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P20438

- CG12_YEAST

UniProt

P20438 - CG12_YEAST

Protein

G1/S-specific cyclin CLN2

Gene

CLN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. re-entry into mitotic cell cycle after pheromone arrest Source: SGD
    3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34141-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin CLN2
    Gene namesi
    Name:CLN2
    Ordered Locus Names:YPL256C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPL256c.
    SGDiS000006177. CLN2.

    Subcellular locationi

    GO - Cellular componenti

    1. cyclin-dependent protein kinase holoenzyme complex Source: SGD
    2. cytoplasm Source: SGD
    3. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 545545G1/S-specific cyclin CLN2PRO_0000080412Add
    BLAST

    Proteomic databases

    PaxDbiP20438.
    PeptideAtlasiP20438.

    Expressioni

    Developmental stagei

    CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

    Gene expression databases

    GenevestigatoriP20438.

    Interactioni

    Protein-protein interaction databases

    BioGridi35907. 204 interactions.
    DIPiDIP-2270N.
    IntActiP20438. 9 interactions.
    MINTiMINT-583803.
    STRINGi4932.YPL256C.

    Structurei

    3D structure databases

    ProteinModelPortaliP20438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00390000006123.
    HOGENOMiHOG000111606.
    KOiK06650.
    OMAiPKLIDQQ.
    OrthoDBiEOG7BZW2S.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR014399. Cyclin_CLN/Puc1.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20438-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAEPRPRM GLVINAKPDY YPIELSNAEL LSHFEMLQEY HQEISTNVIA    50
    QSCKFKPNPK LIDQQPEMNP VETRSNIITF LFELSVVTRV TNGIFFHSVR 100
    LYDRYCSKRI VLRDQAKLVV ATCLWLAAKT WGGCNHIINN VVIPTGGRFY 150
    GPNPRARIPR LSELVHYCGD GQVFDESMFL QMERHILDTL NWNIYEPMIN 200
    DYVLNVDENC LMQYELYENQ VTYDKQCSEK RQSQLSQDSD ATVDERPYQN 250
    EEEEEEDLKL KIKLINLKKF LIDVSAWQYD LLRYELFEVS HGIFSIINQF 300
    TNQDHGPFLM TPMTSESKNG EILSTLMNGI VSIPNSLMEV YKTVNGVLPF 350
    INQVKEYHLD LQRKLQIASN LNISRKLTIS TPSCSFENSN STSIPSPASS 400
    SQSHTPMRNM SSLSDNSVFS RNMEQSSPIT PSMYQFGQQQ SNSICGSTVS 450
    VNSLVNTNNK QRIYEQITGP NSNNATNDYI DLLNLNESNK ENQNPATAHY 500
    LNGGPPKTSF INHGMFPSPT GTINSGKSSS ASSLISFGMG NTQVI 545
    Length:545
    Mass (Da):61,697
    Last modified:February 1, 1996 - v2
    Checksum:iD6426B94E040E960
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti440 – 4401Q → R in AAT93248. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33265 Genomic DNA. Translation: AAA65725.1.
    Z73612 Genomic DNA. Translation: CAA97982.1.
    AY693229 Genomic DNA. Translation: AAT93248.1.
    BK006949 Genomic DNA. Translation: DAA11181.1.
    PIRiB33289. COBYC2.
    RefSeqiNP_015067.1. NM_001184070.1.

    Genome annotation databases

    EnsemblFungiiYPL256C; YPL256C; YPL256C.
    GeneIDi855819.
    KEGGisce:YPL256C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33265 Genomic DNA. Translation: AAA65725.1 .
    Z73612 Genomic DNA. Translation: CAA97982.1 .
    AY693229 Genomic DNA. Translation: AAT93248.1 .
    BK006949 Genomic DNA. Translation: DAA11181.1 .
    PIRi B33289. COBYC2.
    RefSeqi NP_015067.1. NM_001184070.1.

    3D structure databases

    ProteinModelPortali P20438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35907. 204 interactions.
    DIPi DIP-2270N.
    IntActi P20438. 9 interactions.
    MINTi MINT-583803.
    STRINGi 4932.YPL256C.

    Proteomic databases

    PaxDbi P20438.
    PeptideAtlasi P20438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPL256C ; YPL256C ; YPL256C .
    GeneIDi 855819.
    KEGGi sce:YPL256C.

    Organism-specific databases

    CYGDi YPL256c.
    SGDi S000006177. CLN2.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00390000006123.
    HOGENOMi HOG000111606.
    KOi K06650.
    OMAi PKLIDQQ.
    OrthoDBi EOG7BZW2S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34141-MONOMER.

    Miscellaneous databases

    NextBioi 980359.

    Gene expression databases

    Genevestigatori P20438.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR014399. Cyclin_CLN/Puc1.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001770. Cyclin_CLN. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes."
      Hadwiger J.A., Reed S.I.
      Nucleic Acids Res. 18:4025-4025(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Wittenberg C., Chapman-Shimshoni D.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCG12_YEAST
    AccessioniPrimary (citable) accession number: P20438
    Secondary accession number(s): D6W3B5, E9P938
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    A dominant mutation in CLN2 gene (CLN2-1), advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals.
    Present with 1270 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3