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Protein

High affinity immunoglobulin epsilon receptor subunit beta

Gene

Ms4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.1 Publication

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • Fc-epsilon receptor signaling pathway Source: InterPro
  • immune response Source: MGI
  • inflammatory response Source: InterPro
  • signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiR-MMU-2454202. Fc epsilon receptor (FCERI) signaling.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-2871837. FCERI mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:Ms4a2
Synonyms:Fce1b, Fcer1b, Ms4a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95495. Ms4a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 71HelicalSequence analysisAdd BLAST20
Topological domaini72 – 89ExtracellularSequence analysisAdd BLAST18
Transmembranei90 – 109HelicalSequence analysisAdd BLAST20
Topological domaini110 – 122CytoplasmicSequence analysisAdd BLAST13
Transmembranei123 – 142HelicalSequence analysisAdd BLAST20
Topological domaini143 – 171ExtracellularSequence analysisAdd BLAST29
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Topological domaini192 – 235CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • Fc-epsilon receptor I complex Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane raft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586301 – 235High affinity immunoglobulin epsilon receptor subunit betaAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphotyrosineCombined sources1
Modified residuei216PhosphotyrosineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei220PhosphotyrosineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP20490.
PRIDEiP20490.

PTM databases

iPTMnetiP20490.
PhosphoSitePlusiP20490.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024680.
ExpressionAtlasiP20490. baseline and differential.
GenevisibleiP20490. MM.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR (By similarity). Interacts with FGR and FES/FPS. Interacts with LYN.By similarity2 Publications

Protein-protein interaction databases

BioGridi199615. 2 interactors.
STRINGi10090.ENSMUSP00000127373.

Structurei

3D structure databases

ProteinModelPortaliP20490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J28C. Eukaryota.
ENOG4111DU9. LUCA.
GeneTreeiENSGT00730000110654.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiP20490.
KOiK08090.
OMAiSTEIVVM.
OrthoDBiEOG091G0IBB.
PhylomeDBiP20490.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030420. MS4A2.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF66. PTHR23320:SF66. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTENRSRAD LALPNPQESS SAPDIELLEA SPAKAAPPKQ TWRTFLKKEL
60 70 80 90 100
EFLGATQILV GLICLCFGTI VCSVLYVSDF DEEVLLLYKL GYPFWGAVLF
110 120 130 140 150
VLSGFLSIIS ERKNTLYLVR GSLGANIVSS IAAGTGIAML ILNLTNNFAY
160 170 180 190 200
MNNCKNVTED DGCFVASFTT ELVLMMLFLT ILAFCSAVLF TIYRIGQELE
210 220 230
SKKVPDDRLY EELNVYSPIY SELEDKGETS SPVDS
Length:235
Mass (Da):25,963
Last modified:February 1, 1991 - v1
Checksum:i1C2D6BF195738168
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05019 mRNA. Translation: AAA37601.1.
AB033617 Genomic DNA. Translation: BAA94839.1.
CCDSiCCDS29604.1.
PIRiB34342.
RefSeqiNP_038544.1. NM_013516.2.
UniGeneiMm.329735.

Genome annotation databases

EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
GeneIDi14126.
KEGGimmu:14126.
UCSCiuc008gsn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05019 mRNA. Translation: AAA37601.1.
AB033617 Genomic DNA. Translation: BAA94839.1.
CCDSiCCDS29604.1.
PIRiB34342.
RefSeqiNP_038544.1. NM_013516.2.
UniGeneiMm.329735.

3D structure databases

ProteinModelPortaliP20490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199615. 2 interactors.
STRINGi10090.ENSMUSP00000127373.

PTM databases

iPTMnetiP20490.
PhosphoSitePlusiP20490.

Proteomic databases

PaxDbiP20490.
PRIDEiP20490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
GeneIDi14126.
KEGGimmu:14126.
UCSCiuc008gsn.2. mouse.

Organism-specific databases

CTDi2206.
MGIiMGI:95495. Ms4a2.

Phylogenomic databases

eggNOGiENOG410J28C. Eukaryota.
ENOG4111DU9. LUCA.
GeneTreeiENSGT00730000110654.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiP20490.
KOiK08090.
OMAiSTEIVVM.
OrthoDBiEOG091G0IBB.
PhylomeDBiP20490.
TreeFamiTF335157.

Enzyme and pathway databases

ReactomeiR-MMU-2454202. Fc epsilon receptor (FCERI) signaling.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-2871837. FCERI mediated NF-kB activation.

Miscellaneous databases

PROiP20490.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024680.
ExpressionAtlasiP20490. baseline and differential.
GenevisibleiP20490. MM.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030420. MS4A2.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF66. PTHR23320:SF66. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCERB_MOUSE
AccessioniPrimary (citable) accession number: P20490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.