Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P20472

- PRVA_HUMAN

UniProt

P20472 - PRVA_HUMAN

Protein

Parvalbumin alpha

Gene

PVALB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi52 – 63121Add
    BLAST
    Calcium bindingi91 – 102122Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl

    GO - Biological processi

    1. cytosolic calcium ion homeostasis Source: Ensembl

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parvalbumin alpha
    Gene namesi
    Name:PVALB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:9704. PVALB.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: Ensembl
    5. protein complex Source: Ensembl

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi52 – 521D → A: Inactivation. 1 Publication
    Mutagenesisi63 – 631E → V: Inactivation. 1 Publication
    Mutagenesisi91 – 911D → A: Inactivation. 1 Publication
    Mutagenesisi102 – 1021E → V: Inactivation. 1 Publication

    Organism-specific databases

    PharmGKBiPA34049.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 110109Parvalbumin alphaPRO_0000073588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP20472.
    PRIDEiP20472.

    PTM databases

    PhosphoSiteiP20472.

    Expressioni

    Gene expression databases

    ArrayExpressiP20472.
    BgeeiP20472.
    CleanExiHS_PVALB.
    GenevestigatoriP20472.

    Organism-specific databases

    HPAiCAB002515.
    HPA048536.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000216200.

    Structurei

    Secondary structure

    1
    110
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni3 – 86
    Helixi9 – 1810
    Beta strandi21 – 233
    Helixi27 – 337
    Helixi36 – 383
    Helixi41 – 5111
    Helixi61 – 644
    Turni65 – 673
    Helixi68 – 714
    Helixi80 – 9011
    Beta strandi92 – 987
    Helixi100 – 1067
    Turni107 – 1093

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RJVNMR-A1-110[»]
    1RK9NMR-A2-110[»]
    ProteinModelPortaliP20472.
    SMRiP20472. Positions 1-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20472.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini78 – 11033EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the parvalbumin family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG278774.
    HOGENOMiHOG000037438.
    HOVERGENiHBG107490.
    InParanoidiP20472.
    OMAiFHMLDKD.
    OrthoDBiEOG7Z0JZW.
    PhylomeDBiP20472.
    TreeFamiTF332342.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR008080. Parvalbumin.
    [Graphical view]
    PANTHERiPTHR11653. PTHR11653. 1 hit.
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20472-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMTDLLNAE DIKKAVGAFS ATDSFDHKKF FQMVGLKKKS ADDVKKVFHM    50
    LDKDKSGFIE EDELGFILKG FSPDARDLSA KETKMLMAAG DKDGDGKIGV 100
    DEFSTLVAES 110
    Length:110
    Mass (Da):12,059
    Last modified:January 23, 2007 - v2
    Checksum:i03ABDD22E24AEA11
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41T → N in AAH96113. (PubMed:15489334)Curated
    Sequence conflicti99 – 1002Missing in CAA45134. (PubMed:2614829)Curated

    Mass spectrometryi

    Molecular mass is 11927±0.76 Da from positions 2 - 110. Determined by ESI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63578 Genomic DNA. Translation: CAA45134.1.
    X52695
    , X52696, X52697, X52698 Genomic DNA. Translation: CAA36924.1.
    X63070 mRNA. Translation: CAA44792.1.
    CR456552 mRNA. Translation: CAG30438.1.
    AK311832 mRNA. Translation: BAG34774.1.
    Z82184, Z82185 Genomic DNA. Translation: CAI23584.1.
    Z82185, Z82184 Genomic DNA. Translation: CAI23585.1.
    CH471095 Genomic DNA. Translation: EAW60118.1.
    BC069300 mRNA. Translation: AAH69300.1.
    BC096112 mRNA. Translation: AAH96112.1.
    BC096113 mRNA. Translation: AAH96113.1.
    BC096114 mRNA. Translation: AAH96114.1.
    BC096115 mRNA. Translation: AAH96115.1.
    CCDSiCCDS13933.1.
    PIRiS07531.
    RefSeqiNP_002845.1. NM_002854.2.
    XP_006724348.1. XM_006724285.1.
    XP_006725467.1. XM_006725404.1.
    UniGeneiHs.295449.

