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Protein

Phospholipase-D-like protein K4

Gene

K4L

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA nicking enzyme that cleaves extruded cruciform DNA at its apex (By similarity). Probably nicks viral hairpins.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase-D-like protein K4
Gene namesi
ORF Names:K4L
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

  • Virion By similarity
  • Note: Virion core.By similarity

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000996011 – 424Phospholipase-D-like protein K4Add BLAST424

Proteomic databases

PRIDEiP20537

Structurei

3D structure databases

ProteinModelPortaliP20537
SMRiP20537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 137PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini320 – 346PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat

Phylogenomic databases

OrthoDBiVOG090002C0

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF00614 PLDc, 2 hits
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

P20537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDNTIAVI TETIPIGMQF DKVYLSTFNM WREILSNTTK TLDISSFYWS
60 70 80 90 100
LSDEVGTNFG TIILNEIVQL PKRGVRVRVA VNKSNKPLKD VERLQMAGVE
110 120 130 140 150
VRYIDITNIL GGVLHTKFWI SDNTHIYLGS ANMDWRSLTQ VKELGIAIFN
160 170 180 190 200
NRNLAADLTQ IFEVYWYLGV NNLPYNWKNF YPSYYNTDHP LSINVSGVPH
210 220 230 240 250
SVFIASAPQQ LCTMERTNDL TALLSCIRNA SKFVYVSVMN FIPIIYSKAG
260 270 280 290 300
KILFWPYIED ELRRSAIDRQ VSVKLLISCW QRSSFIMRNF LRSIAMLKSK
310 320 330 340 350
NIDIEVKLFI VPDADPPIPY SRVNHAKYMV TDKTAYIGTS NWTGNYFTDT
360 370 380 390 400
CGASINITPD DGLGLRQQLE DIFMRDWNSK YSYELYDTSP TKRCKLLKNM
410 420
KQCTNDIYCD EIQPEKEIPE YSLE
Length:424
Mass (Da):48,877
Last modified:February 1, 1991 - v1
Checksum:iE7A59E450B9C4F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA Translation: AAA48010.1
PIRiC42505 WMVZCX

Similar proteinsi

Entry informationi

Entry nameiK4_VACCC
AccessioniPrimary (citable) accession number: P20537
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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