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Protein

Interferon-induced GTP-binding protein Mx1

Gene

MX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.13 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 848GTPSequence analysis
Nucleotide bindingi178 – 1825GTPSequence analysis
Nucleotide bindingi247 – 2504GTPSequence analysis

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • defense response Source: ProtInc
  • defense response to virus Source: UniProtKB-KW
  • innate immune response Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • response to type I interferon Source: UniProtKB
  • response to virus Source: UniProtKB
  • signal transduction Source: ProtInc
  • type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-909733. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Interferon-induced protein p78
Short name:
IFI-78K
Interferon-regulated resistance GTP-binding protein MxA
Myxoma resistance protein 1
Myxovirus resistance protein 1
Cleaved into the following chain:
Gene namesi
Name:MX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:7532. MX1.

Subcellular locationi

Isoform 2 :

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • nuclear membrane Source: HPA
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi81 – 811S → C: No effect on GTP-binding, nor on viral infection. 1 Publication
Mutagenesisi83 – 831K → A: Loss of GTP-binding. Loss of potentiation of TRPC6 activity. Loss of protection against viral infection. 2 Publications
Mutagenesisi83 – 831K → M: Loss of GTP-binding. Loss of protection against viral infection. 2 Publications
Mutagenesisi103 – 1031T → A: Loss of GTP-binding. Loss of potentiation of TRPC6 activity. Loss of protection against viral infection. 2 Publications
Mutagenesisi554 – 5541K → E: Strong liposome-binding reduction. 1 Publication
Mutagenesisi555 – 5551K → E: Strong liposome-binding reduction. 1 Publication
Mutagenesisi556 – 5561K → E: Strong liposome-binding reduction. 1 Publication
Mutagenesisi557 – 5571K → E: Strong liposome-binding reduction. 1 Publication
Mutagenesisi612 – 6121L → K: Loss of GTP-hydrolysis. No effect on GTP-binding, nor on potentiation of TRPC6 activity. 1 Publication
Mutagenesisi632 – 6321E → A: Reduced antiviral activity. 1 Publication
Mutagenesisi640 – 6401R → A: Fails to sequester viral nucleoproteins, no antiviral activity. 1 Publication
Mutagenesisi645 – 6451E → R: Loss of antiviral activity towards CCHFV and LACV. 2 Publications

Organism-specific databases

PharmGKBiPA31333.

Polymorphism and mutation databases

BioMutaiMX1.
DMDMi251757499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Interferon-induced GTP-binding protein Mx1PRO_0000382943Add
BLAST
Initiator methionineiRemoved; alternate2 Publications
Chaini2 – 662661Interferon-induced GTP-binding protein Mx1, N-terminally processedPRO_0000206592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine; in Interferon-induced GTP-binding protein Mx1; alternate1 Publication

Post-translational modificationi

ISGylated.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiP20591.
MaxQBiP20591.
PaxDbiP20591.
PeptideAtlasiP20591.
PRIDEiP20591.

PTM databases

iPTMnetiP20591.
PhosphoSiteiP20591.

Expressioni

Inductioni

By type I and type III interferons. Isoform 2 is induced by HSV-1.1 Publication

Gene expression databases

BgeeiENSG00000157601.
CleanExiHS_MX1.
ExpressionAtlasiP20591. baseline and differential.
GenevisibleiP20591. HS.

Organism-specific databases

HPAiHPA030917.
HPA049724.

Interactioni

Subunit structurei

Homotetramer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Interacts with HSPA5. Interacts with DDX39A and DDX39B. Interacts with TUBB/TUBB5 (By similarity). The GTP-bound form interacts (via C-terminus) with THOV P5 protein. The GTP-bound form interacts with LACV protein N. Interacts with CCHFV protein N.By similarity10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CAB39LQ9H9S43EBI-929476,EBI-1047244
SIAH1Q8IUQ43EBI-929476,EBI-747107
TRPC3Q135072EBI-929476,EBI-520807
TRPC4Q9UBN42EBI-929476,EBI-929504
TRPC6Q9Y2104EBI-929476,EBI-929362

Protein-protein interaction databases

BioGridi110684. 36 interactions.
DIPiDIP-35694N.
IntActiP20591. 12 interactions.
STRINGi9606.ENSP00000381599.

Structurei

Secondary structure

1
662
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni47 – 493Combined sources
Helixi50 – 6112Combined sources
Helixi64 – 663Combined sources
Beta strandi72 – 787Combined sources
Helixi83 – 919Combined sources
Beta strandi99 – 1013Combined sources
Beta strandi107 – 1137Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi121 – 1266Combined sources
Beta strandi129 – 1335Combined sources
Helixi136 – 1383Combined sources
Helixi139 – 15012Combined sources
Beta strandi153 – 1553Combined sources
Beta strandi162 – 1687Combined sources
Beta strandi173 – 1786Combined sources
Helixi194 – 20613Combined sources
Beta strandi208 – 2103Combined sources
Beta strandi211 – 2188Combined sources
Helixi223 – 2253Combined sources
Helixi227 – 2359Combined sources
Beta strandi240 – 2478Combined sources
Helixi249 – 2513Combined sources
Beta strandi252 – 2565Combined sources
Helixi257 – 2648Combined sources
Beta strandi267 – 2693Combined sources
Beta strandi275 – 2773Combined sources
Helixi283 – 2875Combined sources
Helixi292 – 30413Combined sources
Turni307 – 3093Combined sources
Helixi310 – 3145Combined sources
Helixi320 – 33819Combined sources
Turni339 – 3413Combined sources
Helixi342 – 35817Combined sources
Helixi367 – 39024Combined sources
Helixi403 – 43735Combined sources
Beta strandi444 – 4463Combined sources
Helixi451 – 46313Combined sources
Helixi466 – 49227Combined sources
Helixi496 – 52833Combined sources
Helixi574 – 60431Combined sources
Helixi606 – 61813Combined sources
Helixi623 – 6253Combined sources
Helixi626 – 6294Combined sources
Helixi635 – 65824Combined sources
Turni659 – 6613Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LJBX-ray2.40A/B366-636[»]
3SZRX-ray3.50A33-662[»]
3ZYSelectron microscopy12.20B/E1-662[»]
4P4SX-ray3.30A70-342[»]
B43-662[»]
4P4TX-ray2.30A37-366[»]
A637-662[»]
4P4UX-ray1.90A37-364[»]
A632-661[»]
ProteinModelPortaliP20591.
SMRiP20591. Positions 44-662.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 340274Dynamin-type GAdd
BLAST
Domaini574 – 66289GEDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 340272GTPase domain (Globular)Add
BLAST
Regioni341 – 36626Bundle signaling element (BSE)Add
BLAST
Regioni366 – 533168Middle domainAdd
BLAST
Regioni367 – 632266StalkAdd
BLAST
Regioni554 – 5574Critical for lipid-binding

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.1 Publication
The middle domain mediates self-assembly and oligomerization.1 Publication

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000213785.
HOVERGENiHBG008788.
InParanoidiP20591.
KOiK14754.
OMAiLHTVTDM.
OrthoDBiEOG091G080G.
PhylomeDBiP20591.
TreeFamiTF331484.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20591-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVSEVDIAK ADPAAASHPL LLNGDATVAQ KNPGSVAENN LCSQYEEKVR
60 70 80 90 100
PCIDLIDSLR ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG
110 120 130 140 150
IVTRCPLVLK LKKLVNEDKW RGKVSYQDYE IEISDASEVE KEINKAQNAI
160 170 180 190 200
AGEGMGISHE LITLEISSRD VPDLTLIDLP GITRVAVGNQ PADIGYKIKT
210 220 230 240 250
LIKKYIQRQE TISLVVVPSN VDIATTEALS MAQEVDPEGD RTIGILTKPD
260 270 280 290 300
LVDKGTEDKV VDVVRNLVFH LKKGYMIVKC RGQQEIQDQL SLSEALQREK
310 320 330 340 350
IFFENHPYFR DLLEEGKATV PCLAEKLTSE LITHICKSLP LLENQIKETH
360 370 380 390 400
QRITEELQKY GVDIPEDENE KMFFLIDKVN AFNQDITALM QGEETVGEED
410 420 430 440 450
IRLFTRLRHE FHKWSTIIEN NFQEGHKILS RKIQKFENQY RGRELPGFVN
460 470 480 490 500
YRTFETIVKQ QIKALEEPAV DMLHTVTDMV RLAFTDVSIK NFEEFFNLHR
510 520 530 540 550
TAKSKIEDIR AEQEREGEKL IRLHFQMEQI VYCQDQVYRG ALQKVREKEL
560 570 580 590 600
EEEKKKKSWD FGAFQSSSAT DSSMEEIFQH LMAYHQEASK RISSHIPLII
610 620 630 640 650
QFFMLQTYGQ QLQKAMLQLL QDKDTYSWLL KERSDTSDKR KFLKERLARL
660
TQARRRLAQF PG
Length:662
Mass (Da):75,520
Last modified:July 7, 2009 - v4
Checksum:i626A7DD946F89384
GO
Isoform 2 (identifier: P20591-2) [UniParc]FASTAAdd to basket
Also known as: 56-kda, varMxA

