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P20435

- RPAB2_YEAST

UniProt

P20435 - RPAB2_YEAST

Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC2

Gene

RPO26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.3 Publications

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. protein binding Source: IntAct
    3. RNA polymerase I activity Source: UniProtKB

    GO - Biological processi

    1. ribosome biogenesis Source: UniProtKB-KW
    2. transcription, RNA-templated Source: GOC
    3. transcription from RNA polymerase III promoter Source: SGD
    4. transcription from RNA polymerase II promoter Source: SGD
    5. transcription from RNA polymerase I promoter Source: UniProtKB
    6. tRNA transcription from RNA polymerase III promoter Source: SGD

    Keywords - Biological processi

    Ribosome biogenesis, Transcription

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34310-MONOMER.
    ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC2
    Short name:
    RNA polymerases I, II, and III subunit ABC2
    Alternative name(s):
    ABC23
    DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide
    Gene namesi
    Name:RPO26
    Synonyms:RPB6
    Ordered Locus Names:YPR187W
    ORF Names:P9677.8
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR187w.
    SGDiS000006391. RPO26.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. DNA-directed RNA polymerase I complex Source: UniProtKB
    3. DNA-directed RNA polymerase II, core complex Source: SGD
    4. DNA-directed RNA polymerase III complex Source: SGD
    5. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 155155DNA-directed RNA polymerases I, II, and III subunit RPABC2PRO_0000133797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP20435.
    PaxDbiP20435.
    PeptideAtlasiP20435.
    PRIDEiP20435.

    Expressioni

    Gene expression databases

    GenevestigatoriP20435.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.9 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RPA190P109643EBI-15786,EBI-15730

    Protein-protein interaction databases

    BioGridi36359. 97 interactions.
    DIPiDIP-2194N.
    IntActiP20435. 38 interactions.
    MINTiMINT-569579.
    STRINGi4932.YPR187W.

    Structurei

    Secondary structure

    1
    155
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi56 – 7217
    Beta strandi76 – 783
    Helixi87 – 10216
    Helixi117 – 12610
    Beta strandi132 – 1376
    Beta strandi139 – 1413
    Beta strandi143 – 1475
    Turni148 – 1503

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I3QX-ray3.10F1-155[»]
    1I50X-ray2.80F1-155[»]
    1I6HX-ray3.30F1-155[»]
    1K83X-ray2.80F1-155[»]
    1NIKX-ray4.10F1-155[»]
    1NT9X-ray4.20F1-155[»]
    1PQVX-ray3.80F1-155[»]
    1R5UX-ray4.50F1-155[»]
    1R9SX-ray4.25F1-155[»]
    1R9TX-ray3.50F1-155[»]
    1SFOX-ray3.61F1-155[»]
    1TWAX-ray3.20F1-155[»]
    1TWCX-ray3.00F1-155[»]
    1TWFX-ray2.30F1-155[»]
    1TWGX-ray3.30F1-155[»]
    1TWHX-ray3.40F1-155[»]
    1WCMX-ray3.80F1-155[»]
    1Y1VX-ray3.80F1-155[»]
    1Y1WX-ray4.00F1-155[»]
    1Y1YX-ray4.00F1-155[»]
    1Y77X-ray4.50F1-155[»]
    2B63X-ray3.80F1-155[»]
    2B8KX-ray4.15F1-155[»]
    2E2HX-ray3.95F1-155[»]
    2E2IX-ray3.41F1-155[»]
    2E2JX-ray3.50F1-155[»]
    2JA5X-ray3.80F1-155[»]
    2JA6X-ray4.00F1-155[»]
    2JA7X-ray3.80F/R1-155[»]
    2JA8X-ray3.80F1-155[»]
    2NVQX-ray2.90F1-155[»]
    2NVTX-ray3.36F1-155[»]
    2NVXX-ray3.60F1-155[»]
    2NVYX-ray3.40F1-155[»]
    2NVZX-ray4.30F1-155[»]
    2R7ZX-ray3.80F1-155[»]
    2R92X-ray3.80F1-155[»]
    2R93X-ray4.00F1-155[»]
    2VUMX-ray3.40F1-155[»]
    2YU9X-ray3.40F1-155[»]
    3CQZX-ray2.80F1-155[»]
    3FKIX-ray3.88F1-155[»]
    3GTGX-ray3.78F1-155[»]
    3GTJX-ray3.42F1-155[»]
    3GTKX-ray3.80F1-155[»]
    3GTLX-ray3.38F1-155[»]
    3GTMX-ray3.80F1-155[»]
    3GTOX-ray4.00F1-155[»]
    3GTPX-ray3.90F1-155[»]
    3GTQX-ray3.80F1-155[»]
    3H3VX-ray4.00G1-155[»]
    3HOUX-ray3.20F/R1-155[»]
    3HOVX-ray3.50F1-155[»]
    3HOWX-ray3.60F1-155[»]
    3HOXX-ray3.65F1-155[»]
    3HOYX-ray3.40F1-155[»]
    3HOZX-ray3.65F1-155[»]
    3I4MX-ray3.70F1-155[»]
    3I4NX-ray3.90F1-155[»]
    3J0Kelectron microscopy36.00F72-155[»]
    3J1Nelectron microscopy16.00F72-155[»]
    3K1FX-ray4.30F1-155[»]
    3K7AX-ray3.80F1-155[»]
    3M3YX-ray3.18F1-155[»]
    3M4OX-ray3.57F1-155[»]
    3PO2X-ray3.30F1-155[»]
    3PO3X-ray3.30F1-155[»]
    3QT1X-ray4.30F1-155[»]
    3RZDX-ray3.30F1-155[»]
    3RZOX-ray3.00F1-155[»]
    3S14X-ray2.85F1-155[»]
    3S15X-ray3.30F1-155[»]
    3S16X-ray3.24F1-155[»]
    3S17X-ray3.20F1-155[»]
    3S1MX-ray3.13F1-155[»]
    3S1NX-ray3.10F1-155[»]
    3S1QX-ray3.30F1-155[»]
    3S1RX-ray3.20F1-155[»]
    3S2DX-ray3.20F1-155[»]
    3S2HX-ray3.30F1-155[»]
    4A3BX-ray3.50F1-155[»]
    4A3CX-ray3.50F1-155[»]
    4A3DX-ray3.40F1-155[»]
    4A3EX-ray3.40F1-155[»]
    4A3FX-ray3.50F1-155[»]
    4A3GX-ray3.50F1-155[»]
    4A3IX-ray3.80F1-155[»]
    4A3JX-ray3.70F1-155[»]
    4A3KX-ray3.50F1-155[»]
    4A3LX-ray3.50F1-155[»]
    4A3MX-ray3.90F1-155[»]
    4A93X-ray3.40F1-155[»]
    4BBRX-ray3.40F1-155[»]
    4BBSX-ray3.60F1-155[»]
    4BXXX-ray3.28F1-155[»]
    4BXZX-ray4.80F1-155[»]
    4BY1X-ray3.60F1-155[»]
    4BY7X-ray3.15F1-155[»]
    4C2MX-ray2.80F/U1-155[»]
    4C3HX-ray3.27F1-155[»]
    4C3IX-ray3.0F1-155[»]
    4C3JX-ray3.35F1-155[»]
    ProteinModelPortaliP20435.
    SMRiP20435. Positions 55-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20435.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni111 – 13222Leucine-zipperAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1758.
    GeneTreeiENSGT00390000010415.
    HOGENOMiHOG000225272.
    KOiK03014.
    OMAiINGGFGP.
    OrthoDBiEOG7MWH92.

    Family and domain databases

    Gene3Di3.90.940.10. 1 hit.
    HAMAPiMF_00192. RNApol_arch_K.
    InterProiIPR020708. DNA-dir_RNA_polK_14-18kDa_CS.
    IPR006110. Pol_omega/K/RPB6.
    IPR012293. RNAP_RPB6_omega.
    IPR028363. RPB6.
    IPR006111. RpoK/Rpb6.
    [Graphical view]
    PANTHERiPTHR10773. PTHR10773. 1 hit.
    PfamiPF01192. RNA_pol_Rpb6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500154. RPB6. 1 hit.
    PIRSF000778. RpoK/RPB6. 1 hit.
    SUPFAMiSSF63562. SSF63562. 1 hit.
    PROSITEiPS01111. RNA_POL_K_14KD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20435-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDYEEAFND GNENFEDFDV EHFSDEETYE EKPQFKDGET TDANGKTIVT    50
    GGNGPEDFQQ HEQIRRKTLK EKAIPKDQRA TTPYMTKYER ARILGTRALQ 100
    ISMNAPVFVD LEGETDPLRI AMKELAEKKI PLVIRRYLPD GSFEDWSVEE 150
    LIVDL 155
    Length:155
    Mass (Da):17,910
    Last modified:February 1, 1991 - v1
    Checksum:iAA3DEF529F94A5E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53288 Genomic DNA. Translation: CAA37382.1.
    M33924 Genomic DNA. Translation: AAA34989.1.
    U25841 Genomic DNA. Translation: AAB64616.1.
    BK006949 Genomic DNA. Translation: DAA11603.1.
    PIRiS13307. RNBYR6.
    RefSeqiNP_015513.1. NM_001184284.1.

