SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P20615

- HXB9_MOUSE

UniProt

P20615 - HXB9_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox protein Hox-B9

Gene
Hoxb9, Hox-2.5, Hoxb-9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi185 – 24460HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. canonical Wnt signaling pathway Source: Ensembl
  3. cell chemotaxis Source: Ensembl
  4. embryonic skeletal system development Source: MGI
  5. mammary gland development Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Gene namesi
Name:Hoxb9
Synonyms:Hox-2.5, Hoxb-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96190. Hoxb9.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Homeobox protein Hox-B9PRO_0000200156Add
BLAST

Proteomic databases

PRIDEiP20615.

PTM databases

PhosphoSiteiP20615.

Expressioni

Gene expression databases

ArrayExpressiP20615.
CleanExiMM_HOXB9.
GenevestigatoriP20615.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000010.

Structurei

3D structure databases

ProteinModelPortaliP20615.
SMRiP20615. Positions 185-244.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG325913.
GeneTreeiENSGT00750000117229.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP20615.
KOiK09294.
OMAiCSFQPKP.
OrthoDBiEOG7RRF81.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20615-1 [UniParc]FASTAAdd to Basket

« Hide

MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYANPRQPG HAEHLDFPSC    50
SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YLQPQGAPAA ESRYLRTWLE 100
PAPRAEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN 150
QRAGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL 200
EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE 250
Length:250
Mass (Da):28,015
Last modified:October 3, 2012 - v3
Checksum:i2E14D2F9C34D1CE3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621S → T in AAB28828. 1 Publication
Sequence conflicti171 – 1711D → G in AAB28828. 1 Publication
Sequence conflicti171 – 1711D → G in AAA37847. 1 Publication
Sequence conflicti245 – 2473KEQ → NGA in AAA37847. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S66855 mRNA. Translation: AAB28828.1.
AL645478 Genomic DNA. Translation: CAM27139.1.
CH466556 Genomic DNA. Translation: EDL16022.1.
X64316 Genomic DNA. No translation available.
M34857 mRNA. Translation: AAA37847.1.
CCDSiCCDS25292.1.
PIRiA56572.
RefSeqiNP_032296.2. NM_008270.2.
UniGeneiMm.258271.

Genome annotation databases

EnsembliENSMUST00000000010; ENSMUSP00000000010; ENSMUSG00000020875.
GeneIDi15417.
KEGGimmu:15417.
UCSCiuc007lbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S66855 mRNA. Translation: AAB28828.1 .
AL645478 Genomic DNA. Translation: CAM27139.1 .
CH466556 Genomic DNA. Translation: EDL16022.1 .
X64316 Genomic DNA. No translation available.
M34857 mRNA. Translation: AAA37847.1 .
CCDSi CCDS25292.1.
PIRi A56572.
RefSeqi NP_032296.2. NM_008270.2.
UniGenei Mm.258271.

3D structure databases

ProteinModelPortali P20615.
SMRi P20615. Positions 185-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000000010.

PTM databases

PhosphoSitei P20615.

Proteomic databases

PRIDEi P20615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000010 ; ENSMUSP00000000010 ; ENSMUSG00000020875 .
GeneIDi 15417.
KEGGi mmu:15417.
UCSCi uc007lbn.1. mouse.

Organism-specific databases

CTDi 3219.
MGIi MGI:96190. Hoxb9.

Phylogenomic databases

eggNOGi NOG325913.
GeneTreei ENSGT00750000117229.
HOGENOMi HOG000231180.
HOVERGENi HBG016849.
InParanoidi P20615.
KOi K09294.
OMAi CSFQPKP.
OrthoDBi EOG7RRF81.
TreeFami TF317819.

Miscellaneous databases

NextBioi 288154.
PROi P20615.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20615.
CleanExi MM_HOXB9.
Genevestigatori P20615.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view ]
PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development."
    Malicki J., Bogarad L.D., Martin M.M., Ruddle F.H., McGinnis W.
    Mech. Dev. 42:139-150(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The regulation of the murine Hox-2.5 gene expression during cell differentiation."
    Kondo T., Takahashi N., Muramatsu M.
    Nucleic Acids Res. 20:5729-5735(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
  5. "The developmental expression pattern of a new murine homeo box gene: Hox-2.5."
    Bogarad L.D., Utset M.F., Awgulewitsch A., Miki T., Hart C.P., Ruddle F.H.
    Dev. Biol. 133:537-549(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-250.
  6. "The murine and Drosophila homeobox gene complexes have common features of organization and expression."
    Graham A., Papalopulu N., Krumlauf R.
    Cell 57:367-378(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 185-244.

Entry informationi

Entry nameiHXB9_MOUSE
AccessioniPrimary (citable) accession number: P20615
Secondary accession number(s): A2A9Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi