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Protein

Interleukin-6

Gene

Il6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: RGD
  • growth factor activity Source: UniProtKB-KW
  • interleukin-6 receptor binding Source: RGD
  • signaling receptor binding Source: RGD

GO - Biological processi

  • acute inflammatory response Source: RGD
  • acute-phase response Source: UniProtKB-KW
  • aging Source: RGD
  • bone remodeling Source: RGD
  • branching involved in salivary gland morphogenesis Source: Ensembl
  • cell redox homeostasis Source: RGD
  • cellular response to cytokine stimulus Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to estradiol stimulus Source: RGD
  • cellular response to hepatocyte growth factor stimulus Source: Ensembl
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to nutrient levels Source: RGD
  • cellular response to prolactin Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • defense response to protozoan Source: Ensembl
  • endocrine pancreas development Source: Ensembl
  • epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  • glucagon secretion Source: Ensembl
  • glucose homeostasis Source: Ensembl
  • interleukin-6-mediated signaling pathway Source: Ensembl
  • lymphocyte costimulation Source: RGD
  • muscle cell cellular homeostasis Source: Ensembl
  • negative regulation of bone resorption Source: Ensembl
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of chemokine biosynthetic process Source: Ensembl
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • negative regulation of cytokine secretion Source: RGD
  • negative regulation of gluconeogenesis Source: RGD
  • negative regulation of hormone secretion Source: Ensembl
  • negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
  • negative regulation of membrane potential Source: RGD
  • negative regulation of muscle organ development Source: RGD
  • negative regulation of neuron death Source: RGD
  • negative regulation of protein kinase activity Source: RGD
  • neutrophil apoptotic process Source: Ensembl
  • positive regulation of cell proliferation in bone marrow Source: Ensembl
  • positive regulation of DNA replication Source: RGD
  • positive regulation of epithelial cell proliferation Source: Ensembl
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • positive regulation of nitric oxide biosynthetic process Source: RGD
  • positive regulation of protein import into nucleus, translocation Source: RGD
  • positive regulation of protein kinase B signaling Source: RGD
  • positive regulation of T-helper 2 cell cytokine production Source: Ensembl
  • positive regulation of T-helper 2 cell differentiation Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • positive regulation of transmission of nerve impulse Source: RGD
  • regulation of cell shape Source: RGD
  • regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • response to amino acid Source: RGD
  • response to antibiotic Source: RGD
  • response to auditory stimulus Source: RGD
  • response to bacterium Source: RGD
  • response to caffeine Source: RGD
  • response to calcium ion Source: RGD
  • response to cold Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to electrical stimulus Source: RGD
  • response to heat Source: RGD
  • response to insulin Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to wounding Source: RGD
  • response to yeast Source: RGD
  • T-helper 17 cell lineage commitment Source: UniProtKB
  • wound healing Source: RGD

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAcute phase

Enzyme and pathway databases

ReactomeiR-RNO-1059683 Interleukin-6 signaling
R-RNO-110056 MAPK3 (ERK1) activation
R-RNO-112411 MAPK1 (ERK2) activation
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:Il6
Synonyms:Il-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2901 Il6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001559325 – 211Interleukin-6Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 76By similarity
Modified residuei79PhosphoserineBy similarity1
Disulfide bondi99 ↔ 109By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP20607
PRIDEiP20607

Expressioni

Inductioni

In pancreatic islets, secretion is stimulated by IL1B. In islets from Zucker diabetic fatty (ZDF) rats, but not lean animals, secretion is also increased by endocannabinoid anandamide/AEA.1 Publication

Gene expression databases

BgeeiENSRNOG00000010278
GenevisibleiP20607 RN

Interactioni

GO - Molecular functioni

  • cytokine activity Source: RGD
  • growth factor activity Source: UniProtKB-KW
  • interleukin-6 receptor binding Source: RGD
  • signaling receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013732

Structurei

3D structure databases

ProteinModelPortaliP20607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
GeneTreeiENSGT00390000000878
HOGENOMiHOG000236330
HOVERGENiHBG000471
InParanoidiP20607
KOiK05405
OMAiLQAQNQW
OrthoDBiEOG091G0NW5
PhylomeDBiP20607

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLSARDFQ PVAFLGLMLL TATAFPTSQV RRGDFTEDTT HNRPVYTTSQ
60 70 80 90 100
VGGLITYVLR EILEMRKELC NGNSDCMNSD DALSENNLKL PEIQRNDGCF
110 120 130 140 150
QTGYNQEICL LKICSGLLEF RFYLEFVKNN LQDNKKDKAR VIQSNTETLV
160 170 180 190 200
HIFKQEIKDS YKIVLPTPTS NALLMEKLES QKEWLRTKTI QLILKALEEF
210
LKVTMRSTRQ T
Length:211
Mass (Da):24,357
Last modified:February 1, 1991 - v1
Checksum:i17D248A14F96B5C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26744 mRNA Translation: AAA77659.1
M26745 Genomic DNA Translation: AAA41430.1
PIRiA34247
RefSeqiNP_036721.1, NM_012589.2
UniGeneiRn.9873

Genome annotation databases

EnsembliENSRNOT00000013732; ENSRNOP00000013732; ENSRNOG00000010278
GeneIDi24498
KEGGirno:24498
UCSCiRGD:2901 rat

Similar proteinsi

Entry informationi

Entry nameiIL6_RAT
AccessioniPrimary (citable) accession number: P20607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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