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Protein

Parvalbumin alpha

Gene

PVALB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121Add
BLAST
Calcium bindingi91 – 102122Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:PVALB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 22, Unplaced

Organism-specific databases

HGNCiHGNC:9704. PVALB.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytosol Source: GOC
  • extracellular exosome Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • nucleus Source: Ensembl
  • protein complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi52 – 521D → A: Inactivation. 1 Publication
Mutagenesisi63 – 631E → V: Inactivation. 1 Publication
Mutagenesisi91 – 911D → A: Inactivation. 1 Publication
Mutagenesisi102 – 1021E → V: Inactivation. 1 Publication

Organism-specific databases

PharmGKBiPA34049.

Polymorphism and mutation databases

BioMutaiPVALB.
DMDMi131100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 110109Parvalbumin alphaPRO_0000073588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP20472.
PRIDEiP20472.

PTM databases

PhosphoSiteiP20472.

Expressioni

Gene expression databases

BgeeiP20472.
CleanExiHS_PVALB.
ExpressionAtlasiP20472. baseline and differential.
GenevisibleiP20472. HS.

Organism-specific databases

HPAiCAB002515.
HPA048536.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000216200.

Structurei

Secondary structure

1
110
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni3 – 86Combined sources
Helixi9 – 1810Combined sources
Beta strandi21 – 233Combined sources
Helixi27 – 337Combined sources
Helixi36 – 383Combined sources
Helixi41 – 5111Combined sources
Helixi61 – 644Combined sources
Turni65 – 673Combined sources
Helixi68 – 714Combined sources
Helixi80 – 9011Combined sources
Beta strandi92 – 987Combined sources
Helixi100 – 1067Combined sources
Turni107 – 1093Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJVNMR-A1-110[»]
1RK9NMR-A2-110[»]
ProteinModelPortaliP20472.
SMRiP20472. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20472.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 11033EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG278774.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP20472.
OMAiAVDSFDH.
OrthoDBiEOG7Z0JZW.
PhylomeDBiP20472.
TreeFamiTF332342.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDLLNAE DIKKAVGAFS ATDSFDHKKF FQMVGLKKKS ADDVKKVFHM
60 70 80 90 100
LDKDKSGFIE EDELGFILKG FSPDARDLSA KETKMLMAAG DKDGDGKIGV
110
DEFSTLVAES
Length:110
Mass (Da):12,059
Last modified:January 23, 2007 - v2
Checksum:i03ABDD22E24AEA11
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41T → N in AAH96113 (PubMed:15489334).Curated
Sequence conflicti99 – 1002Missing in CAA45134 (PubMed:2614829).Curated

Mass spectrometryi

Molecular mass is 11927±0.76 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63578 Genomic DNA. Translation: CAA45134.1.
X52695
, X52696, X52697, X52698 Genomic DNA. Translation: CAA36924.1.
X63070 mRNA. Translation: CAA44792.1.
CR456552 mRNA. Translation: CAG30438.1.
AK311832 mRNA. Translation: BAG34774.1.
Z82184, Z82185 Genomic DNA. Translation: CAI23584.1.
Z82185, Z82184 Genomic DNA. Translation: CAI23585.1.
CH471095 Genomic DNA. Translation: EAW60118.1.
BC069300 mRNA. Translation: AAH69300.1.
BC096112 mRNA. Translation: AAH96112.1.
BC096113 mRNA. Translation: AAH96113.1.
BC096114 mRNA. Translation: AAH96114.1.
BC096115 mRNA. Translation: AAH96115.1.
CCDSiCCDS13933.1.
PIRiS07531.
RefSeqiNP_002845.1. NM_002854.2.
XP_006724348.1. XM_006724285.1.
XP_006725467.1. XM_006725404.1.
UniGeneiHs.295449.

Genome annotation databases

EnsembliENST00000216200; ENSP00000216200; ENSG00000100362.
ENST00000417718; ENSP00000400247; ENSG00000100362.
ENST00000620986; ENSP00000480913; ENSG00000274665.
ENST00000625893; ENSP00000486144; ENSG00000274665.
GeneIDi5816.
KEGGihsa:5816.
UCSCiuc003apx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63578 Genomic DNA. Translation: CAA45134.1.
X52695
, X52696, X52697, X52698 Genomic DNA. Translation: CAA36924.1.
X63070 mRNA. Translation: CAA44792.1.
CR456552 mRNA. Translation: CAG30438.1.
AK311832 mRNA. Translation: BAG34774.1.
Z82184, Z82185 Genomic DNA. Translation: CAI23584.1.
Z82185, Z82184 Genomic DNA. Translation: CAI23585.1.
CH471095 Genomic DNA. Translation: EAW60118.1.
BC069300 mRNA. Translation: AAH69300.1.
BC096112 mRNA. Translation: AAH96112.1.
BC096113 mRNA. Translation: AAH96113.1.
BC096114 mRNA. Translation: AAH96114.1.
BC096115 mRNA. Translation: AAH96115.1.
CCDSiCCDS13933.1.
PIRiS07531.
RefSeqiNP_002845.1. NM_002854.2.
XP_006724348.1. XM_006724285.1.
XP_006725467.1. XM_006725404.1.
UniGeneiHs.295449.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJVNMR-A1-110[»]
1RK9NMR-A2-110[»]
ProteinModelPortaliP20472.
SMRiP20472. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000216200.

PTM databases

PhosphoSiteiP20472.

Polymorphism and mutation databases

BioMutaiPVALB.
DMDMi131100.

Proteomic databases

PaxDbiP20472.
PRIDEiP20472.

Protocols and materials databases

DNASUi5816.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216200; ENSP00000216200; ENSG00000100362.
ENST00000417718; ENSP00000400247; ENSG00000100362.
ENST00000620986; ENSP00000480913; ENSG00000274665.
ENST00000625893; ENSP00000486144; ENSG00000274665.
GeneIDi5816.
KEGGihsa:5816.
UCSCiuc003apx.3. human.

Organism-specific databases

CTDi5816.
GeneCardsiGC22M037196.
HGNCiHGNC:9704. PVALB.
HPAiCAB002515.
HPA048536.
MIMi168890. gene.
neXtProtiNX_P20472.
PharmGKBiPA34049.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278774.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP20472.
OMAiAVDSFDH.
OrthoDBiEOG7Z0JZW.
PhylomeDBiP20472.
TreeFamiTF332342.

Miscellaneous databases

ChiTaRSiPVALB. human.
EvolutionaryTraceiP20472.
GenomeRNAii5816.
NextBioi22650.
PROiP20472.
SOURCEiSearch...

Gene expression databases

BgeeiP20472.
CleanExiHS_PVALB.
ExpressionAtlasiP20472. baseline and differential.
GenevisibleiP20472. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Parvalbumin genes from human and rat are identical in intron/exon organization and contain highly homologous regulatory elements and coding sequences."
    Berchtold M.W.
    J. Mol. Biol. 210:417-427(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-110.
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Electrospray ionization mass spectrometry: analysis of the Ca2+-binding properties of human recombinant alpha-parvalbumin and nine mutant proteins."
    Troxler H., Kuster T., Rhyner J.A., Gehrig P., Heizmann C.W.
    Anal. Biochem. 268:64-71(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS, ACETYLATION AT SER-2, MASS SPECTROMETRY.
  9. "Paramagnetism-based refinement strategy for the solution structure of human alpha-parvalbumin."
    Baig I., Bertini I., Del Bianco C., Gupta Y.K., Lee Y.M., Luchinat C., Quattrone A.
    Biochemistry 43:5562-5573(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPRVA_HUMAN
AccessioniPrimary (citable) accession number: P20472
Secondary accession number(s): B2R4H7
, P78378, Q4VB78, Q5R3Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.