P20610 (COXS_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 7s
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide VIIs

Gene names

Name:	cxgS
Synonyms:	cox7s
ORF Names:	DDB_G0277839

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	55 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Slime mold cytochrome c oxidase consists of at least seven different polypeptides species, subunits I, II, III, IV, V, VI, and VIIe/s in order of MW.
Subcellular location	Mitochondrion inner membrane.
Developmental stage	When cells enter the stationary phase of growth, during the vegetative state, subunit VIIe is replaced by VIIs. The switching depends on the oxygen tension.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 55	54	Cytochrome c oxidase subunit 7s		PRO_0000183909
Regions
	Transmembrane	13 – 35	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P20610 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 5584DA48AC2E2E20	FASTA	55	6,275
	10 20 30 40 50 MTHALPKVVK SQLVQDIGVA LILGSIAGCF FKYGVDKKKQ RERVAFYEKY DKEDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subunit change in cytochrome c oxidase: identification of the oxygen switch in Dictyostelium." Bisson R., Vettore S., Aratri E., Sandona D. EMBO J. 16:739-749(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX3.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Expression of cytochrome c oxidase during growth and development of Dictyostelium." Sandona D., Gastaldello S., Rizzuto R., Bisson R. J. Biol. Chem. 270:5587-5593(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35. Strain: AX3.
[4]	"The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium discoideum derive from a common ancestor." Capaldi R.A., Zhang Y.-Z., Rizzuto R., Sandona D., Schiavo G., Bisson R. FEBS Lett. 261:158-160(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-35.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99344 Genomic DNA. Translation: CAA67725.1. AAFI02000023 Genomic DNA. Translation: EAL68092.1. Z30963 Genomic DNA. Translation: CAA83217.1.
PIR	B34254.
RefSeq	XP_642041.1. XM_636949.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0216180; DDB0216180; DDB_G0277839.
GeneID	8621253.
KEGG	ddi:DDB_G0277839.
Organism-specific databases
dictyBase	DDB_G0277839. cxgS.
Phylogenomic databases
OMA	MTHALPK.
ProtClustDB	CLSZ2846829.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

COXS_DICDI

Accession

Primary (citable) accession number: P20610
Secondary accession number(s): Q27561, Q54Z11

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 70 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)