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P20470

- L_BUNYW

UniProt

P20470 - L_BUNYW

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Bunyamwera virus (BUNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

Keywords - Biological processi

Ubl conjugation pathway, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiBunyamwera virus (BUNV)
Taxonomic identifieri35304 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002476: Genome

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22382238RNA-directed RNA polymerase LPRO_0000222020Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1016 – 1207192RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR014384. RNA-dir_pol_orthobunyavirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000824. L_OrthobunV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20470-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDQAYDQYL HRIQAARTAT VAKDISADIL EARHDYFGRE LCNSLGIEYK
60 70 80 90 100
NNVLLDEIIL DVVPGVNLLN YNIPNVTPDN YIWDGHFLII LDYKVSVGND
110 120 130 140 150
SSEITYKKYT SLILPVMSEL GIDTEIAIIR ANPVTYQISI IGEEFKQRFP
160 170 180 190 200
NIPIQLDFGR FFELRKMLLD KFADDEEFLM MIAHGDFTLT APWCTSDTPE
210 220 230 240 250
LEEHEIFQEF INSMPPRFVS LFKEAVNFSA YSSERWNTFL YRARAETEVD
260 270 280 290 300
YNQFLSDKAH KIFMLEGDYM RPTQAEIDKG WELMSQRVYT EREIITDVTK
310 320 330 340 350
QKPSIHFIWV KNADRKLIGS TAKLIYLSNS LQSITEQSTW TDALKAIGKS
360 370 380 390 400
MDIDGKVGQY ETLCAERKMI ARSTGKKVDN KRLEAVKIGN ALVLWEQQFI
410 420 430 440 450
LANDLFKNQE RQKFMKNFFG IGKHKSFKDK TSSDIETDKP KILDFNNTIV
460 470 480 490 500
LMAARTMVNK NKALLAKDNT LQDLHPIIMQ YASEIKEASK DTFDALLKIS
510 520 530 540 550
KTCFWQCIVD VSTIMRNILA VSQYNRHNTF RVAMCANDSV YALVFPSSDI
560 570 580 590 600
KTKRATVVFS IVCMHKEKND LMDAGALFTT LECKNKEYIS ISKAIRLDKE
610 620 630 640 650
RCQRIVSSPG LFILSSMLLY NNNPEVNLVD VLNFTFYTSL SITKSMLSLT
660 670 680 690 700
EPSRYMIMNS LAISSHVRDY IAEKFSPYTK TLFSVYMVNL IKRGCASANE
710 720 730 740 750
QSSKIQLRNI YLSDYDITQK GVNDGRNLDS IWFPGKVNLK EYINQIYLPF
760 770 780 790 800
YFNAKGLHEK HHVMIDLAKT VLEIEMNQRS DNLGIWSKAE KKQHVNLPIL
810 820 830 840 850
IHSIAKSLIL DTSRHNHLRN RVESRNNFRR SITTISTFTS SKSCIKIGDF
860 870 880 890 900
REIKDKETEK SKKSTEKFDK KFRLSNPLFL EDEEANLEVQ HCNYRALIQK
910 920 930 940 950
IPNYKDYISV KVFDRLYELL KNGVLTDKPF IELAMEMMKN HKEFSFTFFN
960 970 980 990 1000
KGQKTAKDRE IFVGEFEAKM CMYVVERISK ERCKLNTDEM ISEPGDSKLK
1010 1020 1030 1040 1050
ILEKKAEEEI RYIVERTKDS IIKGDPSKAL KLEINADMSK WSAQDVFYKY
1060 1070 1080 1090 1100
FWLIAMDPIL YPAEKTRILY FMCNYMQKLL ILPDDLIANI LDQKRPYNDD
1110 1120 1130 1140 1150
LILEMTNGLN YNYVQIKRNW LQGNFNYISS YVHSCAMLVY KDILKECMKL
1160 1170 1180 1190 1200
LDGDCLINSM VHSDDNQTSL AIIQNKVSDQ IVIQYAANTF ESVCLTFGCQ
