P20574 (TRPD_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate phosphoribosyltransferase
EC=2.4.2.18

Gene names

Name:	trpD
Ordered Locus Names:	PA0650

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00211
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. HAMAP MF_00211
Sequence similarities	Belongs to the anthranilate phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Anthranilate phosphoribosyltransferase HAMAP MF_00211		PRO_0000154468

Sequences

	Sequence		Length	Mass (Da)
	P20574 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: CAC05F684969BA4B	FASTA	349	37,384
	10 20 30 40 50 60 MDIKGALNRI VNQLDLTTEE MQAVMRQIMT GQCTDAQIGA FLMGMRMKSE TIDEIVGAVA 70 80 90 100 110 120 VMRELADGVQ LPTLKHVVDV VGTGGDGANI FNVSSAASFV VAAAGGKVAK HGNRAVSGKS 130 140 150 160 170 180 GSADLLEAAG IYLELTSEQV ARCIDTVGVG FMFAQVHHKA MKYAAGPRRE LGLRTLFNML 190 200 210 220 230 240 GPLTNPAGVR HQVVGVFTQE LCKPLAEVLK RLGSEHVLVV HSRDGLDEFS LAAATHIAEL 250 260 270 280 290 300 KDGEVREYEV RPEDFGIKSQ TLMGLEVDSP QASLELIRDA LGRRKTEAGQ KAAELIVMNA 310 320 330 340 GPALYAADLA TSLHEGIQLA HDALHTGLAR EKMDELVAFT AVYREENAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa." Essar D.W., Eberly L., Han C.Y., Crawford I.P. J. Bacteriol. 172:853-866(1990) [PubMed: 2105306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33814 Genomic DNA. Translation: AAA25824.1. AE004091 Genomic DNA. Translation: AAG04039.1.
PIR	B35114.
RefSeq	NP_249341.1. NC_002516.2.
3D structure databases
ProteinModelPortal	P20574.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	880665.
GenomeReviews	Gene locus PA0650 in contig AE004091_GR.
KEGG	pae:PA0650.
PATRIC	19835562. VBIPseAer58763_0681.
Organism-specific databases
PseudoCAP	PA0650.
Phylogenomic databases
HOGENOM	HBG559996.
OMA	VVDTCGT.
ProtClustDB	PRK00188.
Enzyme and pathway databases
BioCyc	PAER208964:PA0650-MONOMER.
Family and domain databases
HAMAP	MF_00211. TrpD. [Tree]
InterPro	IPR005940. Anthranilate_Pribosyl_Tfrase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N. IPR020072. Glycosyl_Trfase_fam3_subgr_N. [Graphical view]
Gene3D	G3DSA:1.20.970.10. Glyco_trans_3. 2 hits. G3DSA:3.40.1030.10. Glyco_trans_3. 2 hits.
KO	K00766.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit.
TIGRFAMs	TIGR01245. TrpD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPD_PSEAE

Accession

Primary (citable) accession number: P20574

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program