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Protein

Homeobox protein Hox-B9

Gene

Hoxb9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi185 – 244HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell chemotaxis Source: MGI
  • embryonic skeletal system development Source: MGI
  • mammary gland development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Gene namesi
Name:Hoxb9
Synonyms:Hox-2.5, Hoxb-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96190. Hoxb9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001561 – 250Homeobox protein Hox-B9Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei133PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP20615.
PaxDbiP20615.
PeptideAtlasiP20615.
PRIDEiP20615.

PTM databases

PhosphoSitePlusiP20615.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020875.
CleanExiMM_HOXB9.
ExpressionAtlasiP20615. baseline and differential.
GenevisibleiP20615. MM.

Interactioni

Protein-protein interaction databases

BioGridi200383. 1 interactor.
STRINGi10090.ENSMUSP00000000010.

Structurei

3D structure databases

ProteinModelPortaliP20615.
SMRiP20615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP20615.
KOiK09294.
OMAiCSFQPKP.
OrthoDBiEOG091G0H4X.
TreeFamiTF317819.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P20615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYANPRQPG HAEHLDFPSC
60 70 80 90 100
SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YLQPQGAPAA ESRYLRTWLE
110 120 130 140 150
PAPRAEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN
160 170 180 190 200
QRAGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL
210 220 230 240 250
EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE
Length:250
Mass (Da):28,015
Last modified:October 3, 2012 - v3
Checksum:i2E14D2F9C34D1CE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62S → T in AAB28828 (PubMed:8105876).Curated1
Sequence conflicti171D → G in AAB28828 (PubMed:8105876).Curated1
Sequence conflicti171D → G in AAA37847 (PubMed:2567250).Curated1
Sequence conflicti245 – 247KEQ → NGA in AAA37847 (PubMed:2567250).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66855 mRNA. Translation: AAB28828.1.
AL645478 Genomic DNA. Translation: CAM27139.1.
CH466556 Genomic DNA. Translation: EDL16022.1.
X64316 Genomic DNA. No translation available.
M34857 mRNA. Translation: AAA37847.1.
CCDSiCCDS25292.1.
PIRiA56572.
RefSeqiNP_032296.2. NM_008270.2.
UniGeneiMm.258271.

Genome annotation databases

EnsembliENSMUST00000000010; ENSMUSP00000000010; ENSMUSG00000020875.
GeneIDi15417.
KEGGimmu:15417.
UCSCiuc007lbn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiHXB9_MOUSE
AccessioniPrimary (citable) accession number: P20615
Secondary accession number(s): A2A9Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: September 27, 2017
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families