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Protein

Parvalbumin alpha

Gene

PVALB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100362-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:PVALB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9704. PVALB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • nucleus Source: Ensembl
  • protein complex Source: Ensembl
  • terminal bouton Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52D → A: Inactivation. 1 Publication1
Mutagenesisi63E → V: Inactivation. 1 Publication1
Mutagenesisi91D → A: Inactivation. 1 Publication1
Mutagenesisi102E → V: Inactivation. 1 Publication1

Organism-specific databases

DisGeNETi5816.
OpenTargetsiENSG00000100362.
ENSG00000274665.
PharmGKBiPA34049.

Polymorphism and mutation databases

BioMutaiPVALB.
DMDMi131100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000735882 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP20472.
PaxDbiP20472.
PeptideAtlasiP20472.
PRIDEiP20472.

PTM databases

iPTMnetiP20472.
PhosphoSitePlusiP20472.

Expressioni

Gene expression databases

BgeeiENSG00000100362.
CleanExiHS_PVALB.
ExpressionAtlasiP20472. baseline and differential.
GenevisibleiP20472. HS.

Organism-specific databases

HPAiCAB002515.
HPA048536.

Interactioni

Protein-protein interaction databases

BioGridi111774. 1 interactor.
STRINGi9606.ENSP00000216200.

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni3 – 8Combined sources6
Helixi9 – 18Combined sources10
Beta strandi21 – 23Combined sources3
Helixi27 – 33Combined sources7
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Helixi61 – 64Combined sources4
Turni65 – 67Combined sources3
Helixi68 – 71Combined sources4
Helixi80 – 90Combined sources11
Beta strandi92 – 98Combined sources7
Helixi100 – 106Combined sources7
Turni107 – 109Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RJVNMR-A1-110[»]
1RK9NMR-A2-110[»]
ProteinModelPortaliP20472.
SMRiP20472.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20472.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP20472.
OMAiAVDSFDH.
OrthoDBiEOG091G0ZAO.
PhylomeDBiP20472.
TreeFamiTF332342.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDLLNAE DIKKAVGAFS ATDSFDHKKF FQMVGLKKKS ADDVKKVFHM
60 70 80 90 100
LDKDKSGFIE EDELGFILKG FSPDARDLSA KETKMLMAAG DKDGDGKIGV
110
DEFSTLVAES
Length:110
Mass (Da):12,059
Last modified:January 23, 2007 - v2
Checksum:i03ABDD22E24AEA11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4T → N in AAH96113 (PubMed:15489334).Curated1
Sequence conflicti99 – 100Missing in CAA45134 (PubMed:2614829).Curated2

Mass spectrometryi

Molecular mass is 11927±0.76 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63578 Genomic DNA. Translation: CAA45134.1.
X52695
, X52696, X52697, X52698 Genomic DNA. Translation: CAA36924.1.
X63070 mRNA. Translation: CAA44792.1.
CR456552 mRNA. Translation: CAG30438.1.
AK311832 mRNA. Translation: BAG34774.1.
Z82184, Z82185 Genomic DNA. Translation: CAI23584.1.
Z82185, Z82184 Genomic DNA. Translation: CAI23585.1.
CH471095 Genomic DNA. Translation: EAW60118.1.
BC069300 mRNA. Translation: AAH69300.1.
BC096112 mRNA. Translation: AAH96112.1.
BC096113 mRNA. Translation: AAH96113.1.
BC096114 mRNA. Translation: AAH96114.1.
BC096115 mRNA. Translation: AAH96115.1.
CCDSiCCDS13933.1.
PIRiS07531.
RefSeqiNP_001302461.1. NM_001315532.1.
NP_002845.1. NM_002854.2.
UniGeneiHs.295449.

Genome annotation databases

EnsembliENST00000216200; ENSP00000216200; ENSG00000100362.
ENST00000417718; ENSP00000400247; ENSG00000100362.
ENST00000620986; ENSP00000480913; ENSG00000274665.
ENST00000625893; ENSP00000486144; ENSG00000274665.
GeneIDi5816.
KEGGihsa:5816.
UCSCiuc003apx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63578 Genomic DNA. Translation: CAA45134.1.
X52695
, X52696, X52697, X52698 Genomic DNA. Translation: CAA36924.1.
X63070 mRNA. Translation: CAA44792.1.
CR456552 mRNA. Translation: CAG30438.1.
AK311832 mRNA. Translation: BAG34774.1.
Z82184, Z82185 Genomic DNA. Translation: CAI23584.1.
Z82185, Z82184 Genomic DNA. Translation: CAI23585.1.
CH471095 Genomic DNA. Translation: EAW60118.1.
BC069300 mRNA. Translation: AAH69300.1.
BC096112 mRNA. Translation: AAH96112.1.
BC096113 mRNA. Translation: AAH96113.1.
BC096114 mRNA. Translation: AAH96114.1.
BC096115 mRNA. Translation: AAH96115.1.
CCDSiCCDS13933.1.
PIRiS07531.
RefSeqiNP_001302461.1. NM_001315532.1.
NP_002845.1. NM_002854.2.
UniGeneiHs.295449.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RJVNMR-A1-110[»]
1RK9NMR-A2-110[»]
ProteinModelPortaliP20472.
SMRiP20472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111774. 1 interactor.
STRINGi9606.ENSP00000216200.

PTM databases

iPTMnetiP20472.
PhosphoSitePlusiP20472.

Polymorphism and mutation databases

BioMutaiPVALB.
DMDMi131100.

Proteomic databases

EPDiP20472.
PaxDbiP20472.
PeptideAtlasiP20472.
PRIDEiP20472.

Protocols and materials databases

DNASUi5816.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216200; ENSP00000216200; ENSG00000100362.
ENST00000417718; ENSP00000400247; ENSG00000100362.
ENST00000620986; ENSP00000480913; ENSG00000274665.
ENST00000625893; ENSP00000486144; ENSG00000274665.
GeneIDi5816.
KEGGihsa:5816.
UCSCiuc003apx.4. human.

Organism-specific databases

CTDi5816.
DisGeNETi5816.
GeneCardsiPVALB.
HGNCiHGNC:9704. PVALB.
HPAiCAB002515.
HPA048536.
MIMi168890. gene.
neXtProtiNX_P20472.
OpenTargetsiENSG00000100362.
ENSG00000274665.
PharmGKBiPA34049.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP20472.
OMAiAVDSFDH.
OrthoDBiEOG091G0ZAO.
PhylomeDBiP20472.
TreeFamiTF332342.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100362-MONOMER.

Miscellaneous databases

ChiTaRSiPVALB. human.
EvolutionaryTraceiP20472.
GenomeRNAii5816.
PROiP20472.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100362.
CleanExiHS_PVALB.
ExpressionAtlasiP20472. baseline and differential.
GenevisibleiP20472. HS.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRVA_HUMAN
AccessioniPrimary (citable) accession number: P20472
Secondary accession number(s): B2R4H7
, P78378, Q4VB78, Q5R3Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.