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P20436

- RPAB3_YEAST

UniProt

P20436 - RPAB3_YEAST

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Protein
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Gene
RPB8, YOR224C, YOR50-14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription. of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.3 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase I activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
  2. tRNA transcription from RNA polymerase III promoter Source: SGD
  3. transcription from RNA polymerase I promoter Source: UniProtKB
  4. transcription from RNA polymerase II promoter Source: SGD
  5. transcription from RNA polymerase III promoter Source: SGD
  6. transcription, RNA-templated Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33723-MONOMER.
ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.
REACT_88842. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Short name:
RNA polymerases I, II, and III subunit ABC3
Alternative name(s):
ABC14.4
ABC14.5
DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide
Gene namesi
Name:RPB8
Ordered Locus Names:YOR224C
ORF Names:YOR50-14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR224c.
SGDiS000005750. RPB8.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. DNA-directed RNA polymerase I complex Source: UniProtKB
  2. DNA-directed RNA polymerase II, core complex Source: SGD
  3. DNA-directed RNA polymerase III complex Source: SGD
  4. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 146145DNA-directed RNA polymerases I, II, and III subunit RPABC3
PRO_0000074001Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei68 – 681Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP20436.
PaxDbiP20436.
PeptideAtlasiP20436.

Expressioni

Gene expression databases

GenevestigatoriP20436.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Directly interacts with POLR2A.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399403EBI-15794,EBI-16219

Protein-protein interaction databases

BioGridi34618. 72 interactions.
DIPiDIP-2195N.
IntActiP20436. 20 interactions.
MINTiMINT-507506.
STRINGi4932.YOR224C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 1610
Beta strandi21 – 3212
Beta strandi37 – 437
Helixi44 – 463
Beta strandi54 – 585
Turni84 – 863
Helixi89 – 924
Beta strandi93 – 1019
Beta strandi108 – 1103
Beta strandi112 – 1187
Beta strandi121 – 1288
Turni129 – 1335
Beta strandi136 – 1383
Beta strandi140 – 1456

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A1DNMR-A1-146[»]
1I3QX-ray3.10H1-146[»]
1I50X-ray2.80H1-146[»]
1I6HX-ray3.30H1-146[»]
1K83X-ray2.80H1-146[»]
1NIKX-ray4.10H1-146[»]
1NT9X-ray4.20H1-146[»]
1PQVX-ray3.80H1-146[»]
1R5UX-ray4.50H1-146[»]
1R9SX-ray4.25H1-146[»]
1R9TX-ray3.50H1-146[»]
1SFOX-ray3.61H1-146[»]
1TWAX-ray3.20H1-146[»]
1TWCX-ray3.00H1-146[»]
1TWFX-ray2.30H1-146[»]
1TWGX-ray3.30H1-146[»]
1TWHX-ray3.40H1-146[»]
1WCMX-ray3.80H1-146[»]
1Y1VX-ray3.80H1-146[»]
1Y1WX-ray4.00H1-146[»]
1Y1YX-ray4.00H1-146[»]
1Y77X-ray4.50H1-146[»]
2B63X-ray3.80H1-146[»]
2B8KX-ray4.15H1-146[»]
2E2HX-ray3.95H1-146[»]
2E2IX-ray3.41H1-146[»]
2E2JX-ray3.50H1-146[»]
2JA5X-ray3.80H1-146[»]
2JA6X-ray4.00H1-146[»]
2JA7X-ray3.80H/T1-146[»]
2JA8X-ray3.80H1-146[»]
2NVQX-ray2.90H1-146[»]
2NVTX-ray3.36H1-146[»]
2NVXX-ray3.60H1-146[»]
2NVYX-ray3.40H1-146[»]
2NVZX-ray4.30H1-146[»]
2R7ZX-ray3.80H1-146[»]
2R92X-ray3.80H1-146[»]
2R93X-ray4.00H1-146[»]
2VUMX-ray3.40H1-146[»]
2YU9X-ray3.40H1-146[»]
3CQZX-ray2.80H1-146[»]
3FKIX-ray3.88H1-146[»]
3GTGX-ray3.78H1-146[»]
3GTJX-ray3.42H1-146[»]
3GTKX-ray3.80H1-146[»]
3GTLX-ray3.38H1-146[»]
3GTMX-ray3.80H1-146[»]
3GTOX-ray4.00H1-146[»]
3GTPX-ray3.90H1-146[»]
3GTQX-ray3.80H1-146[»]
3H3VX-ray4.00I1-146[»]
3HOUX-ray3.20H/T1-146[»]
3HOVX-ray3.50H1-146[»]
3HOWX-ray3.60H1-146[»]
3HOXX-ray3.65H1-146[»]
3HOYX-ray3.40H1-146[»]
3HOZX-ray3.65H1-146[»]
3I4MX-ray3.70H1-146[»]
3I4NX-ray3.90H1-146[»]
3J0Kelectron microscopy36.00H1-146[»]
3J1Nelectron microscopy16.00H1-146[»]
3K1FX-ray4.30H1-146[»]
3K7AX-ray3.80H1-146[»]
3M3YX-ray3.18H1-146[»]
3M4OX-ray3.57H1-146[»]
3PO2X-ray3.30H1-146[»]
3PO3X-ray3.30H1-146[»]
3QT1X-ray4.30H1-146[»]
3RZDX-ray3.30H1-146[»]
3RZOX-ray3.00H1-146[»]
3S14X-ray2.85H1-146[»]
3S15X-ray3.30H1-146[»]
3S16X-ray3.24H1-146[»]
3S17X-ray3.20H1-146[»]
3S1MX-ray3.13H1-146[»]
3S1NX-ray3.10H1-146[»]
3S1QX-ray3.30H1-146[»]
3S1RX-ray3.20H1-146[»]
3S2DX-ray3.20H1-146[»]
3S2HX-ray3.30H1-146[»]
4A3BX-ray3.50H1-146[»]
4A3CX-ray3.50H1-146[»]
4A3DX-ray3.40H1-146[»]
4A3EX-ray3.40H1-146[»]
4A3FX-ray3.50H1-146[»]
4A3GX-ray3.50H1-146[»]
4A3IX-ray3.80H1-146[»]
4A3JX-ray3.70H1-146[»]
4A3KX-ray3.50H1-146[»]
4A3LX-ray3.50H1-146[»]
4A3MX-ray3.90H1-146[»]
4A93X-ray3.40H1-146[»]
4BBRX-ray3.40H1-146[»]
4BBSX-ray3.60H1-146[»]
4BXXX-ray3.28H1-146[»]
4BXZX-ray4.80H1-146[»]
4BY1X-ray3.60H1-146[»]
4BY7X-ray3.15H1-146[»]
4C2MX-ray2.80H/W1-146[»]
4C3HX-ray3.27H1-146[»]
4C3IX-ray3.0H1-146[»]
4C3JX-ray3.35H1-146[»]
ProteinModelPortaliP20436.
SMRiP20436. Positions 1-146.

