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P20592

- MX2_HUMAN

UniProt

P20592 - MX2_HUMAN

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Protein

Interferon-induced GTP-binding protein Mx2

Gene

MX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 1328GTPSequence Analysis
Nucleotide bindingi225 – 2295GTPSequence Analysis
Nucleotide bindingi294 – 2974GTPSequence Analysis

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. GTP binding Source: UniProtKB

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. defense response Source: ProtInc
  3. defense response to virus Source: UniProtKB
  4. GTP catabolic process Source: GOC
  5. mRNA transport Source: UniProtKB-KW
  6. protein transport Source: UniProtKB-KW
  7. regulation of cell cycle Source: UniProtKB
  8. regulation of nucleocytoplasmic transport Source: UniProtKB
  9. response to interferon-alpha Source: UniProtKB
  10. response to virus Source: UniProtKB
  11. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, mRNA transport, Protein transport, Translocation, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_25162. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx2
Alternative name(s):
Interferon-regulated resistance GTP-binding protein MxB
Myxovirus resistance protein 2
p78-related protein
Gene namesi
Name:MX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:7533. MX2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication. Nucleusnuclear pore complex 1 Publication
Note: Localization to nuclear pores requires GTP-binding.

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. cytosol Source: Reactome
  3. nuclear pore Source: UniProtKB
  4. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi131 – 1311K → A: Loss of GTP-binding and localization to nuclear pore. Disruption of nuclear import. 1 Publication
Mutagenesisi151 – 1511T → A: Defective GTP-hydrolysis. Disruption of nuclear import and cell-cycle progression. 1 Publication

Organism-specific databases

PharmGKBiPA31334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Interferon-induced GTP-binding protein Mx2PRO_0000206598Add
BLAST

Proteomic databases

MaxQBiP20592.
PaxDbiP20592.
PRIDEiP20592.

PTM databases

PhosphoSiteiP20592.

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Gene expression databases

BgeeiP20592.
CleanExiHS_MX2.
ExpressionAtlasiP20592. baseline and differential.
GenevestigatoriP20592.

Organism-specific databases

HPAiHPA030235.

Interactioni

Protein-protein interaction databases

BioGridi110685. 2 interactions.
DIPiDIP-59212N.
STRINGi9606.ENSP00000333657.

Structurei

3D structure databases

ProteinModelPortaliP20592.
SMRiP20592. Positions 93-709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 387273Dynamin-type GAdd
BLAST
Domaini623 – 71492GEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0699.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiP20592.
OMAiNTQKVKN.
OrthoDBiEOG7034GF.
PhylomeDBiP20592.
TreeFamiTF331484.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20592-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ
60 70 80 90 100
GAEKDAAFLA KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC
110 120 130 140 150
IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV
160 170 180 190 200
TRCPLVLKLK KQPCEAWAGR ISYRNTELEL QDPGQVEKEI HKAQNVMAGN
210 220 230 240 250
GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD IGLQIKALIK
260 270 280 290 300
KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD
310 320 330 340 350
RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF
360 370 380 390 400
QTHPYFRVLL EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA
410 420 430 440 450
TEELRRCGAD IPSQEADKMF FLIEKIKMFN QDIEKLVEGE EVVRENETRL
460 470 480 490 500
YNKIREDFKN WVGILATNTQ KVKNIIHEEV EKYEKQYRGK ELLGFVNYKT
510 520 530 540 550
FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG EFFNLNQTVQ
560 570 580 590 600
STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL
610 620 630 640 650
GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ
660 670 680 690 700
YFMLRENGDS LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT
710
QARHALCQFS SKEIH
Length:715
Mass (Da):82,089
Last modified:February 1, 1991 - v1
Checksum:i1AE4B80157545344
GO
Isoform 2 (identifier: P20592-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-192: Missing.
     245-246: IK → VS
     247-715: Missing.

Note: No experimental confirmation available.

Show »
Length:201
Mass (Da):22,105
Checksum:i393996B23F611D6E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei148 – 19245Missing in isoform 2. 1 PublicationVSP_056443Add
BLAST
Alternative sequencei245 – 2462IK → VS in isoform 2. 1 PublicationVSP_056444
Alternative sequencei247 – 715469Missing in isoform 2. 1 PublicationVSP_056445Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30818 mRNA. Translation: AAA36338.1.
M33883 mRNA. Translation: AAA36459.1.
AK298780 mRNA. Translation: BAH12869.1.
AL163285 Genomic DNA. Translation: CAB90555.1.
AL773578 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09605.1.
CH471079 Genomic DNA. Translation: EAX09606.1.
BC035293 mRNA. Translation: AAH35293.1.
CCDSiCCDS13672.1. [P20592-1]
PIRiB33481.
RefSeqiNP_002454.1. NM_002463.1. [P20592-1]
XP_005261040.1. XM_005260983.2. [P20592-1]
XP_005261041.1. XM_005260984.1. [P20592-1]
UniGeneiHs.926.

