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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAULO:CC0010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:CC_0010
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Chaperone protein DnaKPRO_0000078440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP20442.

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0010.

Structurei

3D structure databases

ProteinModelPortaliP20442.
SMRiP20442. Positions 4-595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSCVAIMD GKTPKVIENA EGARTTPSVV AFLEDGERLI
60 70 80 90 100
GQPAKRQAVT NPTNTLFAIK RLIGRTASDP VVEKDKGMVP YEIVKGPTGD
110 120 130 140 150
AWVKAHGKDY SPQEVSAFIL QKMKEAAEAH LGEPVTKAVI TVPAYFNDAQ
160 170 180 190 200
RQATKDAGKI AGLEVLRIIN EPTAAALAYG LDKNDGKKIA VYDLGGGTFD
210 220 230 240 250
VSILEIGDGV FEVKSTNGDT FLGGEDFDLR IVDYLADEFK KEQGVDLRKD
260 270 280 290 300
KLALQRLREE AEKAKKELSS TAQYEVNLPF ISMNASGPLH LNIKLSRAKL
310 320 330 340 350
EALVDDLIAR TIGPCEQALK DAGLKKSDID EVILVGGMSR MPKVQQAVQD
360 370 380 390 400
FFGREPHKGV NPDEVVALGA AVQAGVLQGD VKDVLLLDVT PLTLGIETLG
410 420 430 440 450
GVFTPLIERN TTIPTKRSQT FSTADDNQSA VTIRVFQGER PMAQDNKMLG
460 470 480 490 500
QFDLVGIPPA PRGVPQIEVT FDIDANGIVQ VHAKDKATNK EQSIRIQANG
510 520 530 540 550
GLSDSDIERM VKEAEANKAA DEKKKQLVEA KNQGEAILHS TEKALAEHGD
560 570 580 590 600
KVGAAEKTAI ETGITELKTA LEGEDVEAIQ AKTQALIQAS MKLGEAMYAA
610 620 630
QQGSAEGGDA KADDGVVDAE FEEVDDNKPA A
Length:631
Mass (Da):67,616
Last modified:April 27, 2001 - v2
Checksum:i16C27D84CD85CD55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 987EIVKGPT → RSSRARA in AAA62723 (PubMed:2345134).Curated
Sequence conflicti260 – 2601Missing in AAA62723 (PubMed:2345134).Curated
Sequence conflicti397 – 3971E → D in AAA62723 (PubMed:2345134).Curated
Sequence conflicti441 – 4411P → A in AAA62723 (PubMed:2345134).Curated
Sequence conflicti449 – 4491L → Q in AAA62723 (PubMed:2345134).Curated
Sequence conflicti492 – 4921Q → H in AAK21998 (PubMed:11259647).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55224 Genomic DNA. Translation: AAA62723.1.
AE005673 Genomic DNA. Translation: AAK21998.1.
PIRiA35388.
B87250.
RefSeqiNP_418830.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK21998; AAK21998; CC_0010.
GeneIDi944075.
KEGGiccr:CC_0010.
PATRICi21296942. VBICauCre124313_0011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55224 Genomic DNA. Translation: AAA62723.1.
AE005673 Genomic DNA. Translation: AAK21998.1.
PIRiA35388.
B87250.
RefSeqiNP_418830.1. NC_002696.2.

3D structure databases

ProteinModelPortaliP20442.
SMRiP20442. Positions 4-595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_0010.

Proteomic databases

PRIDEiP20442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK21998; AAK21998; CC_0010.
GeneIDi944075.
KEGGiccr:CC_0010.
PATRICi21296942. VBICauCre124313_0011.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Enzyme and pathway databases

BioCyciCAULO:CC0010-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_CAUCR
AccessioniPrimary (citable) accession number: P20442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 27, 2001
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.