P20463 (TRPE_LEPBI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Leptospira biflexa

Taxonomic identifier

172 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Anthranilate synthase component 1		PRO_0000154097

Sequences

	Sequence		Length	Mass (Da)
	P20463 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: C5EECE5C779D1F39	FASTA	462	51,834
	10 20 30 40 50 60 MSQTLPKIKI PKKPNYNSLA LAEGIEFWEL FRVIEAKYEN CFLLESAGDN QYDSRYSVIG 70 80 90 100 110 120 FQPSHLILGE PGILEIDGKK YPVENPYFAL RELTDYNSLS ISYAGGFVGY LGYQSMQFFE 130 140 150 160 170 180 PKLQLKPHPD FPAMIFGLYL DGLIYDKFTG ELIYFDNGTN RIHEVNQILE QLKKENSQKP 190 200 210 220 230 240 KATVSLVKAG LSKEVHKQMV EEALEEVKAG NTFQCQIGFE EIYQVDGNPL AIYETLREIN 250 260 270 280 290 300 PSPHMYYVNL ELVTILGASP SSLFRLRQGE MESFPLAGTT KRGVDAKEDT LLARKLLTDP 310 320 330 340 350 360 KEIAEHNMLI DLHRNDVGRV AKFGTVKVRR RFDVKRFSHV QHISSEVVGI LSSKEDMFSG 370 380 390 400 410 420 LASSFPRGTL SGAPKIESDS KIIERIEKSP RGPYGGAVGS FGLNGDCTFA IPIRSFFVNG 430 440 450 460 KKGFVRASGG IVFGFIEPED EYQEIINKMA SVRKALDLHK GP

References

[1]	"Identification and nucleotide sequence of the Leptospira biflexa serovar patoc trpE and trpG genes." Yelton D.B., Peng S.L. J. Bacteriol. 171:2083-2089(1989) [PubMed: 2703466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Serovar Patoc.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M22468 Genomic DNA. Translation: AAA88216.1.
PIR	B32840.
3D structure databases
ProteinModelPortal	P20463.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_LEPBI

Accession

Primary (citable) accession number: P20463

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program