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Protein

Interferon-induced GTP-binding protein Mx2

Gene

MX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 132GTPSequence analysis8
Nucleotide bindingi225 – 229GTPSequence analysis5
Nucleotide bindingi294 – 297GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB
  • microtubule binding Source: GO_Central

GO - Biological processi

  • defense response Source: ProtInc
  • defense response to virus Source: UniProtKB
  • innate immune response Source: GO_Central
  • mRNA transport Source: UniProtKB-KW
  • organelle fission Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • regulation of cell cycle Source: UniProtKB
  • regulation of nucleocytoplasmic transport Source: UniProtKB
  • response to interferon-alpha Source: UniProtKB
  • response to virus Source: UniProtKB
  • type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, mRNA transport, Protein transport, Translocation, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32346-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-909733. Interferon alpha/beta signaling.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx2
Alternative name(s):
Interferon-regulated resistance GTP-binding protein MxB
Myxovirus resistance protein 2
p78-related protein
Gene namesi
Name:MX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:7533. MX2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • nuclear pore Source: UniProtKB
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131K → A: Loss of GTP-binding and localization to nuclear pore. Disruption of nuclear import. 1 Publication1
Mutagenesisi151T → A: Defective GTP-hydrolysis. Disruption of nuclear import and cell-cycle progression. 1 Publication1

Organism-specific databases

DisGeNETi4600.
OpenTargetsiENSG00000183486.
PharmGKBiPA31334.

Polymorphism and mutation databases

BioMutaiMX2.
DMDMi127571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065981 – 715Interferon-induced GTP-binding protein Mx2Add BLAST715

Proteomic databases

EPDiP20592.
MaxQBiP20592.
PaxDbiP20592.
PeptideAtlasiP20592.
PRIDEiP20592.

PTM databases

iPTMnetiP20592.
PhosphoSitePlusiP20592.

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Gene expression databases

BgeeiENSG00000183486.
CleanExiHS_MX2.
ExpressionAtlasiP20592. baseline and differential.
GenevisibleiP20592. HS.

Organism-specific databases

HPAiHPA030235.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATRIPQ8WXE13EBI-10200618,EBI-747353
EHMT2A2ABF93EBI-10200618,EBI-10174566
PIAS2O759283EBI-10200618,EBI-348555

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110685. 4 interactors.
DIPiDIP-59212N.
IntActiP20592. 4 interactors.
STRINGi9606.ENSP00000333657.

Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi94 – 109Combined sources16
Beta strandi120 – 126Combined sources7
Helixi131 – 139Combined sources9
Beta strandi155 – 160Combined sources6
Beta strandi167 – 172Combined sources6
Turni173 – 175Combined sources3
Beta strandi176 – 179Combined sources4
Helixi183 – 198Combined sources16
Beta strandi200 – 202Combined sources3
Beta strandi209 – 214Combined sources6
Beta strandi220 – 225Combined sources6
Helixi242 – 253Combined sources12
Beta strandi258 – 265Combined sources8
Helixi270 – 272Combined sources3
Helixi274 – 282Combined sources9
Beta strandi287 – 294Combined sources8
Beta strandi296 – 298Combined sources3
Helixi302 – 312Combined sources11
Beta strandi322 – 324Combined sources3
Helixi339 – 352Combined sources14
Helixi356 – 361Combined sources6
Beta strandi362 – 364Combined sources3
Helixi370 – 406Combined sources37
Turni413 – 415Combined sources3
Helixi418 – 421Combined sources4
Helixi422 – 438Combined sources17
Helixi450 – 487Combined sources38
Helixi500 – 539Combined sources40
Helixi543 – 579Combined sources37
Helixi623 – 653Combined sources31
Helixi655 – 668Combined sources14
Helixi672 – 677Combined sources6
Helixi685 – 710Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHJX-ray3.20A/B84-715[»]
4X0RX-ray2.90A/B413-678[»]
ProteinModelPortaliP20592.
SMRiP20592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 387Dynamin-type GAdd BLAST273
Domaini623 – 714GEDPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiP20592.
OMAiNTQKVKN.
OrthoDBiEOG091G080G.
PhylomeDBiP20592.
TreeFamiTF331484.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20592-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ
60 70 80 90 100
GAEKDAAFLA KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC
110 120 130 140 150
IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV
160 170 180 190 200
TRCPLVLKLK KQPCEAWAGR ISYRNTELEL QDPGQVEKEI HKAQNVMAGN
210 220 230 240 250
GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD IGLQIKALIK
260 270 280 290 300
KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD
310 320 330 340 350
RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF
360 370 380 390 400
QTHPYFRVLL EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA
410 420 430 440 450
TEELRRCGAD IPSQEADKMF FLIEKIKMFN QDIEKLVEGE EVVRENETRL
460 470 480 490 500
YNKIREDFKN WVGILATNTQ KVKNIIHEEV EKYEKQYRGK ELLGFVNYKT
510 520 530 540 550
FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG EFFNLNQTVQ
560 570 580 590 600
STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL
610 620 630 640 650
GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ
660 670 680 690 700
YFMLRENGDS LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT
710
QARHALCQFS SKEIH
Length:715
Mass (Da):82,089
Last modified:February 1, 1991 - v1
Checksum:i1AE4B80157545344
GO
Isoform 2 (identifier: P20592-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-192: Missing.
     245-246: IK → VS
     247-715: Missing.

