Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein L1

Gene

L1R

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein L1
Alternative name(s):
Virion membrane protein M25
Gene namesi
ORF Names:L1R
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 183Virion surfaceSequence analysisAdd BLAST182
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 250IntravirionSequence analysisAdd BLAST46

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Complete loss of myristoylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by host
ChainiPRO_00000996122 – 250Protein L1Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine; by host1 Publication1
Disulfide bondi34 ↔ 57By similarity
Disulfide bondi49 ↔ 136By similarity
Disulfide bondi116 ↔ 158By similarity

Post-translational modificationi

Myristoylated.By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Interactioni

Subunit structurei

Interacts with G4; this interaction involves formation of a transient disulfide-bonded intermediate, allowing disulfide bond transfer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP20540.
SMRiP20540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 12Targeting to MV membraneBy similarityAdd BLAST11

Sequence similaritiesi

Belongs to the chordopoxvirinae L1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000VH.

Family and domain databases

InterProiView protein in InterPro
IPR003472. Virion_mem_poxvirus_L1.
PfamiView protein in Pfam
PF02442. L1R_F9L. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAASIQTT VNTLSERISS KLEQEANASA QTKCDIEIGN FYIRQNHGCN
60 70 80 90 100
LTVKNMCSAD ADAQLDAVLS AATETYSGLT PEQKAYVPAM FTAALNIQTS
110 120 130 140 150
VNTVVRDFEN YVKQTCNSSA VVDNKLKIQN VIIDECYGAP GSPTNLEFIN
160 170 180 190 200
TGSSKGNCAI KALMQLTTKA TTQIAPRQVA GTGVQFYMIV IGVIILAALF
210 220 230 240 250
MYYAKRMLFT STNDKIKLIL ANKENVHWTT YMDTFFRTSP MVIATTDMQN
Length:250
Mass (Da):27,307
Last modified:January 23, 2007 - v3
Checksum:i28E1ABB817410A2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48076.1.
PIRiH42512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48076.1.
PIRiH42512.

3D structure databases

ProteinModelPortaliP20540.
SMRiP20540.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000VH.

Family and domain databases

InterProiView protein in InterPro
IPR003472. Virion_mem_poxvirus_L1.
PfamiView protein in Pfam
PF02442. L1R_F9L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiL1_VACCC
AccessioniPrimary (citable) accession number: P20540
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.