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Protein

Interleukin-6

Gene

Il6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: RGD
  • interleukin-6 receptor binding Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • aging Source: RGD
  • bone remodeling Source: RGD
  • branching involved in salivary gland morphogenesis Source: Ensembl
  • cell growth Source: RGD
  • cell redox homeostasis Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to hydrogen peroxide Source: Ensembl
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: Ensembl
  • cellular response to tumor necrosis factor Source: RGD
  • defense response to Gram-negative bacterium Source: Ensembl
  • defense response to Gram-positive bacterium Source: Ensembl
  • defense response to protozoan Source: Ensembl
  • defense response to virus Source: Ensembl
  • endocrine pancreas development Source: Ensembl
  • epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  • glucagon secretion Source: Ensembl
  • glucose homeostasis Source: Ensembl
  • interleukin-6-mediated signaling pathway Source: Ensembl
  • muscle cell cellular homeostasis Source: Ensembl
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of chemokine biosynthetic process Source: Ensembl
  • negative regulation of collagen biosynthetic process Source: Ensembl
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • negative regulation of cytokine secretion Source: RGD
  • negative regulation of gluconeogenesis Source: RGD
  • negative regulation of hormone secretion Source: Ensembl
  • negative regulation of muscle organ development Source: RGD
  • negative regulation of neuron death Source: RGD
  • negative regulation of protein kinase activity Source: RGD
  • neuron projection development Source: Ensembl
  • neutrophil apoptotic process Source: Ensembl
  • positive regulation of acute inflammatory response Source: Ensembl
  • positive regulation of apoptotic process Source: Ensembl
  • positive regulation of B cell activation Source: Ensembl
  • positive regulation of chemokine production Source: Ensembl
  • positive regulation of DNA replication Source: RGD
  • positive regulation of epithelial cell proliferation Source: Ensembl
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of immunoglobulin secretion Source: Ensembl
  • positive regulation of interleukin-6 production Source: Ensembl
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of nitric oxide biosynthetic process Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  • positive regulation of protein import into nucleus, translocation Source: RGD
  • positive regulation of protein kinase B signaling Source: RGD
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  • positive regulation of smooth muscle cell proliferation Source: Ensembl
  • positive regulation of T cell proliferation Source: Ensembl
  • positive regulation of T-helper 2 cell differentiation Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of translation Source: Ensembl
  • positive regulation of transmission of nerve impulse Source: RGD
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
  • regulation of cell shape Source: RGD
  • regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • regulation of vascular endothelial growth factor production Source: Ensembl
  • response to amino acid Source: RGD
  • response to antibiotic Source: RGD
  • response to auditory stimulus Source: RGD
  • response to bacterium Source: RGD
  • response to caffeine Source: RGD
  • response to calcium ion Source: RGD
  • response to cold Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to electrical stimulus Source: RGD
  • response to heat Source: RGD
  • response to insulin Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptidoglycan Source: Ensembl
  • response to wounding Source: RGD
  • response to yeast Source: RGD
  • T-helper 17 cell lineage commitment Source: UniProtKB
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiREACT_289590. ERK1 activation.
REACT_317180. ERK2 activation.
REACT_319332. Interleukin-6 signaling.
REACT_324145. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:Il6
Synonyms:Il-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2901. Il6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: RGD
  • interleukin-6 receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 211187Interleukin-6PRO_0000015593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 76By similarity
Disulfide bondi99 ↔ 109By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP20607.

Expressioni

Gene expression databases

GenevisibleiP20607. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-189606.
STRINGi10116.ENSRNOP00000013732.

Structurei

3D structure databases

ProteinModelPortaliP20607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG48083.
GeneTreeiENSGT00390000000878.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP20607.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG7QG453.
PhylomeDBiP20607.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR003573. IL-6/IL-23/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLSARDFQ PVAFLGLMLL TATAFPTSQV RRGDFTEDTT HNRPVYTTSQ
60 70 80 90 100
VGGLITYVLR EILEMRKELC NGNSDCMNSD DALSENNLKL PEIQRNDGCF
110 120 130 140 150
QTGYNQEICL LKICSGLLEF RFYLEFVKNN LQDNKKDKAR VIQSNTETLV
160 170 180 190 200
HIFKQEIKDS YKIVLPTPTS NALLMEKLES QKEWLRTKTI QLILKALEEF
210
LKVTMRSTRQ T
Length:211
Mass (Da):24,357
Last modified:February 1, 1991 - v1
Checksum:i17D248A14F96B5C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26744 mRNA. Translation: AAA77659.1.
M26745 Genomic DNA. Translation: AAA41430.1.
PIRiA34247.
RefSeqiNP_036721.1. NM_012589.2.
UniGeneiRn.9873.

Genome annotation databases

EnsembliENSRNOT00000013732; ENSRNOP00000013732; ENSRNOG00000010278.
GeneIDi24498.
KEGGirno:24498.
UCSCiRGD:2901. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26744 mRNA. Translation: AAA77659.1.
M26745 Genomic DNA. Translation: AAA41430.1.
PIRiA34247.
RefSeqiNP_036721.1. NM_012589.2.
UniGeneiRn.9873.

3D structure databases

ProteinModelPortaliP20607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-189606.
STRINGi10116.ENSRNOP00000013732.

Proteomic databases

PRIDEiP20607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013732; ENSRNOP00000013732; ENSRNOG00000010278.
GeneIDi24498.
KEGGirno:24498.
UCSCiRGD:2901. rat.

Organism-specific databases

CTDi3569.
RGDi2901. Il6.

Phylogenomic databases

eggNOGiNOG48083.
GeneTreeiENSGT00390000000878.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP20607.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG7QG453.
PhylomeDBiP20607.

Enzyme and pathway databases

ReactomeiREACT_289590. ERK1 activation.
REACT_317180. ERK2 activation.
REACT_319332. Interleukin-6 signaling.
REACT_324145. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

NextBioi603495.
PROiP20607.

Gene expression databases

GenevisibleiP20607. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR003573. IL-6/IL-23/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells."
    Northemann W., Braciak T.A., Hattori M., Lee F., Fey G.H.
    J. Biol. Chem. 264:16072-16082(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiIL6_RAT
AccessioniPrimary (citable) accession number: P20607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.