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P20470 (L_BUNYW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismBunyamwera virus (BUNV) [Reference proteome]
Taxonomic identifier35304 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length2238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the orthobunyavirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22382238RNA-directed RNA polymerase L
PRO_0000222020

Regions

Domain1016 – 1207192RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P20470 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 1ED00AB156BAC8DA

FASTA2,238258,670
        10         20         30         40         50         60 
MEDQAYDQYL HRIQAARTAT VAKDISADIL EARHDYFGRE LCNSLGIEYK NNVLLDEIIL 

        70         80         90        100        110        120 
DVVPGVNLLN YNIPNVTPDN YIWDGHFLII LDYKVSVGND SSEITYKKYT SLILPVMSEL 

       130        140        150        160        170        180 
GIDTEIAIIR ANPVTYQISI IGEEFKQRFP NIPIQLDFGR FFELRKMLLD KFADDEEFLM 

       190        200        210        220        230        240 
MIAHGDFTLT APWCTSDTPE LEEHEIFQEF INSMPPRFVS LFKEAVNFSA YSSERWNTFL 

       250        260        270        280        290        300 
YRARAETEVD YNQFLSDKAH KIFMLEGDYM RPTQAEIDKG WELMSQRVYT EREIITDVTK 

       310        320        330        340        350        360 
QKPSIHFIWV KNADRKLIGS TAKLIYLSNS LQSITEQSTW TDALKAIGKS MDIDGKVGQY 

       370        380        390        400        410        420 
ETLCAERKMI ARSTGKKVDN KRLEAVKIGN ALVLWEQQFI LANDLFKNQE RQKFMKNFFG 

       430        440        450        460        470        480 
IGKHKSFKDK TSSDIETDKP KILDFNNTIV LMAARTMVNK NKALLAKDNT LQDLHPIIMQ 

       490        500        510        520        530        540 
YASEIKEASK DTFDALLKIS KTCFWQCIVD VSTIMRNILA VSQYNRHNTF RVAMCANDSV 

       550        560        570        580        590        600 
YALVFPSSDI KTKRATVVFS IVCMHKEKND LMDAGALFTT LECKNKEYIS ISKAIRLDKE 

       610        620        630        640        650        660 
RCQRIVSSPG LFILSSMLLY NNNPEVNLVD VLNFTFYTSL SITKSMLSLT EPSRYMIMNS 

       670        680        690        700        710        720 
LAISSHVRDY IAEKFSPYTK TLFSVYMVNL IKRGCASANE QSSKIQLRNI YLSDYDITQK 

       730        740        750        760        770        780 
GVNDGRNLDS IWFPGKVNLK EYINQIYLPF YFNAKGLHEK HHVMIDLAKT VLEIEMNQRS 

       790        800        810        820        830        840 
DNLGIWSKAE KKQHVNLPIL IHSIAKSLIL DTSRHNHLRN RVESRNNFRR SITTISTFTS 

       850        860        870        880        890        900 
SKSCIKIGDF REIKDKETEK SKKSTEKFDK KFRLSNPLFL EDEEANLEVQ HCNYRALIQK 

       910        920        930        940        950        960 
IPNYKDYISV KVFDRLYELL KNGVLTDKPF IELAMEMMKN HKEFSFTFFN KGQKTAKDRE 

       970        980        990       1000       1010       1020 
IFVGEFEAKM CMYVVERISK ERCKLNTDEM ISEPGDSKLK ILEKKAEEEI RYIVERTKDS 

      1030       1040       1050       1060       1070       1080 
IIKGDPSKAL KLEINADMSK WSAQDVFYKY FWLIAMDPIL YPAEKTRILY FMCNYMQKLL 

      1090       1100       1110       1120       1130       1140 
ILPDDLIANI LDQKRPYNDD LILEMTNGLN YNYVQIKRNW LQGNFNYISS YVHSCAMLVY 

      1150       1160       1170       1180       1190       1200 
KDILKECMKL LDGDCLINSM VHSDDNQTSL AIIQNKVSDQ IVIQYAANTF ESVCLTFGCQ 

