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P20615 (HXB9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Gene names
Name:Hoxb9
Synonyms:Hox-2.5, Hoxb-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Homeobox protein Hox-B9
PRO_0000200156

Regions

DNA binding185 – 24460Homeobox

Experimental info

Sequence conflict621S → T in AAB28828. Ref.1
Sequence conflict1711D → G in AAB28828. Ref.1
Sequence conflict1711D → G in AAA37847. Ref.5
Sequence conflict245 – 2473KEQ → NGA in AAA37847. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P20615 [UniParc].

Last modified October 3, 2012. Version 3.
Checksum: 2E14D2F9C34D1CE3

FASTA25028,015
        10         20         30         40         50         60 
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYANPRQPG HAEHLDFPSC SFQPKAPVFG 

        70         80         90        100        110        120 
ASWAPLSPHA SGSLPSVYHP YLQPQGAPAA ESRYLRTWLE PAPRAEAAPG QGQAAVKAEP 

       130        140        150        160        170        180 
LLGAPGELLK QGTPEYSLET SAGREAVLSN QRAGYGDNKI CEGSEDKERP DQTNPSANWL 

       190        200        210        220        230        240 
HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM 

       250 
KKMNKEQGKE 

« Hide

References

« Hide 'large scale' references
[1]"Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development."
Malicki J., Bogarad L.D., Martin M.M., Ruddle F.H., McGinnis W.
Mech. Dev. 42:139-150(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The regulation of the murine Hox-2.5 gene expression during cell differentiation."
Kondo T., Takahashi N., Muramatsu M.
Nucleic Acids Res. 20:5729-5735(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
[5]"The developmental expression pattern of a new murine homeo box gene: Hox-2.5."
Bogarad L.D., Utset M.F., Awgulewitsch A., Miki T., Hart C.P., Ruddle F.H.
Dev. Biol. 133:537-549(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-250.
[6]"The murine and Drosophila homeobox gene complexes have common features of organization and expression."
Graham A., Papalopulu N., Krumlauf R.
Cell 57:367-378(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 185-244.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S66855 mRNA. Translation: AAB28828.1.
AL645478 Genomic DNA. Translation: CAM27139.1.
CH466556 Genomic DNA. Translation: EDL16022.1.
X64316 Genomic DNA. No translation available.
M34857 mRNA. Translation: AAA37847.1.
CCDSCCDS25292.1.
PIRA56572.
RefSeqNP_032296.2. NM_008270.2.
UniGeneMm.258271.

3D structure databases

ProteinModelPortalP20615.
SMRP20615. Positions 185-244.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000000010.

PTM databases

PhosphoSiteP20615.

Proteomic databases

PRIDEP20615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000010; ENSMUSP00000000010; ENSMUSG00000020875.
GeneID15417.
KEGGmmu:15417.
UCSCuc007lbn.1. mouse.

Organism-specific databases

CTD3219.
MGIMGI:96190. Hoxb9.

Phylogenomic databases

eggNOGNOG325913.
GeneTreeENSGT00750000117229.
HOGENOMHOG000231180.
HOVERGENHBG016849.
InParanoidP20615.
KOK09294.
OMACSFQPKP.
OrthoDBEOG7RRF81.
TreeFamTF317819.

Gene expression databases

ArrayExpressP20615.
CleanExMM_HOXB9.
GenevestigatorP20615.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288154.
PROP20615.
SOURCESearch...

Entry information

Entry nameHXB9_MOUSE
AccessionPrimary (citable) accession number: P20615
Secondary accession number(s): A2A9Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries