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P20615

- HXB9_MOUSE

UniProt

P20615 - HXB9_MOUSE

Protein

Homeobox protein Hox-B9

Gene

Hoxb9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi185 – 24460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. canonical Wnt signaling pathway Source: Ensembl
    3. cell chemotaxis Source: Ensembl
    4. embryonic skeletal system development Source: MGI
    5. mammary gland development Source: MGI
    6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B9
    Alternative name(s):
    Homeobox protein Hox-2.5
    Gene namesi
    Name:Hoxb9
    Synonyms:Hox-2.5, Hoxb-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96190. Hoxb9.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Homeobox protein Hox-B9PRO_0000200156Add
    BLAST

    Proteomic databases

    PRIDEiP20615.

    PTM databases

    PhosphoSiteiP20615.

    Expressioni

    Gene expression databases

    ArrayExpressiP20615.
    CleanExiMM_HOXB9.
    GenevestigatoriP20615.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000000010.

    Structurei

    3D structure databases

    ProteinModelPortaliP20615.
    SMRiP20615. Positions 185-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG325913.
    GeneTreeiENSGT00750000117229.
    HOGENOMiHOG000231180.
    HOVERGENiHBG016849.
    InParanoidiP20615.
    KOiK09294.
    OMAiCSFQPKP.
    OrthoDBiEOG7RRF81.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYANPRQPG HAEHLDFPSC    50
    SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YLQPQGAPAA ESRYLRTWLE 100
    PAPRAEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN 150
    QRAGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL 200
    EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE 250
    Length:250
    Mass (Da):28,015
    Last modified:October 3, 2012 - v3
    Checksum:i2E14D2F9C34D1CE3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621S → T in AAB28828. (PubMed:8105876)Curated
    Sequence conflicti171 – 1711D → G in AAB28828. (PubMed:8105876)Curated
    Sequence conflicti171 – 1711D → G in AAA37847. (PubMed:2567250)Curated
    Sequence conflicti245 – 2473KEQ → NGA in AAA37847. (PubMed:2567250)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S66855 mRNA. Translation: AAB28828.1.
    AL645478 Genomic DNA. Translation: CAM27139.1.
    CH466556 Genomic DNA. Translation: EDL16022.1.
    X64316 Genomic DNA. No translation available.
    M34857 mRNA. Translation: AAA37847.1.
    CCDSiCCDS25292.1.
    PIRiA56572.
    RefSeqiNP_032296.2. NM_008270.2.
    UniGeneiMm.258271.

    Genome annotation databases

    EnsembliENSMUST00000000010; ENSMUSP00000000010; ENSMUSG00000020875.
    GeneIDi15417.
    KEGGimmu:15417.
    UCSCiuc007lbn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S66855 mRNA. Translation: AAB28828.1 .
    AL645478 Genomic DNA. Translation: CAM27139.1 .
    CH466556 Genomic DNA. Translation: EDL16022.1 .
    X64316 Genomic DNA. No translation available.
    M34857 mRNA. Translation: AAA37847.1 .
    CCDSi CCDS25292.1.
    PIRi A56572.
    RefSeqi NP_032296.2. NM_008270.2.
    UniGenei Mm.258271.

    3D structure databases

    ProteinModelPortali P20615.
    SMRi P20615. Positions 185-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000000010.

    PTM databases

    PhosphoSitei P20615.

    Proteomic databases

    PRIDEi P20615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000010 ; ENSMUSP00000000010 ; ENSMUSG00000020875 .
    GeneIDi 15417.
    KEGGi mmu:15417.
    UCSCi uc007lbn.1. mouse.

    Organism-specific databases

    CTDi 3219.
    MGIi MGI:96190. Hoxb9.

    Phylogenomic databases

    eggNOGi NOG325913.
    GeneTreei ENSGT00750000117229.
    HOGENOMi HOG000231180.
    HOVERGENi HBG016849.
    InParanoidi P20615.
    KOi K09294.
    OMAi CSFQPKP.
    OrthoDBi EOG7RRF81.
    TreeFami TF317819.

    Miscellaneous databases

    NextBioi 288154.
    PROi P20615.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20615.
    CleanExi MM_HOXB9.
    Genevestigatori P20615.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development."
      Malicki J., Bogarad L.D., Martin M.M., Ruddle F.H., McGinnis W.
      Mech. Dev. 42:139-150(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The regulation of the murine Hox-2.5 gene expression during cell differentiation."
      Kondo T., Takahashi N., Muramatsu M.
      Nucleic Acids Res. 20:5729-5735(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
    5. "The developmental expression pattern of a new murine homeo box gene: Hox-2.5."
      Bogarad L.D., Utset M.F., Awgulewitsch A., Miki T., Hart C.P., Ruddle F.H.
      Dev. Biol. 133:537-549(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-250.
    6. "The murine and Drosophila homeobox gene complexes have common features of organization and expression."
      Graham A., Papalopulu N., Krumlauf R.
      Cell 57:367-378(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 185-244.

    Entry informationi

    Entry nameiHXB9_MOUSE
    AccessioniPrimary (citable) accession number: P20615
    Secondary accession number(s): A2A9Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3