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P20435

- RPAB2_YEAST

UniProt

P20435 - RPAB2_YEAST

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Protein
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Gene
RPO26, RPB6, YPR187W, P9677.8
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.3 Publications

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. RNA polymerase I activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
  2. tRNA transcription from RNA polymerase III promoter Source: SGD
  3. transcription from RNA polymerase I promoter Source: UniProtKB
  4. transcription from RNA polymerase II promoter Source: SGD
  5. transcription from RNA polymerase III promoter Source: SGD
  6. transcription, RNA-templated Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-34310-MONOMER.
ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Short name:
RNA polymerases I, II, and III subunit ABC2
Alternative name(s):
ABC23
DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide
Gene namesi
Name:RPO26
Synonyms:RPB6
Ordered Locus Names:YPR187W
ORF Names:P9677.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR187w.
SGDiS000006391. RPO26.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. DNA-directed RNA polymerase I complex Source: UniProtKB
  2. DNA-directed RNA polymerase II, core complex Source: SGD
  3. DNA-directed RNA polymerase III complex Source: SGD
  4. cytoplasm Source: UniProtKB-SubCell
  5. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155DNA-directed RNA polymerases I, II, and III subunit RPABC2UniRule annotation
PRO_0000133797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP20435.
PaxDbiP20435.
PeptideAtlasiP20435.
PRIDEiP20435.

Expressioni

Gene expression databases

GenevestigatoriP20435.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RPA190P109643EBI-15786,EBI-15730

Protein-protein interaction databases

BioGridi36359. 97 interactions.
DIPiDIP-2194N.
IntActiP20435. 38 interactions.
MINTiMINT-569579.
STRINGi4932.YPR187W.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi56 – 7217
Beta strandi76 – 783
Helixi87 – 10216
Helixi117 – 12610
Beta strandi132 – 1376
Beta strandi139 – 1413
Beta strandi143 – 1475
Turni148 – 1503

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I3QX-ray3.10F1-155[»]
1I50X-ray2.80F1-155[»]
1I6HX-ray3.30F1-155[»]
1K83X-ray2.80F1-155[»]
1NIKX-ray4.10F1-155[»]
1NT9X-ray4.20F1-155[»]
1PQVX-ray3.80F1-155[»]
1R5UX-ray4.50F1-155[»]
1R9SX-ray4.25F1-155[»]
1R9TX-ray3.50F1-155[»]
1SFOX-ray3.61F1-155[»]
1TWAX-ray3.20F1-155[»]
1TWCX-ray3.00F1-155[»]
1TWFX-ray2.30F1-155[»]
1TWGX-ray3.30F1-155[»]
1TWHX-ray3.40F1-155[»]
1WCMX-ray3.80F1-155[»]
1Y1VX-ray3.80F1-155[»]
1Y1WX-ray4.00F1-155[»]
1Y1YX-ray4.00F1-155[»]
1Y77X-ray4.50F1-155[»]
2B63X-ray3.80F1-155[»]
2B8KX-ray4.15F1-155[»]
2E2HX-ray3.95F1-155[»]
2E2IX-ray3.41F1-155[»]
2E2JX-ray3.50F1-155[»]
2JA5X-ray3.80F1-155[»]
2JA6X-ray4.00F1-155[»]
2JA7X-ray3.80F/R1-155[»]
2JA8X-ray3.80F1-155[»]
2NVQX-ray2.90F1-155[»]
2NVTX-ray3.36F1-155[»]
2NVXX-ray3.60F1-155[»]
2NVYX-ray3.40F1-155[»]
2NVZX-ray4.30F1-155[»]
2R7ZX-ray3.80F1-155[»]
2R92X-ray3.80F1-155[»]
2R93X-ray4.00F1-155[»]
2VUMX-ray3.40F1-155[»]
2YU9X-ray3.40F1-155[»]
3CQZX-ray2.80F1-155[»]
3FKIX-ray3.88F1-155[»]
3GTGX-ray3.78F1-155[»]
3GTJX-ray3.42F1-155[»]
3GTKX-ray3.80F1-155[»]
3GTLX-ray3.38F1-155[»]
3GTMX-ray3.80F1-155[»]
3GTOX-ray4.00F1-155[»]
3GTPX-ray3.90F1-155[»]
3GTQX-ray3.80F1-155[»]
3H3VX-ray4.00G1-155[»]
3HOUX-ray3.20F/R1-155[»]
3HOVX-ray3.50F1-155[»]
3HOWX-ray3.60F1-155[»]
3HOXX-ray3.65F1-155[»]
3HOYX-ray3.40F1-155[»]
3HOZX-ray3.65F1-155[»]
3I4MX-ray3.70F1-155[»]
3I4NX-ray3.90F1-155[»]
3J0Kelectron microscopy36.00F72-155[»]
3J1Nelectron microscopy16.00F72-155[»]
3K1FX-ray4.30F1-155[»]
3K7AX-ray3.80F1-155[»]
3M3YX-ray3.18F1-155[»]
3M4OX-ray3.57F1-155[»]
3PO2X-ray3.30F1-155[»]
3PO3X-ray3.30F1-155[»]
3QT1X-ray4.30F1-155[»]
3RZDX-ray3.30F1-155[»]
3RZOX-ray3.00F1-155[»]
3S14X-ray2.85F1-155[»]
3S15X-ray3.30F1-155[»]
3S16X-ray3.24F1-155[»]
3S17X-ray3.20F1-155[»]
3S1MX-ray3.13F1-155[»]
3S1NX-ray3.10F1-155[»]
3S1QX-ray3.30F1-155[»]
3S1RX-ray3.20F1-155[»]
3S2DX-ray3.20F1-155[»]
3S2HX-ray3.30F1-155[»]
4A3BX-ray3.50F1-155[»]
4A3CX-ray3.50F1-155[»]
4A3DX-ray3.40F1-155[»]
4A3EX-ray3.40F1-155[»]
4A3FX-ray3.50F1-155[»]
4A3GX-ray3.50F1-155[»]
4A3IX-ray3.80F1-155[»]
4A3JX-ray3.70F1-155[»]
4A3KX-ray3.50F1-155[»]
4A3LX-ray3.50F1-155[»]
4A3MX-ray3.90F1-155[»]
4A93X-ray3.40F1-155[»]
4BBRX-ray3.40F1-155[»]
4BBSX-ray3.60F1-155[»]
4BXXX-ray3.28F1-155[»]
4BXZX-ray4.80F1-155[»]
4BY1X-ray3.60F1-155[»]
4BY7X-ray3.15F1-155[»]
4C2MX-ray2.80F/U1-155[»]
4C3HX-ray3.27F1-155[»]
4C3IX-ray3.0F1-155[»]
4C3JX-ray3.35F1-155[»]
ProteinModelPortaliP20435.
SMRiP20435. Positions 55-154.

Miscellaneous databases

EvolutionaryTraceiP20435.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 13222Leucine-zipperUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1758.
GeneTreeiENSGT00390000010415.
HOGENOMiHOG000225272.
KOiK03014.
OMAiINGGFGP.
OrthoDBiEOG7MWH92.

Family and domain databases

Gene3Di3.90.940.10. 1 hit.
HAMAPiMF_00192. RNApol_arch_K.
InterProiIPR020708. DNA-dir_RNA_polK_14-18kDa_CS.
IPR006110. Pol_omega/K/RPB6.
IPR012293. RNAP_RPB6_omega.
IPR028363. RPB6.
IPR006111. RpoK/Rpb6.
[Graphical view]
PANTHERiPTHR10773. PTHR10773. 1 hit.
PfamiPF01192. RNA_pol_Rpb6. 1 hit.
[Graphical view]
PIRSFiPIRSF500154. RPB6. 1 hit.
PIRSF000778. RpoK/RPB6. 1 hit.
SUPFAMiSSF63562. SSF63562. 1 hit.
PROSITEiPS01111. RNA_POL_K_14KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20435-1 [UniParc]FASTAAdd to Basket