1210 1220 1230 1240 1250
ANMKKTYITH TCKEFVSLFN LHGEPLSVFG RFLLPSVGDC AYIGPYEDLA
1260 1270 1280 1290 1300
SRLSAAQQSL KHGCPPSLVW LAISCSHWIT FFTYNMLDDQ INAPQQHLPF
1310 1320 1330 1340 1350
NNRKEIPVEL NGYLNAPLYL IALVGLEAGN LWFLINILKK LVPLDKQKET
1360 1370 1380 1390 1400
IQSQCLHLCN SIDKLTESEK FKLKILRYLT LDTEMSVDNN MGETSDMRSR
1410 1420 1430 1440 1450
SLLTPRKFTT LGSLNKLVSY NDFRSSLDDQ RFTDNLNFML NNPELLVTKG
1460 1470 1480 1490 1500
ENKEQFMQSV LFRYNSKRFK ESLSIQNPAQ LFIEQILFSH KPIIDYSSIF
1510 1520 1530 1540 1550
DKLTSLAEAD IIEELPEIIG RVTFPQAYQM INRDIGQLPL DIDDIKLIFR
1560 1570 1580 1590 1600
YCILNDPLMI TAANTSLLCV KGTPQDRTGL SASQMPEFRN MKLIHHSPAL
1610 1620 1630 1640 1650
VLKAFSKGTS DIPGADPIEL EKDLHHLNEF VETTAIKEKI LHNIDNPPKH
1660 1670 1680 1690 1700
LIGNEILIYR IREMTKLYQV CYDYVKSTEH KVKIFILPMK SYTAIDFCTL
1710 1720 1730 1740 1750
IQGNTISDNK WYTMHYLKQI ASGSIKGNIV TTSTSEQIIA NECFRVLCHF
1760 1770 1780 1790 1800
ADSFVEEASR LSFINEVLDN FTYKNISVNS LFNTLLASTT RLDFIPLLFR
1810 1820 1830 1840 1850
LKVLTQTDLN RFDALKTNER VSWNNWQTNR SLNSGLIDLT ISGYLRSIRV
1860 1870 1880 1890 1900
VGEDNKLKIA ELTIPNFYPN TVFHAGNKLL NSRHGLKFEY MEEIVLDEKY
1910 1920 1930 1940 1950
NYYITYQKKR AHIYTYQVST IEHILRRNNE GLQSRGPRYN KMVPVCPVVL
1960 1970 1980 1990 2000
SVRDELFRMS LENVFSLNMT NFSMSRLFVS PDEVATVKKA HMSKMMFFSG
2010 2020 2030 2040 2050
PTIKAGIINL TSLMRTQELL TLNYDNLCKS SIVPFCRILE CNGDEQGELI
2060 2070 2080 2090 2100
FLSDEVMDFT ISEEIESMPL FTIRYQKRGT EIMTYKNAIM KLVSAGVDEI
2110 2120 2130 2140 2150
KEVFDFSKQG FYSKKNLGII NTICSIINIL ETNEWSTILY NSFHIAMLLE
2160 2170 2180 2190 2200
SMDREFHMFT LPEAFFINVA GGVVNWTKLL KFIKSLPVIE QEPWSMMMSR
2210 2220 2230
FVEKTVYLIE REMNKDVDFT DFLDELEFSS GKSLFTFF
Length:2,238
Mass (Da):258,670
Last modified:February 1, 1991 - v1
Checksum:i1ED00AB156BAC8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14383 Genomic RNA. Translation: CAA32553.1.
PIRiA33744. RRVUBY.
RefSeqiNP_047211.1. NC_001925.1.

Genome annotation databases

GeneIDi2648215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14383 Genomic RNA. Translation: CAA32553.1 .
PIRi A33744. RRVUBY.
RefSeqi NP_047211.1. NC_001925.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2648215.

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR014384. RNA-dir_pol_orthobunyavirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000824. L_OrthobunV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence analysis of the large (L) genomic RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae."
    Elliott R.M.
    Virology 173:426-436(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_BUNYW
AccessioniPrimary (citable) accession number: P20470
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3