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P20438

- CG12_YEAST

UniProt

P20438 - CG12_YEAST

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Protein

G1/S-specific cyclin CLN2

Gene

CLN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. re-entry into mitotic cell cycle after pheromone arrest Source: SGD
  3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-34141-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CLN2
Gene namesi
Name:CLN2
Ordered Locus Names:YPL256C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL256c.
SGDiS000006177. CLN2.

Subcellular locationi

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: SGD
  2. cytoplasm Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545G1/S-specific cyclin CLN2PRO_0000080412Add
BLAST

Proteomic databases

PaxDbiP20438.
PeptideAtlasiP20438.

Expressioni

Developmental stagei

CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

Gene expression databases

GenevestigatoriP20438.

Interactioni

Protein-protein interaction databases

BioGridi35907. 206 interactions.
DIPiDIP-2270N.
IntActiP20438. 9 interactions.
MINTiMINT-583803.
STRINGi4932.YPL256C.

Structurei

3D structure databases

ProteinModelPortaliP20438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00390000006123.
HOGENOMiHOG000111606.
InParanoidiP20438.
KOiK06650.
OMAiPKLIDQQ.
OrthoDBiEOG7BZW2S.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20438-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASAEPRPRM GLVINAKPDY YPIELSNAEL LSHFEMLQEY HQEISTNVIA
60 70 80 90 100
QSCKFKPNPK LIDQQPEMNP VETRSNIITF LFELSVVTRV TNGIFFHSVR
110 120 130 140 150
LYDRYCSKRI VLRDQAKLVV ATCLWLAAKT WGGCNHIINN VVIPTGGRFY
160 170 180 190 200
GPNPRARIPR LSELVHYCGD GQVFDESMFL QMERHILDTL NWNIYEPMIN
210 220 230 240 250
DYVLNVDENC LMQYELYENQ VTYDKQCSEK RQSQLSQDSD ATVDERPYQN
260 270 280 290 300
EEEEEEDLKL KIKLINLKKF LIDVSAWQYD LLRYELFEVS HGIFSIINQF
310 320 330 340 350
TNQDHGPFLM TPMTSESKNG EILSTLMNGI VSIPNSLMEV YKTVNGVLPF
360 370 380 390 400
INQVKEYHLD LQRKLQIASN LNISRKLTIS TPSCSFENSN STSIPSPASS
410 420 430 440 450
SQSHTPMRNM SSLSDNSVFS RNMEQSSPIT PSMYQFGQQQ SNSICGSTVS
460 470 480 490 500
VNSLVNTNNK QRIYEQITGP NSNNATNDYI DLLNLNESNK ENQNPATAHY
510 520 530 540
LNGGPPKTSF INHGMFPSPT GTINSGKSSS ASSLISFGMG NTQVI
Length:545
Mass (Da):61,697
Last modified:February 1, 1996 - v2
Checksum:iD6426B94E040E960
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti440 – 4401Q → R in AAT93248. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33265 Genomic DNA. Translation: AAA65725.1.
Z73612 Genomic DNA. Translation: CAA97982.1.
AY693229 Genomic DNA. Translation: AAT93248.1.
BK006949 Genomic DNA. Translation: DAA11181.1.
PIRiB33289. COBYC2.
RefSeqiNP_015067.1. NM_001184070.1.

Genome annotation databases

EnsemblFungiiYPL256C; YPL256C; YPL256C.
GeneIDi855819.
KEGGisce:YPL256C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33265 Genomic DNA. Translation: AAA65725.1 .
Z73612 Genomic DNA. Translation: CAA97982.1 .
AY693229 Genomic DNA. Translation: AAT93248.1 .
BK006949 Genomic DNA. Translation: DAA11181.1 .
PIRi B33289. COBYC2.
RefSeqi NP_015067.1. NM_001184070.1.

3D structure databases

ProteinModelPortali P20438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35907. 206 interactions.
DIPi DIP-2270N.
IntActi P20438. 9 interactions.
MINTi MINT-583803.
STRINGi 4932.YPL256C.

Proteomic databases

PaxDbi P20438.
PeptideAtlasi P20438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL256C ; YPL256C ; YPL256C .
GeneIDi 855819.
KEGGi sce:YPL256C.

Organism-specific databases

CYGDi YPL256c.
SGDi S000006177. CLN2.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00390000006123.
HOGENOMi HOG000111606.
InParanoidi P20438.
KOi K06650.
OMAi PKLIDQQ.
OrthoDBi EOG7BZW2S.

Enzyme and pathway databases

BioCyci YEAST:G3O-34141-MONOMER.

Miscellaneous databases

NextBioi 980359.

Gene expression databases

Genevestigatori P20438.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001770. Cyclin_CLN. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes."
    Hadwiger J.A., Reed S.I.
    Nucleic Acids Res. 18:4025-4025(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Wittenberg C., Chapman-Shimshoni D.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCG12_YEAST
AccessioniPrimary (citable) accession number: P20438
Secondary accession number(s): D6W3B5, E9P938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

A dominant mutation in CLN2 gene (CLN2-1), advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals.
Present with 1270 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3