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P20490

- FCERB_MOUSE

UniProt

P20490 - FCERB_MOUSE

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Protein
High affinity immunoglobulin epsilon receptor subunit beta
Gene
Ms4a2, Fce1b, Fcer1b, Ms4a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.1 Publication

GO - Biological processi

  1. activation of phospholipase C activity Source: Ensembl
  2. cell surface receptor signaling pathway Source: MGI
  3. cytokine secretion Source: Ensembl
  4. immune response Source: Ensembl
  5. inflammatory response Source: Ensembl
  6. positive regulation of mast cell degranulation Source: Ensembl
  7. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  8. regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  9. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiREACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188204. Fc epsilon receptor (FCERI) signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_205561. FCERI mediated NF-kB activation.
REACT_213364. Role of LAT2/NTAL/LAB on calcium mobilization.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit beta
Short name:
FcERI
Alternative name(s):
Fc epsilon receptor I beta-chain
IgE Fc receptor subunit beta
Membrane-spanning 4-domains subfamily A member 2
Gene namesi
Name:Ms4a2
Synonyms:Fce1b, Fcer1b, Ms4a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:95495. Ms4a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei52 – 7120Helical; Reviewed prediction
Add
BLAST
Topological domaini72 – 8918Extracellular Reviewed prediction
Add
BLAST
Transmembranei90 – 10920Helical; Reviewed prediction
Add
BLAST
Topological domaini110 – 12213Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei123 – 14220Helical; Reviewed prediction
Add
BLAST
Topological domaini143 – 17129Extracellular Reviewed prediction
Add
BLAST
Transmembranei172 – 19120Helical; Reviewed prediction
Add
BLAST
Topological domaini192 – 23544Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Fc-epsilon receptor I complex Source: MGI
  2. endosome Source: Ensembl
  3. external side of plasma membrane Source: MGI
  4. integral component of plasma membrane Source: MGI
  5. membrane raft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235High affinity immunoglobulin epsilon receptor subunit beta
PRO_0000158630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101Phosphotyrosine1 Publication
Modified residuei216 – 2161Phosphotyrosine1 Publication
Modified residuei217 – 2171Phosphoserine1 Publication
Modified residuei220 – 2201Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP20490.

PTM databases

PhosphoSiteiP20490.

Expressioni

Gene expression databases

BgeeiP20490.
GenevestigatoriP20490.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR By similarity. Interacts with FGR and FES/FPS. Interacts with LYN.2 Publications

Protein-protein interaction databases

BioGridi199615. 2 interactions.
STRINGi10090.ENSMUSP00000025583.

Structurei

3D structure databases

ProteinModelPortaliP20490.

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47093.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000060211.
HOVERGENiHBG051600.
InParanoidiP20490.
KOiK08090.
OMAiSTEIVVM.
PhylomeDBiP20490.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
[Graphical view]
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20490-1 [UniParc]FASTAAdd to Basket

« Hide

MDTENRSRAD LALPNPQESS SAPDIELLEA SPAKAAPPKQ TWRTFLKKEL    50
EFLGATQILV GLICLCFGTI VCSVLYVSDF DEEVLLLYKL GYPFWGAVLF 100
VLSGFLSIIS ERKNTLYLVR GSLGANIVSS IAAGTGIAML ILNLTNNFAY 150
MNNCKNVTED DGCFVASFTT ELVLMMLFLT ILAFCSAVLF TIYRIGQELE 200
SKKVPDDRLY EELNVYSPIY SELEDKGETS SPVDS 235
Length:235
Mass (Da):25,963
Last modified:February 1, 1991 - v1
Checksum:i1C2D6BF195738168
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05019 mRNA. Translation: AAA37601.1.
AB033617 Genomic DNA. Translation: BAA94839.1.
CCDSiCCDS29604.1.
PIRiB34342.
RefSeqiNP_038544.1. NM_013516.2.
XP_006526721.1. XM_006526658.1.
UniGeneiMm.329735.

Genome annotation databases

EnsembliENSMUST00000164792; ENSMUSP00000127373; ENSMUSG00000024680.
GeneIDi14126.
KEGGimmu:14126.
UCSCiuc008gsn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05019 mRNA. Translation: AAA37601.1 .
AB033617 Genomic DNA. Translation: BAA94839.1 .
CCDSi CCDS29604.1.
PIRi B34342.
RefSeqi NP_038544.1. NM_013516.2.
XP_006526721.1. XM_006526658.1.
UniGenei Mm.329735.

3D structure databases

ProteinModelPortali P20490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199615. 2 interactions.
STRINGi 10090.ENSMUSP00000025583.

PTM databases

PhosphoSitei P20490.

Proteomic databases

PRIDEi P20490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000164792 ; ENSMUSP00000127373 ; ENSMUSG00000024680 .
GeneIDi 14126.
KEGGi mmu:14126.
UCSCi uc008gsn.1. mouse.

Organism-specific databases

CTDi 2206.
MGIi MGI:95495. Ms4a2.

Phylogenomic databases

eggNOGi NOG47093.
GeneTreei ENSGT00730000111024.
HOGENOMi HOG000060211.
HOVERGENi HBG051600.
InParanoidi P20490.
KOi K08090.
OMAi STEIVVM.
PhylomeDBi P20490.
TreeFami TF335157.

Enzyme and pathway databases

Reactomei REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188204. Fc epsilon receptor (FCERI) signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_205561. FCERI mediated NF-kB activation.
REACT_213364. Role of LAT2/NTAL/LAB on calcium mobilization.

Miscellaneous databases

NextBioi 285210.
PROi P20490.
SOURCEi Search...

Gene expression databases

Bgeei P20490.
Genevestigatori P20490.

Family and domain databases

InterProi IPR007237. CD20-like.
[Graphical view ]
Pfami PF04103. CD20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells."
    Ra C., Jouvin M.H.E., Kinet J.-P.
    J. Biol. Chem. 264:15323-15327(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genomic structure of the allergy associated Fc receptor beta subunit and its high content of SINEs."
    Hiraoka S., Watanabe M., Takagaki Y., Fujita-Suzuki K., Shinohara N., Okumura K., Ra C.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI."
    Xiao W., Nishimoto H., Hong H., Kitaura J., Nunomura S., Maeda-Yamamoto M., Kawakami Y., Lowell C.A., Ra C., Kawakami T.
    J. Immunol. 175:6885-6892(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH LYN.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-210; TYR-216; SER-217 AND TYR-220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  5. "Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells."
    McPherson V.A., Everingham S., Karisch R., Smith J.A., Udell C.M., Zheng J., Jia Z., Craig A.W.
    Mol. Cell. Biol. 29:389-401(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FES/FPS.

Entry informationi

Entry nameiFCERB_MOUSE
AccessioniPrimary (citable) accession number: P20490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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