« Hide

MSDYEEAFND GNENFEDFDV EHFSDEETYE EKPQFKDGET TDANGKTIVT    50
GGNGPEDFQQ HEQIRRKTLK EKAIPKDQRA TTPYMTKYER ARILGTRALQ 100
ISMNAPVFVD LEGETDPLRI AMKELAEKKI PLVIRRYLPD GSFEDWSVEE 150
LIVDL 155
Length:155
Mass (Da):17,910
Last modified:February 1, 1991 - v1
Checksum:iAA3DEF529F94A5E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53288 Genomic DNA. Translation: CAA37382.1.
M33924 Genomic DNA. Translation: AAA34989.1.
U25841 Genomic DNA. Translation: AAB64616.1.
BK006949 Genomic DNA. Translation: DAA11603.1.
PIRiS13307. RNBYR6.
RefSeqiNP_015513.1. NM_001184284.1.

Genome annotation databases

EnsemblFungiiYPR187W; YPR187W; YPR187W.
GeneIDi856317.
KEGGisce:YPR187W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53288 Genomic DNA. Translation: CAA37382.1 .
M33924 Genomic DNA. Translation: AAA34989.1 .
U25841 Genomic DNA. Translation: AAB64616.1 .
BK006949 Genomic DNA. Translation: DAA11603.1 .
PIRi S13307. RNBYR6.
RefSeqi NP_015513.1. NM_001184284.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I3Q X-ray 3.10 F 1-155 [» ]
1I50 X-ray 2.80 F 1-155 [» ]
1I6H X-ray 3.30 F 1-155 [» ]
1K83 X-ray 2.80 F 1-155 [» ]
1NIK X-ray 4.10 F 1-155 [» ]
1NT9 X-ray 4.20 F 1-155 [» ]
1PQV X-ray 3.80 F 1-155 [» ]
1R5U X-ray 4.50 F 1-155 [» ]
1R9S X-ray 4.25 F 1-155 [» ]
1R9T X-ray 3.50 F 1-155 [» ]
1SFO X-ray 3.61 F 1-155 [» ]
1TWA X-ray 3.20 F 1-155 [» ]
1TWC X-ray 3.00 F 1-155 [» ]
1TWF X-ray 2.30 F 1-155 [» ]
1TWG X-ray 3.30 F 1-155 [» ]
1TWH X-ray 3.40 F 1-155 [» ]
1WCM X-ray 3.80 F 1-155 [» ]
1Y1V X-ray 3.80 F 1-155 [» ]
1Y1W X-ray 4.00 F 1-155 [» ]
1Y1Y X-ray 4.00 F 1-155 [» ]
1Y77 X-ray 4.50 F 1-155 [» ]
2B63 X-ray 3.80 F 1-155 [» ]
2B8K X-ray 4.15 F 1-155 [» ]
2E2H X-ray 3.95 F 1-155 [» ]
2E2I X-ray 3.41 F 1-155 [» ]
2E2J X-ray 3.50 F 1-155 [» ]
2JA5 X-ray 3.80 F 1-155 [» ]
2JA6 X-ray 4.00 F 1-155 [» ]
2JA7 X-ray 3.80 F/R 1-155 [» ]
2JA8 X-ray 3.80 F 1-155 [» ]
2NVQ X-ray 2.90 F 1-155 [» ]
2NVT X-ray 3.36 F 1-155 [» ]
2NVX X-ray 3.60 F 1-155 [» ]
2NVY X-ray 3.40 F 1-155 [» ]
2NVZ X-ray 4.30 F 1-155 [» ]
2R7Z X-ray 3.80 F 1-155 [» ]
2R92 X-ray 3.80 F 1-155 [» ]
2R93 X-ray 4.00 F 1-155 [» ]
2VUM X-ray 3.40 F 1-155 [» ]
2YU9 X-ray 3.40 F 1-155 [» ]
3CQZ X-ray 2.80 F 1-155 [» ]
3FKI X-ray 3.88 F 1-155 [» ]
3GTG X-ray 3.78 F 1-155 [» ]
3GTJ X-ray 3.42 F 1-155 [» ]
3GTK X-ray 3.80 F 1-155 [» ]
3GTL X-ray 3.38 F 1-155 [» ]
3GTM X-ray 3.80 F 1-155 [» ]
3GTO X-ray 4.00 F 1-155 [» ]
3GTP X-ray 3.90 F 1-155 [» ]
3GTQ X-ray 3.80 F 1-155 [» ]
3H3V X-ray 4.00 G 1-155 [» ]
3HOU X-ray 3.20 F/R 1-155 [» ]
3HOV X-ray 3.50 F 1-155 [» ]
3HOW X-ray 3.60 F 1-155 [» ]
3HOX X-ray 3.65 F 1-155 [» ]
3HOY X-ray 3.40 F 1-155 [» ]
3HOZ X-ray 3.65 F 1-155 [» ]
3I4M X-ray 3.70 F 1-155 [» ]
3I4N X-ray 3.90 F 1-155 [» ]
3J0K electron microscopy 36.00 F 72-155 [» ]
3J1N electron microscopy 16.00 F 72-155 [» ]
3K1F X-ray 4.30 F 1-155 [» ]
3K7A X-ray 3.80 F 1-155 [» ]
3M3Y X-ray 3.18 F 1-155 [» ]
3M4O X-ray 3.57 F 1-155 [» ]
3PO2 X-ray 3.30 F 1-155 [» ]
3PO3 X-ray 3.30 F 1-155 [» ]
3QT1 X-ray 4.30 F 1-155 [» ]
3RZD X-ray 3.30 F 1-155 [» ]
3RZO X-ray 3.00 F 1-155 [» ]
3S14 X-ray 2.85 F 1-155 [» ]
3S15 X-ray 3.30 F 1-155 [» ]
3S16 X-ray 3.24 F 1-155 [» ]
3S17 X-ray 3.20 F 1-155 [» ]
3S1M X-ray 3.13 F 1-155 [» ]
3S1N X-ray 3.10 F 1-155 [» ]
3S1Q X-ray 3.30 F 1-155 [» ]
3S1R X-ray 3.20 F 1-155 [» ]
3S2D X-ray 3.20 F 1-155 [» ]
3S2H X-ray 3.30 F 1-155 [» ]
4A3B X-ray 3.50 F 1-155 [» ]
4A3C X-ray 3.50 F 1-155 [» ]
4A3D X-ray 3.40 F 1-155 [» ]
4A3E X-ray 3.40 F 1-155 [» ]
4A3F X-ray 3.50 F 1-155 [» ]
4A3G X-ray 3.50 F 1-155 [» ]
4A3I X-ray 3.80 F 1-155 [» ]
4A3J X-ray 3.70 F 1-155 [» ]
4A3K X-ray 3.50 F 1-155 [» ]
4A3L X-ray 3.50 F 1-155 [» ]
4A3M X-ray 3.90 F 1-155 [» ]
4A93 X-ray 3.40 F 1-155 [» ]
4BBR X-ray 3.40 F 1-155 [» ]
4BBS X-ray 3.60 F 1-155 [» ]
4BXX X-ray 3.28 F 1-155 [» ]
4BXZ X-ray 4.80 F 1-155 [» ]
4BY1 X-ray 3.60 F 1-155 [» ]
4BY7 X-ray 3.15 F 1-155 [» ]
4C2M X-ray 2.80 F/U 1-155 [» ]
4C3H X-ray 3.27 F 1-155 [» ]
4C3I X-ray 3.0 F 1-155 [» ]
4C3J X-ray 3.35 F 1-155 [» ]
ProteinModelPortali P20435.
SMRi P20435. Positions 55-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36359. 97 interactions.
DIPi DIP-2194N.
IntActi P20435. 38 interactions.
MINTi MINT-569579.
STRINGi 4932.YPR187W.

Proteomic databases

MaxQBi P20435.
PaxDbi P20435.
PeptideAtlasi P20435.
PRIDEi P20435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR187W ; YPR187W ; YPR187W .
GeneIDi 856317.
KEGGi sce:YPR187W.

Organism-specific databases

CYGDi YPR187w.
SGDi S000006391. RPO26.

Phylogenomic databases

eggNOGi COG1758.
GeneTreei ENSGT00390000010415.
HOGENOMi HOG000225272.
KOi K03014.
OMAi INGGFGP.
OrthoDBi EOG7MWH92.

Enzyme and pathway databases

BioCyci YEAST:G3O-34310-MONOMER.
Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

Miscellaneous databases

EvolutionaryTracei P20435.
NextBioi 981703.
PROi P20435.

Gene expression databases

Genevestigatori P20435.

Family and domain databases

Gene3Di 3.90.940.10. 1 hit.
HAMAPi MF_00192. RNApol_arch_K.
InterProi IPR020708. DNA-dir_RNA_polK_14-18kDa_CS.
IPR006110. Pol_omega/K/RPB6.
IPR012293. RNAP_RPB6_omega.
IPR028363. RPB6.
IPR006111. RpoK/Rpb6.
[Graphical view ]
PANTHERi PTHR10773. PTHR10773. 1 hit.
Pfami PF01192. RNA_pol_Rpb6. 1 hit.
[Graphical view ]
PIRSFi PIRSF500154. RPB6. 1 hit.
PIRSF000778. RpoK/RPB6. 1 hit.
SUPFAMi SSF63562. SSF63562. 1 hit.
PROSITEi PS01111. RNA_POL_K_14KD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subunits shared by eukaryotic nuclear RNA polymerases."
    Woychik N.A., Liao S.-M., Kolodziej P.A., Young R.A.
    Genes Dev. 4:313-323(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A suppressor of an RNA polymerase II mutation of Saccharomyces cerevisiae encodes a subunit common to RNA polymerases I, II, and III."
    Archambault J., Schappert K.T., Friesen J.D.
    Mol. Cell. Biol. 10:6123-6131(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Differential roles of phosphorylation in the formation of transcriptional active RNA polymerase I."
    Fath S., Milkereit P., Peyroche G., Riva M., Carles C., Tschochner H.
    Proc. Natl. Acad. Sci. U.S.A. 98:14334-14339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
  6. "Rpa12p, a conserved RNA polymerase I subunit with two functional domains."
    Van Mullem V., Landrieux E., Vandenhaute J., Thuriaux P.
    Mol. Microbiol. 43:1105-1113(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
  7. "The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits."
    Peyroche G., Levillain E., Siaut M., Callebaut I., Schultz P., Sentenac A., Riva M., Carles C.
    Proc. Natl. Acad. Sci. U.S.A. 99:14670-14675(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX, INTERACTION WITH RPA43.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  10. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
    Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
    Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE RNA POL III COMPLEX, PHOSPHORYLATION.
  11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
  13. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
    Cramer P., Bushnell D.A., Kornberg R.D.
    Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  14. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
    Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
    Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  15. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
    Bushnell D.A., Cramer P., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
  16. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  17. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  18. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
    Bushnell D.A., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  19. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
    Westover K.D., Bushnell D.A., Kornberg R.D.
    Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  20. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
  21. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
    Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
    Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  22. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  23. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
    Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
    Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
  24. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  25. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
  26. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  27. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  28. "RNA polymerase I structure and transcription regulation."
    Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
    Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiRPAB2_YEAST
AccessioniPrimary (citable) accession number: P20435
Secondary accession number(s): D6W4I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6090 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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