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P20437 (CG11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin CLN1
Gene names
Name:CLN1
Ordered Locus Names:YMR199W
ORF Names:YM9646.13
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

Developmental stage

CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cyclin family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDC28P005466EBI-4479,EBI-4253
PHO85P171572EBI-4479,EBI-13327

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546G1/S-specific cyclin CLN1
PRO_0000080411

Sequences

Sequence LengthMass (Da)Tools
P20437 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 4D7189B83D7A2B34

FASTA54662,050
        10         20         30         40         50         60 
MNHSEVKTGL IVTAKQTYYP IELSNAELLT HYETIQEYHE EISQNVLVQS SKTKPDIKLI 

        70         80         90        100        110        120 
DQQPEMNPHQ TREAIVTFLY QLSVMTRVSN GIFFHAVRFY DRYCSKRVVL KDQAKLVVGT 

       130        140        150        160        170        180 
CLWLAAKTWG GCNHIINNVS IPTGGRFYGP NPRARIPRLS ELVHYCGGSD LFDESMFIQM 

       190        200        210        220        230        240 
ERHILDTLNW DVYEPMINDY ILNVDENCLI QYELYKNQLQ NNNSNGKEWS CKRKSQSSDD 

       250        260        270        280        290        300 
SDATVEEHIS SSPQSTGLDG DTTTMDEDEE LNSKIKLINL KRFLIDLSCW QYNLLKFELY 

       310        320        330        340        350        360 
EICNGMFSII NKFTNQDQGP FLSMPIGNDI NSNTQTQVFS IIINGIVNSP PSLVEVYKEQ 

       370        380        390        400        410        420 
YGIVPFILQV KDYNLELQKK LQLASTIDLT RKIAVNSRYF DQNASSSSVS SPSTYSSGTN 

       430        440        450        460        470        480 
YTPMRNFSAQ SDNSVFSTTN IDHSSPITPH MYTFNQFKNE SACDSAISVS SLPNQTQNGN 

       490        500        510        520        530        540 
MPLSSNYQNM MLEERNKENR IPNSSSAEIP QRAKFMTTGI FQNTGELTNR ASSISLSLRN 


HNSSQL 

« Hide

References

« Hide 'large scale' references
[1]"A family of cyclin homologs that control the G1 phase in yeast."
Hadwiger J.A., Wittenberg C., Richardson H.E., de Barros Lopes M., Reed S.I.
Proc. Natl. Acad. Sci. U.S.A. 86:6255-6259(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes."
Hadwiger J.A., Reed S.I.
Nucleic Acids Res. 18:4025-4025(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Wittenberg C., Chapman-Shimshoni D.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33264 Genomic DNA. Translation: AAA65724.1.
Z47815 Genomic DNA. Translation: CAA87822.1.
AY723855 Genomic DNA. Translation: AAU09772.1.
BK006946 Genomic DNA. Translation: DAA10098.1.
PIRCOBYC1. S50929.
RefSeqNP_013926.1. NM_001182706.1.

3D structure databases

ProteinModelPortalP20437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35377. 188 interactions.
DIPDIP-2269N.
IntActP20437. 6 interactions.
MINTMINT-512367.
STRING4932.YMR199W.

Proteomic databases

PaxDbP20437.
PeptideAtlasP20437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR199W; YMR199W; YMR199W.
GeneID855239.
KEGGsce:YMR199W.

Organism-specific databases

CYGDYMR199w.
SGDS000004812. CLN1.

Phylogenomic databases

eggNOGCOG5024.
GeneTreeENSGT00390000006123.
HOGENOMHOG000111606.
KOK12760.
OMATAKQTYY.
OrthoDBEOG7BZW2S.

Enzyme and pathway databases

BioCycYEAST:G3O-32886-MONOMER.

Gene expression databases

GenevestigatorP20437.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR013763. Cyclin-like.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001770. Cyclin_CLN. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 1 hit.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978789.

Entry information

Entry nameCG11_YEAST
AccessionPrimary (citable) accession number: P20437
Secondary accession number(s): D6W024
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families