Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P20490 (FCERB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High affinity immunoglobulin epsilon receptor subunit beta

Short name=FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene names
Name:Ms4a2
Synonyms:Fce1b, Fcer1b, Ms4a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Ref.5

Subunit structure

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR By similarity. Interacts with FGR and FES/FPS. Interacts with LYN. Ref.3 Ref.5

Subcellular location

Membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylated on tyrosine residues by LYN. Ref.3

Sequence similarities

Belongs to the MS4A family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandIgE-binding protein
   Molecular functionReceptor
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

cell surface receptor signaling pathway

Inferred from direct assay PubMed 9000133. Source: MGI

cytokine secretion

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of mast cell degranulation

Inferred from electronic annotation. Source: Ensembl

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

signal transduction

Inferred from direct assay PubMed 12192036. Source: MGI

   Cellular_componentFc-epsilon receptor I complex

Inferred from direct assay PubMed 14764707. Source: MGI

endosome

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from direct assay PubMed 14764707Ref.1. Source: MGI

integral component of plasma membrane

Inferred from direct assay Ref.1. Source: MGI

membrane raft

Traceable author statement PubMed 12192036. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235High affinity immunoglobulin epsilon receptor subunit beta
PRO_0000158630

Regions

Topological domain1 – 5151Cytoplasmic Potential
Transmembrane52 – 7120Helical; Potential
Topological domain72 – 8918Extracellular Potential
Transmembrane90 – 10920Helical; Potential
Topological domain110 – 12213Cytoplasmic Potential
Transmembrane123 – 14220Helical; Potential
Topological domain143 – 17129Extracellular Potential
Transmembrane172 – 19120Helical; Potential
Topological domain192 – 23544Cytoplasmic Potential

Amino acid modifications

Modified residue2101Phosphotyrosine Ref.4
Modified residue2161Phosphotyrosine Ref.4
Modified residue2171Phosphoserine Ref.4
Modified residue2201Phosphotyrosine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P20490 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 1C2D6BF195738168

FASTA23525,963
        10         20         30         40         50         60 
MDTENRSRAD LALPNPQESS SAPDIELLEA SPAKAAPPKQ TWRTFLKKEL EFLGATQILV 

        70         80         90        100        110        120 
GLICLCFGTI VCSVLYVSDF DEEVLLLYKL GYPFWGAVLF VLSGFLSIIS ERKNTLYLVR 

       130        140        150        160        170        180 
GSLGANIVSS IAAGTGIAML ILNLTNNFAY MNNCKNVTED DGCFVASFTT ELVLMMLFLT 

       190        200        210        220        230 
ILAFCSAVLF TIYRIGQELE SKKVPDDRLY EELNVYSPIY SELEDKGETS SPVDS 

« Hide

References

« Hide 'large scale' references
[1]"Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells."
Ra C., Jouvin M.H.E., Kinet J.-P.
J. Biol. Chem. 264:15323-15327(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genomic structure of the allergy associated Fc receptor beta subunit and its high content of SINEs."
Hiraoka S., Watanabe M., Takagaki Y., Fujita-Suzuki K., Shinohara N., Okumura K., Ra C.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[3]"Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI."
Xiao W., Nishimoto H., Hong H., Kitaura J., Nunomura S., Maeda-Yamamoto M., Kawakami Y., Lowell C.A., Ra C., Kawakami T.
J. Immunol. 175:6885-6892(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
[4]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-210; TYR-216; SER-217 AND TYR-220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Mast cell.
[5]"Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells."
McPherson V.A., Everingham S., Karisch R., Smith J.A., Udell C.M., Zheng J., Jia Z., Craig A.W.
Mol. Cell. Biol. 29:389-401(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FES/FPS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05019 mRNA. Translation: AAA37601.1.
AB033617 Genomic DNA. Translation: BAA94839.1.
CCDSCCDS29604.1.
PIRB34342.
RefSeqNP_038544.1. NM_013516.2.
XP_006526721.1. XM_006526658.1.
UniGeneMm.329735.

3D structure databases

ProteinModelPortalP20490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199615. 2 interactions.
STRING10090.ENSMUSP00000025583.

PTM databases

PhosphoSiteP20490.

Proteomic databases

PRIDEP20490.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
GeneID14126.
KEGGmmu:14126.
UCSCuc008gsn.1. mouse.

Organism-specific databases

CTD2206.
MGIMGI:95495. Ms4a2.

Phylogenomic databases

eggNOGNOG47093.
GeneTreeENSGT00730000111024.
HOGENOMHOG000060211.
HOVERGENHBG051600.
InParanoidP20490.
KOK08090.
OMASTEIVVM.
PhylomeDBP20490.
TreeFamTF335157.

Gene expression databases

BgeeP20490.
GenevestigatorP20490.

Family and domain databases

InterProIPR007237. CD20-like.
[Graphical view]
PfamPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285210.
PROP20490.
SOURCESearch...

Entry information

Entry nameFCERB_MOUSE
AccessionPrimary (citable) accession number: P20490
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot