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P20645

- MPRD_HUMAN

UniProt

P20645 - MPRD_HUMAN

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Protein

Cation-dependent mannose-6-phosphate receptor

Gene

M6PR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

GO - Molecular functioni

  1. mannose binding Source: InterPro
  2. mannose transmembrane transporter activity Source: InterPro
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. endosome to lysosome transport Source: ProtInc
  2. receptor-mediated endocytosis Source: ProtInc
  3. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_19287. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name:
CD Man-6-P receptor
Short name:
CD-MPR
Alternative name(s):
46 kDa mannose 6-phosphate receptor
Short name:
MPR 46
Gene namesi
Name:M6PR
Synonyms:MPR46, MPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6752. M6PR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 185159LumenalSequence AnalysisAdd
BLAST
Transmembranei186 – 21025HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 27767CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endosome Source: MGI
  2. integral component of plasma membrane Source: ProtInc
  3. late endosome Source: Ensembl
  4. lysosome Source: UniProtKB-KW
  5. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 277251Cation-dependent mannose-6-phosphate receptorPRO_0000019226Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)1 Publication
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)1 Publication
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Modified residuei267 – 2671PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP20645.
PaxDbiP20645.
PeptideAtlasiP20645.
PRIDEiP20645.

PTM databases

PhosphoSiteiP20645.

Expressioni

Gene expression databases

BgeeiP20645.
CleanExiHS_M6PR.
ExpressionAtlasiP20645. baseline and differential.
GenevestigatoriP20645.

Organism-specific databases

HPAiCAB034464.

Interactioni

Subunit structurei

Homodimer. Binds GGA1, GGA2 and GGA3.

Protein-protein interaction databases

BioGridi110251. 20 interactions.
IntActiP20645. 5 interactions.
MINTiMINT-4999970.
STRINGi9606.ENSP00000000412.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JUQX-ray2.20E/F/G/H265-277[»]
ProteinModelPortaliP20645.
SMRiP20645. Positions 27-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45234.
GeneTreeiENSGT00390000002109.
HOGENOMiHOG000013085.
HOVERGENiHBG006395.
InParanoidiP20645.
KOiK10089.
OMAiSDWIMLI.
PhylomeDBiP20645.
TreeFamiTF328910.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR028927. Man-6-P_rcpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR000296. Man_6_P_rcpt.
[Graphical view]
PfamiPF02157. Man-6-P_recep. 1 hit.
[Graphical view]
PRINTSiPR00715. MAN6PRECEPTR.
SUPFAMiSSF50911. SSF50911. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20645-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK
60 70 80 90 100
RLKPLFNKSF ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE
110 120 130 140 150
TVVGRLNETH IFNGSNWIML IYKGGDEYDN HCGKEQRRAV VMISCNRHTL
160 170 180 190 200
ADNFNPVSEE RGKVQDCFYL FEMDSSLACS PEISHLSVGS ILLVTFASLV
210 220 230 240 250
AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC DFVCRSKPRN
260 270
VPAAYRGVGD DQLGEESEER DDHLLPM
Length:277
Mass (Da):30,993
Last modified:February 1, 1991 - v1
Checksum:i1093FE25DEB6C8E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16985 mRNA. Translation: AAA59542.1.
X56254
, X56255, X56256, X56257 Genomic DNA. Translation: CAB94715.1.
AK291143 mRNA. Translation: BAF83832.1.
CH471116 Genomic DNA. Translation: EAW88596.1.
CH471116 Genomic DNA. Translation: EAW88597.1.
CH471116 Genomic DNA. Translation: EAW88598.1.
CH471116 Genomic DNA. Translation: EAW88599.1.
BC024206 mRNA. Translation: AAH24206.1.
CCDSiCCDS8598.1.
PIRiS15368. A32700.
RefSeqiNP_002346.1. NM_002355.3.
XP_005253433.1. XM_005253376.1.
UniGeneiHs.134084.
Hs.744902.

Genome annotation databases

EnsembliENST00000000412; ENSP00000000412; ENSG00000003056.
GeneIDi4074.
KEGGihsa:4074.
UCSCiuc001qvf.3. human.

Polymorphism databases

DMDMi127293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16985 mRNA. Translation: AAA59542.1 .
X56254
, X56255 , X56256 , X56257 Genomic DNA. Translation: CAB94715.1 .
AK291143 mRNA. Translation: BAF83832.1 .
CH471116 Genomic DNA. Translation: EAW88596.1 .
CH471116 Genomic DNA. Translation: EAW88597.1 .
CH471116 Genomic DNA. Translation: EAW88598.1 .
CH471116 Genomic DNA. Translation: EAW88599.1 .
BC024206 mRNA. Translation: AAH24206.1 .
CCDSi CCDS8598.1.
PIRi S15368. A32700.
RefSeqi NP_002346.1. NM_002355.3.
XP_005253433.1. XM_005253376.1.
UniGenei Hs.134084.
Hs.744902.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JUQ X-ray 2.20 E/F/G/H 265-277 [» ]
ProteinModelPortali P20645.
SMRi P20645. Positions 27-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110251. 20 interactions.
IntActi P20645. 5 interactions.
MINTi MINT-4999970.
STRINGi 9606.ENSP00000000412.

Chemistry

BindingDBi P20645.
ChEMBLi CHEMBL5788.
DrugBanki DB01272. Alglucosidase alfa.

PTM databases

PhosphoSitei P20645.

Polymorphism databases

DMDMi 127293.

Proteomic databases

MaxQBi P20645.
PaxDbi P20645.
PeptideAtlasi P20645.
PRIDEi P20645.

Protocols and materials databases

DNASUi 4074.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000000412 ; ENSP00000000412 ; ENSG00000003056 .
GeneIDi 4074.
KEGGi hsa:4074.
UCSCi uc001qvf.3. human.

Organism-specific databases

CTDi 4074.
GeneCardsi GC12M009092.
HGNCi HGNC:6752. M6PR.
HPAi CAB034464.
MIMi 154540. gene.
neXtProti NX_P20645.
PharmGKBi PA30513.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45234.
GeneTreei ENSGT00390000002109.
HOGENOMi HOG000013085.
HOVERGENi HBG006395.
InParanoidi P20645.
KOi K10089.
OMAi SDWIMLI.
PhylomeDBi P20645.
TreeFami TF328910.

Enzyme and pathway databases

Reactomei REACT_19287. Lysosome Vesicle Biogenesis.

Miscellaneous databases

GeneWikii Cation-dependent_mannose-6-phosphate_receptor.
GenomeRNAii 4074.
NextBioi 15968.
PROi P20645.
SOURCEi Search...

Gene expression databases

Bgeei P20645.
CleanExi HS_M6PR.
ExpressionAtlasi P20645. baseline and differential.
Genevestigatori P20645.

Family and domain databases

Gene3Di 2.70.130.10. 1 hit.
InterProi IPR028927. Man-6-P_rcpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR000296. Man_6_P_rcpt.
[Graphical view ]
Pfami PF02157. Man-6-P_recep. 1 hit.
[Graphical view ]
PRINTSi PR00715. MAN6PRECEPTR.
SUPFAMi SSF50911. SSF50911. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and analysis of the human 46-kDa mannose 6-phosphate receptor gene."
    Klier H.J., von Figura K., Pohlmann R.
    Eur. J. Biochem. 197:23-28(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leukocyte.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  6. "Sorting of mannose 6-phosphate receptors mediated by the GGAs."
    Puertollano R., Aguilar R.C., Gorshkova I., Crouch R.J., Bonifacino J.S.
    Science 292:1712-1716(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GGA1 AND GGA3.
  7. "Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins."
    Doray B., Bruns K., Ghosh P., Kornfeld S.
    J. Biol. Chem. 277:18477-18482(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GGA2.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-83 AND ASN-107.
    Tissue: Liver.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMPRD_HUMAN
AccessioniPrimary (citable) accession number: P20645
Secondary accession number(s): A8K528, D3DUV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3