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P20470

- L_BUNYW

UniProt

P20470 - L_BUNYW

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Bunyamwera virus (BUNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

    Keywords - Biological processi

    Ubl conjugation pathway, Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiBunyamwera virus (BUNV)
    Taxonomic identifieri35304 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
    Homo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000002476: Genome

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22382238RNA-directed RNA polymerase LPRO_0000222020Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1016 – 1207192RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR026382. CapSnatchArena.
    IPR029124. L_protein_N.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014384. RNA-dir_pol_orthobunyavirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF15518. L_protein_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000824. L_OrthobunV. 1 hit.
    TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20470-1 [UniParc]FASTAAdd to Basket

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    MEDQAYDQYL HRIQAARTAT VAKDISADIL EARHDYFGRE LCNSLGIEYK     50
    NNVLLDEIIL DVVPGVNLLN YNIPNVTPDN YIWDGHFLII LDYKVSVGND 100
    SSEITYKKYT SLILPVMSEL GIDTEIAIIR ANPVTYQISI IGEEFKQRFP 150
    NIPIQLDFGR FFELRKMLLD KFADDEEFLM MIAHGDFTLT APWCTSDTPE 200
    LEEHEIFQEF INSMPPRFVS LFKEAVNFSA YSSERWNTFL YRARAETEVD 250
    YNQFLSDKAH KIFMLEGDYM RPTQAEIDKG WELMSQRVYT EREIITDVTK 300
    QKPSIHFIWV KNADRKLIGS TAKLIYLSNS LQSITEQSTW TDALKAIGKS 350
    MDIDGKVGQY ETLCAERKMI ARSTGKKVDN KRLEAVKIGN ALVLWEQQFI 400
    LANDLFKNQE RQKFMKNFFG IGKHKSFKDK TSSDIETDKP KILDFNNTIV 450
    LMAARTMVNK NKALLAKDNT LQDLHPIIMQ YASEIKEASK DTFDALLKIS 500
    KTCFWQCIVD VSTIMRNILA VSQYNRHNTF RVAMCANDSV YALVFPSSDI 550
    KTKRATVVFS IVCMHKEKND LMDAGALFTT LECKNKEYIS ISKAIRLDKE 600
    RCQRIVSSPG LFILSSMLLY NNNPEVNLVD VLNFTFYTSL SITKSMLSLT 650
    EPSRYMIMNS LAISSHVRDY IAEKFSPYTK TLFSVYMVNL IKRGCASANE 700
    QSSKIQLRNI YLSDYDITQK GVNDGRNLDS IWFPGKVNLK EYINQIYLPF 750
    YFNAKGLHEK HHVMIDLAKT VLEIEMNQRS DNLGIWSKAE KKQHVNLPIL 800
    IHSIAKSLIL DTSRHNHLRN RVESRNNFRR SITTISTFTS SKSCIKIGDF 850
    REIKDKETEK SKKSTEKFDK KFRLSNPLFL EDEEANLEVQ HCNYRALIQK 900
    IPNYKDYISV KVFDRLYELL KNGVLTDKPF IELAMEMMKN HKEFSFTFFN 950
    KGQKTAKDRE IFVGEFEAKM CMYVVERISK ERCKLNTDEM ISEPGDSKLK 1000
    ILEKKAEEEI RYIVERTKDS IIKGDPSKAL KLEINADMSK WSAQDVFYKY 1050
    FWLIAMDPIL YPAEKTRILY FMCNYMQKLL ILPDDLIANI LDQKRPYNDD 1100
    LILEMTNGLN YNYVQIKRNW LQGNFNYISS YVHSCAMLVY KDILKECMKL 1150
    LDGDCLINSM VHSDDNQTSL AIIQNKVSDQ IVIQYAANTF ESVCLTFGCQ 1200
    ANMKKTYITH TCKEFVSLFN LHGEPLSVFG RFLLPSVGDC AYIGPYEDLA 1250
    SRLSAAQQSL KHGCPPSLVW LAISCSHWIT FFTYNMLDDQ INAPQQHLPF 1300
    NNRKEIPVEL NGYLNAPLYL IALVGLEAGN LWFLINILKK LVPLDKQKET 1350
    IQSQCLHLCN SIDKLTESEK FKLKILRYLT LDTEMSVDNN MGETSDMRSR 1400
    SLLTPRKFTT LGSLNKLVSY NDFRSSLDDQ RFTDNLNFML NNPELLVTKG 1450
    ENKEQFMQSV LFRYNSKRFK ESLSIQNPAQ LFIEQILFSH KPIIDYSSIF 1500
    DKLTSLAEAD IIEELPEIIG RVTFPQAYQM INRDIGQLPL DIDDIKLIFR 1550
    YCILNDPLMI TAANTSLLCV KGTPQDRTGL SASQMPEFRN MKLIHHSPAL 1600
    VLKAFSKGTS DIPGADPIEL EKDLHHLNEF VETTAIKEKI LHNIDNPPKH 1650
    LIGNEILIYR IREMTKLYQV CYDYVKSTEH KVKIFILPMK SYTAIDFCTL 1700
    IQGNTISDNK WYTMHYLKQI ASGSIKGNIV TTSTSEQIIA NECFRVLCHF 1750
    ADSFVEEASR LSFINEVLDN FTYKNISVNS LFNTLLASTT RLDFIPLLFR 1800
    LKVLTQTDLN RFDALKTNER VSWNNWQTNR SLNSGLIDLT ISGYLRSIRV 1850
    VGEDNKLKIA ELTIPNFYPN TVFHAGNKLL NSRHGLKFEY MEEIVLDEKY 1900
    NYYITYQKKR AHIYTYQVST IEHILRRNNE GLQSRGPRYN KMVPVCPVVL 1950
    SVRDELFRMS LENVFSLNMT NFSMSRLFVS PDEVATVKKA HMSKMMFFSG 2000
    PTIKAGIINL TSLMRTQELL TLNYDNLCKS SIVPFCRILE CNGDEQGELI 2050
    FLSDEVMDFT ISEEIESMPL FTIRYQKRGT EIMTYKNAIM KLVSAGVDEI 2100
    KEVFDFSKQG FYSKKNLGII NTICSIINIL ETNEWSTILY NSFHIAMLLE 2150
    SMDREFHMFT LPEAFFINVA GGVVNWTKLL KFIKSLPVIE QEPWSMMMSR 2200
    FVEKTVYLIE REMNKDVDFT DFLDELEFSS GKSLFTFF 2238
    Length:2,238
    Mass (Da):258,670
    Last modified:February 1, 1991 - v1
    Checksum:i1ED00AB156BAC8DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14383 Genomic RNA. Translation: CAA32553.1.
    PIRiA33744. RRVUBY.
    RefSeqiNP_047211.1. NC_001925.1.

    Genome annotation databases

    GeneIDi2648215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14383 Genomic RNA. Translation: CAA32553.1 .
    PIRi A33744. RRVUBY.
    RefSeqi NP_047211.1. NC_001925.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2648215.

    Family and domain databases

    InterProi IPR026382. CapSnatchArena.
    IPR029124. L_protein_N.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014384. RNA-dir_pol_orthobunyavirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF15518. L_protein_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000824. L_OrthobunV. 1 hit.
    TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence analysis of the large (L) genomic RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae."
      Elliott R.M.
      Virology 173:426-436(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiL_BUNYW
    AccessioniPrimary (citable) accession number: P20470
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3