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P20610

- COXS_DICDI

UniProt

P20610 - COXS_DICDI

Protein

Cytochrome c oxidase subunit 7s

Gene

cxgS

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7s (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIIs
    Gene namesi
    Name:cxgS
    Synonyms:cox7s
    ORF Names:DDB_G0277839
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0277839. cxgS.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 5554Cytochrome c oxidase subunit 7sPRO_0000183909Add
    BLAST

    Expressioni

    Developmental stagei

    When cells enter the stationary phase of growth, during the vegetative state, subunit VIIe is replaced by VIIs. The switching depends on the oxygen tension.

    Interactioni

    Subunit structurei

    Slime mold cytochrome c oxidase consists of at least seven different polypeptides species, subunits I, II, III, IV, V, VI, and VIIe/s in order of MW.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiFLANCRA.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20610-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHALPKVVK SQLVQDIGVA LILGSIAGCF FKYGVDKKKQ RERVAFYEKY   50
    DKEDL 55
    Length:55
    Mass (Da):6,275
    Last modified:January 23, 2007 - v4
    Checksum:i5584DA48AC2E2E20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99344 Genomic DNA. Translation: CAA67725.1.
    AAFI02000023 Genomic DNA. Translation: EAL68092.1.
    Z30963 Genomic DNA. Translation: CAA83217.1.
    PIRiB34254.
    RefSeqiXP_642041.1. XM_636949.1.

    Genome annotation databases

    EnsemblProtistsiDDB0216180; DDB0216180; DDB_G0277839.
    GeneIDi8621253.
    KEGGiddi:DDB_G0277839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99344 Genomic DNA. Translation: CAA67725.1 .
    AAFI02000023 Genomic DNA. Translation: EAL68092.1 .
    Z30963 Genomic DNA. Translation: CAA83217.1 .
    PIRi B34254.
    RefSeqi XP_642041.1. XM_636949.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0216180 ; DDB0216180 ; DDB_G0277839 .
    GeneIDi 8621253.
    KEGGi ddi:DDB_G0277839.

    Organism-specific databases

    dictyBasei DDB_G0277839. cxgS.

    Phylogenomic databases

    OMAi FLANCRA.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Subunit change in cytochrome c oxidase: identification of the oxygen switch in Dictyostelium."
      Bisson R., Vettore S., Aratri E., Sandona D.
      EMBO J. 16:739-749(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AX3.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. "Expression of cytochrome c oxidase during growth and development of Dictyostelium."
      Sandona D., Gastaldello S., Rizzuto R., Bisson R.
      J. Biol. Chem. 270:5587-5593(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
      Strain: AX3.
    4. "The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium discoideum derive from a common ancestor."
      Capaldi R.A., Zhang Y.-Z., Rizzuto R., Sandona D., Schiavo G., Bisson R.
      FEBS Lett. 261:158-160(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-35.

    Entry informationi

    Entry nameiCOXS_DICDI
    AccessioniPrimary (citable) accession number: P20610
    Secondary accession number(s): Q27561, Q54Z11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

    External Data

    Dasty 3