P20577 (TRPC_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	PA0651

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154238

Sequences

	Sequence		Length	Mass (Da)
	P20577 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 478FEF45378B55F8	FASTA	278	30,347
	10 20 30 40 50 60 MSVPTVLQKI LARKAEEVAE RRARVNLAEV ERLARSADAP RGFANALLER AKRKEPAVIA 70 80 90 100 110 120 EIKKASPSKG VLREHFVPAE IARSYEAGGA ACLSVLTDVD FFQGADAYLK EARAACALPV 130 140 150 160 170 180 IRKDFMIDPY QIVEARAIGA DCILLIVSAL DDVLMAELAA TAKSVGLDVL VEVHDGTELE 190 200 210 220 230 240 RALKTLDTPL VGINNRNLHT FEVSLETTLD LLPEIPRDRL VVTESGILNR ADVELMEVSE 250 260 270 VYAFLVGEAF MRADDPGLEL KRLFFQERGA VVLGADPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa." Essar D.W., Eberly L., Han C.Y., Crawford I.P. J. Bacteriol. 172:853-866(1990) [PubMed: 2105306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[3]	"The vfr gene product, required for Pseudomonas aeruginosa exotoxin A and protease production, belongs to the cyclic AMP receptor protein family." West S.E.H., Sample A.K., Runyen-Janecky L.J. J. Bacteriol. 176:7532-7542(1994) [PubMed: 8002577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-278. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33814 Genomic DNA. Translation: AAA25825.1. AE004091 Genomic DNA. Translation: AAG04040.1.
PIR	C35114.
RefSeq	NP_249342.1. NC_002516.2.
3D structure databases
ProteinModelPortal	P20577.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	882120.
GenomeReviews	Gene locus PA0651 in contig AE004091_GR.
KEGG	pae:PA0651.
NMPDR	fig|208964.1.peg.652.
PATRIC	19835564. VBIPseAer58763_0682.
Organism-specific databases
PseudoCAP	PA0651.
Phylogenomic databases
HOGENOM	HBG540956.
OMA	LEYAVPH.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	PAER208964:PA0651-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_PSEAE

Accession

Primary (citable) accession number: P20577

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program