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Protein

Homeobox protein Hox-B9

Gene

Hoxb9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi185 – 24460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. canonical Wnt signaling pathway Source: MGI
  3. cell chemotaxis Source: MGI
  4. embryonic skeletal system development Source: MGI
  5. mammary gland development Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Gene namesi
Name:Hoxb9
Synonyms:Hox-2.5, Hoxb-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96190. Hoxb9.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Homeobox protein Hox-B9PRO_0000200156Add
BLAST

Proteomic databases

MaxQBiP20615.
PRIDEiP20615.

PTM databases

PhosphoSiteiP20615.

Expressioni

Gene expression databases

CleanExiMM_HOXB9.
ExpressionAtlasiP20615. baseline and differential.
GenevestigatoriP20615.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000010.

Structurei

3D structure databases

ProteinModelPortaliP20615.
SMRiP20615. Positions 185-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG325913.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP20615.
KOiK09294.
OMAiNDPSANW.
OrthoDBiEOG7RRF81.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20615-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYANPRQPG HAEHLDFPSC
60 70 80 90 100
SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YLQPQGAPAA ESRYLRTWLE
110 120 130 140 150
PAPRAEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN
160 170 180 190 200
QRAGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL
210 220 230 240 250
EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE
Length:250
Mass (Da):28,015
Last modified:October 3, 2012 - v3
Checksum:i2E14D2F9C34D1CE3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621S → T in AAB28828. (PubMed:8105876)Curated
Sequence conflicti171 – 1711D → G in AAB28828. (PubMed:8105876)Curated
Sequence conflicti171 – 1711D → G in AAA37847. (PubMed:2567250)Curated
Sequence conflicti245 – 2473KEQ → NGA in AAA37847. (PubMed:2567250)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66855 mRNA. Translation: AAB28828.1.
AL645478 Genomic DNA. Translation: CAM27139.1.
CH466556 Genomic DNA. Translation: EDL16022.1.
X64316 Genomic DNA. No translation available.
M34857 mRNA. Translation: AAA37847.1.
CCDSiCCDS25292.1.
PIRiA56572.
RefSeqiNP_032296.2. NM_008270.2.
UniGeneiMm.258271.

Genome annotation databases

EnsembliENSMUST00000000010; ENSMUSP00000000010; ENSMUSG00000020875.
GeneIDi15417.
KEGGimmu:15417.
UCSCiuc007lbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66855 mRNA. Translation: AAB28828.1.
AL645478 Genomic DNA. Translation: CAM27139.1.
CH466556 Genomic DNA. Translation: EDL16022.1.
X64316 Genomic DNA. No translation available.
M34857 mRNA. Translation: AAA37847.1.
CCDSiCCDS25292.1.
PIRiA56572.
RefSeqiNP_032296.2. NM_008270.2.
UniGeneiMm.258271.

3D structure databases

ProteinModelPortaliP20615.
SMRiP20615. Positions 185-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000010.

PTM databases

PhosphoSiteiP20615.

Proteomic databases

MaxQBiP20615.
PRIDEiP20615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000010; ENSMUSP00000000010; ENSMUSG00000020875.
GeneIDi15417.
KEGGimmu:15417.
UCSCiuc007lbn.1. mouse.

Organism-specific databases

CTDi3219.
MGIiMGI:96190. Hoxb9.

Phylogenomic databases

eggNOGiNOG325913.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP20615.
KOiK09294.
OMAiNDPSANW.
OrthoDBiEOG7RRF81.
TreeFamiTF317819.

Miscellaneous databases

NextBioi288154.
PROiP20615.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HOXB9.
ExpressionAtlasiP20615. baseline and differential.
GenevestigatoriP20615.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development."
    Malicki J., Bogarad L.D., Martin M.M., Ruddle F.H., McGinnis W.
    Mech. Dev. 42:139-150(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The regulation of the murine Hox-2.5 gene expression during cell differentiation."
    Kondo T., Takahashi N., Muramatsu M.
    Nucleic Acids Res. 20:5729-5735(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
  5. "The developmental expression pattern of a new murine homeo box gene: Hox-2.5."
    Bogarad L.D., Utset M.F., Awgulewitsch A., Miki T., Hart C.P., Ruddle F.H.
    Dev. Biol. 133:537-549(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-250.
  6. "The murine and Drosophila homeobox gene complexes have common features of organization and expression."
    Graham A., Papalopulu N., Krumlauf R.
    Cell 57:367-378(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 185-244.

Entry informationi

Entry nameiHXB9_MOUSE
AccessioniPrimary (citable) accession number: P20615
Secondary accession number(s): A2A9Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: February 4, 2015
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.