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Protein

Potassium-transporting ATPase alpha chain 1

Gene

ATP4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei387 – 38714-aspartylphosphate intermediateBy similarity
Metal bindingi728 – 7281MagnesiumBy similarity
Metal bindingi732 – 7321MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrogen:potassium-exchanging ATPase activity Source: ProtInc
  3. magnesium ion binding Source: InterPro
  4. sodium:potassium-exchanging ATPase activity Source: InterPro

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. ion transmembrane transport Source: Reactome
  3. pH reduction Source: Ensembl
  4. regulation of proton transport Source: Ensembl
  5. response to drug Source: Ensembl
  6. transmembrane transport Source: Reactome
  7. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciMetaCyc:HS02790-MONOMER.
BRENDAi3.6.3.10. 2681.
ReactomeiREACT_25149. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:819. ATP4A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 9897CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence AnalysisAdd
BLAST
Topological domaini120 – 14223LumenalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 299136CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei300 – 31920HelicalSequence AnalysisAdd
BLAST
Topological domaini320 – 33112LumenalSequence AnalysisAdd
BLAST
Transmembranei332 – 34918HelicalSequence AnalysisAdd
BLAST
Topological domaini350 – 783434CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei784 – 80320HelicalSequence AnalysisAdd
BLAST
Topological domaini804 – 81310LumenalSequence Analysis
Transmembranei814 – 83421HelicalSequence AnalysisAdd
BLAST
Topological domaini835 – 85420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei855 – 87723HelicalSequence AnalysisAdd
BLAST
Topological domaini878 – 92952LumenalSequence AnalysisAdd
BLAST
Transmembranei930 – 94920HelicalSequence AnalysisAdd
BLAST
Topological domaini950 – 96314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei964 – 98219HelicalSequence AnalysisAdd
BLAST
Topological domaini983 – 99715LumenalSequence AnalysisAdd
BLAST
Transmembranei998 – 101821HelicalSequence AnalysisAdd
BLAST
Topological domaini1019 – 103517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 10351034Potassium-transporting ATPase alpha chain 1PRO_0000046253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphotyrosineBy similarity
Modified residuei10 – 101PhosphotyrosineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei954 – 9541Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP20648.
PaxDbiP20648.
PRIDEiP20648.

PTM databases

PhosphoSiteiP20648.

Expressioni

Tissue specificityi

Found in gastric mucosa.

Gene expression databases

BgeeiP20648.
CleanExiHS_ATP4A.
GenevestigatoriP20648.

Organism-specific databases

HPAiHPA039154.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridi106985. 86 interactions.
STRINGi9606.ENSP00000262623.

Structurei

3D structure databases

SMRiP20648. Positions 1-34, 43-1035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00760000119003.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP20648.
KOiK01542.
OMAiHVMNSIL.
OrthoDBiEOG7327N0.
PhylomeDBiP20648.
TreeFamiTF312838.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKAENYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM
60 70 80 90 100
EINDHQLSVA ELEQKYQTSA TKGLSASLAA ELLLRDGPNA LRPPRGTPEY
110 120 130 140 150
VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLAIALIAV
160 170 180 190 200
VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD
210 220 230 240 250
LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET
260 270 280 290 300
RNIAFFSTMC LEGTVQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE
310 320 330 340 350
HFVDIIAGLA ILFGATFFIV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT
360 370 380 390 400
VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS
410 420 430 440 450
HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA
460 470 480 490 500
VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ
510 520 530 540 550
LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ
560 570 580 590 600
TAYLSLGGLG ERVLGFCQLY LNEKDYPPGY AFDVEAMNFP SSGLCFAGLV
610 620 630 640 650
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE
660 670 680 690 700
TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV
710 720 730 740 750
FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS
760 770 780 790 800
DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP
810 820 830 840 850
YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP
860 870 880 890 900
KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRAQ
910 920 930 940 950
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEVC QIADVLIRKT
960 970 980 990 1000
RRLSAFQQGF FRNKILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW
1010 1020 1030
LVPLPYGILI FVYDEIRKLG VRCCPGSWWD QELYY
Length:1,035
Mass (Da):114,119
Last modified:May 29, 2007 - v5
Checksum:iE320595E7D9E0E28
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti265 – 2651V → A.1 Publication
Corresponds to variant rs2733743 [ dbSNP | Ensembl ].
VAR_019428

