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Protein

High affinity immunoglobulin epsilon receptor subunit alpha

Gene

Fcer1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

GO - Molecular functioni

  • IgE binding Source: MGI
  • IgE receptor activity Source: MGI

GO - Biological processi

  • activation of JUN kinase activity Source: MGI
  • activation of MAPK activity Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • Fc-epsilon receptor signaling pathway Source: GOC
  • leukotriene biosynthetic process Source: MGI
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process Source: MGI
  • positive regulation of interleukin-3 biosynthetic process Source: MGI
  • positive regulation of mast cell degranulation Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • serotonin secretion Source: MGI
  • signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiR-MMU-2454202. Fc epsilon receptor (FCERI) signaling.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-2871837. FCERI mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit alpha
Alternative name(s):
Fc-epsilon RI-alpha
Short name:
FcERI
IgE Fc receptor subunit alpha
Gene namesi
Name:Fcer1a
Synonyms:Fce1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95494. Fcer1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 204181ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22319HelicalSequence analysisAdd
BLAST
Topological domaini224 – 25027CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of plasma membrane Source: MGI
  • intracellular Source: GOC
  • membrane raft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 250227High affinity immunoglobulin epsilon receptor subunit alphaPRO_0000015162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 92PROSITE-ProRule annotation
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi131 ↔ 174PROSITE-ProRule annotation
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20489.

PTM databases

iPTMnetiP20489.
PhosphoSiteiP20489.

Expressioni

Tissue specificityi

Expressed in bone marrow mast cells, as well as in the pineal gland at night.1 Publication

Inductioni

Exhibits night/day variations with an increased expression at night in the pineal gland.1 Publication

Gene expression databases

ExpressionAtlasiP20489. baseline and differential.
GenevisibleiP20489. MM.

Interactioni

Subunit structurei

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.

GO - Molecular functioni

  • IgE binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056882.

Structurei

3D structure databases

ProteinModelPortaliP20489.
SMRiP20489. Positions 27-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10477Ig-like 1Add
BLAST
Domaini114 – 18168Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJME. Eukaryota.
ENOG410ZPGM. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP20489.
KOiK08089.
OMAiYENHNIS.
OrthoDBiEOG72NRRC.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTGRSAQLC LALLFMSLDV ILTATEKSVL TLDPPWIRIF TGEKVTLSCY
60 70 80 90 100
GNNHLQMNST TKWIHNGTVS EVNSSHLVIV SATVQDSGKY ICQKQGLFKS
110 120 130 140 150
KPVYLNVTQD WLLLQTSADM VLVHGSFDIR CHGWKNWNVR KVIYYRNDHA
160 170 180 190 200
FNYSYESPVS IREATLNDSG TYHCKGYLRQ VKYESDKFRI AVVKAYKCKY
210 220 230 240 250
YWLQLIFPLL VAILFAVDTG LLLSTEEQFK SVLEIQKTGK YKKVETELLT
Length:250
Mass (Da):28,657
Last modified:October 3, 2012 - v2
Checksum:iDDC9E2AD2CF42C54
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211V → I in AAA37600 (PubMed:2527850).Curated
Sequence conflicti182 – 1821K → E in AAA37600 (PubMed:2527850).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05018 mRNA. Translation: AAA37600.1.
AC125268 Genomic DNA. No translation available.
CCDSiCCDS35788.1.
PIRiA34342.
RefSeqiNP_034314.2. NM_010184.2.
UniGeneiMm.5266.

Genome annotation databases

EnsembliENSMUST00000049706; ENSMUSP00000056882; ENSMUSG00000005339.
GeneIDi14125.
KEGGimmu:14125.
UCSCiuc007dre.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05018 mRNA. Translation: AAA37600.1.
AC125268 Genomic DNA. No translation available.
CCDSiCCDS35788.1.
PIRiA34342.
RefSeqiNP_034314.2. NM_010184.2.
UniGeneiMm.5266.

3D structure databases

ProteinModelPortaliP20489.
SMRiP20489. Positions 27-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056882.

PTM databases

iPTMnetiP20489.
PhosphoSiteiP20489.

Proteomic databases

PaxDbiP20489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049706; ENSMUSP00000056882; ENSMUSG00000005339.
GeneIDi14125.
KEGGimmu:14125.
UCSCiuc007dre.2. mouse.

Organism-specific databases

CTDi2205.
MGIiMGI:95494. Fcer1a.

Phylogenomic databases

eggNOGiENOG410IJME. Eukaryota.
ENOG410ZPGM. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP20489.
KOiK08089.
OMAiYENHNIS.
OrthoDBiEOG72NRRC.
TreeFamiTF335097.

Enzyme and pathway databases

ReactomeiR-MMU-2454202. Fc epsilon receptor (FCERI) signaling.
R-MMU-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-2871837. FCERI mediated NF-kB activation.

Miscellaneous databases

PROiP20489.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP20489. baseline and differential.
GenevisibleiP20489. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells."
    Ra C., Jouvin M.H.E., Kinet J.-P.
    J. Biol. Chem. 264:15323-15327(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "mRNA variants encoding multiple forms of the high-affinity IgE receptor alpha subunit in transformed and nontransformed mast cells."
    Robertson M.W., Mehl V.S., Richards M.L., Liu F.T.
    Int. Arch. Allergy Appl. Immunol. 96:289-295(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-194.
  4. "Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?"
    Ganguly S., Grodzki C., Sugden D., Moller M., Odom S., Gaildrat P., Gery I., Siraganian R.P., Rivera J., Klein D.C.
    J. Biol. Chem. 282:32758-32764(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiFCERA_MOUSE
AccessioniPrimary (citable) accession number: P20489
Secondary accession number(s): E9QLR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.