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P20472

- PRVA_HUMAN

UniProt

P20472 - PRVA_HUMAN

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Protein
Parvalbumin alpha
Gene
PVALB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121
Add
BLAST
Calcium bindingi91 – 102122
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl

GO - Biological processi

  1. cytosolic calcium ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:PVALB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:9704. PVALB.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular vesicular exosome Source: UniProt
  4. nucleus Source: Ensembl
  5. protein complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi52 – 521D → A: Inactivation.
Mutagenesisi63 – 631E → V: Inactivation.
Mutagenesisi91 – 911D → A: Inactivation.
Mutagenesisi102 – 1021E → V: Inactivation.

Organism-specific databases

PharmGKBiPA34049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 110109Parvalbumin alpha
PRO_0000073588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP20472.
PRIDEiP20472.

PTM databases

PhosphoSiteiP20472.

Expressioni

Gene expression databases

ArrayExpressiP20472.
BgeeiP20472.
CleanExiHS_PVALB.
GenevestigatoriP20472.

Organism-specific databases

HPAiCAB002515.
HPA048536.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000216200.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni3 – 86
Helixi9 – 1810
Beta strandi21 – 233
Helixi27 – 337
Helixi36 – 383
Helixi41 – 5111
Helixi61 – 644
Turni65 – 673
Helixi68 – 714
Helixi80 – 9011
Beta strandi92 – 987
Helixi100 – 1067
Turni107 – 1093

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJVNMR-A1-110[»]
1RK9NMR-A2-110[»]
ProteinModelPortaliP20472.
SMRiP20472. Positions 1-110.

Miscellaneous databases

EvolutionaryTraceiP20472.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1
Add
BLAST
Domaini78 – 11033EF-hand 2
Add
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.
Contains 2 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG278774.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP20472.
OMAiFHMLDKD.
OrthoDBiEOG7Z0JZW.
PhylomeDBiP20472.
TreeFamiTF332342.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20472-1 [UniParc]FASTAAdd to Basket

« Hide

MSMTDLLNAE DIKKAVGAFS ATDSFDHKKF FQMVGLKKKS ADDVKKVFHM    50
LDKDKSGFIE EDELGFILKG FSPDARDLSA KETKMLMAAG DKDGDGKIGV 100
DEFSTLVAES 110
Length:110
Mass (Da):12,059
Last modified:January 23, 2007 - v2
Checksum:i03ABDD22E24AEA11
GO

Mass spectrometryi

Molecular mass is 11927±0.76 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41T → N in AAH96113. 1 Publication
Sequence conflicti99 – 1002Missing in CAA45134. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63578 Genomic DNA. Translation: CAA45134.1.
X52695
, X52696, X52697, X52698 Genomic DNA. Translation: CAA36924.1.
X63070 mRNA. Translation: CAA44792.1.
CR456552 mRNA. Translation: CAG30438.1.
AK311832 mRNA. Translation: BAG34774.1.
Z82184, Z82185 Genomic DNA. Translation: CAI23584.1.
Z82185, Z82184 Genomic DNA. Translation: CAI23585.1.
CH471095 Genomic DNA. Translation: EAW60118.1.
BC069300 mRNA. Translation: AAH69300.1.
BC096112 mRNA. Translation: AAH96112.1.
BC096113 mRNA. Translation: AAH96113.1.
BC096114 mRNA. Translation: AAH96114.1.
BC096115 mRNA. Translation: AAH96115.1.
CCDSiCCDS13933.1.
PIRiS07531.
RefSeqiNP_002845.1. NM_002854.2.
XP_006724348.1. XM_006724285.1.
XP_006725467.1. XM_006725404.1.
UniGeneiHs.295449.

Genome annotation databases

EnsembliENST00000216200; ENSP00000216200; ENSG00000100362.
ENST00000417718; ENSP00000400247; ENSG00000100362.
GeneIDi5816.
KEGGihsa:5816.
UCSCiuc003apx.3. human.

Polymorphism databases

DMDMi131100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63578 Genomic DNA. Translation: CAA45134.1 .
X52695
, X52696 , X52697 , X52698 Genomic DNA. Translation: CAA36924.1 .
X63070 mRNA. Translation: CAA44792.1 .
CR456552 mRNA. Translation: CAG30438.1 .
AK311832 mRNA. Translation: BAG34774.1 .
Z82184 , Z82185 Genomic DNA. Translation: CAI23584.1 .
Z82185 , Z82184 Genomic DNA. Translation: CAI23585.1 .
CH471095 Genomic DNA. Translation: EAW60118.1 .
BC069300 mRNA. Translation: AAH69300.1 .
BC096112 mRNA. Translation: AAH96112.1 .
BC096113 mRNA. Translation: AAH96113.1 .
BC096114 mRNA. Translation: AAH96114.1 .
BC096115 mRNA. Translation: AAH96115.1 .
CCDSi CCDS13933.1.
PIRi S07531.
RefSeqi NP_002845.1. NM_002854.2.
XP_006724348.1. XM_006724285.1.
XP_006725467.1. XM_006725404.1.
UniGenei Hs.295449.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1RJV NMR - A 1-110 [» ]
1RK9 NMR - A 2-110 [» ]
ProteinModelPortali P20472.
SMRi P20472. Positions 1-110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000216200.

PTM databases

PhosphoSitei P20472.

Polymorphism databases

DMDMi 131100.

Proteomic databases

PaxDbi P20472.
PRIDEi P20472.

Protocols and materials databases

DNASUi 5816.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216200 ; ENSP00000216200 ; ENSG00000100362 .
ENST00000417718 ; ENSP00000400247 ; ENSG00000100362 .
GeneIDi 5816.
KEGGi hsa:5816.
UCSCi uc003apx.3. human.

Organism-specific databases

CTDi 5816.
GeneCardsi GC22M037196.
HGNCi HGNC:9704. PVALB.
HPAi CAB002515.
HPA048536.
MIMi 168890. gene.
neXtProti NX_P20472.
PharmGKBi PA34049.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278774.
HOGENOMi HOG000037438.
HOVERGENi HBG107490.
InParanoidi P20472.
OMAi FHMLDKD.
OrthoDBi EOG7Z0JZW.
PhylomeDBi P20472.
TreeFami TF332342.

Miscellaneous databases

ChiTaRSi PVALB. human.
EvolutionaryTracei P20472.
GenomeRNAii 5816.
NextBioi 22650.
PROi P20472.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20472.
Bgeei P20472.
CleanExi HS_PVALB.
Genevestigatori P20472.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view ]
PANTHERi PTHR11653. PTHR11653. 1 hit.
Pfami PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Parvalbumin genes from human and rat are identical in intron/exon organization and contain highly homologous regulatory elements and coding sequences."
    Berchtold M.W.
    J. Mol. Biol. 210:417-427(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-110.
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Electrospray ionization mass spectrometry: analysis of the Ca2+-binding properties of human recombinant alpha-parvalbumin and nine mutant proteins."
    Troxler H., Kuster T., Rhyner J.A., Gehrig P., Heizmann C.W.
    Anal. Biochem. 268:64-71(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS, ACETYLATION AT SER-2, MASS SPECTROMETRY.
  9. "Paramagnetism-based refinement strategy for the solution structure of human alpha-parvalbumin."
    Baig I., Bertini I., Del Bianco C., Gupta Y.K., Lee Y.M., Luchinat C., Quattrone A.
    Biochemistry 43:5562-5573(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPRVA_HUMAN
AccessioniPrimary (citable) accession number: P20472
Secondary accession number(s): B2R4H7
, P78378, Q4VB78, Q5R3Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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