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P20648

- ATP4A_HUMAN

UniProt

P20648 - ATP4A_HUMAN

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Protein
Potassium-transporting ATPase alpha chain 1
Gene
ATP4A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei387 – 38714-aspartylphosphate intermediate By similarity
Metal bindingi728 – 7281Magnesium By similarity
Metal bindingi732 – 7321Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrogen:potassium-exchanging ATPase activity Source: ProtInc
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. ATP hydrolysis coupled proton transport Source: InterPro
  3. ion transmembrane transport Source: Reactome
  4. pH reduction Source: Ensembl
  5. regulation of proton transport Source: Ensembl
  6. response to drug Source: Ensembl
  7. transmembrane transport Source: Reactome
  8. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciMetaCyc:HS02790-MONOMER.
BRENDAi3.6.3.10. 2681.
ReactomeiREACT_25149. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:819. ATP4A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 9897Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei99 – 11921Helical; Reviewed prediction
Add
BLAST
Topological domaini120 – 14223Lumenal Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Topological domaini164 – 299136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei300 – 31920Helical; Reviewed prediction
Add
BLAST
Topological domaini320 – 33112Lumenal Reviewed prediction
Add
BLAST
Transmembranei332 – 34918Helical; Reviewed prediction
Add
BLAST
Topological domaini350 – 783434Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei784 – 80320Helical; Reviewed prediction
Add
BLAST
Topological domaini804 – 81310Lumenal Reviewed prediction
Transmembranei814 – 83421Helical; Reviewed prediction
Add
BLAST
Topological domaini835 – 85420Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei855 – 87723Helical; Reviewed prediction
Add
BLAST
Topological domaini878 – 92952Lumenal Reviewed prediction
Add
BLAST
Transmembranei930 – 94920Helical; Reviewed prediction
Add
BLAST
Topological domaini950 – 96314Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei964 – 98219Helical; Reviewed prediction
Add
BLAST
Topological domaini983 – 99715Lumenal Reviewed prediction
Add
BLAST
Transmembranei998 – 101821Helical; Reviewed prediction
Add
BLAST
Topological domaini1019 – 103517Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 10351034Potassium-transporting ATPase alpha chain 1
PRO_0000046253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphotyrosine By similarity
Modified residuei10 – 101Phosphotyrosine By similarity
Modified residuei27 – 271Phosphoserine By similarity
Modified residuei954 – 9541Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP20648.
PaxDbiP20648.
PRIDEiP20648.

PTM databases

PhosphoSiteiP20648.

Expressioni

Tissue specificityi

Found in gastric mucosa.

Gene expression databases

BgeeiP20648.
CleanExiHS_ATP4A.
GenevestigatoriP20648.

Organism-specific databases

HPAiHPA039154.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridi106985. 77 interactions.
STRINGi9606.ENSP00000262623.

Structurei

3D structure databases

ProteinModelPortaliP20648.
SMRiP20648. Positions 1-34, 43-1035.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP20648.
KOiK01542.
OMAiRVIVICQ.
OrthoDBiEOG7327N0.
PhylomeDBiP20648.
TreeFamiTF312838.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20648-1 [UniParc]FASTAAdd to Basket

« Hide

MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM     50
EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY 100
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV 150
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD 200
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET 250
RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 300
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT 350
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS 400
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA 450
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ 500
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ 550
TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV 600
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE 650
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV 700
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS 750
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP 800
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP 850
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ 900
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT 950
RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW 1000
LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY 1035
Length:1,035
Mass (Da):114,119
Last modified:May 29, 2007 - v5
Checksum:iE320595E7D9E0E28
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti265 – 2651V → A.1 Publication
Corresponds to variant rs2733743 [ dbSNP | Ensembl ].
VAR_019428

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05451 Genomic DNA. Translation: AAA51010.1.
M63962 Genomic DNA. Translation: AAA35988.1.
AD000090 Genomic DNA. Translation: AAB50172.1.
AC002389 Genomic DNA. Translation: AAB64182.1.
M27575 Genomic DNA. Translation: AAA35577.1.
CCDSiCCDS12467.1.
PIRiA36558. A35292.
C27397.
RefSeqiNP_000695.2. NM_000704.2.
UniGeneiHs.36992.

Genome annotation databases

EnsembliENST00000262623; ENSP00000262623; ENSG00000105675.
GeneIDi495.
KEGGihsa:495.
UCSCiuc002oal.1. human.

Polymorphism databases

DMDMi148877240.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05451 Genomic DNA. Translation: AAA51010.1 .
M63962 Genomic DNA. Translation: AAA35988.1 .
AD000090 Genomic DNA. Translation: AAB50172.1 .
AC002389 Genomic DNA. Translation: AAB64182.1 .
M27575 Genomic DNA. Translation: AAA35577.1 .
CCDSi CCDS12467.1.
PIRi A36558. A35292.
C27397.
RefSeqi NP_000695.2. NM_000704.2.
UniGenei Hs.36992.

3D structure databases

ProteinModelPortali P20648.
SMRi P20648. Positions 1-34, 43-1035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106985. 77 interactions.
STRINGi 9606.ENSP00000262623.

Chemistry

BindingDBi P20648.
ChEMBLi CHEMBL2095173.
DrugBanki DB00736. Esomeprazole.
DB00448. Lansoprazole.
DB00338. Omeprazole.
DB00213. Pantoprazole.
DB01129. Rabeprazole.
DB00831. Trifluoperazine.
GuidetoPHARMACOLOGYi 849.

Protein family/group databases

TCDBi 3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSitei P20648.

Polymorphism databases

DMDMi 148877240.

Proteomic databases

MaxQBi P20648.
PaxDbi P20648.
PRIDEi P20648.

Protocols and materials databases

DNASUi 495.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262623 ; ENSP00000262623 ; ENSG00000105675 .
GeneIDi 495.
KEGGi hsa:495.
UCSCi uc002oal.1. human.

Organism-specific databases

CTDi 495.
GeneCardsi GC19M036540.
HGNCi HGNC:819. ATP4A.
HPAi HPA039154.
MIMi 137216. gene.
neXtProti NX_P20648.
PharmGKBi PA25113.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
HOGENOMi HOG000265622.
HOVERGENi HBG004298.
InParanoidi P20648.
KOi K01542.
OMAi RVIVICQ.
OrthoDBi EOG7327N0.
PhylomeDBi P20648.
TreeFami TF312838.

Enzyme and pathway databases

BioCyci MetaCyc:HS02790-MONOMER.
BRENDAi 3.6.3.10. 2681.
Reactomei REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii 495.
NextBioi 2079.
PROi P20648.
SOURCEi Search...

Gene expression databases

Bgeei P20648.
CleanExi HS_ATP4A.
Genevestigatori P20648.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region."
    Maeda M., Oshiman K., Tamura S., Futai M.
    J. Biol. Chem. 265:9027-9032(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-265.
  2. "Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes."
    Newman P.R., Greeb J., Keeton T.P., Reyes A.A., Shull G.E.
    DNA Cell Biol. 9:749-762(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 355-401.
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiATP4A_HUMAN
AccessioniPrimary (citable) accession number: P20648
Secondary accession number(s): O00738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 156 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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