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P20490

- FCERB_MOUSE

UniProt

P20490 - FCERB_MOUSE

Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

Ms4a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.1 Publication

    GO - Biological processi

    1. activation of phospholipase C activity Source: Ensembl
    2. cell surface receptor signaling pathway Source: MGI
    3. cytokine secretion Source: Ensembl
    4. immune response Source: Ensembl
    5. inflammatory response Source: Ensembl
    6. positive regulation of mast cell degranulation Source: Ensembl
    7. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    8. regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    9. signal transduction Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    IgE-binding protein

    Enzyme and pathway databases

    ReactomeiREACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188204. Fc epsilon receptor (FCERI) signaling.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_213364. Role of LAT2/NTAL/LAB on calcium mobilization.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit beta
    Short name:
    FcERI
    Alternative name(s):
    Fc epsilon receptor I beta-chain
    IgE Fc receptor subunit beta
    Membrane-spanning 4-domains subfamily A member 2
    Gene namesi
    Name:Ms4a2
    Synonyms:Fce1b, Fcer1b, Ms4a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:95495. Ms4a2.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: Ensembl
    2. external side of plasma membrane Source: MGI
    3. Fc-epsilon receptor I complex Source: MGI
    4. integral component of plasma membrane Source: MGI
    5. membrane raft Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235High affinity immunoglobulin epsilon receptor subunit betaPRO_0000158630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei210 – 2101Phosphotyrosine2 Publications
    Modified residuei216 – 2161Phosphotyrosine2 Publications
    Modified residuei217 – 2171Phosphoserine2 Publications
    Modified residuei220 – 2201Phosphotyrosine2 Publications

    Post-translational modificationi

    Phosphorylated on tyrosine residues by LYN.2 Publications

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PRIDEiP20490.

    PTM databases

    PhosphoSiteiP20490.

    Expressioni

    Gene expression databases

    BgeeiP20490.
    GenevestigatoriP20490.

    Interactioni

    Subunit structurei

    Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR By similarity. Interacts with FGR and FES/FPS. Interacts with LYN.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi199615. 2 interactions.
    STRINGi10090.ENSMUSP00000025583.

    Structurei

    3D structure databases

    ProteinModelPortaliP20490.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini72 – 8918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini143 – 17129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 23544CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 10920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19120HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MS4A family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47093.
    GeneTreeiENSGT00730000111024.
    HOGENOMiHOG000060211.
    HOVERGENiHBG051600.
    InParanoidiP20490.
    KOiK08090.
    OMAiSTEIVVM.
    PhylomeDBiP20490.
    TreeFamiTF335157.

    Family and domain databases

    InterProiIPR007237. CD20-like.
    [Graphical view]
    PfamiPF04103. CD20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20490-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTENRSRAD LALPNPQESS SAPDIELLEA SPAKAAPPKQ TWRTFLKKEL    50
    EFLGATQILV GLICLCFGTI VCSVLYVSDF DEEVLLLYKL GYPFWGAVLF 100
    VLSGFLSIIS ERKNTLYLVR GSLGANIVSS IAAGTGIAML ILNLTNNFAY 150
    MNNCKNVTED DGCFVASFTT ELVLMMLFLT ILAFCSAVLF TIYRIGQELE 200
    SKKVPDDRLY EELNVYSPIY SELEDKGETS SPVDS 235
    Length:235
    Mass (Da):25,963
    Last modified:February 1, 1991 - v1
    Checksum:i1C2D6BF195738168
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05019 mRNA. Translation: AAA37601.1.
    AB033617 Genomic DNA. Translation: BAA94839.1.
    CCDSiCCDS29604.1.
    PIRiB34342.
    RefSeqiNP_038544.1. NM_013516.2.
    XP_006526721.1. XM_006526658.1.
    UniGeneiMm.329735.

    Genome annotation databases

    EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
    GeneIDi14126.
    KEGGimmu:14126.
    UCSCiuc008gsn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05019 mRNA. Translation: AAA37601.1 .
    AB033617 Genomic DNA. Translation: BAA94839.1 .
    CCDSi CCDS29604.1.
    PIRi B34342.
    RefSeqi NP_038544.1. NM_013516.2.
    XP_006526721.1. XM_006526658.1.
    UniGenei Mm.329735.

    3D structure databases

    ProteinModelPortali P20490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199615. 2 interactions.
    STRINGi 10090.ENSMUSP00000025583.

    PTM databases

    PhosphoSitei P20490.

    Proteomic databases

    PRIDEi P20490.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000164792 ; ENSMUSP00000127373 ; ENSMUSG00000024680 .
    GeneIDi 14126.
    KEGGi mmu:14126.
    UCSCi uc008gsn.1. mouse.

    Organism-specific databases

    CTDi 2206.
    MGIi MGI:95495. Ms4a2.

    Phylogenomic databases

    eggNOGi NOG47093.
    GeneTreei ENSGT00730000111024.
    HOGENOMi HOG000060211.
    HOVERGENi HBG051600.
    InParanoidi P20490.
    KOi K08090.
    OMAi STEIVVM.
    PhylomeDBi P20490.
    TreeFami TF335157.

    Enzyme and pathway databases

    Reactomei REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188204. Fc epsilon receptor (FCERI) signaling.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_213364. Role of LAT2/NTAL/LAB on calcium mobilization.

    Miscellaneous databases

    NextBioi 285210.
    PROi P20490.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20490.
    Genevestigatori P20490.

    Family and domain databases

    InterProi IPR007237. CD20-like.
    [Graphical view ]
    Pfami PF04103. CD20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells."
      Ra C., Jouvin M.H.E., Kinet J.-P.
      J. Biol. Chem. 264:15323-15327(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genomic structure of the allergy associated Fc receptor beta subunit and its high content of SINEs."
      Hiraoka S., Watanabe M., Takagaki Y., Fujita-Suzuki K., Shinohara N., Okumura K., Ra C.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    3. "Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI."
      Xiao W., Nishimoto H., Hong H., Kitaura J., Nunomura S., Maeda-Yamamoto M., Kawakami Y., Lowell C.A., Ra C., Kawakami T.
      J. Immunol. 175:6885-6892(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-210; TYR-216; SER-217 AND TYR-220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    5. "Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells."
      McPherson V.A., Everingham S., Karisch R., Smith J.A., Udell C.M., Zheng J., Jia Z., Craig A.W.
      Mol. Cell. Biol. 29:389-401(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FES/FPS.

    Entry informationi

    Entry nameiFCERB_MOUSE
    AccessioniPrimary (citable) accession number: P20490
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3