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Protein

Interferon-induced GTP-binding protein Mx2

Gene

MX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 132GTPSequence analysis8
Nucleotide bindingi225 – 229GTPSequence analysis5
Nucleotide bindingi294 – 297GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB
  • microtubule binding Source: GO_Central

GO - Biological processi

  • defense response Source: ProtInc
  • defense response to virus Source: UniProtKB
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • innate immune response Source: GO_Central
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: GO_Central
  • mRNA transport Source: UniProtKB-KW
  • protein transport Source: UniProtKB-KW
  • regulation of cell cycle Source: UniProtKB
  • regulation of nucleocytoplasmic transport Source: UniProtKB
  • response to interferon-alpha Source: UniProtKB
  • response to virus Source: UniProtKB
  • type I interferon signaling pathway Source: Reactome

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, mRNA transport, Protein transport, Translocation, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-909733 Interferon alpha/beta signaling

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx2
Alternative name(s):
Interferon-regulated resistance GTP-binding protein MxB
Myxovirus resistance protein 2
p78-related protein
Gene namesi
Name:MX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000183486.12
HGNCiHGNC:7533 MX2
MIMi147890 gene
neXtProtiNX_P20592

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131K → A: Loss of GTP-binding and localization to nuclear pore. Disruption of nuclear import. 1 Publication1
Mutagenesisi151T → A: Defective GTP-hydrolysis. Disruption of nuclear import and cell-cycle progression. 1 Publication1

Organism-specific databases

DisGeNETi4600
OpenTargetsiENSG00000183486
PharmGKBiPA31334

Polymorphism and mutation databases

BioMutaiMX2
DMDMi127571

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065981 – 715Interferon-induced GTP-binding protein Mx2Add BLAST715

Proteomic databases

EPDiP20592
MaxQBiP20592
PaxDbiP20592
PeptideAtlasiP20592
PRIDEiP20592

PTM databases

iPTMnetiP20592
PhosphoSitePlusiP20592

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Gene expression databases

BgeeiENSG00000183486
CleanExiHS_MX2
ExpressionAtlasiP20592 baseline and differential
GenevisibleiP20592 HS

Organism-specific databases

HPAiHPA030235

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110685, 4 interactors
DIPiDIP-59212N
IntActiP20592, 5 interactors
STRINGi9606.ENSP00000333657

Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi94 – 109Combined sources16
Beta strandi120 – 126Combined sources7
Helixi131 – 139Combined sources9
Beta strandi155 – 160Combined sources6
Beta strandi167 – 172Combined sources6
Turni173 – 175Combined sources3
Beta strandi176 – 179Combined sources4
Helixi183 – 198Combined sources16
Beta strandi200 – 202Combined sources3
Beta strandi209 – 214Combined sources6
Beta strandi220 – 225Combined sources6
Helixi242 – 253Combined sources12
Beta strandi258 – 265Combined sources8
Helixi270 – 272Combined sources3
Helixi274 – 282Combined sources9
Beta strandi287 – 294Combined sources8
Beta strandi296 – 298Combined sources3
Helixi302 – 312Combined sources11
Beta strandi322 – 324Combined sources3
Helixi339 – 352Combined sources14
Helixi356 – 361Combined sources6
Beta strandi362 – 364Combined sources3
Helixi370 – 406Combined sources37
Turni413 – 415Combined sources3
Helixi418 – 421Combined sources4
Helixi422 – 438Combined sources17
Helixi450 – 487Combined sources38
Helixi500 – 539Combined sources40
Helixi543 – 579Combined sources37
Helixi623 – 653Combined sources31
Helixi655 – 668Combined sources14
Helixi672 – 677Combined sources6
Helixi685 – 710Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHJX-ray3.20A/B84-715[»]
4X0RX-ray2.90A/B413-678[»]
5UOTelectron microscopy4.600/1/2/3/4/5/6/7/8/9/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T93-711[»]
ProteinModelPortaliP20592
SMRiP20592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 387Dynamin-type GPROSITE-ProRule annotationAdd BLAST273
Domaini623 – 714GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 132G1 motifPROSITE-ProRule annotation8
Regioni150 – 152G2 motifPROSITE-ProRule annotation3
Regioni225 – 228G3 motifPROSITE-ProRule annotation4
Regioni294 – 297G4 motifPROSITE-ProRule annotation4
Regioni326 – 329G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000063238
HOVERGENiHBG008788
InParanoidiP20592
OMAiARHALCQ
OrthoDBiEOG091G080G
PhylomeDBiP20592
TreeFamiTF331484

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20592-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ
60 70 80 90 100
GAEKDAAFLA KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC
110 120 130 140 150
IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV
160 170 180 190 200
TRCPLVLKLK KQPCEAWAGR ISYRNTELEL QDPGQVEKEI HKAQNVMAGN
210 220 230 240 250
GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD IGLQIKALIK
260 270 280 290 300
KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD
310 320 330 340 350
RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF
360 370 380 390 400
QTHPYFRVLL EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA
410 420 430 440 450
TEELRRCGAD IPSQEADKMF FLIEKIKMFN QDIEKLVEGE EVVRENETRL
460 470 480 490 500
YNKIREDFKN WVGILATNTQ KVKNIIHEEV EKYEKQYRGK ELLGFVNYKT
510 520 530 540 550
FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG EFFNLNQTVQ
560 570 580 590 600
STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL
610 620 630 640 650
GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ
660 670 680 690 700
YFMLRENGDS LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT
710
QARHALCQFS SKEIH
Length:715
Mass (Da):82,089
Last modified:February 1, 1991 - v1
Checksum:i1AE4B80157545344
GO
Isoform 2 (identifier: P20592-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-192: Missing.
     245-246: IK → VS
     247-715: Missing.

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,105
Checksum:i393996B23F611D6E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056443148 – 192Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_056444245 – 246IK → VS in isoform 2. 1 Publication2
Alternative sequenceiVSP_056445247 – 715Missing in isoform 2. 1 PublicationAdd BLAST469

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30818 mRNA Translation: AAA36338.1
M33883 mRNA Translation: AAA36459.1
AK298780 mRNA Translation: BAH12869.1
AL163285 Genomic DNA Translation: CAB90555.1
AL773578 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09605.1
CH471079 Genomic DNA Translation: EAX09606.1
BC035293 mRNA Translation: AAH35293.1
CCDSiCCDS13672.1 [P20592-1]
PIRiB33481
RefSeqiNP_002454.1, NM_002463.1 [P20592-1]
XP_005261040.1, XM_005260983.4 [P20592-1]
XP_005261041.1, XM_005260984.1 [P20592-1]
XP_011527873.1, XM_011529571.1 [P20592-1]
XP_011527874.1, XM_011529572.1 [P20592-1]
UniGeneiHs.926

Genome annotation databases

EnsembliENST00000330714; ENSP00000333657; ENSG00000183486 [P20592-1]
GeneIDi4600
KEGGihsa:4600
UCSCiuc002yzf.2 human [P20592-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMX2_HUMAN
AccessioniPrimary (citable) accession number: P20592
Secondary accession number(s): B7Z5D3, D3DSI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health