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P20607

- IL6_RAT

UniProt

P20607 - IL6_RAT

Protein

Interleukin-6

Gene

Il6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation By similarity.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: RGD
    2. interleukin-6 receptor binding Source: RGD
    3. receptor binding Source: RGD

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. aging Source: RGD
    3. bone remodeling Source: RGD
    4. branching involved in salivary gland morphogenesis Source: Ensembl
    5. cell growth Source: RGD
    6. cell redox homeostasis Source: RGD
    7. cellular response to dexamethasone stimulus Source: RGD
    8. cellular response to hydrogen peroxide Source: Ensembl
    9. cellular response to interleukin-1 Source: RGD
    10. cellular response to tumor necrosis factor Source: RGD
    11. defense response to Gram-negative bacterium Source: Ensembl
    12. defense response to Gram-positive bacterium Source: Ensembl
    13. defense response to protozoan Source: Ensembl
    14. defense response to virus Source: Ensembl
    15. endocrine pancreas development Source: Ensembl
    16. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    17. glucagon secretion Source: Ensembl
    18. interleukin-6-mediated signaling pathway Source: Ensembl
    19. muscle cell cellular homeostasis Source: Ensembl
    20. negative regulation of apoptotic process Source: Ensembl
    21. negative regulation of cell proliferation Source: RGD
    22. negative regulation of chemokine biosynthetic process Source: Ensembl
    23. negative regulation of collagen biosynthetic process Source: Ensembl
    24. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    25. negative regulation of cytokine secretion Source: RGD
    26. negative regulation of gluconeogenesis Source: RGD
    27. negative regulation of hormone secretion Source: Ensembl
    28. negative regulation of muscle organ development Source: RGD
    29. negative regulation of neuron death Source: RGD
    30. negative regulation of protein kinase activity Source: RGD
    31. neuron projection development Source: Ensembl
    32. neutrophil apoptotic process Source: Ensembl
    33. positive regulation of acute inflammatory response Source: Ensembl
    34. positive regulation of apoptotic process Source: Ensembl
    35. positive regulation of B cell activation Source: Ensembl
    36. positive regulation of chemokine production Source: Ensembl
    37. positive regulation of DNA replication Source: RGD
    38. positive regulation of epithelial cell proliferation Source: Ensembl
    39. positive regulation of ERK1 and ERK2 cascade Source: RGD
    40. positive regulation of gene expression Source: RGD
    41. positive regulation of immunoglobulin secretion Source: Ensembl
    42. positive regulation of interleukin-6 production Source: Ensembl
    43. positive regulation of JAK-STAT cascade Source: RGD
    44. positive regulation of neuron differentiation Source: RGD
    45. positive regulation of nitric oxide biosynthetic process Source: RGD
    46. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    47. positive regulation of protein import into nucleus, translocation Source: RGD
    48. positive regulation of protein kinase B signaling Source: RGD
    49. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    50. positive regulation of smooth muscle cell proliferation Source: Ensembl
    51. positive regulation of T cell proliferation Source: Ensembl
    52. positive regulation of T-helper 2 cell differentiation Source: Ensembl
    53. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    54. positive regulation of translation Source: Ensembl
    55. positive regulation of transmission of nerve impulse Source: RGD
    56. positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
    57. regulation of cell shape Source: RGD
    58. regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
    59. regulation of vascular endothelial growth factor production Source: Ensembl
    60. response to amino acid Source: RGD
    61. response to antibiotic Source: RGD
    62. response to auditory stimulus Source: RGD
    63. response to bacterium Source: RGD
    64. response to caffeine Source: RGD
    65. response to calcium ion Source: RGD
    66. response to cold Source: RGD
    67. response to cytokine Source: RGD
    68. response to drug Source: RGD
    69. response to electrical stimulus Source: RGD
    70. response to heat Source: RGD
    71. response to insulin Source: RGD
    72. response to lipopolysaccharide Source: RGD
    73. response to mechanical stimulus Source: RGD
    74. response to nutrient levels Source: RGD
    75. response to organic cyclic compound Source: RGD
    76. response to peptidoglycan Source: Ensembl
    77. response to wounding Source: RGD
    78. T-helper 17 cell lineage commitment Source: UniProtKB
    79. wound healing Source: RGD

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    Acute phase

    Enzyme and pathway databases

    ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_199244. Interleukin-6 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-6
    Short name:
    IL-6
    Gene namesi
    Name:Il6
    Synonyms:Il-6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi2901. Il6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. external side of plasma membrane Source: Ensembl
    3. extracellular space Source: RGD
    4. interleukin-6 receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 211187Interleukin-6PRO_0000015593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 76By similarity
    Disulfide bondi99 ↔ 109By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP20607.

