P20437 (CG11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G1/S-specific cyclin CLN1

Gene names

Name:	CLN1
Ordered Locus Names:	YMR199W
ORF Names:	YM9646.13

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.
Developmental stage	CLN1 and CLN2 mRNAs fluctuate periodically in the cell cycle, peaking in G1 phase.
Miscellaneous	Present with 319 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the cyclin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Molecular function	Cyclin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from direct assay PubMed 10409718PubMed 8387915. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 11080155. Source: SGD nucleus Inferred from direct assay PubMed 11080155. Source: SGD
Molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity Inferred from direct assay PubMed 10409718PubMed 8387915. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC28	P00546	7	EBI-4479,EBI-4253
PHO85	P17157	2	EBI-4479,EBI-13327

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	G1/S-specific cyclin CLN1		PRO_0000080411

Sequences

	Sequence		Length	Mass (Da)
	P20437 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 4D7189B83D7A2B34	FASTA	546	62,050
	10 20 30 40 50 60 MNHSEVKTGL IVTAKQTYYP IELSNAELLT HYETIQEYHE EISQNVLVQS SKTKPDIKLI 70 80 90 100 110 120 DQQPEMNPHQ TREAIVTFLY QLSVMTRVSN GIFFHAVRFY DRYCSKRVVL KDQAKLVVGT 130 140 150 160 170 180 CLWLAAKTWG GCNHIINNVS IPTGGRFYGP NPRARIPRLS ELVHYCGGSD LFDESMFIQM 190 200 210 220 230 240 ERHILDTLNW DVYEPMINDY ILNVDENCLI QYELYKNQLQ NNNSNGKEWS CKRKSQSSDD 250 260 270 280 290 300 SDATVEEHIS SSPQSTGLDG DTTTMDEDEE LNSKIKLINL KRFLIDLSCW QYNLLKFELY 310 320 330 340 350 360 EICNGMFSII NKFTNQDQGP FLSMPIGNDI NSNTQTQVFS IIINGIVNSP PSLVEVYKEQ 370 380 390 400 410 420 YGIVPFILQV KDYNLELQKK LQLASTIDLT RKIAVNSRYF DQNASSSSVS SPSTYSSGTN 430 440 450 460 470 480 YTPMRNFSAQ SDNSVFSTTN IDHSSPITPH MYTFNQFKNE SACDSAISVS SLPNQTQNGN 490 500 510 520 530 540 MPLSSNYQNM MLEERNKENR IPNSSSAEIP QRAKFMTTGI FQNTGELTNR ASSISLSLRN HNSSQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of cyclin homologs that control the G1 phase in yeast." Hadwiger J.A., Wittenberg C., Richardson H.E., de Barros Lopes M., Reed S.I. Proc. Natl. Acad. Sci. U.S.A. 86:6255-6259(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes." Hadwiger J.A., Reed S.I. Nucleic Acids Res. 18:4025-4025(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Wittenberg C., Chapman-Shimshoni D. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[5]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[6]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33264 Genomic DNA. Translation: AAA65724.1. Z47815 Genomic DNA. Translation: CAA87822.1. AY723855 Genomic DNA. Translation: AAU09772.1. BK006946 Genomic DNA. Translation: DAA10098.1.
PIR	COBYC1. S50929.
RefSeq	NP_013926.1. NM_001182706.1.
3D structure databases
ProteinModelPortal	P20437.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2269N.
IntAct	P20437. 7 interactions.
MINT	MINT-512367.
STRING	4932.YMR199W.
Proteomic databases
PaxDb	P20437.
PeptideAtlas	P20437.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR199W; YMR199W; YMR199W.
GeneID	855239.
KEGG	sce:YMR199W.
Organism-specific databases
CYGD	YMR199w.
SGD	S000004812. CLN1.
Phylogenomic databases
eggNOG	COG5024.
GeneTree	ENSGT00390000006123.
HOGENOM	HOG000111606.
KO	K12760.
OMA	TAKQTYY.
OrthoDB	EOG498Z8K.
Gene expression databases
Genevestigator	P20437.
GermOnline	YMR199W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.10.472.10. 1 hit.
InterPro	IPR013763. Cyclin-like. IPR014399. Cyclin_CLN/Puc1. IPR006671. Cyclin_N. [Graphical view]
Pfam	PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001770. Cyclin_CLN. 1 hit.
SMART	SM00385. CYCLIN. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 1 hit.
PROSITE	PS00292. CYCLINS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978789.

Entry information

Entry name

CG11_YEAST

Accession

Primary (citable) accession number: P20437
Secondary accession number(s): D6W024

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program