High affinity immunoglobulin epsilon receptor subunit beta

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P20490 (FCERB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 109. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name=FcERI

Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2

Gene names

Name:	Ms4a2
Synonyms:	Fce1b, Fcer1b, Ms4a1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Ref.5
Subunit structure	Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR By similarity. Interacts with FGR and FES/FPS. Interacts with LYN. Ref.3 Ref.5
Subcellular location	Membrane; Multi-pass membrane protein.
Post-translational modification	Phosphorylated on tyrosine residues by LYN. Ref.3
Sequence similarities	Belongs to the MS4A family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	IgE-binding protein
Molecular function	Receptor
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Inferred from electronic annotation. Source: Compara cell surface receptor signaling pathway Inferred from direct assay PubMed 9000133. Source: MGI cytokine secretion Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of mast cell degranulation Inferred from electronic annotation. Source: Compara protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara
Cellular_component	Fc-epsilon receptor I complex Inferred from direct assay PubMed 14764707. Source: MGI endosome Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from direct assay PubMed 14764707 Ref.1. Source: MGI integral to plasma membrane Inferred from direct assay Ref.1. Source: MGI membrane raft Traceable author statement PubMed 12192036. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 235

235

High affinity immunoglobulin epsilon receptor subunit beta

PRO_0000158630

Regions

Topological domain

1 – 51

Cytoplasmic Potential

Transmembrane

52 – 71

Helical; Potential

Topological domain

72 – 89

Extracellular Potential

Transmembrane

90 – 109

Helical; Potential

Topological domain

110 – 122

Cytoplasmic Potential

Transmembrane

123 – 142

Helical; Potential

Topological domain

143 – 171

Extracellular Potential

Transmembrane

172 – 191

Helical; Potential

Topological domain

192 – 235

Cytoplasmic Potential

Amino acid modifications

Modified residue

210

Phosphotyrosine Ref.4

Modified residue

216

Phosphotyrosine Ref.4

Modified residue

217

Phosphoserine Ref.4

Modified residue

220

Phosphotyrosine Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P20490 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 1C2D6BF195738168
Show »

FASTA

235

25,963

        10         20         30         40         50         60 
MDTENRSRAD LALPNPQESS SAPDIELLEA SPAKAAPPKQ TWRTFLKKEL EFLGATQILV 

        70         80         90        100        110        120 
GLICLCFGTI VCSVLYVSDF DEEVLLLYKL GYPFWGAVLF VLSGFLSIIS ERKNTLYLVR 

       130        140        150        160        170        180 
GSLGANIVSS IAAGTGIAML ILNLTNNFAY MNNCKNVTED DGCFVASFTT ELVLMMLFLT 

       190        200        210        220        230 
ILAFCSAVLF TIYRIGQELE SKKVPDDRLY EELNVYSPIY SELEDKGETS SPVDS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells." Ra C., Jouvin M.H.E., Kinet J.-P. J. Biol. Chem. 264:15323-15327(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genomic structure of the allergy associated Fc receptor beta subunit and its high content of SINEs." Hiraoka S., Watanabe M., Takagaki Y., Fujita-Suzuki K., Shinohara N., Okumura K., Ra C. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[3]	"Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI." Xiao W., Nishimoto H., Hong H., Kitaura J., Nunomura S., Maeda-Yamamoto M., Kawakami Y., Lowell C.A., Ra C., Kawakami T. J. Immunol. 175:6885-6892(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
[4]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-210; TYR-216; SER-217 AND TYR-220, MASS SPECTROMETRY. Tissue: Mast cell.
[5]	"Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells." McPherson V.A., Everingham S., Karisch R., Smith J.A., Udell C.M., Zheng J., Jia Z., Craig A.W. Mol. Cell. Biol. 29:389-401(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FES/FPS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J05019 mRNA. Translation: AAA37601.1. AB033617 Genomic DNA. Translation: BAA94839.1.
IPI	IPI00119291.
PIR	B34342.
RefSeq	NP_038544.1. NM_013516.2.
UniGene	Mm.329735.
3D structure databases
ProteinModelPortal	P20490.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000025583.
PTM databases
PhosphoSite	P20490.
Proteomic databases
PRIDE	P20490.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
GeneID	14126.
KEGG	mmu:14126.
Organism-specific databases
CTD	2206.
MGI	MGI:95495. Ms4a2.
Phylogenomic databases
eggNOG	NOG47093.
GeneTree	ENSGT00530000062969.
HOGENOM	HOG000060211.
HOVERGEN	HBG051600.
InParanoid	P20490.
KO	K08090.
OMA	LTILGFC.
OrthoDB	EOG4F4SBZ.
Gene expression databases
ArrayExpress	P20490.
Bgee	P20490.
Genevestigator	P20490.
GermOnline	ENSMUSG00000024680. Mus musculus.
Family and domain databases
InterPro	IPR007237. CD20-like. [Graphical view]
Pfam	PF04103. CD20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285210.
SOURCE	Search...

Entry information

Entry name

FCERB_MOUSE

Accession

Primary (citable) accession number: P20490

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	April 3, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents