UniProtKB - P20486 (CKS1_YEAST)
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Protein
Cyclin-dependent kinases regulatory subunit
Gene
CKS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Binds to the catalytic subunit of the cyclin dependent kinase (CDC28) and is essential for its biological function.
Miscellaneous
Present with 8780 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase activator activity Source: GO_Central
- histone binding Source: SGD
- protein kinase activator activity Source: SGD
- protein kinase binding Source: GO_Central
- ubiquitin binding Source: SGD
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: SGD
- regulation of mitotic cell cycle Source: SGD
- regulation of nucleosome density Source: SGD
- regulation of transcription by RNA polymerase II Source: SGD
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29089-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinases regulatory subunitAlternative name(s): Cell division control protein CKS1 |
Gene namesi | Name:CKS1 Ordered Locus Names:YBR135W ORF Names:YBR1011 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YBR135W. |
SGDi | S000000339. CKS1. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206245 | 1 – 150 | Cyclin-dependent kinases regulatory subunitAdd BLAST | 150 |
Proteomic databases
PaxDbi | P20486. |
PRIDEi | P20486. |
TopDownProteomicsi | P20486. |
Interactioni
Binary interactionsi
GO - Molecular functioni
- histone binding Source: SGD
- protein kinase binding Source: GO_Central
- ubiquitin binding Source: SGD
Protein-protein interaction databases
BioGridi | 32835. 582 interactors. |
DIPi | DIP-1262N. |
ELMi | P20486. |
IntActi | P20486. 37 interactors. |
MINTi | P20486. |
STRINGi | 4932.YBR135W. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 15 – 22 | Combined sources | 8 | |
Helixi | 23 – 27 | Combined sources | 5 | |
Beta strandi | 37 – 45 | Combined sources | 9 | |
Helixi | 48 – 53 | Combined sources | 6 | |
Helixi | 56 – 58 | Combined sources | 3 | |
Turni | 61 – 63 | Combined sources | 3 | |
Beta strandi | 64 – 66 | Combined sources | 3 | |
Helixi | 71 – 76 | Combined sources | 6 | |
Beta strandi | 86 – 88 | Combined sources | 3 | |
Beta strandi | 97 – 103 | Combined sources | 7 | |
Turni | 106 – 109 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QB3 | X-ray | 3.00 | A/B/C | 1-150 | [»] | |
3QY2 | X-ray | 2.59 | A/B | 1-117 | [»] | |
4LPA | X-ray | 2.90 | A/B/C/D | 1-113 | [»] | |
ProteinModelPortali | P20486. | |||||
SMRi | P20486. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20486. |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 118 – 133 | Poly-GlnAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the CKS family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000011006. |
HOGENOMi | HOG000157009. |
InParanoidi | P20486. |
KOi | K02219. |
OMAi | DYFNSEV. |
OrthoDBi | EOG092C5VM2. |
Family and domain databases
Gene3Di | 3.30.170.10. 1 hit. |
InterProi | View protein in InterPro IPR000789. Cyclin-dep_kinase_reg-sub. IPR036858. Cyclin-dep_kinase_reg-sub_sf. |
Pfami | View protein in Pfam PF01111. CKS. 1 hit. |
PRINTSi | PR00296. CYCLINKINASE. |
SMARTi | View protein in SMART SM01084. CKS. 1 hit. |
SUPFAMi | SSF55637. SSF55637. 1 hit. |
PROSITEi | View protein in PROSITE PS00944. CKS_1. 1 hit. PS00945. CKS_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P20486-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYHHYHAFQG RKLTDQERAR VLEFQDSIHY SPRYSDDNYE YRHVMLPKAM
60 70 80 90 100
LKVIPSDYFN SEVGTLRILT EDEWRGLGIT QSLGWEHYEC HAPEPHILLF
110 120 130 140 150
KRPLNYEAEL RAATAAAQQQ QQQQQQQQQQ QQQHQTQSIS NDMQVPPQIS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26033 Genomic DNA. Translation: AAA34879.1. X75891 Genomic DNA. Translation: CAA53493.1. Z36004 Genomic DNA. Translation: CAA85092.1. AY558186 Genomic DNA. Translation: AAS56512.1. D11088 Genomic DNA. Translation: BAA01859.1. BK006936 Genomic DNA. Translation: DAA07251.1. |
PIRi | A32793. OKBYS1. |
RefSeqi | NP_009693.3. NM_001178483.3. |
Genome annotation databases
EnsemblFungii | YBR135W; YBR135W; YBR135W. |
GeneIDi | 852432. |
KEGGi | sce:YBR135W. |
Similar proteinsi
Entry informationi
Entry namei | CKS1_YEAST | |
Accessioni | P20486Primary (citable) accession number: P20486 Secondary accession number(s): D6VQD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | March 28, 2018 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |