases

iPTMnetiP20648.
PhosphoSitePlusiP20648.
SwissPalmiP20648.

Expressioni

Tissue specificityi

Found in gastric mucosa.

Gene expression databases

BgeeiENSG00000105675.
CleanExiHS_ATP4A.
ExpressionAtlasiP20648. baseline and differential.
GenevisibleiP20648. HS.

Organism-specific databases

HPAiHPA039154.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridi106985. 89 interactors.
CORUMiP20648.
STRINGi9606.ENSP00000262623.

Chemistry databases

BindingDBiP20648.

Structurei

3D structure databases

ProteinModelPortaliP20648.
SMRiP20648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00890000139334.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP20648.
KOiK01542.
OMAiESDIMHL.
OrthoDBiEOG091G01BB.
PhylomeDBiP20648.
TreeFamiTF312838.

Family and domain databases

CDDicd02608. P-type_ATPase_Na-K_like. 1 hit.
Gene3Di3.40.1110.10. 2 hits.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR036412. HAD-like_sf.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

P20648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM
60 70 80 90 100
EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY
110 120 130 140 150
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV
160 170 180 190 200
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD
210 220 230 240 250
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET
260 270 280 290 300
RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE
310 320 330 340 350
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT
360 370 380 390 400
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS
410 420 430 440 450
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA
460 470 480 490 500
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ
510 520 530 540 550
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ
560 570 580 590 600
TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV
610 620 630 640 650
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE
660 670 680 690 700
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV
710 720 730 740 750
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS
760 770 780 790 800
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP
810 820 830 840 850
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP
860 870 880 890 900
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ
910 920 930 940 950
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT
960 970 980 990 1000
RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW
1010 1020 1030
LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY
Length:1,035
Mass (Da):114,119
Last modified:May 29, 2007 - v5
Checksum:iE320595E7D9E0E28
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019428265V → A1 PublicationCorresponds to variant dbSNP:rs2733743Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05451 Genomic DNA. Translation: AAA51010.1.
M63962 Genomic DNA. Translation: AAA35988.1.
AD000090 Genomic DNA. Translation: AAB50172.1.
AC002389 Genomic DNA. Translation: AAB64182.1.
M27575 Genomic DNA. Translation: AAA35577.1.
CCDSiCCDS12467.1.
PIRiA36558. A35292.
C27397.
RefSeqiNP_000695.2. NM_000704.2.
UniGeneiHs.36992.

Genome annotation databases

EnsembliENST00000262623; ENSP00000262623; ENSG00000105675.
GeneIDi495.
KEGGihsa:495.
UCSCiuc002oal.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiATP4A_HUMAN
AccessioniPrimary (citable) accession number: P20648
Secondary accession number(s): O00738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 29, 2007
Last modified: November 22, 2017
This is version 187 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families