ID COXS_DICDI Reviewed; 55 AA. AC P20610; Q27561; Q54Z11; DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 4. DT 24-JAN-2024, entry version 115. DE RecName: Full=Cytochrome c oxidase subunit 7s; DE EC=7.1.1.9; DE AltName: Full=Cytochrome c oxidase polypeptide VIIs; GN Name=cxgS; Synonyms=cox7s; ORFNames=DDB_G0277839; OS Dictyostelium discoideum (Social amoeba). OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; OC Dictyosteliaceae; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=AX3; RX PubMed=9049303; DOI=10.1093/emboj/16.4.739; RA Bisson R., Vettore S., Aratri E., Sandona D.; RT "Subunit change in cytochrome c oxidase: identification of the oxygen RT switch in Dictyostelium."; RL EMBO J. 16:739-749(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX PubMed=15875012; DOI=10.1038/nature03481; RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.; RT "The genome of the social amoeba Dictyostelium discoideum."; RL Nature 435:43-57(2005). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35. RC STRAIN=AX3; RX PubMed=7890678; DOI=10.1074/jbc.270.10.5587; RA Sandona D., Gastaldello S., Rizzuto R., Bisson R.; RT "Expression of cytochrome c oxidase during growth and development of RT Dictyostelium."; RL J. Biol. Chem. 270:5587-5593(1995). RN [4] RP PROTEIN SEQUENCE OF 2-35. RX PubMed=2155132; DOI=10.1016/0014-5793(90)80660-b; RA Capaldi R.A., Zhang Y.-Z., Rizzuto R., Sandona D., Schiavo G., Bisson R.; RT "The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium RT discoideum derive from a common ancestor."; RL FEBS Lett. 261:158-160(1990). CC -!- FUNCTION: This protein is one of the nuclear-coded polypeptide chains CC of cytochrome c oxidase, the terminal oxidase in mitochondrial electron CC transport. CC -!- CATALYTIC ACTIVITY: CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)- CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, CC ChEBI:CHEBI:29034; EC=7.1.1.9; CC -!- SUBUNIT: Slime mold cytochrome c oxidase consists of at least seven CC different polypeptides species, subunits I, II, III, IV, V, VI, and CC VIIe/s in order of MW. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane. CC -!- DEVELOPMENTAL STAGE: When cells enter the stationary phase of growth, CC during the vegetative state, subunit VIIe is replaced by VIIs. The CC switching depends on the oxygen tension. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X99344; CAA67725.1; -; Genomic_DNA. DR EMBL; AAFI02000023; EAL68092.1; -; Genomic_DNA. DR EMBL; Z30963; CAA83217.1; -; Genomic_DNA. DR PIR; B34254; B34254. DR RefSeq; XP_642041.1; XM_636949.1. DR AlphaFoldDB; P20610; -. DR SMR; P20610; -. DR STRING; 44689.P20610; -. DR PaxDb; 44689-DDB0216180; -. DR EnsemblProtists; EAL68092; EAL68092; DDB_G0277839. DR GeneID; 8621253; -. DR KEGG; ddi:DDB_G0277839; -. DR dictyBase; DDB_G0277839; cxgS. DR HOGENOM; CLU_3072688_0_0_1; -. DR InParanoid; P20610; -. DR OMA; MTHALPK; -. DR PRO; PR:P20610; -. DR Proteomes; UP000002195; Chromosome 3. DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central. DR GO; GO:0001666; P:response to hypoxia; IDA:dictyBase. DR CDD; cd00927; CcO_VIc-like; 1. DR Gene3D; 4.10.93.10; Mitochondrial cytochrome c oxidase subunit VIc/VIIs; 1. DR InterPro; IPR004204; Cox7e/7s. DR InterPro; IPR034884; Cytochrome_c_oxidase_VIc/VIIs. DR InterPro; IPR037169; Cytochrome_c_oxidase_VIc_sf. DR PANTHER; PTHR28264:SF1; CYTOCHROME C OXIDASE SUBUNIT 6C; 1. DR PANTHER; PTHR28264; CYTOCHROME C OXIDASE SUBUNIT 7A; 1. DR Pfam; PF02937; COX6C; 1. DR SUPFAM; SSF81415; Mitochondrial cytochrome c oxidase subunit VIc; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Membrane; Mitochondrion; KW Mitochondrion inner membrane; Reference proteome; Translocase; KW Transmembrane; Transmembrane helix. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000269|PubMed:2155132" FT CHAIN 2..55 FT /note="Cytochrome c oxidase subunit 7s" FT /id="PRO_0000183909" FT TRANSMEM 13..35 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 55 AA; 6275 MW; 5584DA48AC2E2E20 CRC64; MTHALPKVVK SQLVQDIGVA LILGSIAGCF FKYGVDKKKQ RERVAFYEKY DKEDL //