      1210       1220       1230       1240       1250       1260 
ANMKKTYITH TCKEFVSLFN LHGEPLSVFG RFLLPSVGDC AYIGPYEDLA SRLSAAQQSL 

      1270       1280       1290       1300       1310       1320 
KHGCPPSLVW LAISCSHWIT FFTYNMLDDQ INAPQQHLPF NNRKEIPVEL NGYLNAPLYL 

      1330       1340       1350       1360       1370       1380 
IALVGLEAGN LWFLINILKK LVPLDKQKET IQSQCLHLCN SIDKLTESEK FKLKILRYLT 

      1390       1400       1410       1420       1430       1440 
LDTEMSVDNN MGETSDMRSR SLLTPRKFTT LGSLNKLVSY NDFRSSLDDQ RFTDNLNFML 

      1450       1460       1470       1480       1490       1500 
NNPELLVTKG ENKEQFMQSV LFRYNSKRFK ESLSIQNPAQ LFIEQILFSH KPIIDYSSIF 

      1510       1520       1530       1540       1550       1560 
DKLTSLAEAD IIEELPEIIG RVTFPQAYQM INRDIGQLPL DIDDIKLIFR YCILNDPLMI 

      1570       1580       1590       1600       1610       1620 
TAANTSLLCV KGTPQDRTGL SASQMPEFRN MKLIHHSPAL VLKAFSKGTS DIPGADPIEL 

      1630       1640       1650       1660       1670       1680 
EKDLHHLNEF VETTAIKEKI LHNIDNPPKH LIGNEILIYR IREMTKLYQV CYDYVKSTEH 

      1690       1700       1710       1720       1730       1740 
KVKIFILPMK SYTAIDFCTL IQGNTISDNK WYTMHYLKQI ASGSIKGNIV TTSTSEQIIA 

      1750       1760       1770       1780       1790       1800 
NECFRVLCHF ADSFVEEASR LSFINEVLDN FTYKNISVNS LFNTLLASTT RLDFIPLLFR 

      1810       1820       1830       1840       1850       1860 
LKVLTQTDLN RFDALKTNER VSWNNWQTNR SLNSGLIDLT ISGYLRSIRV VGEDNKLKIA 

      1870       1880       1890       1900       1910       1920 
ELTIPNFYPN TVFHAGNKLL NSRHGLKFEY MEEIVLDEKY NYYITYQKKR AHIYTYQVST 

      1930       1940       1950       1960       1970       1980 
IEHILRRNNE GLQSRGPRYN KMVPVCPVVL SVRDELFRMS LENVFSLNMT NFSMSRLFVS 

      1990       2000       2010       2020       2030       2040 
PDEVATVKKA HMSKMMFFSG PTIKAGIINL TSLMRTQELL TLNYDNLCKS SIVPFCRILE 

      2050       2060       2070       2080       2090       2100 
CNGDEQGELI FLSDEVMDFT ISEEIESMPL FTIRYQKRGT EIMTYKNAIM KLVSAGVDEI 

      2110       2120       2130       2140       2150       2160 
KEVFDFSKQG FYSKKNLGII NTICSIINIL ETNEWSTILY NSFHIAMLLE SMDREFHMFT 

      2170       2180       2190       2200       2210       2220 
LPEAFFINVA GGVVNWTKLL KFIKSLPVIE QEPWSMMMSR FVEKTVYLIE REMNKDVDFT 

      2230 
DFLDELEFSS GKSLFTFF 

« Hide

References

[1]"Nucleotide sequence analysis of the large (L) genomic RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae."
Elliott R.M.
Virology 173:426-436(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14383 Genomic RNA. Translation: CAA32553.1.
PIRRRVUBY. A33744.
RefSeqNP_047211.1. NC_001925.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2648215.

Family and domain databases

InterProIPR026382. CapSnatchArena.
IPR007099. RNA-dir_pol_NSvirus.
IPR014384. RNA-dir_pol_orthobunyavirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
[Graphical view]
PIRSFPIRSF000824. L_OrthobunV. 1 hit.
TIGRFAMsTIGR04202. capSnatchArena. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_BUNYW
AccessionPrimary (citable) accession number: P20470
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families