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,105
Checksum:i393996B23F611D6E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056443148 – 192Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_056444245 – 246IK → VS in isoform 2. 1 Publication2
Alternative sequenceiVSP_056445247 – 715Missing in isoform 2. 1 PublicationAdd BLAST469

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30818 mRNA. Translation: AAA36338.1.
M33883 mRNA. Translation: AAA36459.1.
AK298780 mRNA. Translation: BAH12869.1.
AL163285 Genomic DNA. Translation: CAB90555.1.
AL773578 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09605.1.
CH471079 Genomic DNA. Translation: EAX09606.1.
BC035293 mRNA. Translation: AAH35293.1.
CCDSiCCDS13672.1. [P20592-1]
PIRiB33481.
RefSeqiNP_002454.1. NM_002463.1. [P20592-1]
XP_005261040.1. XM_005260983.4. [P20592-1]
XP_005261041.1. XM_005260984.1. [P20592-1]
XP_011527873.1. XM_011529571.1. [P20592-1]
XP_011527874.1. XM_011529572.1. [P20592-1]
UniGeneiHs.926.

Genome annotation databases

EnsembliENST00000330714; ENSP00000333657; ENSG00000183486. [P20592-1]
GeneIDi4600.
KEGGihsa:4600.
UCSCiuc002yzf.2. human. [P20592-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30818 mRNA. Translation: AAA36338.1.
M33883 mRNA. Translation: AAA36459.1.
AK298780 mRNA. Translation: BAH12869.1.
AL163285 Genomic DNA. Translation: CAB90555.1.
AL773578 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09605.1.
CH471079 Genomic DNA. Translation: EAX09606.1.
BC035293 mRNA. Translation: AAH35293.1.
CCDSiCCDS13672.1. [P20592-1]
PIRiB33481.
RefSeqiNP_002454.1. NM_002463.1. [P20592-1]
XP_005261040.1. XM_005260983.4. [P20592-1]
XP_005261041.1. XM_005260984.1. [P20592-1]
XP_011527873.1. XM_011529571.1. [P20592-1]
XP_011527874.1. XM_011529572.1. [P20592-1]
UniGeneiHs.926.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WHJX-ray3.20A/B84-715[»]
4X0RX-ray2.90A/B413-678[»]
ProteinModelPortaliP20592.
SMRiP20592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110685. 4 interactors.
DIPiDIP-59212N.
IntActiP20592. 4 interactors.
STRINGi9606.ENSP00000333657.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiP20592.
PhosphoSitePlusiP20592.

Polymorphism and mutation databases

BioMutaiMX2.
DMDMi127571.

Proteomic databases

EPDiP20592.
MaxQBiP20592.
PaxDbiP20592.
PeptideAtlasiP20592.
PRIDEiP20592.

Protocols and materials databases

DNASUi4600.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330714; ENSP00000333657; ENSG00000183486. [P20592-1]
GeneIDi4600.
KEGGihsa:4600.
UCSCiuc002yzf.2. human. [P20592-1]

Organism-specific databases

CTDi4600.
DisGeNETi4600.
GeneCardsiMX2.
HGNCiHGNC:7533. MX2.
HPAiHPA030235.
MIMi147890. gene.
neXtProtiNX_P20592.
OpenTargetsiENSG00000183486.
PharmGKBiPA31334.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiP20592.
OMAiNTQKVKN.
OrthoDBiEOG091G080G.
PhylomeDBiP20592.
TreeFamiTF331484.

Enzyme and pathway databases

BioCyciZFISH:G66-32346-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-909733. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiMX2. human.
GeneWikiiMX2.
GenomeRNAii4600.
PROiP20592.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183486.
CleanExiHS_MX2.
ExpressionAtlasiP20592. baseline and differential.
GenevisibleiP20592. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMX2_HUMAN
AccessioniPrimary (citable) accession number: P20592
Secondary accession number(s): B7Z5D3, D3DSI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.