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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

Fcer1g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.2 Publications

GO - Molecular functioni

  • IgE binding Source: MGI
  • IgE receptor activity Source: MGI
  • IgG binding Source: MGI

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
  • defense response to bacterium Source: MGI
  • Fc-gamma receptor signaling pathway Source: MGI
  • Fc receptor mediated stimulatory signaling pathway Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB
  • mast cell activation Source: MGI
  • negative regulation of mast cell apoptotic process Source: MGI
  • neutrophil activation involved in immune response Source: UniProtKB
  • neutrophil chemotaxis Source: MGI
  • phagocytosis, engulfment Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of interleukin-10 production Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of mast cell cytokine production Source: MGI
  • positive regulation of mast cell degranulation Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of tumor necrosis factor production Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
  • positive regulation of type III hypersensitivity Source: MGI
  • protein localization to plasma membrane Source: MGI
  • receptor internalization Source: UniProtKB
  • regulation of immune response Source: MGI
  • regulation of platelet activation Source: UniProtKB
  • serotonin secretion by platelet Source: UniProtKB
  • signal transduction Source: MGI
  • stimulatory C-type lectin receptor signaling pathway Source: Reactome
  • T cell differentiation involved in immune response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2454202. Fc epsilon receptor (FCERI) signaling.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-5621480. Dectin-2 family.
R-MMU-75892. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:Fcer1g
Synonyms:Fce1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95496. Fcer1g.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 235ExtracellularSequence analysis
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Topological domaini45 – 8642CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • external side of plasma membrane Source: MGI
  • Fc-epsilon receptor I complex Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane raft Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 8668High affinity immunoglobulin epsilon receptor subunit gammaPRO_0000016503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 – 25InterchainBy similarity
Modified residuei65 – 651PhosphotyrosineCombined sources
Modified residuei76 – 761PhosphotyrosineCombined sources
Modified residuei78 – 781PhosphothreonineCombined sources

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP20491.
PaxDbiP20491.
PeptideAtlasiP20491.
PRIDEiP20491.

PTM databases

iPTMnetiP20491.
PhosphoSiteiP20491.
SwissPalmiP20491.

Expressioni

Gene expression databases

BgeeiP20491.
ExpressionAtlasiP20491. baseline and differential.
GenevisibleiP20491. MM.

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A (By similarity). Associated with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages. Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Jak2Q621202EBI-9306159,EBI-646604

GO - Molecular functioni

  • IgE binding Source: MGI
  • IgG binding Source: MGI

Protein-protein interaction databases

BioGridi199616. 2 interactions.
IntActiP20491. 1 interaction.
STRINGi10090.ENSMUSP00000078875.

Structurei

3D structure databases

ProteinModelPortaliP20491.
SMRiP20491. Positions 21-53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 8229ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP20491.
KOiK07983.
OMAiRSQETYE.
OrthoDBiEOG747PMP.
PhylomeDBiP20491.
TreeFamiTF330937.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAVILFLL LLVEQAAALG EPQLCYILDA VLFLYGIVLT LLYCRLKIQV
60 70 80
RKAAIASREK ADAVYTGLNT RSQETYETLK HEKPPQ
Length:86
Mass (Da):9,652
Last modified:February 1, 1991 - v1
Checksum:i83184DE22FCC9ECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05020 mRNA. Translation: AAA37602.1.
BC034163 mRNA. Translation: AAH34163.1.
CCDSiCCDS15483.1.
RefSeqiNP_034315.1. NM_010185.4.
UniGeneiMm.22673.

Genome annotation databases

EnsembliENSMUST00000079957; ENSMUSP00000078875; ENSMUSG00000058715.
GeneIDi14127.
KEGGimmu:14127.
UCSCiuc007dnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05020 mRNA. Translation: AAA37602.1.
BC034163 mRNA. Translation: AAH34163.1.
CCDSiCCDS15483.1.
RefSeqiNP_034315.1. NM_010185.4.
UniGeneiMm.22673.

3D structure databases

ProteinModelPortaliP20491.
SMRiP20491. Positions 21-53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199616. 2 interactions.
IntActiP20491. 1 interaction.
STRINGi10090.ENSMUSP00000078875.

PTM databases

iPTMnetiP20491.
PhosphoSiteiP20491.
SwissPalmiP20491.

Proteomic databases

MaxQBiP20491.
PaxDbiP20491.
PeptideAtlasiP20491.
PRIDEiP20491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079957; ENSMUSP00000078875; ENSMUSG00000058715.
GeneIDi14127.
KEGGimmu:14127.
UCSCiuc007dnl.1. mouse.

Organism-specific databases

CTDi2207.
MGIiMGI:95496. Fcer1g.

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP20491.
KOiK07983.
OMAiRSQETYE.
OrthoDBiEOG747PMP.
PhylomeDBiP20491.
TreeFamiTF330937.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2454202. Fc epsilon receptor (FCERI) signaling.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-5621480. Dectin-2 family.
R-MMU-75892. Platelet Adhesion to exposed collagen.

Miscellaneous databases

PROiP20491.
SOURCEiSearch...

Gene expression databases

BgeeiP20491.
ExpressionAtlasiP20491. baseline and differential.
GenevisibleiP20491. MM.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells."
    Ra C., Jouvin M.H.E., Kinet J.-P.
    J. Biol. Chem. 264:15323-15327(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. "The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen."
    Poole A., Gibbins J.M., Turner M., van Vugt M.J., van de Winkel J.G., Saito T., Tybulewicz V.L., Watson S.P.
    EMBO J. 16:2333-2341(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ACTIVATION OF PLATELETS BY COLLAGEN, FUNCTION IN PLCG2 PHOSPHORYLATION.
  4. "Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses."
    Sato K., Yang X.L., Yudate T., Chung J.S., Wu J., Luby-Phelps K., Kimberly R.P., Underhill D., Cruz P.D. Jr., Ariizumi K.
    J. Biol. Chem. 281:38854-38866(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC6A.
  5. "Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs."
    Mocsai A., Abram C.L., Jakus Z., Hu Y., Lanier L.L., Lowell C.A.
    Nat. Immunol. 7:1326-1333(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN INTEGRIN-MEDIATED NEUTROPHIL ACTIVATION, INTERACTION WITH SYK.
  6. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65; TYR-76 AND THR-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  7. "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
    Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
    Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC4E.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65 AND TYR-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5."
    Enomoto Y., Yamanishi Y., Izawa K., Kaitani A., Takahashi M., Maehara A., Oki T., Takamatsu R., Kajikawa M., Takai T., Kitamura T., Kitaura J.
    J. Biol. Chem. 285:35274-35283(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD300LH AND CD300LD.

Entry informationi

Entry nameiFCERG_MOUSE
AccessioniPrimary (citable) accession number: P20491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 6, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.