Genome annotation databases

EnsembliENST00000330714; ENSP00000333657; ENSG00000183486. [P20592-1]
GeneIDi4600.
KEGGihsa:4600.
UCSCiuc002yzf.1. human. [P20592-1]

Polymorphism databases

DMDMi127571.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30818 mRNA. Translation: AAA36338.1 .
M33883 mRNA. Translation: AAA36459.1 .
AK298780 mRNA. Translation: BAH12869.1 .
AL163285 Genomic DNA. Translation: CAB90555.1 .
AL773578 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09605.1 .
CH471079 Genomic DNA. Translation: EAX09606.1 .
BC035293 mRNA. Translation: AAH35293.1 .
CCDSi CCDS13672.1. [P20592-1 ]
PIRi B33481.
RefSeqi NP_002454.1. NM_002463.1. [P20592-1 ]
XP_005261040.1. XM_005260983.2. [P20592-1 ]
XP_005261041.1. XM_005260984.1. [P20592-1 ]
UniGenei Hs.926.

3D structure databases

ProteinModelPortali P20592.
SMRi P20592. Positions 93-709.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110685. 2 interactions.
DIPi DIP-59212N.
STRINGi 9606.ENSP00000333657.

PTM databases

PhosphoSitei P20592.

Polymorphism databases

DMDMi 127571.

Proteomic databases

MaxQBi P20592.
PaxDbi P20592.
PRIDEi P20592.

Protocols and materials databases

DNASUi 4600.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330714 ; ENSP00000333657 ; ENSG00000183486 . [P20592-1 ]
GeneIDi 4600.
KEGGi hsa:4600.
UCSCi uc002yzf.1. human. [P20592-1 ]

Organism-specific databases

CTDi 4600.
GeneCardsi GC21P042734.
HGNCi HGNC:7533. MX2.
HPAi HPA030235.
MIMi 147890. gene.
neXtProti NX_P20592.
PharmGKBi PA31334.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0699.
GeneTreei ENSGT00760000119213.
HOGENOMi HOG000063238.
HOVERGENi HBG008788.
InParanoidi P20592.
OMAi NTQKVKN.
OrthoDBi EOG7034GF.
PhylomeDBi P20592.
TreeFami TF331484.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
REACT_25162. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSi MX2. human.
GeneWikii MX2.
GenomeRNAii 4600.
NextBioi 17688.
PROi P20592.
SOURCEi Search...

Gene expression databases

Bgeei P20592.
CleanExi HS_MX2.
ExpressionAtlasi P20592. baseline and differential.
Genevestigatori P20592.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11566. PTHR11566. 1 hit.
Pfami PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view ]
PRINTSi PR00195. DYNAMIN.
SMARTi SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA structures and regulation of two interferon-induced human Mx proteins."
    Aebi M., Faeh J., Hurt N., Samuel C.E., Thomis D., Bazzigher L., Pavlovic J., Haller O., Staeheli P.
    Mol. Cell. Biol. 9:5062-5072(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter."
    Horisberger M.A., McMaster G.K., Zeller H., Wathelet M.G., Dellis J., Content J.
    J. Virol. 64:1171-1181(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-715 (ISOFORM 1).
  7. "Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB."
    King M.C., Raposo G., Lemmon M.A.
    Proc. Natl. Acad. Sci. U.S.A. 101:8957-8962(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-131 AND THR-151.
  8. "The Mx GTPase family of interferon-induced antiviral proteins."
    Haller O., Stertz S., Kochs G.
    Microbes Infect. 9:1636-1643(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, INDUCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Dynamins are forever: MxB inhibits HIV-1."
    Haller O.
    Cell Host Microbe 14:371-373(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "The interferon-inducible MxB protein inhibits HIV-1 infection."
    Liu Z., Pan Q., Ding S., Qian J., Xu F., Zhou J., Cen S., Guo F., Liang C.
    Cell Host Microbe 14:398-410(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HIV-1 RESTRICTION.
  12. "Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection."
    Goujon C., Moncorge O., Bauby H., Doyle T., Ward C.C., Schaller T., Hue S., Barclay W.S., Schulz R., Malim M.H.
    Nature 502:559-562(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HIV-1 RESTRICTION.
  13. Cited for: FUNCTION IN HIV-1 RESTRICTION.

Entry informationi

Entry nameiMX2_HUMAN
AccessioniPrimary (citable) accession number: P20592
Secondary accession number(s): B7Z5D3, D3DSI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 26, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3