The sequence of this isoform differs from the canonical sequence as follows:
     425-662: GHKILSRKIQ...ARRRLAQFPG → GGQQAHLQPH...PRLTTLCPAP

Show »
Length:508
Mass (Da):55,661
Checksum:i4681FED66E2F8C21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641L → R in AAA36337 (PubMed:2481229).Curated
Sequence conflicti250 – 2501D → G in BAG53272 (PubMed:20603636).Curated
Sequence conflicti297 – 2971Q → H in BAG37852 (PubMed:20603636).Curated
Sequence conflicti299 – 2991E → G in BAG53272 (PubMed:20603636).Curated
Sequence conflicti582 – 5821M → I in BAG37852 (PubMed:20603636).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti379 – 3791V → I.6 Publications
Corresponds to variant rs469390 [ dbSNP | Ensembl ].
VAR_058010
Natural varianti381 – 3811A → V.
Corresponds to variant rs34717738 [ dbSNP | Ensembl ].
VAR_034116
Natural varianti611 – 6111Q → H.
Corresponds to variant rs2230454 [ dbSNP | Ensembl ].
VAR_034117

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei425 – 662238GHKIL…AQFPG → GGQQAHLQPHPFDHPVLHAP DVRPAASEGHAAAPAGQGHL QLAPEGAERHQRQAEVPEGA ACTADAGSAPACPVPRLTTL CPAP in isoform 2. 1 PublicationVSP_042904Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30817 mRNA. Translation: AAA36337.1.
M33882 mRNA. Translation: AAA36458.1.
AF135187 Genomic DNA. Translation: AAD43063.1.
AK096355 mRNA. Translation: BAG53272.1.
AK315465 mRNA. Translation: BAG37852.1.
AL163285 Genomic DNA. Translation: CAB90556.1.
AL773577 Genomic DNA. No translation available.
AL773578 Genomic DNA. No translation available.
AP001610 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09600.1.
CH471079 Genomic DNA. Translation: EAX09601.1.
CH471079 Genomic DNA. Translation: EAX09602.1.
CH471079 Genomic DNA. Translation: EAX09603.1.
CH471079 Genomic DNA. Translation: EAX09604.1.
BC014222 mRNA. Translation: AAH14222.2.
BC032602 mRNA. Translation: AAH32602.1.
AY186254 mRNA. Translation: AAO31807.1.
CCDSiCCDS13673.1. [P20591-1]
CCDS74796.1. [P20591-2]
PIRiA33481.
RefSeqiNP_001138397.1. NM_001144925.2. [P20591-1]
NP_001171517.1. NM_001178046.2. [P20591-1]
NP_001269849.1. NM_001282920.1. [P20591-2]
NP_002453.2. NM_002462.4. [P20591-1]
XP_005261035.1. XM_005260978.4. [P20591-1]
XP_005261036.1. XM_005260979.2. [P20591-1]
XP_005261037.1. XM_005260980.2. [P20591-1]
XP_005261038.1. XM_005260981.2. [P20591-1]
XP_005261039.1. XM_005260982.2. [P20591-1]
XP_011527870.1. XM_011529568.2. [P20591-1]
UniGeneiHs.517307.

