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P20438 (CG12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin CLN2
Gene names
Name:CLN2
Ordered Locus Names:YPL256C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

Developmental stage

CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

Miscellaneous

A dominant mutation in CLN2 gene (CLN2-1), advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals.

Present with 1270 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cyclin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 545545G1/S-specific cyclin CLN2
PRO_0000080412

Experimental info

Sequence conflict4401Q → R in AAT93248. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P20438 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: D6426B94E040E960

FASTA54561,697
        10         20         30         40         50         60 
MASAEPRPRM GLVINAKPDY YPIELSNAEL LSHFEMLQEY HQEISTNVIA QSCKFKPNPK 

        70         80         90        100        110        120 
LIDQQPEMNP VETRSNIITF LFELSVVTRV TNGIFFHSVR LYDRYCSKRI VLRDQAKLVV 

       130        140        150        160        170        180 
ATCLWLAAKT WGGCNHIINN VVIPTGGRFY GPNPRARIPR LSELVHYCGD GQVFDESMFL 

       190        200        210        220        230        240 
QMERHILDTL NWNIYEPMIN DYVLNVDENC LMQYELYENQ VTYDKQCSEK RQSQLSQDSD 

       250        260        270        280        290        300 
ATVDERPYQN EEEEEEDLKL KIKLINLKKF LIDVSAWQYD LLRYELFEVS HGIFSIINQF 

       310        320        330        340        350        360 
TNQDHGPFLM TPMTSESKNG EILSTLMNGI VSIPNSLMEV YKTVNGVLPF INQVKEYHLD 

       370        380        390        400        410        420 
LQRKLQIASN LNISRKLTIS TPSCSFENSN STSIPSPASS SQSHTPMRNM SSLSDNSVFS 

       430        440        450        460        470        480 
RNMEQSSPIT PSMYQFGQQQ SNSICGSTVS VNSLVNTNNK QRIYEQITGP NSNNATNDYI 

       490        500        510        520        530        540 
DLLNLNESNK ENQNPATAHY LNGGPPKTSF INHGMFPSPT GTINSGKSSS ASSLISFGMG 


NTQVI 

« Hide

References

« Hide 'large scale' references
[1]"A family of cyclin homologs that control the G1 phase in yeast."
Hadwiger J.A., Wittenberg C., Richardson H.E., de Barros Lopes M., Reed S.I.
Proc. Natl. Acad. Sci. U.S.A. 86:6255-6259(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes."
Hadwiger J.A., Reed S.I.
Nucleic Acids Res. 18:4025-4025(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Wittenberg C., Chapman-Shimshoni D.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33265 Genomic DNA. Translation: AAA65725.1.
Z73612 Genomic DNA. Translation: CAA97982.1.
AY693229 Genomic DNA. Translation: AAT93248.1.
BK006949 Genomic DNA. Translation: DAA11181.1.
PIRCOBYC2. B33289.
RefSeqNP_015067.1. NM_001184070.1.

3D structure databases

ProteinModelPortalP20438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35907. 204 interactions.
DIPDIP-2270N.
IntActP20438. 9 interactions.
MINTMINT-583803.
STRING4932.YPL256C.

Proteomic databases

PaxDbP20438.
PeptideAtlasP20438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPL256C; YPL256C; YPL256C.
GeneID855819.
KEGGsce:YPL256C.

Organism-specific databases

CYGDYPL256c.
SGDS000006177. CLN2.

Phylogenomic databases

eggNOGCOG5024.
GeneTreeENSGT00390000006123.
HOGENOMHOG000111606.
KOK06650.
OMAPKLIDQQ.
OrthoDBEOG7BZW2S.

Enzyme and pathway databases

BioCycYEAST:G3O-34141-MONOMER.

Gene expression databases

GenevestigatorP20438.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR013763. Cyclin-like.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001770. Cyclin_CLN. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 1 hit.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio980359.

Entry information

Entry nameCG12_YEAST
AccessionPrimary (citable) accession number: P20438
Secondary accession number(s): D6W3B5, E9P938
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families