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P20443

- ARRS_MOUSE

UniProt

P20443 - ARRS_MOUSE

Protein

S-arrestin

Gene

Sag

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.

    GO - Molecular functioni

    1. opsin binding Source: MGI
    2. phosphoprotein binding Source: MGI
    3. spectrin binding Source: MGI

    GO - Biological processi

    1. signal transduction Source: InterPro
    2. visual perception Source: UniProtKB-KW

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-arrestin
    Alternative name(s):
    48 kDa protein
    Retinal S-antigen
    Short name:
    S-AG
    Rod photoreceptor arrestin
    Gene namesi
    Name:Sag
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98227. Sag.

    Subcellular locationi

    GO - Cellular componenti

    1. photoreceptor inner segment Source: MGI
    2. photoreceptor outer segment Source: MGI

    Pathology & Biotechi

    Involvement in diseasei

    S-antigen induces autoimmune uveitis.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi86 – 861F → A: Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-198, or with A-198 and V-349. 1 Publication
    Mutagenesisi198 – 1981F → A: Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-86, or with A-86 and V-349. 1 Publication
    Mutagenesisi349 – 3491A → V: Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-86 and A-198. 1 Publication

    Keywords - Diseasei

    Autoimmune uveitis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403S-arrestinPRO_0000205187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi129 ↔ 144Curated
    Modified residuei231 – 2311PhosphothreonineBy similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiP20443.
    PRIDEiP20443.

    PTM databases

    PhosphoSiteiP20443.

    Expressioni

    Tissue specificityi

    Retina and pineal gland.

    Gene expression databases

    ArrayExpressiP20443.
    BgeeiP20443.
    CleanExiMM_SAG.
    GenevestigatoriP20443.

    Interactioni

    Subunit structurei

    Monomer. Homodimer. Homotetramer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP20443.
    SMRiP20443. Positions 11-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arrestin family.Curated

    Phylogenomic databases

    eggNOGiNOG330592.
    HOGENOMiHOG000231319.
    HOVERGENiHBG002399.
    InParanoidiP20443.
    OMAiKEIYFHG.
    OrthoDBiEOG79W954.
    PhylomeDBiP20443.
    TreeFamiTF314260.

    Family and domain databases

    Gene3Di2.60.40.640. 1 hit.
    2.60.40.840. 1 hit.
    InterProiIPR000698. Arrestin.
    IPR011021. Arrestin-like_N.
    IPR014752. Arrestin_C.
    IPR011022. Arrestin_C-like.
    IPR017864. Arrestin_CS.
    IPR014753. Arrestin_N.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR11792. PTHR11792. 1 hit.
    PfamiPF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view]
    PRINTSiPR00309. ARRESTIN.
    SMARTiSM01017. Arrestin_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 2 hits.
    PROSITEiPS00295. ARRESTINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20443-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAACGKTNKS HVIFKKVSRD KSVTIYLGKR DYVDHVSQVE PVDGVVLVDP    50
    ELVKGKKVYV TLTCAFRYGQ EDIDVMGLTF RRDLYFSRVQ VYPPVGAMSV 100
    LTQLQESLLK KLGDNTYPFL LTFPDYLPCS VMLQPAPQDV GKSCGVDFEV 150
    KAFASDITDP EEDKIPKKSS VRLLIRKVQH APPEMGPQPS AEASWQFFMS 200
    DKPLNLSVSL SKEIYFHGEP IPVTVTVTNN TDKVVKKIKV SVEQIANVVL 250
    YSSDYYVKPV ASEETQEKVQ PNSTLTKTLV LVPLLANNRE RRGIALDGKI 300
    KHEDTNLASS TIIKEGIDRT VMGILVSYHI KVKLTVSGFL GELTSSEVAT 350
    EVPFRLMHPQ PEDPAKESVQ DENLVFEEFA RQNLKDTGEN TEGKKDEDAG 400
    QDE 403
    Length:403
    Mass (Da):44,930
    Last modified:February 1, 1991 - v1
    Checksum:i2D4CFEAF81C5FC6D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti391 – 3911T → P in AAH16498. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24086 mRNA. Translation: AAA40090.1.
    BC016498 mRNA. Translation: AAH16498.1.
    CCDSiCCDS35656.1.
    PIRiJS0066.
    RefSeqiNP_033144.1. NM_009118.2.
    UniGeneiMm.1276.

    Genome annotation databases

    EnsembliENSMUST00000077772; ENSMUSP00000076948; ENSMUSG00000056055.
    GeneIDi20215.
    KEGGimmu:20215.
    UCSCiuc007bxp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24086 mRNA. Translation: AAA40090.1 .
    BC016498 mRNA. Translation: AAH16498.1 .
    CCDSi CCDS35656.1.
    PIRi JS0066.
    RefSeqi NP_033144.1. NM_009118.2.
    UniGenei Mm.1276.

    3D structure databases

    ProteinModelPortali P20443.
    SMRi P20443. Positions 11-361.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P20443.

    Proteomic databases

    MaxQBi P20443.
    PRIDEi P20443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077772 ; ENSMUSP00000076948 ; ENSMUSG00000056055 .
    GeneIDi 20215.
    KEGGi mmu:20215.
    UCSCi uc007bxp.1. mouse.

    Organism-specific databases

    CTDi 6295.
    MGIi MGI:98227. Sag.

    Phylogenomic databases

    eggNOGi NOG330592.
    HOGENOMi HOG000231319.
    HOVERGENi HBG002399.
    InParanoidi P20443.
    OMAi KEIYFHG.
    OrthoDBi EOG79W954.
    PhylomeDBi P20443.
    TreeFami TF314260.

    Enzyme and pathway databases

    Reactomei REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    NextBioi 297813.
    PROi P20443.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20443.
    Bgeei P20443.
    CleanExi MM_SAG.
    Genevestigatori P20443.

    Family and domain databases

    Gene3Di 2.60.40.640. 1 hit.
    2.60.40.840. 1 hit.
    InterProi IPR000698. Arrestin.
    IPR011021. Arrestin-like_N.
    IPR014752. Arrestin_C.
    IPR011022. Arrestin_C-like.
    IPR017864. Arrestin_CS.
    IPR014753. Arrestin_N.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR11792. PTHR11792. 1 hit.
    Pfami PF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00309. ARRESTIN.
    SMARTi SM01017. Arrestin_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 2 hits.
    PROSITEi PS00295. ARRESTINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "Robust self-association is a common feature of mammalian visual arrestin-1."
      Kim M., Hanson S.M., Vishnivetskiy S.A., Song X., Cleghorn W.M., Hubbell W.L., Gurevich V.V.
      Biochemistry 50:2235-2242(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, MUTAGENESIS OF PHE-86; PHE-198 AND ALA-349.

    Entry informationi

    Entry nameiARRS_MOUSE
    AccessioniPrimary (citable) accession number: P20443
    Secondary accession number(s): Q91W62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Arrestin binds calcium.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3