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Protein

G1/S-specific cyclin CLN1

Gene

CLN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • traversing start control point of mitotic cell cycle Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-32886-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CLN1
Gene namesi
Name:CLN1
Ordered Locus Names:YMR199W
ORF Names:YM9646.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR199W
SGDiS000004812 CLN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804111 – 546G1/S-specific cyclin CLN1Add BLAST546

Proteomic databases

PaxDbiP20437
PRIDEiP20437
TopDownProteomicsiP20437

PTM databases

iPTMnetiP20437

Expressioni

Developmental stagei

CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35377, 215 interactors
ComplexPortaliCPX-1699 CLN1-CDC28 kinase complex
DIPiDIP-2269N
IntActiP20437, 9 interactors
MINTiP20437
STRINGi4932.YMR199W

Structurei

3D structure databases

ProteinModelPortaliP20437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000148806
HOGENOMiHOG000111606
InParanoidiP20437
KOiK12760
OMAiWDVYEPM
OrthoDBiEOG092C2O65

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR014399 Cyclin_CLN
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001770 Cyclin_CLN, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P20437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSEVKTGL IVTAKQTYYP IELSNAELLT HYETIQEYHE EISQNVLVQS
60 70 80 90 100
SKTKPDIKLI DQQPEMNPHQ TREAIVTFLY QLSVMTRVSN GIFFHAVRFY
110 120 130 140 150
DRYCSKRVVL KDQAKLVVGT CLWLAAKTWG GCNHIINNVS IPTGGRFYGP
160 170 180 190 200
NPRARIPRLS ELVHYCGGSD LFDESMFIQM ERHILDTLNW DVYEPMINDY
210 220 230 240 250
ILNVDENCLI QYELYKNQLQ NNNSNGKEWS CKRKSQSSDD SDATVEEHIS
260 270 280 290 300
SSPQSTGLDG DTTTMDEDEE LNSKIKLINL KRFLIDLSCW QYNLLKFELY
310 320 330 340 350
EICNGMFSII NKFTNQDQGP FLSMPIGNDI NSNTQTQVFS IIINGIVNSP
360 370 380 390 400
PSLVEVYKEQ YGIVPFILQV KDYNLELQKK LQLASTIDLT RKIAVNSRYF
410 420 430 440 450
DQNASSSSVS SPSTYSSGTN YTPMRNFSAQ SDNSVFSTTN IDHSSPITPH
460 470 480 490 500
MYTFNQFKNE SACDSAISVS SLPNQTQNGN MPLSSNYQNM MLEERNKENR
510 520 530 540
IPNSSSAEIP QRAKFMTTGI FQNTGELTNR ASSISLSLRN HNSSQL
Length:546
Mass (Da):62,050
Last modified:February 1, 1996 - v2
Checksum:i4D7189B83D7A2B34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33264 Genomic DNA Translation: AAA65724.1
Z47815 Genomic DNA Translation: CAA87822.1
AY723855 Genomic DNA Translation: AAU09772.1
BK006946 Genomic DNA Translation: DAA10098.1
PIRiS50929 COBYC1
RefSeqiNP_013926.1, NM_001182706.1

Genome annotation databases

EnsemblFungiiYMR199W; YMR199W; YMR199W
GeneIDi855239
KEGGisce:YMR199W

Similar proteinsi

Entry informationi

Entry nameiCG11_YEAST
AccessioniPrimary (citable) accession number: P20437
Secondary accession number(s): D6W024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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