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Protein

Synaptophysin

Gene

SYP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).By similarity

GO - Molecular functioni

  • GTPase binding Source: AgBase
  • transporter activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin
Alternative name(s):
Major synaptic vesicle protein p38
Gene namesi
Name:SYP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4924HelicalSequence analysisAdd
BLAST
Topological domaini50 – 10657VesicularSequence analysisAdd
BLAST
Transmembranei107 – 13024HelicalSequence analysisAdd
BLAST
Topological domaini131 – 1377CytoplasmicSequence analysis
Transmembranei138 – 16124HelicalSequence analysisAdd
BLAST
Topological domaini162 – 19938VesicularSequence analysisAdd
BLAST
Transmembranei200 – 22324HelicalSequence analysisAdd
BLAST
Topological domaini224 – 31390CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • chromaffin granule membrane Source: AgBase
  • clathrin-coated vesicle Source: AgBase
  • integral component of synaptic vesicle membrane Source: GO_Central
  • neuron projection Source: UniProtKB-SubCell
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313SynaptophysinPRO_0000179160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Modified residuei81 – 811PhosphotyrosineBy similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP20488.

Expressioni

Tissue specificityi

Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Interactioni

Subunit structurei

Homohexamer or homotetramer. Interacts with SRCIN1 (By similarity).By similarity

GO - Molecular functioni

  • GTPase binding Source: AgBase

Protein-protein interaction databases

DIPiDIP-29431N.
STRINGi9913.ENSBTAP00000021428.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 227207MARVELPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 30451Repeats, Gly/Tyr-richAdd
BLAST

Domaini

The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiP20488.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
IPR028714. SYP.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 2 hits.
PTHR10306:SF10. PTHR10306:SF10. 2 hits.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYSGE
60 70 80 90 100
LQLSVDCANK TKSDLNIEVE FEYPFRLHEV YFEAPTCQGD PKKIFLVGNY
110 120 130 140 150
SSSAEFFVTV AVFAFLYSMG ALATYIFLQN KYRENNKGPM LDFLATAVFA
160 170 180 190 200
FMWLVSSSAW AKGLSDVKMA TDPENIIKGM HVCHQPGNTC KELRDPVTSG
210 220 230 240 250
LNTSVVFGFL NLVLWVGNLW FVFKETGWAA PFLRAPPGAP EKQPAPGDAY
260 270 280 290 300
GQAGYGQGPG GYGPQDSYGP QGGYQPDYGQ PASSGGGGYG PQGDYGQQGY
310
GPQGAPTSFS NQM
Length:313
Mass (Da):33,910
Last modified:July 19, 2003 - v3
Checksum:i3D787D4288304587
GO

Sequence cautioni

The sequence AAA30767.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22967 mRNA. Translation: AAA30767.1. Different initiation.
PIRiA32208.
RefSeqiNP_776388.1. NM_173963.1.
UniGeneiBt.674.

Genome annotation databases

GeneIDi280937.
KEGGibta:280937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22967 mRNA. Translation: AAA30767.1. Different initiation.
PIRiA32208.
RefSeqiNP_776388.1. NM_173963.1.
UniGeneiBt.674.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29431N.
STRINGi9913.ENSBTAP00000021428.

Proteomic databases

PaxDbiP20488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280937.
KEGGibta:280937.

Organism-specific databases

CTDi6855.

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiP20488.

Miscellaneous databases

NextBioi20805053.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
IPR028714. SYP.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 2 hits.
PTHR10306:SF10. PTHR10306:SF10. 2 hits.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Transmembrane topography and evolutionary conservation of synaptophysin."
    Johnston P.A., Jahn R., Suedhof T.C.
    J. Biol. Chem. 264:1268-1273(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSYPH_BOVIN
AccessioniPrimary (citable) accession number: P20488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 19, 2003
Last modified: February 17, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.