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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

Fcer1g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.2 Publications

GO - Molecular functioni

  • IgE binding Source: MGI
  • IgE receptor activity Source: MGI
  • IgG binding Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
  • defense response to bacterium Source: MGI
  • Fc-epsilon receptor signaling pathway Source: MGI
  • Fc-gamma receptor signaling pathway Source: MGI
  • Fc receptor mediated stimulatory signaling pathway Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB
  • interleukin-2 production Source: MGI
  • mast cell activation Source: MGI
  • negative regulation of mast cell apoptotic process Source: MGI
  • neutrophil activation involved in immune response Source: UniProtKB
  • neutrophil chemotaxis Source: MGI
  • osteoclast differentiation Source: MGI
  • phagocytosis, engulfment Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of interleukin-10 production Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of mast cell cytokine production Source: MGI
  • positive regulation of mast cell degranulation Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • positive regulation of tumor necrosis factor production Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
  • positive regulation of type III hypersensitivity Source: MGI
  • protein homooligomerization Source: MGI
  • protein localization to plasma membrane Source: MGI
  • receptor internalization Source: UniProtKB
  • regulation of immune response Source: MGI
  • regulation of platelet activation Source: UniProtKB
  • serotonin secretion by platelet Source: UniProtKB
  • signal transduction Source: MGI
  • T cell differentiation involved in immune response Source: MGI

Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-75892 Platelet Adhesion to exposed collagen

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:Fcer1g
Synonyms:Fce1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95496 Fcer1g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 23ExtracellularSequence analysis5
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 86CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001650319 – 86High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainBy similarity
Modified residuei65PhosphotyrosineCombined sources1
Modified residuei76PhosphotyrosineCombined sources1
Modified residuei78PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP20491
PaxDbiP20491
PeptideAtlasiP20491
PRIDEiP20491

PTM databases

iPTMnetiP20491
PhosphoSitePlusiP20491
SwissPalmiP20491

Expressioni

Gene expression databases

BgeeiENSMUSG00000058715
ExpressionAtlasiP20491 baseline and differential
GenevisibleiP20491 MM

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A (By similarity). Associated with CLEC6A (PubMed:17050534). Interacts with CLEC4E (PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (PubMed:17086186). Interacts with CD300LH; the interaction may be indirect (PubMed:20817736). Interacts with CD300LD (PubMed:20817736). Interacts with TARM1 (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Jak2Q621202EBI-9306159,EBI-646604

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi199616, 2 interactors
IntActiP20491, 1 interactor
STRINGi10090.ENSMUSP00000078875

Structurei

3D structure databases

ProteinModelPortaliP20491
SMRiP20491
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 82ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ Eukaryota
ENOG410Z3W0 LUCA
GeneTreeiENSGT00390000003894
HOGENOMiHOG000293158
HOVERGENiHBG051601
InParanoidiP20491
KOiK07983
OMAiLYCRLKL
PhylomeDBiP20491
TreeFamiTF330937

Family and domain databases

InterProiView protein in InterPro
IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma
IPR003110 Phos_immunorcpt_sig_ITAM
PfamiView protein in Pfam
PF02189 ITAM, 1 hit
PF11628 TCR_zetazeta, 1 hit
SMARTiView protein in SMART
SM00077 ITAM, 1 hit
PROSITEiView protein in PROSITE
PS51055 ITAM_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAVILFLL LLVEQAAALG EPQLCYILDA VLFLYGIVLT LLYCRLKIQV
60 70 80
RKAAIASREK ADAVYTGLNT RSQETYETLK HEKPPQ
Length:86
Mass (Da):9,652
Last modified:February 1, 1991 - v1
Checksum:i83184DE22FCC9ECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05020 mRNA Translation: AAA37602.1
BC034163 mRNA Translation: AAH34163.1
CCDSiCCDS15483.1
RefSeqiNP_034315.1, NM_010185.4
UniGeneiMm.22673

Genome annotation databases

EnsembliENSMUST00000079957; ENSMUSP00000078875; ENSMUSG00000058715
GeneIDi14127
KEGGimmu:14127
UCSCiuc007dnl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFCERG_MOUSE
AccessioniPrimary (citable) accession number: P20491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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