P20579 (TRPE_PSEPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Pseudomonas putida (Arthrobacter siderocapsulatus)

Taxonomic identifier

303 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas putida group

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Anthranilate synthase component 1		PRO_0000154107

Sequences

	Sequence		Length	Mass (Da)
	P20579 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: FBD05348D0D94A76	FASTA	493	54,449
	10 20 30 40 50 60 MNREEFLRLA AVGYNRIPLA CETLADFDTP LSIYLKLADQ PNSYLLESVQ GGEKWGRYSM 70 80 90 100 110 120 IGLPSRTVMR VHGYHVSILH DGVEVESHDV EDPLAFVESF KDRYKVADIP GLPRFNGGLV 130 140 150 160 170 180 GYFGYDCVRY VEKRLGVSPN PDPLGVPDIL LMVSDAVVVF DNLAGKMHAI VLVDPAEEQA 190 200 210 220 230 240 FEQGQARLQG LLETLRQPIT PRRGLDLSGP QAAEPEFRSS YTREDYENAV GRIKEYILAG 250 260 270 280 290 300 DCMQVVPSQR MSIDFKAAPI DLYRALRCFN PTPYMYFFNF GDFHVVGSSP EVLVRVEDNL 310 320 330 340 350 360 VTVRPIAGTR PRGATEEADR ALEDDLLSDD KEIAEHLMLI DLGRNDVGRV SSTGSVRLTE 370 380 390 400 410 420 KMVIERYSNV MHIVSNVAGQ LREGLTAMDA LRAILPAGTL SGAPKIRAME IIDELEPVKR 430 440 450 460 470 480 GVYGGAVGYF AWNGNMDTAI AIRTAVINDG ELHVQAGGGI VADSVPALEW EETINKRRAM 490 FRAVALAEQT SAK

References

[1]

"Evolutionary differences in chromosomal locations of four early genes of the tryptophan pathway in fluorescent pseudomonads: DNA sequences and characterization of Pseudomonas putida trpE and trpGDC." Essar D.W., Eberly L., Crawford I.P. J. Bacteriol. 172:867-883(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 23287 / C1S.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33799 Genomic DNA. Translation: AAA80551.1.
PIR	E35115.
3D structure databases
ProteinModelPortal	P20579.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00035; UER00040.
Family and domain databases
Gene3D	3.60.120.10. 1 hit.
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. trpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_PSEPU

Accession

Primary (citable) accession number: P20579

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program