P20443 (ARRS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
S-arrestin

Alternative name(s):
48 kDa protein
Retinal S-antigen
Short name=S-AG
Rod photoreceptor arrestin

Gene names

Name:

Sag

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.
Tissue specificity	Retina and pineal gland.
Involvement in disease	S-antigen induces autoimmune uveitis.
Miscellaneous	Arrestin binds calcium.
Sequence similarities	Belongs to the arrestin family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Disease	Autoimmune uveitis
Ligand	Calcium
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	photoreceptor inner segment Inferred from electronic annotation. Source: Compara photoreceptor outer segment Inferred from electronic annotation. Source: Compara
Molecular_function	opsin binding Inferred from direct assay PubMed 12486395. Source: MGI phosphoprotein binding Inferred from direct assay PubMed 12486395. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 403	403	S-arrestin		PRO_0000205187
Amino acid modifications
	Disulfide bond	129 ↔ 144		Probable
Experimental info
	Sequence conflict	391	1	T → P in AAH16498. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P20443 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 2D4CFEAF81C5FC6D	FASTA	403	44,930
	10 20 30 40 50 60 MAACGKTNKS HVIFKKVSRD KSVTIYLGKR DYVDHVSQVE PVDGVVLVDP ELVKGKKVYV 70 80 90 100 110 120 TLTCAFRYGQ EDIDVMGLTF RRDLYFSRVQ VYPPVGAMSV LTQLQESLLK KLGDNTYPFL 130 140 150 160 170 180 LTFPDYLPCS VMLQPAPQDV GKSCGVDFEV KAFASDITDP EEDKIPKKSS VRLLIRKVQH 190 200 210 220 230 240 APPEMGPQPS AEASWQFFMS DKPLNLSVSL SKEIYFHGEP IPVTVTVTNN TDKVVKKIKV 250 260 270 280 290 300 SVEQIANVVL YSSDYYVKPV ASEETQEKVQ PNSTLTKTLV LVPLLANNRE RRGIALDGKI 310 320 330 340 350 360 KHEDTNLASS TIIKEGIDRT VMGILVSYHI KVKLTVSGFL GELTSSEVAT EVPFRLMHPQ 370 380 390 400 PEDPAKESVQ DENLVFEEFA RQNLKDTGEN TEGKKDEDAG QDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of mouse S-antigen." Tsuda M., Syed M., Bugra K., Whelan J.P., McGinnis J.F., Shinohara T. Gene 73:11-20(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M24086 mRNA. Translation: AAA40090.1. BC016498 mRNA. Translation: AAH16498.1.
IPI	IPI00229940.
PIR	JS0066.
RefSeq	NP_033144.1. NM_009118.2.
UniGene	Mm.1276.
3D structure databases
ProteinModelPortal	P20443.
SMR	P20443. Positions 6-364.
ModBase	Search...
PTM databases
PhosphoSite	P20443.
Proteomic databases
PRIDE	P20443.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000077772; ENSMUSP00000076948; ENSMUSG00000056055.
GeneID	20215.
KEGG	mmu:20215.
Organism-specific databases
CTD	6295.
MGI	MGI:98227. Sag.
Phylogenomic databases
eggNOG	NOG330592.
HOGENOM	HOG000231319.
HOVERGEN	HBG002399.
InParanoid	P20443.
OMA	KEIYFHG.
OrthoDB	EOG4FTW15.
Gene expression databases
ArrayExpress	P20443.
Bgee	P20443.
CleanEx	MM_SAG.
Genevestigator	P20443.
GermOnline	ENSMUSG00000056055. Mus musculus.
Family and domain databases
Gene3D	2.60.40.640. 1 hit. 2.60.40.840. 1 hit.
InterPro	IPR000698. Arrestin. IPR011021. Arrestin-like_N. IPR014752. Arrestin_C. IPR011022. Arrestin_C-like. IPR017864. Arrestin_CS. IPR014753. Arrestin_N. IPR014756. Ig_E-set. [Graphical view]
PANTHER	PTHR11792. PTHR11792. 1 hit.
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
PRINTS	PR00309. ARRESTIN.
SMART	SM01017. Arrestin_C. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 2 hits.
PROSITE	PS00295. ARRESTINS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297813.
SOURCE	Search...

Entry information

Entry name

ARRS_MOUSE

Accession

Primary (citable) accession number: P20443
Secondary accession number(s): Q91W62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program