Potassium-transporting ATPase alpha chain 1

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P20648 (ATP4A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 131. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium-transporting ATPase alpha chain 1
EC=3.6.3.10

Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump

Gene names

Name:

ATP4A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1035 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. Responsible for acid production in the stomach.
Catalytic activity	ATP + H₂O + H⁺(In) + K⁺(Out) = ADP + phosphate + H⁺(Out) + K⁺(In).
Subunit structure	Composed of two subunits: alpha (catalytic) and beta.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Found in gastric mucosa.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding Potassium
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hydrogen:potassium-exchanging ATPase activity Traceable author statement. Source: Reactome magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 1035

1034

Potassium-transporting ATPase alpha chain 1

PRO_0000046253

Regions

Topological domain

2 – 98

Cytoplasmic Potential

Transmembrane

99 – 119

Helical; Potential

Topological domain

120 – 142

Lumenal Potential

Transmembrane

143 – 163

Helical; Potential

Topological domain

164 – 299

136

Cytoplasmic Potential

Transmembrane

300 – 319

Helical; Potential

Topological domain

320 – 331

Lumenal Potential

Transmembrane

332 – 349

Helical; Potential

Topological domain

350 – 783

434

Cytoplasmic Potential

Transmembrane

784 – 803

Helical; Potential

Topological domain

804 – 813

Lumenal Potential

Transmembrane

814 – 834

Helical; Potential

Topological domain

835 – 854

Cytoplasmic Potential

Transmembrane

855 – 877

Helical; Potential

Topological domain

878 – 929

Lumenal Potential

Transmembrane

930 – 949

Helical; Potential

Topological domain

950 – 963

Cytoplasmic Potential

Transmembrane

964 – 982

Helical; Potential

Topological domain

983 – 997

Lumenal Potential

Transmembrane

998 – 1018

Helical; Potential

Topological domain

1019 – 1035

Cytoplasmic Potential

Sites

Active site

387

4-aspartylphosphate intermediate By similarity

Metal binding

728

Magnesium By similarity

Metal binding

732

Magnesium By similarity

Amino acid modifications

Modified residue

954

Phosphoserine; by PKA By similarity

Natural variations

Natural variant

265

V → A. Ref.1
Corresponds to variant rs2733743 [ dbSNP | Ensembl ].

VAR_019428

Sequences

Sequence

Length

Mass (Da)

Tools

P20648 [UniParc].

Last modified May 29, 2007. Version 5.
Checksum: E320595E7D9E0E28
Show »

FASTA

1,035

114,119

        10         20         30         40         50         60 
MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA 

        70         80         90        100        110        120 
ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA 

       130        140        150        160        170        180 
ICLIAFAIQA SEGDLTTDDN LYLAIALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA 

       190        200        210        220        230        240 
TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP 

       250        260        270        280        290        300 
ECTHESPLET RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 

       310        320        330        340        350        360 
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK 

       370        380        390        400        410        420 
RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ 

       430        440        450        460        470        480 
TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG 

       490        500        510        520        530        540 
YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP 

       550        560        570        580        590        600 
LDEQWREAFQ TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 

       610        620        630        640        650        660 
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR 

       670        680        690        700        710        720 
VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG 

       730        740        750        760        770        780 
AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF 

       790        800        810        820        830        840 
DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES 

       850        860        870        880        890        900 
DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 

       910        920        930        940        950        960 
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT RRLSAFQQGF 

       970        980        990       1000       1010       1020 
FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPLPYGILI FVYDEIRKLG 

      1030 
VRCCPGSWWD QELYY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region." Maeda M., Oshiman K., Tamura S., Futai M. J. Biol. Chem. 265:9027-9032(1990) [PubMed: 2160952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-265.
[2]	"Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes." Newman P.R., Greeb J., Keeton T.P., Reyes A.A., Shull G.E. DNA Cell Biol. 9:749-762(1990) [PubMed: 2176086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit." Sverdlov E.D., Monastyrskaya G.S., Broude N.E., Ushkaryov Y.A., Allikmets R.L., Melkov A.M., Smirnov Y.V., Malyshev I.V., Dulubova I.E., Petrukhin K.E., Gryshin A.V., Kiyatkin N.I., Kostina M.B., Sverdlov V.E., Modyanov N.N., Ovchinnikov Y.A. FEBS Lett. 217:275-278(1987) [PubMed: 3036582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 355-401. Tissue: Brain and Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J05451 Genomic DNA. Translation: AAA51010.1. M63962 Genomic DNA. Translation: AAA35988.1. AD000090 Genomic DNA. Translation: AAB50172.1. AC002389 Genomic DNA. Translation: AAB64182.1. M27575 Genomic DNA. Translation: AAA35577.1.
IPI	IPI00218919.
PIR	A35292. A36558. C27397.
RefSeq	NP_000695.2. NM_000704.2.
UniGene	Hs.36992.
3D structure databases
ProteinModelPortal	P20648.
SMR	P20648. Positions 1-34, 50-1035.
ModBase	Search...
Protein-protein interaction databases
STRING	P20648.
Protein family/group databases
TCDB	3.A.3.1.2. P-type ATPase (P-ATPase) superfamily.
PTM databases
PhosphoSite	P20648.
Polymorphism databases
DMDM	148877240.
Proteomic databases
PRIDE	P20648.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262623; ENSP00000262623; ENSG00000105675.
GeneID	495.
KEGG	hsa:495.
UCSC	uc002oal.1. human.
Organism-specific databases
CTD	495.
GeneCards	GC19M036041.
HGNC	HGNC:819. ATP4A.
HPA	HPA039154.
MIM	137216. gene.
neXtProt	NX_P20648.
PharmGKB	PA25113.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12961.
HOGENOM	HBG456486.
HOVERGEN	HBG004298.
InParanoid	P20648.
OMA	FIVAMCI.
OrthoDB	EOG41C6VF.
PhylomeDB	P20648.
Enzyme and pathway databases
BioCyc	MetaCyc:HS02790-MONOMER.
BRENDA	3.6.3.10. 2681.
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P20648.
Bgee	P20648.
CleanEx	HS_ATP4A.
Genevestigator	P20648.
GermOnline	ENSG00000105675. Homo sapiens.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR005775. ATPase_P-typ_cation-ex_asu_euk. IPR006069. ATPase_P-typ_cation-exchng_asu. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR015127. ATPase_P-typ_H/K-transp_N. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
KO	K01542.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF09040. H-K_ATPase_N. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00121. NAKATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01106. ATPase-IIC_X-K. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00736. Esomeprazole. DB00448. Lansoprazole. DB00338. Omeprazole. DB00213. Pantoprazole. DB01129. Rabeprazole. DB00831. Trifluoperazine.
NextBio	2079.
SOURCE	Search...

Entry information

Entry name

ATP4A_HUMAN

Accession

Primary (citable) accession number: P20648
Secondary accession number(s): O00738

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	May 29, 2007
Last modified:	January 25, 2012
This is version 131 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents