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P20437

- CG11_YEAST

UniProt

P20437 - CG11_YEAST

Protein

G1/S-specific cyclin CLN1

Gene

CLN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32886-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin CLN1
    Gene namesi
    Name:CLN1
    Ordered Locus Names:YMR199W
    ORF Names:YM9646.13
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR199w.
    SGDiS000004812. CLN1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 546546G1/S-specific cyclin CLN1PRO_0000080411Add
    BLAST

    Proteomic databases

    PaxDbiP20437.
    PeptideAtlasiP20437.

    Expressioni

    Developmental stagei

    CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.

    Gene expression databases

    GenevestigatoriP20437.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC28P005466EBI-4479,EBI-4253
    PHO85P171572EBI-4479,EBI-13327

    Protein-protein interaction databases

    BioGridi35377. 188 interactions.
    DIPiDIP-2269N.
    IntActiP20437. 6 interactions.
    MINTiMINT-512367.
    STRINGi4932.YMR199W.

    Structurei

    3D structure databases

    ProteinModelPortaliP20437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00390000006123.
    HOGENOMiHOG000111606.
    KOiK12760.
    OMAiTAKQTYY.
    OrthoDBiEOG7BZW2S.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR014399. Cyclin_CLN/Puc1.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHSEVKTGL IVTAKQTYYP IELSNAELLT HYETIQEYHE EISQNVLVQS    50
    SKTKPDIKLI DQQPEMNPHQ TREAIVTFLY QLSVMTRVSN GIFFHAVRFY 100
    DRYCSKRVVL KDQAKLVVGT CLWLAAKTWG GCNHIINNVS IPTGGRFYGP 150
    NPRARIPRLS ELVHYCGGSD LFDESMFIQM ERHILDTLNW DVYEPMINDY 200
    ILNVDENCLI QYELYKNQLQ NNNSNGKEWS CKRKSQSSDD SDATVEEHIS 250
    SSPQSTGLDG DTTTMDEDEE LNSKIKLINL KRFLIDLSCW QYNLLKFELY 300
    EICNGMFSII NKFTNQDQGP FLSMPIGNDI NSNTQTQVFS IIINGIVNSP 350
    PSLVEVYKEQ YGIVPFILQV KDYNLELQKK LQLASTIDLT RKIAVNSRYF 400
    DQNASSSSVS SPSTYSSGTN YTPMRNFSAQ SDNSVFSTTN IDHSSPITPH 450
    MYTFNQFKNE SACDSAISVS SLPNQTQNGN MPLSSNYQNM MLEERNKENR 500
    IPNSSSAEIP QRAKFMTTGI FQNTGELTNR ASSISLSLRN HNSSQL 546
    Length:546
    Mass (Da):62,050
    Last modified:February 1, 1996 - v2
    Checksum:i4D7189B83D7A2B34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33264 Genomic DNA. Translation: AAA65724.1.
    Z47815 Genomic DNA. Translation: CAA87822.1.
    AY723855 Genomic DNA. Translation: AAU09772.1.
    BK006946 Genomic DNA. Translation: DAA10098.1.
    PIRiS50929. COBYC1.
    RefSeqiNP_013926.1. NM_001182706.1.

    Genome annotation databases

    EnsemblFungiiYMR199W; YMR199W; YMR199W.
    GeneIDi855239.
    KEGGisce:YMR199W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33264 Genomic DNA. Translation: AAA65724.1 .
    Z47815 Genomic DNA. Translation: CAA87822.1 .
    AY723855 Genomic DNA. Translation: AAU09772.1 .
    BK006946 Genomic DNA. Translation: DAA10098.1 .
    PIRi S50929. COBYC1.
    RefSeqi NP_013926.1. NM_001182706.1.

    3D structure databases

    ProteinModelPortali P20437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35377. 188 interactions.
    DIPi DIP-2269N.
    IntActi P20437. 6 interactions.
    MINTi MINT-512367.
    STRINGi 4932.YMR199W.

    Proteomic databases

    PaxDbi P20437.
    PeptideAtlasi P20437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR199W ; YMR199W ; YMR199W .
    GeneIDi 855239.
    KEGGi sce:YMR199W.

    Organism-specific databases

    CYGDi YMR199w.
    SGDi S000004812. CLN1.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00390000006123.
    HOGENOMi HOG000111606.
    KOi K12760.
    OMAi TAKQTYY.
    OrthoDBi EOG7BZW2S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32886-MONOMER.

    Miscellaneous databases

    NextBioi 978789.

    Gene expression databases

    Genevestigatori P20437.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR014399. Cyclin_CLN/Puc1.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001770. Cyclin_CLN. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes."
      Hadwiger J.A., Reed S.I.
      Nucleic Acids Res. 18:4025-4025(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Wittenberg C., Chapman-Shimshoni D.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCG11_YEAST
    AccessioniPrimary (citable) accession number: P20437
    Secondary accession number(s): D6W024
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 319 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3