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P20648

- ATP4A_HUMAN

UniProt

P20648 - ATP4A_HUMAN

Protein

Potassium-transporting ATPase alpha chain 1

Gene

ATP4A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 5 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

    Catalytic activityi

    ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei387 – 38714-aspartylphosphate intermediateBy similarity
    Metal bindingi728 – 7281MagnesiumBy similarity
    Metal bindingi732 – 7321MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydrogen:potassium-exchanging ATPase activity Source: ProtInc
    3. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. ATP hydrolysis coupled proton transport Source: InterPro
    3. ion transmembrane transport Source: Reactome
    4. pH reduction Source: Ensembl
    5. regulation of proton transport Source: Ensembl
    6. response to drug Source: Ensembl
    7. transmembrane transport Source: Reactome
    8. transport Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

    Enzyme and pathway databases

    BioCyciMetaCyc:HS02790-MONOMER.
    BRENDAi3.6.3.10. 2681.
    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Protein family/group databases

    TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
    Alternative name(s):
    Gastric H(+)/K(+) ATPase subunit alpha
    Proton pump
    Gene namesi
    Name:ATP4A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:819. ATP4A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25113.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 10351034Potassium-transporting ATPase alpha chain 1PRO_0000046253Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71PhosphotyrosineBy similarity
    Modified residuei10 – 101PhosphotyrosineBy similarity
    Modified residuei27 – 271PhosphoserineBy similarity
    Modified residuei954 – 9541Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP20648.
    PaxDbiP20648.
    PRIDEiP20648.

    PTM databases

    PhosphoSiteiP20648.

    Expressioni

    Tissue specificityi

    Found in gastric mucosa.

    Gene expression databases

    BgeeiP20648.
    CleanExiHS_ATP4A.
    GenevestigatoriP20648.

    Organism-specific databases

    HPAiHPA039154.

    Interactioni

    Subunit structurei

    Composed of two subunits: alpha (catalytic) and beta.

    Protein-protein interaction databases

    BioGridi106985. 77 interactions.
    STRINGi9606.ENSP00000262623.

    Structurei

    3D structure databases

    ProteinModelPortaliP20648.
    SMRiP20648. Positions 1-34, 43-1035.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 9897CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini120 – 14223LumenalSequence AnalysisAdd
    BLAST
    Topological domaini164 – 299136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini320 – 33112LumenalSequence AnalysisAdd
    BLAST
    Topological domaini350 – 783434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini804 – 81310LumenalSequence Analysis
    Topological domaini835 – 85420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini878 – 92952LumenalSequence AnalysisAdd
    BLAST
    Topological domaini950 – 96314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini983 – 99715LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1019 – 103517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei300 – 31920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 34918HelicalSequence AnalysisAdd
    BLAST
    Transmembranei784 – 80320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei814 – 83421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei855 – 87723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei930 – 94920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei964 – 98219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei998 – 101821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000265622.
    HOVERGENiHBG004298.
    InParanoidiP20648.
    KOiK01542.
    OMAiRVIVICQ.
    OrthoDBiEOG7327N0.
    PhylomeDBiP20648.
    TreeFamiTF312838.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR015127. ATPase_P-typ_H/K-transp_N.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF09040. H-K_ATPase_N. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20648-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM     50
    EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY 100
    VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV 150
    VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD 200
    LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET 250
    RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 300
    HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT 350
    VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS 400
    HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA 450
    VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ 500
    LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ 550
    TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 600
    SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE 650
    TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV 700
    FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS 750
    DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP 800
    YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP 850
    KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 900
    WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT 950
    RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW 1000
    LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY 1035
    Length:1,035
    Mass (Da):114,119
    Last modified:May 29, 2007 - v5
    Checksum:iE320595E7D9E0E28
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti265 – 2651V → A.1 Publication
    Corresponds to variant rs2733743 [ dbSNP | Ensembl ].
    VAR_019428

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05451 Genomic DNA. Translation: AAA51010.1.
    M63962 Genomic DNA. Translation: AAA35988.1.
    AD000090 Genomic DNA. Translation: AAB50172.1.
    AC002389 Genomic DNA. Translation: AAB64182.1.
    M27575 Genomic DNA. Translation: AAA35577.1.
    CCDSiCCDS12467.1.
    PIRiA36558. A35292.
    C27397.
    RefSeqiNP_000695.2. NM_000704.2.
    UniGeneiHs.36992.

    Genome annotation databases

    EnsembliENST00000262623; ENSP00000262623; ENSG00000105675.
    GeneIDi495.
    KEGGihsa:495.
    UCSCiuc002oal.1. human.

    Polymorphism databases

    DMDMi148877240.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05451 Genomic DNA. Translation: AAA51010.1 .
    M63962 Genomic DNA. Translation: AAA35988.1 .
    AD000090 Genomic DNA. Translation: AAB50172.1 .
    AC002389 Genomic DNA. Translation: AAB64182.1 .
    M27575 Genomic DNA. Translation: AAA35577.1 .
    CCDSi CCDS12467.1.
    PIRi A36558. A35292.
    C27397.
    RefSeqi NP_000695.2. NM_000704.2.
    UniGenei Hs.36992.

    3D structure databases

    ProteinModelPortali P20648.
    SMRi P20648. Positions 1-34, 43-1035.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106985. 77 interactions.
    STRINGi 9606.ENSP00000262623.

    Chemistry

    BindingDBi P20648.
    ChEMBLi CHEMBL2095173.
    DrugBanki DB00736. Esomeprazole.
    DB00448. Lansoprazole.
    DB00338. Omeprazole.
    DB00213. Pantoprazole.
    DB01129. Rabeprazole.
    GuidetoPHARMACOLOGYi 849.

    Protein family/group databases

    TCDBi 3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

    PTM databases

    PhosphoSitei P20648.

    Polymorphism databases

    DMDMi 148877240.

    Proteomic databases

    MaxQBi P20648.
    PaxDbi P20648.
    PRIDEi P20648.

    Protocols and materials databases

    DNASUi 495.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262623 ; ENSP00000262623 ; ENSG00000105675 .
    GeneIDi 495.
    KEGGi hsa:495.
    UCSCi uc002oal.1. human.

    Organism-specific databases

    CTDi 495.
    GeneCardsi GC19M036540.
    HGNCi HGNC:819. ATP4A.
    HPAi HPA039154.
    MIMi 137216. gene.
    neXtProti NX_P20648.
    PharmGKBi PA25113.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000265622.
    HOVERGENi HBG004298.
    InParanoidi P20648.
    KOi K01542.
    OMAi RVIVICQ.
    OrthoDBi EOG7327N0.
    PhylomeDBi P20648.
    TreeFami TF312838.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS02790-MONOMER.
    BRENDAi 3.6.3.10. 2681.
    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    GenomeRNAii 495.
    NextBioi 2079.
    PROi P20648.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20648.
    CleanExi HS_ATP4A.
    Genevestigatori P20648.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR015127. ATPase_P-typ_H/K-transp_N.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF09040. H-K_ATPase_N. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region."
      Maeda M., Oshiman K., Tamura S., Futai M.
      J. Biol. Chem. 265:9027-9032(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-265.
    2. "Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes."
      Newman P.R., Greeb J., Keeton T.P., Reyes A.A., Shull G.E.
      DNA Cell Biol. 9:749-762(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 355-401.
      Tissue: Brain and Placenta.

    Entry informationi

    Entry nameiATP4A_HUMAN
    AccessioniPrimary (citable) accession number: P20648
    Secondary accession number(s): O00738
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 157 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3