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05451 Genomic DNA. Translation: AAA51010.1.
M63962 Genomic DNA. Translation: AAA35988.1.
AD000090 Genomic DNA. Translation: AAB50172.1.
AC002389 Genomic DNA. Translation: AAB64182.1.
M27575 Genomic DNA. Translation: AAA35577.1.
CCDSiCCDS12467.1.
PIRiA36558. A35292.
C27397.
RefSeqiNP_000695.2. NM_000704.2.
UniGeneiHs.36992.

Genome annotation databases

EnsembliENST00000262623; ENSP00000262623; ENSG00000105675.
GeneIDi495.
KEGGihsa:495.
UCSCiuc002oal.1. human.

Polymorphism databases

DMDMi148877240.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05451 Genomic DNA. Translation: AAA51010.1.
M63962 Genomic DNA. Translation: AAA35988.1.
AD000090 Genomic DNA. Translation: AAB50172.1.
AC002389 Genomic DNA. Translation: AAB64182.1.
M27575 Genomic DNA. Translation: AAA35577.1.
CCDSiCCDS12467.1.
PIRiA36558. A35292.
C27397.
RefSeqiNP_000695.2. NM_000704.2.
UniGeneiHs.36992.

3D structure databases

SMRiP20648. Positions 1-34, 43-1035.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106985. 86 interactions.
STRINGi9606.ENSP00000262623.

Chemistry

BindingDBiP20648.
ChEMBLiCHEMBL2095173.
DrugBankiDB00736. Esomeprazole.
DB00448. Lansoprazole.
DB00338. Omeprazole.
DB00213. Pantoprazole.
DB01129. Rabeprazole.
GuidetoPHARMACOLOGYi849.

Protein family/group databases

TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSiteiP20648.

Polymorphism databases

DMDMi148877240.

Proteomic databases

MaxQBiP20648.
PaxDbiP20648.
PRIDEiP20648.

Protocols and materials databases

DNASUi495.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262623; ENSP00000262623; ENSG00000105675.
GeneIDi495.
KEGGihsa:495.
UCSCiuc002oal.1. human.

Organism-specific databases

CTDi495.
GeneCardsiGC19M037058.
HGNCiHGNC:819. ATP4A.
HPAiHPA039154.
MIMi137216. gene.
neXtProtiNX_P20648.
PharmGKBiPA25113.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00760000119003.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP20648.
KOiK01542.
OMAiHVMNSIL.
OrthoDBiEOG7327N0.
PhylomeDBiP20648.
TreeFamiTF312838.

Enzyme and pathway databases

BioCyciMetaCyc:HS02790-MONOMER.
BRENDAi3.6.3.10. 2681.
ReactomeiREACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii495.
NextBioi2079.
PROiP20648.
SOURCEiSearch...

Gene expression databases

BgeeiP20648.
CleanExiHS_ATP4A.
GenevestigatoriP20648.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR015127. ATPase_P-typ_H/K-transp_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF09040. H-K_ATPase_N. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region."
    Maeda M., Oshiman K., Tamura S., Futai M.
    J. Biol. Chem. 265:9027-9032(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-265.
  2. "Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes."
    Newman P.R., Greeb J., Keeton T.P., Reyes A.A., Shull G.E.
    DNA Cell Biol. 9:749-762(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 355-401.
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiATP4A_HUMAN
AccessioniPrimary (citable) accession number: P20648
Secondary accession number(s): O00738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 29, 2007
Last modified: April 1, 2015
This is version 161 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.