Genome annotation databases

EnsembliENST00000398598; ENSP00000381599; ENSG00000157601. [P20591-1]
ENST00000398600; ENSP00000381601; ENSG00000157601. [P20591-1]
ENST00000455164; ENSP00000410523; ENSG00000157601. [P20591-1]
ENST00000619682; ENSP00000478441; ENSG00000157601. [P20591-2]
GeneIDi4599.
KEGGihsa:4599.
UCSCiuc002yzh.5. human. [P20591-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30817 mRNA. Translation: AAA36337.1.
M33882 mRNA. Translation: AAA36458.1.
AF135187 Genomic DNA. Translation: AAD43063.1.
AK096355 mRNA. Translation: BAG53272.1.
AK315465 mRNA. Translation: BAG37852.1.
AL163285 Genomic DNA. Translation: CAB90556.1.
AL773577 Genomic DNA. No translation available.
AL773578 Genomic DNA. No translation available.
AP001610 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09600.1.
CH471079 Genomic DNA. Translation: EAX09601.1.
CH471079 Genomic DNA. Translation: EAX09602.1.
CH471079 Genomic DNA. Translation: EAX09603.1.
CH471079 Genomic DNA. Translation: EAX09604.1.
BC014222 mRNA. Translation: AAH14222.2.
BC032602 mRNA. Translation: AAH32602.1.
AY186254 mRNA. Translation: AAO31807.1.
CCDSiCCDS13673.1. [P20591-1]
CCDS74796.1. [P20591-2]
PIRiA33481.
RefSeqiNP_001138397.1. NM_001144925.2. [P20591-1]
NP_001171517.1. NM_001178046.2. [P20591-1]
NP_001269849.1. NM_001282920.1. [P20591-2]
NP_002453.2. NM_002462.4. [P20591-1]
XP_005261035.1. XM_005260978.4. [P20591-1]
XP_005261036.1. XM_005260979.2. [P20591-1]
XP_005261037.1. XM_005260980.2. [P20591-1]
XP_005261038.1. XM_005260981.2. [P20591-1]
XP_005261039.1. XM_005260982.2. [P20591-1]
XP_011527870.1. XM_011529568.2. [P20591-1]
UniGeneiHs.517307.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LJBX-ray2.40A/B366-636[»]
3SZRX-ray3.50A33-662[»]
3ZYSelectron microscopy12.20B/E1-662[»]
4P4SX-ray3.30A70-342[»]
B43-662[»]
4P4TX-ray2.30A37-366[»]
A637-662[»]
4P4UX-ray1.90A37-364[»]
A632-661[»]
ProteinModelPortaliP20591.
SMRiP20591. Positions 44-662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110684. 36 interactions.
DIPiDIP-35694N.
IntActiP20591. 12 interactions.
STRINGi9606.ENSP00000381599.

PTM databases

iPTMnetiP20591.
PhosphoSiteiP20591.

Polymorphism and mutation databases

BioMutaiMX1.
DMDMi251757499.

Proteomic databases

EPDiP20591.
MaxQBiP20591.
PaxDbiP20591.
PeptideAtlasiP20591.
PRIDEiP20591.

Protocols and materials databases

DNASUi4599.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398598; ENSP00000381599; ENSG00000157601. [P20591-1]
ENST00000398600; ENSP00000381601; ENSG00000157601. [P20591-1]
ENST00000455164; ENSP00000410523; ENSG00000157601. [P20591-1]
ENST00000619682; ENSP00000478441; ENSG00000157601. [P20591-2]
GeneIDi4599.
KEGGihsa:4599.
UCSCiuc002yzh.5. human. [P20591-1]

Organism-specific databases

CTDi4599.
GeneCardsiMX1.
H-InvDBHIX0027784.
HGNCiHGNC:7532. MX1.
HPAiHPA030917.
HPA049724.
MIMi147150. gene.
neXtProtiNX_P20591.
PharmGKBiPA31333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000213785.
HOVERGENiHBG008788.
InParanoidiP20591.
KOiK14754.
OMAiLHTVTDM.
OrthoDBiEOG091G080G.
PhylomeDBiP20591.
TreeFamiTF331484.

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-909733. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiMX1. human.
EvolutionaryTraceiP20591.
GeneWikiiMX1.
GenomeRNAii4599.
PROiP20591.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157601.
CleanExiHS_MX1.
ExpressionAtlasiP20591. baseline and differential.
GenevisibleiP20591. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMX1_HUMAN
AccessioniPrimary (citable) accession number: P20591
Secondary accession number(s): B2RDA5
, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, Q86YP5, Q96CI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 7, 2009
Last modified: September 7, 2016
This is version 158 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.