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Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

Ms4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiREACT_314186. FCERI mediated MAPK activation.
REACT_315145. FCERI mediated NF-kB activation.
REACT_340694. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_345245. Fc epsilon receptor (FCERI) signaling.
REACT_348733. FCERI mediated Ca+2 mobilization.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:Ms4a2
Synonyms:Fce1b, Fcer1b, Ms4a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95495. Ms4a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7120HelicalSequence AnalysisAdd
BLAST
Topological domaini72 – 8918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei90 – 10920HelicalSequence AnalysisAdd
BLAST
Topological domaini110 – 12213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei123 – 14220HelicalSequence AnalysisAdd
BLAST
Topological domaini143 – 17129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei172 – 19120HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 23544CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endosome Source: Ensembl
  • external side of plasma membrane Source: MGI
  • Fc-epsilon receptor I complex Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane raft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235High affinity immunoglobulin epsilon receptor subunit betaPRO_0000158630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101Phosphotyrosine1 Publication
Modified residuei216 – 2161Phosphotyrosine1 Publication
Modified residuei217 – 2171Phosphoserine1 Publication
Modified residuei220 – 2201Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP20490.

PTM databases

PhosphoSiteiP20490.

Expressioni

Gene expression databases

BgeeiP20490.
ExpressionAtlasiP20490. baseline and differential.
GenevisibleiP20490. MM.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR (By similarity). Interacts with FGR and FES/FPS. Interacts with LYN.By similarity2 Publications

Protein-protein interaction databases

BioGridi199615. 2 interactions.
STRINGi10090.ENSMUSP00000127373.

Structurei

3D structure databases

ProteinModelPortaliP20490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47093.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiP20490.
OMAiSTEIVVM.
PhylomeDBiP20490.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030420. MS4A2.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF9. PTHR23320:SF9. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTENRSRAD LALPNPQESS SAPDIELLEA SPAKAAPPKQ TWRTFLKKEL
60 70 80 90 100
EFLGATQILV GLICLCFGTI VCSVLYVSDF DEEVLLLYKL GYPFWGAVLF
110 120 130 140 150
VLSGFLSIIS ERKNTLYLVR GSLGANIVSS IAAGTGIAML ILNLTNNFAY
160 170 180 190 200
MNNCKNVTED DGCFVASFTT ELVLMMLFLT ILAFCSAVLF TIYRIGQELE
210 220 230
SKKVPDDRLY EELNVYSPIY SELEDKGETS SPVDS
Length:235
Mass (Da):25,963
Last modified:February 1, 1991 - v1
Checksum:i1C2D6BF195738168
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05019 mRNA. Translation: AAA37601.1.
AB033617 Genomic DNA. Translation: BAA94839.1.
CCDSiCCDS29604.1.
PIRiB34342.
RefSeqiNP_038544.1. NM_013516.2.
XP_006526721.1. XM_006526658.1.
UniGeneiMm.329735.

Genome annotation databases

EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
GeneIDi14126.
UCSCiuc008gsn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05019 mRNA. Translation: AAA37601.1.
AB033617 Genomic DNA. Translation: BAA94839.1.
CCDSiCCDS29604.1.
PIRiB34342.
RefSeqiNP_038544.1. NM_013516.2.
XP_006526721.1. XM_006526658.1.
UniGeneiMm.329735.

3D structure databases

ProteinModelPortaliP20490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199615. 2 interactions.
STRINGi10090.ENSMUSP00000127373.

PTM databases

PhosphoSiteiP20490.

Proteomic databases

PRIDEiP20490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
GeneIDi14126.
UCSCiuc008gsn.2. mouse.

Organism-specific databases

CTDi2206.
MGIiMGI:95495. Ms4a2.

Phylogenomic databases

eggNOGiNOG47093.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiP20490.
OMAiSTEIVVM.
PhylomeDBiP20490.
TreeFamiTF335157.

Enzyme and pathway databases

ReactomeiREACT_314186. FCERI mediated MAPK activation.
REACT_315145. FCERI mediated NF-kB activation.
REACT_340694. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_345245. Fc epsilon receptor (FCERI) signaling.
REACT_348733. FCERI mediated Ca+2 mobilization.

Miscellaneous databases

NextBioi285210.
PROiP20490.
SOURCEiSearch...

Gene expression databases

BgeeiP20490.
ExpressionAtlasiP20490. baseline and differential.
GenevisibleiP20490. MM.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030420. MS4A2.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF9. PTHR23320:SF9. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells."
    Ra C., Jouvin M.H.E., Kinet J.-P.
    J. Biol. Chem. 264:15323-15327(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genomic structure of the allergy associated Fc receptor beta subunit and its high content of SINEs."
    Hiraoka S., Watanabe M., Takagaki Y., Fujita-Suzuki K., Shinohara N., Okumura K., Ra C.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI."
    Xiao W., Nishimoto H., Hong H., Kitaura J., Nunomura S., Maeda-Yamamoto M., Kawakami Y., Lowell C.A., Ra C., Kawakami T.
    J. Immunol. 175:6885-6892(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-210; TYR-216; SER-217 AND TYR-220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  5. "Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells."
    McPherson V.A., Everingham S., Karisch R., Smith J.A., Udell C.M., Zheng J., Jia Z., Craig A.W.
    Mol. Cell. Biol. 29:389-401(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FES/FPS.

Entry informationi

Entry nameiFCERB_MOUSE
AccessioniPrimary (citable) accession number: P20490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 22, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.