    Genome annotation databases

    EnsembliENST00000216200; ENSP00000216200; ENSG00000100362.
    ENST00000417718; ENSP00000400247; ENSG00000100362.
    GeneIDi5816.
    KEGGihsa:5816.
    UCSCiuc003apx.3. human.

    Polymorphism databases

    DMDMi131100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63578 Genomic DNA. Translation: CAA45134.1 .
    X52695
    , X52696 , X52697 , X52698 Genomic DNA. Translation: CAA36924.1 .
    X63070 mRNA. Translation: CAA44792.1 .
    CR456552 mRNA. Translation: CAG30438.1 .
    AK311832 mRNA. Translation: BAG34774.1 .
    Z82184 , Z82185 Genomic DNA. Translation: CAI23584.1 .
    Z82185 , Z82184 Genomic DNA. Translation: CAI23585.1 .
    CH471095 Genomic DNA. Translation: EAW60118.1 .
    BC069300 mRNA. Translation: AAH69300.1 .
    BC096112 mRNA. Translation: AAH96112.1 .
    BC096113 mRNA. Translation: AAH96113.1 .
    BC096114 mRNA. Translation: AAH96114.1 .
    BC096115 mRNA. Translation: AAH96115.1 .
    CCDSi CCDS13933.1.
    PIRi S07531.
    RefSeqi NP_002845.1. NM_002854.2.
    XP_006724348.1. XM_006724285.1.
    XP_006725467.1. XM_006725404.1.
    UniGenei Hs.295449.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RJV NMR - A 1-110 [» ]
    1RK9 NMR - A 2-110 [» ]
    ProteinModelPortali P20472.
    SMRi P20472. Positions 1-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000216200.

    PTM databases

    PhosphoSitei P20472.

    Polymorphism databases

    DMDMi 131100.

    Proteomic databases

    PaxDbi P20472.
    PRIDEi P20472.

    Protocols and materials databases

    DNASUi 5816.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216200 ; ENSP00000216200 ; ENSG00000100362 .
    ENST00000417718 ; ENSP00000400247 ; ENSG00000100362 .
    GeneIDi 5816.
    KEGGi hsa:5816.
    UCSCi uc003apx.3. human.

    Organism-specific databases

    CTDi 5816.
    GeneCardsi GC22M037196.
    HGNCi HGNC:9704. PVALB.
    HPAi CAB002515.
    HPA048536.
    MIMi 168890. gene.
    neXtProti NX_P20472.
    PharmGKBi PA34049.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278774.
    HOGENOMi HOG000037438.
    HOVERGENi HBG107490.
    InParanoidi P20472.
    OMAi FHMLDKD.
    OrthoDBi EOG7Z0JZW.
    PhylomeDBi P20472.
    TreeFami TF332342.

    Miscellaneous databases

    ChiTaRSi PVALB. human.
    EvolutionaryTracei P20472.
    GenomeRNAii 5816.
    NextBioi 22650.
    PROi P20472.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20472.
    Bgeei P20472.
    CleanExi HS_PVALB.
    Genevestigatori P20472.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR008080. Parvalbumin.
    [Graphical view ]
    PANTHERi PTHR11653. PTHR11653. 1 hit.
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Parvalbumin genes from human and rat are identical in intron/exon organization and contain highly homologous regulatory elements and coding sequences."
      Berchtold M.W.
      J. Mol. Biol. 210:417-427(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-110.
      Tissue: Cerebellum.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    5. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Electrospray ionization mass spectrometry: analysis of the Ca2+-binding properties of human recombinant alpha-parvalbumin and nine mutant proteins."
      Troxler H., Kuster T., Rhyner J.A., Gehrig P., Heizmann C.W.
      Anal. Biochem. 268:64-71(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS, ACETYLATION AT SER-2, MASS SPECTROMETRY.
    9. "Paramagnetism-based refinement strategy for the solution structure of human alpha-parvalbumin."
      Baig I., Bertini I., Del Bianco C., Gupta Y.K., Lee Y.M., Luchinat C., Quattrone A.
      Biochemistry 43:5562-5573(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiPRVA_HUMAN
    AccessioniPrimary (citable) accession number: P20472
    Secondary accession number(s): B2R4H7
    , P78378, Q4VB78, Q5R3Q9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3