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Protein

G1/S-specific cyclin CLN2

Gene

CLN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

Miscellaneous

A dominant mutation in CLN2 gene (CLN2-1), advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals.
Present with 1270 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • re-entry into mitotic cell cycle after pheromone arrest Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • traversing start control point of mitotic cell cycle Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-34141-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CLN2
Gene namesi
Name:CLN2
Ordered Locus Names:YPL256C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL256C
SGDiS000006177 CLN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804121 – 545G1/S-specific cyclin CLN2Add BLAST545

Proteomic databases

PaxDbiP20438
PRIDEiP20438

PTM databases

iPTMnetiP20438

Expressioni

Developmental stagei

CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC28P0054610EBI-4483,EBI-4253

Protein-protein interaction databases

BioGridi35907, 298 interactors
DIPiDIP-2270N
IntActiP20438, 14 interactors
MINTiP20438
STRINGi4932.YPL256C

Structurei

3D structure databases

ProteinModelPortaliP20438
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000148806
HOGENOMiHOG000111606
InParanoidiP20438
KOiK06650
OMAiKQMEVHV
OrthoDBiEOG092C2O65

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR014399 Cyclin_CLN
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001770 Cyclin_CLN, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P20438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAEPRPRM GLVINAKPDY YPIELSNAEL LSHFEMLQEY HQEISTNVIA
60 70 80 90 100
QSCKFKPNPK LIDQQPEMNP VETRSNIITF LFELSVVTRV TNGIFFHSVR
110 120 130 140 150
LYDRYCSKRI VLRDQAKLVV ATCLWLAAKT WGGCNHIINN VVIPTGGRFY
160 170 180 190 200
GPNPRARIPR LSELVHYCGD GQVFDESMFL QMERHILDTL NWNIYEPMIN
210 220 230 240 250
DYVLNVDENC LMQYELYENQ VTYDKQCSEK RQSQLSQDSD ATVDERPYQN
260 270 280 290 300
EEEEEEDLKL KIKLINLKKF LIDVSAWQYD LLRYELFEVS HGIFSIINQF
310 320 330 340 350
TNQDHGPFLM TPMTSESKNG EILSTLMNGI VSIPNSLMEV YKTVNGVLPF
360 370 380 390 400
INQVKEYHLD LQRKLQIASN LNISRKLTIS TPSCSFENSN STSIPSPASS
410 420 430 440 450
SQSHTPMRNM SSLSDNSVFS RNMEQSSPIT PSMYQFGQQQ SNSICGSTVS
460 470 480 490 500
VNSLVNTNNK QRIYEQITGP NSNNATNDYI DLLNLNESNK ENQNPATAHY
510 520 530 540
LNGGPPKTSF INHGMFPSPT GTINSGKSSS ASSLISFGMG NTQVI
Length:545
Mass (Da):61,697
Last modified:February 1, 1996 - v2
Checksum:iD6426B94E040E960
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440Q → R in AAT93248 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33265 Genomic DNA Translation: AAA65725.1
Z73612 Genomic DNA Translation: CAA97982.1
AY693229 Genomic DNA Translation: AAT93248.1
BK006949 Genomic DNA Translation: DAA11181.1
PIRiB33289 COBYC2
RefSeqiNP_015067.1, NM_001184070.1

Genome annotation databases

EnsemblFungiiYPL256C; YPL256C; YPL256C
GeneIDi855819
KEGGisce:YPL256C

Similar proteinsi

Entry informationi

Entry nameiCG12_YEAST
AccessioniPrimary (citable) accession number: P20438
Secondary accession number(s): D6W3B5, E9P938
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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