    Expressioni

    Gene expression databases

    GenevestigatoriP20607.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-189606.
    STRINGi10116.ENSRNOP00000013732.

    Structurei

    3D structure databases

    ProteinModelPortaliP20607.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-6 superfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG48083.
    GeneTreeiENSGT00390000000878.
    HOGENOMiHOG000236330.
    HOVERGENiHBG000471.
    InParanoidiP20607.
    KOiK05405.
    OMAiFNQETCL.
    OrthoDBiEOG7QG453.
    PhylomeDBiP20607.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003574. IL-6.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view]
    PANTHERiPTHR11457. PTHR11457. 1 hit.
    PfamiPF00489. IL6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
    PRINTSiPR00433. IL6GCSFMGF.
    PR00434. INTERLEUKIN6.
    SMARTiSM00126. IL6. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20607-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFLSARDFQ PVAFLGLMLL TATAFPTSQV RRGDFTEDTT HNRPVYTTSQ    50
    VGGLITYVLR EILEMRKELC NGNSDCMNSD DALSENNLKL PEIQRNDGCF 100
    QTGYNQEICL LKICSGLLEF RFYLEFVKNN LQDNKKDKAR VIQSNTETLV 150
    HIFKQEIKDS YKIVLPTPTS NALLMEKLES QKEWLRTKTI QLILKALEEF 200
    LKVTMRSTRQ T 211
    Length:211
    Mass (Da):24,357
    Last modified:February 1, 1991 - v1
    Checksum:i17D248A14F96B5C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26744 mRNA. Translation: AAA77659.1.
    M26745 Genomic DNA. Translation: AAA41430.1.
    PIRiA34247.
    RefSeqiNP_036721.1. NM_012589.2.
    UniGeneiRn.9873.

    Genome annotation databases

    EnsembliENSRNOT00000013732; ENSRNOP00000013732; ENSRNOG00000010278.
    GeneIDi24498.
    KEGGirno:24498.
    UCSCiRGD:2901. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26744 mRNA. Translation: AAA77659.1 .
    M26745 Genomic DNA. Translation: AAA41430.1 .
    PIRi A34247.
    RefSeqi NP_036721.1. NM_012589.2.
    UniGenei Rn.9873.

    3D structure databases

    ProteinModelPortali P20607.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-189606.
    STRINGi 10116.ENSRNOP00000013732.

    Proteomic databases

    PRIDEi P20607.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013732 ; ENSRNOP00000013732 ; ENSRNOG00000010278 .
    GeneIDi 24498.
    KEGGi rno:24498.
    UCSCi RGD:2901. rat.

    Organism-specific databases

    CTDi 3569.
    RGDi 2901. Il6.

    Phylogenomic databases

    eggNOGi NOG48083.
    GeneTreei ENSGT00390000000878.
    HOGENOMi HOG000236330.
    HOVERGENi HBG000471.
    InParanoidi P20607.
    KOi K05405.
    OMAi FNQETCL.
    OrthoDBi EOG7QG453.
    PhylomeDBi P20607.

    Enzyme and pathway databases

    Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_199244. Interleukin-6 signaling.

    Miscellaneous databases

    NextBioi 603495.
    PROi P20607.

    Gene expression databases

    Genevestigatori P20607.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003574. IL-6.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view ]
    PANTHERi PTHR11457. PTHR11457. 1 hit.
    Pfami PF00489. IL6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001935. IL6_MGF_GCSF. 1 hit.
    PRINTSi PR00433. IL6GCSFMGF.
    PR00434. INTERLEUKIN6.
    SMARTi SM00126. IL6. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells."
      Northemann W., Braciak T.A., Hattori M., Lee F., Fey G.H.
      J. Biol. Chem. 264:16072-16082(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiIL6_RAT
    AccessioniPrimary (citable) accession number: P20607
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3