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P20607 (IL6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-6

Short name=IL-6
Gene names
Name:Il6
Synonyms:Il-6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-6 superfamily.

Ontologies

Keywords
   Biological processAcute phase
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT-helper 17 cell lineage commitment

Inferred from sequence or structural similarity. Source: UniProtKB

acute-phase response

Inferred from electronic annotation. Source: UniProtKB-KW

aging

Inferred from expression pattern PubMed 19262026. Source: RGD

bone remodeling

Inferred from expression pattern PubMed 16193234. Source: RGD

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell growth

Inferred from direct assay PubMed 20227492. Source: RGD

cell redox homeostasis

Inferred from mutant phenotype PubMed 7538937. Source: RGD

cellular response to dexamethasone stimulus

Inferred from expression pattern PubMed 2121800. Source: RGD

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from expression pattern PubMed 2121800. Source: RGD

cellular response to tumor necrosis factor

Inferred from expression pattern PubMed 2121800. Source: RGD

defense response to Gram-negative bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-positive bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to protozoan

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: Ensembl

endocrine pancreas development

Inferred from electronic annotation. Source: Ensembl

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

glucagon secretion

Inferred from electronic annotation. Source: Ensembl

interleukin-6-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

muscle cell cellular homeostasis

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 9645688. Source: RGD

negative regulation of chemokine biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from direct assay PubMed 19061939. Source: RGD

negative regulation of cytokine secretion

Inferred from direct assay PubMed 19057004. Source: RGD

negative regulation of gluconeogenesis

Inferred from direct assay PubMed 16308834. Source: RGD

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of muscle organ development

Inferred from direct assay PubMed 19057004. Source: RGD

negative regulation of neuron death

Inferred from direct assay PubMed 19061939. Source: RGD

negative regulation of protein kinase activity

Inferred from direct assay PubMed 15845578. Source: RGD

neuron projection development

Inferred from electronic annotation. Source: Ensembl

neutrophil apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of B cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from mutant phenotype PubMed 15828022. Source: RGD

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 19061939PubMed 20227492. Source: RGD

positive regulation of JAK-STAT cascade

Inferred from direct assay PubMed 15659221PubMed 16413512PubMed 20227492. Source: RGD

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 2 cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from direct assay PubMed 19057004. Source: RGD

positive regulation of immunoglobulin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from mutant phenotype PubMed 7538937. Source: RGD

positive regulation of nitric oxide biosynthetic process

Inferred from direct assay PubMed 15845578. Source: RGD

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein import into nucleus, translocation

Inferred from direct assay PubMed 12015387. Source: RGD

positive regulation of protein kinase B signaling

Inferred from direct assay PubMed 20227492. Source: RGD

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of translation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transmission of nerve impulse

Inferred from direct assay PubMed 19258490. Source: RGD

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 20227492. Source: RGD

regulation of cell shape

Inferred from direct assay PubMed 15845578. Source: RGD

regulation of circadian sleep/wake cycle, non-REM sleep

Inferred from mutant phenotype PubMed 12667648. Source: RGD

regulation of vascular endothelial growth factor production

Inferred from electronic annotation. Source: Ensembl

response to amino acid

Inferred from expression pattern PubMed 19344884. Source: RGD

response to antibiotic

Inferred from expression pattern PubMed 19401694. Source: RGD

response to auditory stimulus

Inferred from expression pattern PubMed 16429448. Source: RGD

response to bacterium

Inferred from expression pattern PubMed 19374258. Source: RGD

response to caffeine

Inferred from expression pattern PubMed 15845578. Source: RGD

response to calcium ion

Inferred from expression pattern PubMed 15845578. Source: RGD

response to cold

Inferred from expression pattern PubMed 19406216. Source: RGD

response to cytokine

Inferred from expression pattern PubMed 19395591. Source: RGD

response to drug

Inferred from expression pattern PubMed 19413671. Source: RGD

response to electrical stimulus

Inferred from expression pattern PubMed 19410369. Source: RGD

response to heat

Inferred from expression pattern PubMed 19365172. Source: RGD

response to insulin

Inferred from expression pattern PubMed 19373130. Source: RGD

response to lipopolysaccharide

Inferred from expression pattern PubMed 19410080. Source: RGD

response to mechanical stimulus

Inferred from expression pattern PubMed 11834488. Source: RGD

response to nutrient levels

Inferred from expression pattern PubMed 19374947. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 19399939. Source: RGD

response to peptidoglycan

Inferred from electronic annotation. Source: Ensembl

response to wounding

Inferred from expression pattern PubMed 19394966. Source: RGD

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 16429448. Source: RGD

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 19406831. Source: RGD

interleukin-6 receptor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 16413512. Source: RGD

interleukin-6 receptor binding

Inferred from direct assay PubMed 12604335PubMed 16413512. Source: RGD

receptor binding

Inferred from direct assay PubMed 1620288. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 211187Interleukin-6
PRO_0000015593

Amino acid modifications

Disulfide bond70 ↔ 76 By similarity
Disulfide bond99 ↔ 109 By similarity

Sequences

Sequence LengthMass (Da)Tools
P20607 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 17D248A14F96B5C1

FASTA21124,357
        10         20         30         40         50         60 
MKFLSARDFQ PVAFLGLMLL TATAFPTSQV RRGDFTEDTT HNRPVYTTSQ VGGLITYVLR 

        70         80         90        100        110        120 
EILEMRKELC NGNSDCMNSD DALSENNLKL PEIQRNDGCF QTGYNQEICL LKICSGLLEF 

       130        140        150        160        170        180 
RFYLEFVKNN LQDNKKDKAR VIQSNTETLV HIFKQEIKDS YKIVLPTPTS NALLMEKLES 

       190        200        210 
QKEWLRTKTI QLILKALEEF LKVTMRSTRQ T 

« Hide

References

[1]"Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells."
Northemann W., Braciak T.A., Hattori M., Lee F., Fey G.H.
J. Biol. Chem. 264:16072-16082(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26744 mRNA. Translation: AAA77659.1.
M26745 Genomic DNA. Translation: AAA41430.1.
PIRA34247.
RefSeqNP_036721.1. NM_012589.2.
UniGeneRn.9873.

3D structure databases

ProteinModelPortalP20607.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-189606.
STRING10116.ENSRNOP00000013732.

Proteomic databases

PRIDEP20607.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013732; ENSRNOP00000013732; ENSRNOG00000010278.
GeneID24498.
KEGGrno:24498.
UCSCRGD:2901. rat.

Organism-specific databases

CTD3569.
RGD2901. Il6.

Phylogenomic databases

eggNOGNOG48083.
GeneTreeENSGT00390000000878.
HOGENOMHOG000236330.
HOVERGENHBG000471.
InParanoidP20607.
KOK05405.
OMALQFSLRA.
OrthoDBEOG7QG453.
PhylomeDBP20607.

Gene expression databases

GenevestigatorP20607.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERPTHR11457. PTHR11457. 1 hit.
PfamPF00489. IL6. 1 hit.
[Graphical view]
PIRSFPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSPR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603495.
PROP20607.

Entry information

Entry nameIL6_RAT
AccessionPrimary (citable) accession number: P20607
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families