Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1/S-specific cyclin CLN1

Gene

CLN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-32886-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CLN1
Gene namesi
Name:CLN1
Ordered Locus Names:YMR199W
ORF Names:YM9646.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR199w.
SGDiS000004812. CLN1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546G1/S-specific cyclin CLN1PRO_0000080411Add
BLAST

Proteomic databases

PaxDbiP20437.
PeptideAtlasiP20437.

Expressioni

Developmental stagei

CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

Gene expression databases

GenevestigatoriP20437.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC28P005466EBI-4479,EBI-4253
PHO85P171572EBI-4479,EBI-13327

Protein-protein interaction databases

BioGridi35377. 191 interactions.
DIPiDIP-2269N.
IntActiP20437. 6 interactions.
MINTiMINT-512367.
STRINGi4932.YMR199W.

Structurei

3D structure databases

ProteinModelPortaliP20437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00390000006123.
HOGENOMiHOG000111606.
InParanoidiP20437.
KOiK12760.
OMAiTAKQTYY.
OrthoDBiEOG7BZW2S.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSEVKTGL IVTAKQTYYP IELSNAELLT HYETIQEYHE EISQNVLVQS
60 70 80 90 100
SKTKPDIKLI DQQPEMNPHQ TREAIVTFLY QLSVMTRVSN GIFFHAVRFY
110 120 130 140 150
DRYCSKRVVL KDQAKLVVGT CLWLAAKTWG GCNHIINNVS IPTGGRFYGP
160 170 180 190 200
NPRARIPRLS ELVHYCGGSD LFDESMFIQM ERHILDTLNW DVYEPMINDY
210 220 230 240 250
ILNVDENCLI QYELYKNQLQ NNNSNGKEWS CKRKSQSSDD SDATVEEHIS
260 270 280 290 300
SSPQSTGLDG DTTTMDEDEE LNSKIKLINL KRFLIDLSCW QYNLLKFELY
310 320 330 340 350
EICNGMFSII NKFTNQDQGP FLSMPIGNDI NSNTQTQVFS IIINGIVNSP
360 370 380 390 400
PSLVEVYKEQ YGIVPFILQV KDYNLELQKK LQLASTIDLT RKIAVNSRYF
410 420 430 440 450
DQNASSSSVS SPSTYSSGTN YTPMRNFSAQ SDNSVFSTTN IDHSSPITPH
460 470 480 490 500
MYTFNQFKNE SACDSAISVS SLPNQTQNGN MPLSSNYQNM MLEERNKENR
510 520 530 540
IPNSSSAEIP QRAKFMTTGI FQNTGELTNR ASSISLSLRN HNSSQL
Length:546
Mass (Da):62,050
Last modified:February 1, 1996 - v2
Checksum:i4D7189B83D7A2B34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33264 Genomic DNA. Translation: AAA65724.1.
Z47815 Genomic DNA. Translation: CAA87822.1.
AY723855 Genomic DNA. Translation: AAU09772.1.
BK006946 Genomic DNA. Translation: DAA10098.1.
PIRiS50929. COBYC1.
RefSeqiNP_013926.1. NM_001182706.1.

Genome annotation databases

EnsemblFungiiYMR199W; YMR199W; YMR199W.
GeneIDi855239.
KEGGisce:YMR199W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33264 Genomic DNA. Translation: AAA65724.1.
Z47815 Genomic DNA. Translation: CAA87822.1.
AY723855 Genomic DNA. Translation: AAU09772.1.
BK006946 Genomic DNA. Translation: DAA10098.1.
PIRiS50929. COBYC1.
RefSeqiNP_013926.1. NM_001182706.1.

3D structure databases

ProteinModelPortaliP20437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35377. 191 interactions.
DIPiDIP-2269N.
IntActiP20437. 6 interactions.
MINTiMINT-512367.
STRINGi4932.YMR199W.

Proteomic databases

PaxDbiP20437.
PeptideAtlasiP20437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR199W; YMR199W; YMR199W.
GeneIDi855239.
KEGGisce:YMR199W.

Organism-specific databases

CYGDiYMR199w.
SGDiS000004812. CLN1.

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00390000006123.
HOGENOMiHOG000111606.
InParanoidiP20437.
KOiK12760.
OMAiTAKQTYY.
OrthoDBiEOG7BZW2S.

Enzyme and pathway databases

BioCyciYEAST:G3O-32886-MONOMER.

Miscellaneous databases

NextBioi978789.

Gene expression databases

GenevestigatoriP20437.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes."
    Hadwiger J.A., Reed S.I.
    Nucleic Acids Res. 18:4025-4025(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Wittenberg C., Chapman-Shimshoni D.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCG11_YEAST
AccessioniPrimary (citable) accession number: P20437
Secondary accession number(s): D6W024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.