Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinases regulatory subunit

Gene

CKS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinase (CDC28) and is essential for its biological function.

Miscellaneous

Present with 8780 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase activator activity Source: GO_Central
  • histone binding Source: SGD
  • protein kinase activator activity Source: SGD
  • protein kinase binding Source: GO_Central
  • ubiquitin binding Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • regulation of mitotic cell cycle Source: SGD
  • regulation of nucleosome density Source: SGD
  • regulation of transcription from RNA polymerase II promoter Source: SGD

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-29089-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit
Alternative name(s):
Cell division control protein CKS1
Gene namesi
Name:CKS1
Ordered Locus Names:YBR135W
ORF Names:YBR1011
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR135W.
SGDiS000000339. CKS1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062451 – 150Cyclin-dependent kinases regulatory subunitAdd BLAST150

Proteomic databases

PRIDEiP20486.
TopDownProteomicsiP20486.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone binding Source: SGD
  • protein kinase binding Source: GO_Central
  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi32835. 571 interactors.
DIPiDIP-1262N.
ELMiP20486.
IntActiP20486. 18 interactors.
MINTiMINT-410972.
STRINGi4932.YBR135W.

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 22Combined sources8
Helixi23 – 27Combined sources5
Beta strandi37 – 45Combined sources9
Helixi48 – 53Combined sources6
Helixi56 – 58Combined sources3
Turni61 – 63Combined sources3
Beta strandi64 – 66Combined sources3
Helixi71 – 76Combined sources6
Beta strandi86 – 88Combined sources3
Beta strandi97 – 103Combined sources7
Turni106 – 109Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QB3X-ray3.00A/B/C1-150[»]
3QY2X-ray2.59A/B1-117[»]
4LPAX-ray2.90A/B/C/D1-113[»]
ProteinModelPortaliP20486.
SMRiP20486.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20486.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 133Poly-GlnAdd BLAST16

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000011006.
HOGENOMiHOG000157009.
InParanoidiP20486.
KOiK02219.
OMAiDYFNSEV.
OrthoDBiEOG092C5VM2.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiView protein in InterPro
IPR000789. Cyclin-dep_kinase_reg-sub.
PfamiView protein in Pfam
PF01111. CKS. 1 hit.
PRINTSiPR00296. CYCLINKINASE.
SMARTiView protein in SMART
SM01084. CKS. 1 hit.
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiView protein in PROSITE
PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P20486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHHYHAFQG RKLTDQERAR VLEFQDSIHY SPRYSDDNYE YRHVMLPKAM
60 70 80 90 100
LKVIPSDYFN SEVGTLRILT EDEWRGLGIT QSLGWEHYEC HAPEPHILLF
110 120 130 140 150
KRPLNYEAEL RAATAAAQQQ QQQQQQQQQQ QQQHQTQSIS NDMQVPPQIS
Length:150
Mass (Da):17,795
Last modified:February 1, 1991 - v1
Checksum:i0DD0910E01D373FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26033 Genomic DNA. Translation: AAA34879.1.
X75891 Genomic DNA. Translation: CAA53493.1.
Z36004 Genomic DNA. Translation: CAA85092.1.
AY558186 Genomic DNA. Translation: AAS56512.1.
D11088 Genomic DNA. Translation: BAA01859.1.
BK006936 Genomic DNA. Translation: DAA07251.1.
PIRiA32793. OKBYS1.
RefSeqiNP_009693.3. NM_001178483.3.

Genome annotation databases

EnsemblFungiiYBR135W; YBR135W; YBR135W.
GeneIDi852432.
KEGGisce:YBR135W.

Similar proteinsi

Entry informationi

Entry nameiCKS1_YEAST
AccessioniPrimary (citable) accession number: P20486
Secondary accession number(s): D6VQD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: August 30, 2017
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names