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P20607

- IL6_RAT

UniProt

P20607 - IL6_RAT

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Protein

Interleukin-6

Gene

Il6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Molecular functioni

  1. cytokine activity Source: RGD
  2. interleukin-6 receptor binding Source: RGD
  3. receptor binding Source: RGD

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. aging Source: RGD
  3. bone remodeling Source: RGD
  4. branching involved in salivary gland morphogenesis Source: Ensembl
  5. cell growth Source: RGD
  6. cell redox homeostasis Source: RGD
  7. cellular response to dexamethasone stimulus Source: RGD
  8. cellular response to hydrogen peroxide Source: Ensembl
  9. cellular response to interleukin-1 Source: RGD
  10. cellular response to lipopolysaccharide Source: Ensembl
  11. cellular response to tumor necrosis factor Source: RGD
  12. defense response to Gram-negative bacterium Source: Ensembl
  13. defense response to Gram-positive bacterium Source: Ensembl
  14. defense response to protozoan Source: Ensembl
  15. defense response to virus Source: Ensembl
  16. endocrine pancreas development Source: Ensembl
  17. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  18. glucagon secretion Source: Ensembl
  19. interleukin-6-mediated signaling pathway Source: Ensembl
  20. muscle cell cellular homeostasis Source: Ensembl
  21. negative regulation of apoptotic process Source: Ensembl
  22. negative regulation of cell proliferation Source: RGD
  23. negative regulation of chemokine biosynthetic process Source: Ensembl
  24. negative regulation of collagen biosynthetic process Source: Ensembl
  25. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  26. negative regulation of cytokine secretion Source: RGD
  27. negative regulation of gluconeogenesis Source: RGD
  28. negative regulation of hormone secretion Source: Ensembl
  29. negative regulation of muscle organ development Source: RGD
  30. negative regulation of neuron death Source: RGD
  31. negative regulation of protein kinase activity Source: RGD
  32. neuron projection development Source: Ensembl
  33. neutrophil apoptotic process Source: Ensembl
  34. positive regulation of acute inflammatory response Source: Ensembl
  35. positive regulation of apoptotic process Source: Ensembl
  36. positive regulation of B cell activation Source: Ensembl
  37. positive regulation of chemokine production Source: Ensembl
  38. positive regulation of DNA replication Source: RGD
  39. positive regulation of epithelial cell proliferation Source: Ensembl
  40. positive regulation of ERK1 and ERK2 cascade Source: RGD
  41. positive regulation of gene expression Source: RGD
  42. positive regulation of immunoglobulin secretion Source: Ensembl
  43. positive regulation of interleukin-6 production Source: Ensembl
  44. positive regulation of JAK-STAT cascade Source: RGD
  45. positive regulation of neuron differentiation Source: RGD
  46. positive regulation of nitric oxide biosynthetic process Source: RGD
  47. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  48. positive regulation of protein import into nucleus, translocation Source: RGD
  49. positive regulation of protein kinase B signaling Source: RGD
  50. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  51. positive regulation of smooth muscle cell proliferation Source: Ensembl
  52. positive regulation of T cell proliferation Source: Ensembl
  53. positive regulation of T-helper 2 cell differentiation Source: Ensembl
  54. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  55. positive regulation of translation Source: Ensembl
  56. positive regulation of transmission of nerve impulse Source: RGD
  57. positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
  58. regulation of cell shape Source: RGD
  59. regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  60. regulation of vascular endothelial growth factor production Source: Ensembl
  61. response to amino acid Source: RGD
  62. response to antibiotic Source: RGD
  63. response to auditory stimulus Source: RGD
  64. response to bacterium Source: RGD
  65. response to caffeine Source: RGD
  66. response to calcium ion Source: RGD
  67. response to cold Source: RGD
  68. response to cytokine Source: RGD
  69. response to drug Source: RGD
  70. response to electrical stimulus Source: RGD
  71. response to heat Source: RGD
  72. response to insulin Source: RGD
  73. response to lipopolysaccharide Source: RGD
  74. response to mechanical stimulus Source: RGD
  75. response to nutrient levels Source: RGD
  76. response to organic cyclic compound Source: RGD
  77. response to peptidoglycan Source: Ensembl
  78. response to wounding Source: RGD
  79. response to yeast Source: RGD
  80. T-helper 17 cell lineage commitment Source: UniProtKB
  81. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).
REACT_199244. Interleukin-6 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:Il6
Synonyms:Il-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi2901. Il6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. external side of plasma membrane Source: Ensembl
  3. extracellular space Source: RGD
  4. interleukin-6 receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 211187Interleukin-6PRO_0000015593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 76By similarity
Disulfide bondi99 ↔ 109By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP20607.

Expressioni

Gene expression databases

GenevestigatoriP20607.

Interactioni

Protein-protein interaction databases

MINTiMINT-189606.
STRINGi10116.ENSRNOP00000013732.

Structurei

3D structure databases

ProteinModelPortaliP20607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG48083.
GeneTreeiENSGT00390000000878.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP20607.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG7QG453.
PhylomeDBiP20607.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20607-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFLSARDFQ PVAFLGLMLL TATAFPTSQV RRGDFTEDTT HNRPVYTTSQ
60 70 80 90 100
VGGLITYVLR EILEMRKELC NGNSDCMNSD DALSENNLKL PEIQRNDGCF
110 120 130 140 150
QTGYNQEICL LKICSGLLEF RFYLEFVKNN LQDNKKDKAR VIQSNTETLV
160 170 180 190 200
HIFKQEIKDS YKIVLPTPTS NALLMEKLES QKEWLRTKTI QLILKALEEF
210
LKVTMRSTRQ T
Length:211
Mass (Da):24,357
Last modified:February 1, 1991 - v1
Checksum:i17D248A14F96B5C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26744 mRNA. Translation: AAA77659.1.
M26745 Genomic DNA. Translation: AAA41430.1.
PIRiA34247.
RefSeqiNP_036721.1. NM_012589.2.
UniGeneiRn.9873.

Genome annotation databases

EnsembliENSRNOT00000013732; ENSRNOP00000013732; ENSRNOG00000010278.
GeneIDi24498.
KEGGirno:24498.
UCSCiRGD:2901. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26744 mRNA. Translation: AAA77659.1 .
M26745 Genomic DNA. Translation: AAA41430.1 .
PIRi A34247.
RefSeqi NP_036721.1. NM_012589.2.
UniGenei Rn.9873.

3D structure databases

ProteinModelPortali P20607.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-189606.
STRINGi 10116.ENSRNOP00000013732.

Proteomic databases

PRIDEi P20607.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013732 ; ENSRNOP00000013732 ; ENSRNOG00000010278 .
GeneIDi 24498.
KEGGi rno:24498.
UCSCi RGD:2901. rat.

Organism-specific databases

CTDi 3569.
RGDi 2901. Il6.

Phylogenomic databases

eggNOGi NOG48083.
GeneTreei ENSGT00390000000878.
HOGENOMi HOG000236330.
HOVERGENi HBG000471.
InParanoidi P20607.
KOi K05405.
OMAi FNQETCL.
OrthoDBi EOG7QG453.
PhylomeDBi P20607.

Enzyme and pathway databases

Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
REACT_199244. Interleukin-6 signaling.

Miscellaneous databases

NextBioi 603495.
PROi P20607.

Gene expression databases

Genevestigatori P20607.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view ]
PANTHERi PTHR11457. PTHR11457. 1 hit.
Pfami PF00489. IL6. 1 hit.
[Graphical view ]
PIRSFi PIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSi PR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTi SM00126. IL6. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells."
    Northemann W., Braciak T.A., Hattori M., Lee F., Fey G.H.
    J. Biol. Chem. 264:16072-16082(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiIL6_RAT
AccessioniPrimary (citable) accession number: P20607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3