Miscellaneous databases

EvolutionaryTraceiP20436.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 3924Non-specific ssDNA binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG279425.
GeneTreeiENSGT00390000018195.
HOGENOMiHOG000175572.
KOiK03016.
OMAiWRPDGKG.
OrthoDBiEOG78D7XD.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR005570. RNA_pol_Rpb8.
[Graphical view]
PANTHERiPTHR10917. PTHR10917. 1 hit.
PfamiPF03870. RNA_pol_Rpb8. 1 hit.
[Graphical view]
PIRSFiPIRSF000779. RNA_pol_Rpb8. 1 hit.
SMARTiSM00658. RPOL8c. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20436-1 [UniParc]FASTAAdd to Basket

« Hide

MSNTLFDDIF QVSEVDPGRY NKVCRIEAAS TTQDQCKLTL DINVELFPVA    50
AQDSLTVTIA SSLNLEDTPA NDSSATRSWR PPQAGDRSLA DDYDYVMYGT 100
AYKFEEVSKD LIAVYYSFGG LLMRLEGNYR NLNNLKQENA YLLIRR 146
Length:146
Mass (Da):16,511
Last modified:February 1, 1991 - v1
Checksum:i5B71693FE6FD8863
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53289 Genomic DNA. Translation: CAA37383.1.
X92441 Genomic DNA. Translation: CAA63187.1.
Z75132 Genomic DNA. Translation: CAA99443.1.
AY693087 Genomic DNA. Translation: AAT93106.1.
BK006948 Genomic DNA. Translation: DAA10995.1.
PIRiC34588.
RefSeqiNP_014867.1. NM_001183643.1.

Genome annotation databases

EnsemblFungiiYOR224C; YOR224C; YOR224C.
GeneIDi854399.
KEGGisce:YOR224C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53289 Genomic DNA. Translation: CAA37383.1 .
X92441 Genomic DNA. Translation: CAA63187.1 .
Z75132 Genomic DNA. Translation: CAA99443.1 .
AY693087 Genomic DNA. Translation: AAT93106.1 .
BK006948 Genomic DNA. Translation: DAA10995.1 .
PIRi C34588.
RefSeqi NP_014867.1. NM_001183643.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A1D NMR - A 1-146 [» ]
1I3Q X-ray 3.10 H 1-146 [» ]
1I50 X-ray 2.80 H 1-146 [» ]
1I6H X-ray 3.30 H 1-146 [» ]
1K83 X-ray 2.80 H 1-146 [» ]
1NIK X-ray 4.10 H 1-146 [» ]
1NT9 X-ray 4.20 H 1-146 [» ]
1PQV X-ray 3.80 H 1-146 [» ]
1R5U X-ray 4.50 H 1-146 [» ]
1R9S X-ray 4.25 H 1-146 [» ]
1R9T X-ray 3.50 H 1-146 [» ]
1SFO X-ray 3.61 H 1-146 [» ]
1TWA X-ray 3.20 H 1-146 [» ]
1TWC X-ray 3.00 H 1-146 [» ]
1TWF X-ray 2.30 H 1-146 [» ]
1TWG X-ray 3.30 H 1-146 [» ]
1TWH X-ray 3.40 H 1-146 [» ]
1WCM X-ray 3.80 H 1-146 [» ]
1Y1V X-ray 3.80 H 1-146 [» ]
1Y1W X-ray 4.00 H 1-146 [» ]
1Y1Y X-ray 4.00 H 1-146 [» ]
1Y77 X-ray 4.50 H 1-146 [» ]
2B63 X-ray 3.80 H 1-146 [» ]
2B8K X-ray 4.15 H 1-146 [» ]
2E2H X-ray 3.95 H 1-146 [» ]
2E2I X-ray 3.41 H 1-146 [» ]
2E2J X-ray 3.50 H 1-146 [» ]
2JA5 X-ray 3.80 H 1-146 [» ]
2JA6 X-ray 4.00 H 1-146 [» ]
2JA7 X-ray 3.80 H/T 1-146 [» ]
2JA8 X-ray 3.80 H 1-146 [» ]
2NVQ X-ray 2.90 H 1-146 [» ]
2NVT X-ray 3.36 H 1-146 [» ]
2NVX X-ray 3.60 H 1-146 [» ]
2NVY X-ray 3.40 H 1-146 [» ]
2NVZ X-ray 4.30 H 1-146 [» ]
2R7Z X-ray 3.80 H 1-146 [» ]
2R92 X-ray 3.80 H 1-146 [» ]
2R93 X-ray 4.00 H 1-146 [» ]
2VUM X-ray 3.40 H 1-146 [» ]
2YU9 X-ray 3.40 H 1-146 [» ]
3CQZ X-ray 2.80 H 1-146 [» ]
3FKI X-ray 3.88 H 1-146 [» ]
3GTG X-ray 3.78 H 1-146 [» ]
3GTJ X-ray 3.42 H 1-146 [» ]
3GTK X-ray 3.80 H 1-146 [» ]
3GTL X-ray 3.38 H 1-146 [» ]
3GTM X-ray 3.80 H 1-146 [» ]
3GTO X-ray 4.00 H 1-146 [» ]
3GTP X-ray 3.90 H 1-146 [» ]
3GTQ X-ray 3.80 H 1-146 [» ]
3H3V X-ray 4.00 I 1-146 [» ]
3HOU X-ray 3.20 H/T 1-146 [» ]
3HOV X-ray 3.50 H 1-146 [» ]
3HOW X-ray 3.60 H 1-146 [» ]
3HOX X-ray 3.65 H 1-146 [» ]
3HOY X-ray 3.40 H 1-146 [» ]
3HOZ X-ray 3.65 H 1-146 [» ]
3I4M X-ray 3.70 H 1-146 [» ]
3I4N X-ray 3.90 H 1-146 [» ]
3J0K electron microscopy 36.00 H 1-146 [» ]
3J1N electron microscopy 16.00 H 1-146 [» ]
3K1F X-ray 4.30 H 1-146 [» ]
3K7A X-ray 3.80 H 1-146 [» ]
3M3Y X-ray 3.18 H 1-146 [» ]
3M4O X-ray 3.57 H 1-146 [» ]
3PO2 X-ray 3.30 H 1-146 [» ]
3PO3 X-ray 3.30 H 1-146 [» ]
3QT1 X-ray 4.30 H 1-146 [» ]
3RZD X-ray 3.30 H 1-146 [» ]
3RZO X-ray 3.00 H 1-146 [» ]
3S14 X-ray 2.85 H 1-146 [» ]
3S15 X-ray 3.30 H 1-146 [» ]
3S16 X-ray 3.24 H 1-146 [» ]
3S17 X-ray 3.20 H 1-146 [» ]
3S1M X-ray 3.13 H 1-146 [» ]
3S1N X-ray 3.10 H 1-146 [» ]
3S1Q X-ray 3.30 H 1-146 [» ]
3S1R X-ray 3.20 H 1-146 [» ]
3S2D X-ray 3.20 H 1-146 [» ]
3S2H X-ray 3.30 H 1-146 [» ]
4A3B X-ray 3.50 H 1-146 [» ]
4A3C X-ray 3.50 H 1-146 [» ]
4A3D X-ray 3.40 H 1-146 [» ]
4A3E X-ray 3.40 H 1-146 [» ]
4A3F X-ray 3.50 H 1-146 [» ]
4A3G X-ray 3.50 H 1-146 [» ]
4A3I X-ray 3.80 H 1-146 [» ]
4A3J X-ray 3.70 H 1-146 [» ]
4A3K X-ray 3.50 H 1-146 [» ]
4A3L X-ray 3.50 H 1-146 [» ]
4A3M X-ray 3.90 H 1-146 [» ]
4A93 X-ray 3.40 H 1-146 [» ]
4BBR X-ray 3.40 H 1-146 [» ]
4BBS X-ray 3.60 H 1-146 [» ]
4BXX X-ray 3.28 H 1-146 [» ]
4BXZ X-ray 4.80 H 1-146 [» ]
4BY1 X-ray 3.60 H 1-146 [» ]
4BY7 X-ray 3.15 H 1-146 [» ]
4C2M X-ray 2.80 H/W 1-146 [» ]
4C3H X-ray 3.27 H 1-146 [» ]
4C3I X-ray 3.0 H 1-146 [» ]
4C3J X-ray 3.35 H 1-146 [» ]
ProteinModelPortali P20436.
SMRi P20436. Positions 1-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34618. 72 interactions.
DIPi DIP-2195N.
IntActi P20436. 20 interactions.
MINTi MINT-507506.
STRINGi 4932.YOR224C.

Proteomic databases

MaxQBi P20436.
PaxDbi P20436.
PeptideAtlasi P20436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR224C ; YOR224C ; YOR224C .
GeneIDi 854399.
KEGGi sce:YOR224C.

Organism-specific databases

CYGDi YOR224c.
SGDi S000005750. RPB8.

Phylogenomic databases

eggNOGi NOG279425.
GeneTreei ENSGT00390000018195.
HOGENOMi HOG000175572.
KOi K03016.
OMAi WRPDGKG.
OrthoDBi EOG78D7XD.

Enzyme and pathway databases

BioCyci YEAST:G3O-33723-MONOMER.
Reactomei REACT_191540. mRNA Splicing - Minor Pathway.
REACT_88842. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

EvolutionaryTracei P20436.
NextBioi 976571.
PROi P20436.

Gene expression databases

Genevestigatori P20436.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR005570. RNA_pol_Rpb8.
[Graphical view ]
PANTHERi PTHR10917. PTHR10917. 1 hit.
Pfami PF03870. RNA_pol_Rpb8. 1 hit.
[Graphical view ]
PIRSFi PIRSF000779. RNA_pol_Rpb8. 1 hit.
SMARTi SM00658. RPOL8c. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subunits shared by eukaryotic nuclear RNA polymerases."
    Woychik N.A., Liao S.-M., Kolodziej P.A., Young R.A.
    Genes Dev. 4:313-323(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae."
    Galisson F., Dujon B.
    Yeast 12:877-885(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
    Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
    Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE RNA POL III COMPLEX.
  7. "The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits."
    Peyroche G., Levillain E., Siaut M., Callebaut I., Schultz P., Sentenac A., Riva M., Carles C.
    Proc. Natl. Acad. Sci. U.S.A. 99:14670-14675(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. "Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family."
    Krapp S., Kelly G., Reischi J., Weinzierl R.O.J., Matthews S.
    Nat. Struct. Biol. 5:110-114(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  13. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
  14. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
    Cramer P., Bushnell D.A., Kornberg R.D.
    Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  15. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
    Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
    Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  16. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
    Bushnell D.A., Cramer P., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
  17. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  18. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  19. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
    Bushnell D.A., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  20. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
    Westover K.D., Bushnell D.A., Kornberg R.D.
    Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  21. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
  22. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
    Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
    Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  23. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  24. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
    Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
    Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
  25. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  26. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
  27. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  28. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  29. "RNA polymerase I structure and transcription regulation."
    Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
    Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiRPAB3_YEAST
AccessioniPrimary (citable) accession number: P20436
Secondary accession number(s): D6W2S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6210 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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