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Protein

Cytochrome c oxidase subunit 7s

Gene

cxgS

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7s (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VIIs
Gene namesi
Name:cxgS
Synonyms:cox7s
ORF Names:DDB_G0277839
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277839. cxgS.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3523HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 5554Cytochrome c oxidase subunit 7sPRO_0000183909Add
BLAST

Expressioni

Developmental stagei

When cells enter the stationary phase of growth, during the vegetative state, subunit VIIe is replaced by VIIs. The switching depends on the oxygen tension.

Interactioni

Subunit structurei

Slime mold cytochrome c oxidase consists of at least seven different polypeptides species, subunits I, II, III, IV, V, VI, and VIIe/s in order of MW.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiMTHALPK.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHALPKVVK SQLVQDIGVA LILGSIAGCF FKYGVDKKKQ RERVAFYEKY

DKEDL
Length:55
Mass (Da):6,275
Last modified:January 23, 2007 - v4
Checksum:i5584DA48AC2E2E20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99344 Genomic DNA. Translation: CAA67725.1.
AAFI02000023 Genomic DNA. Translation: EAL68092.1.
Z30963 Genomic DNA. Translation: CAA83217.1.
PIRiB34254.
RefSeqiXP_642041.1. XM_636949.1.

Genome annotation databases

EnsemblProtistsiDDB0216180; DDB0216180; DDB_G0277839.
GeneIDi8621253.
KEGGiddi:DDB_G0277839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99344 Genomic DNA. Translation: CAA67725.1.
AAFI02000023 Genomic DNA. Translation: EAL68092.1.
Z30963 Genomic DNA. Translation: CAA83217.1.
PIRiB34254.
RefSeqiXP_642041.1. XM_636949.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0216180; DDB0216180; DDB_G0277839.
GeneIDi8621253.
KEGGiddi:DDB_G0277839.

Organism-specific databases

dictyBaseiDDB_G0277839. cxgS.

Phylogenomic databases

OMAiMTHALPK.

Miscellaneous databases

PROiP20610.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Subunit change in cytochrome c oxidase: identification of the oxygen switch in Dictyostelium."
    Bisson R., Vettore S., Aratri E., Sandona D.
    EMBO J. 16:739-749(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX3.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Expression of cytochrome c oxidase during growth and development of Dictyostelium."
    Sandona D., Gastaldello S., Rizzuto R., Bisson R.
    J. Biol. Chem. 270:5587-5593(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
    Strain: AX3.
  4. "The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium discoideum derive from a common ancestor."
    Capaldi R.A., Zhang Y.-Z., Rizzuto R., Sandona D., Schiavo G., Bisson R.
    FEBS Lett. 261:158-160(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-35.

Entry informationi

Entry nameiCOXS_DICDI
AccessioniPrimary (citable) accession number: P20610
Secondary accession number(s): Q27561, Q54Z11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 79 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.