    Genome annotation databases

    EnsemblFungiiYPR187W; YPR187W; YPR187W.
    GeneIDi856317.
    KEGGisce:YPR187W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53288 Genomic DNA. Translation: CAA37382.1 .
    M33924 Genomic DNA. Translation: AAA34989.1 .
    U25841 Genomic DNA. Translation: AAB64616.1 .
    BK006949 Genomic DNA. Translation: DAA11603.1 .
    PIRi S13307. RNBYR6.
    RefSeqi NP_015513.1. NM_001184284.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I3Q X-ray 3.10 F 1-155 [» ]
    1I50 X-ray 2.80 F 1-155 [» ]
    1I6H X-ray 3.30 F 1-155 [» ]
    1K83 X-ray 2.80 F 1-155 [» ]
    1NIK X-ray 4.10 F 1-155 [» ]
    1NT9 X-ray 4.20 F 1-155 [» ]
    1PQV X-ray 3.80 F 1-155 [» ]
    1R5U X-ray 4.50 F 1-155 [» ]
    1R9S X-ray 4.25 F 1-155 [» ]
    1R9T X-ray 3.50 F 1-155 [» ]
    1SFO X-ray 3.61 F 1-155 [» ]
    1TWA X-ray 3.20 F 1-155 [» ]
    1TWC X-ray 3.00 F 1-155 [» ]
    1TWF X-ray 2.30 F 1-155 [» ]
    1TWG X-ray 3.30 F 1-155 [» ]
    1TWH X-ray 3.40 F 1-155 [» ]
    1WCM X-ray 3.80 F 1-155 [» ]
    1Y1V X-ray 3.80 F 1-155 [» ]
    1Y1W X-ray 4.00 F 1-155 [» ]
    1Y1Y X-ray 4.00 F 1-155 [» ]
    1Y77 X-ray 4.50 F 1-155 [» ]
    2B63 X-ray 3.80 F 1-155 [» ]
    2B8K X-ray 4.15 F 1-155 [» ]
    2E2H X-ray 3.95 F 1-155 [» ]
    2E2I X-ray 3.41 F 1-155 [» ]
    2E2J X-ray 3.50 F 1-155 [» ]
    2JA5 X-ray 3.80 F 1-155 [» ]
    2JA6 X-ray 4.00 F 1-155 [» ]
    2JA7 X-ray 3.80 F/R 1-155 [» ]
    2JA8 X-ray 3.80 F 1-155 [» ]
    2NVQ X-ray 2.90 F 1-155 [» ]
    2NVT X-ray 3.36 F 1-155 [» ]
    2NVX X-ray 3.60 F 1-155 [» ]
    2NVY X-ray 3.40 F 1-155 [» ]
    2NVZ X-ray 4.30 F 1-155 [» ]
    2R7Z X-ray 3.80 F 1-155 [» ]
    2R92 X-ray 3.80 F 1-155 [» ]
    2R93 X-ray 4.00 F 1-155 [» ]
    2VUM X-ray 3.40 F 1-155 [» ]
    2YU9 X-ray 3.40 F 1-155 [» ]
    3CQZ X-ray 2.80 F 1-155 [» ]
    3FKI X-ray 3.88 F 1-155 [» ]
    3GTG X-ray 3.78 F 1-155 [» ]
    3GTJ X-ray 3.42 F 1-155 [» ]
    3GTK X-ray 3.80 F 1-155 [» ]
    3GTL X-ray 3.38 F 1-155 [» ]
    3GTM X-ray 3.80 F 1-155 [» ]
    3GTO X-ray 4.00 F 1-155 [» ]
    3GTP X-ray 3.90 F 1-155 [» ]
    3GTQ X-ray 3.80 F 1-155 [» ]
    3H3V X-ray 4.00 G 1-155 [» ]
    3HOU X-ray 3.20 F/R 1-155 [» ]
    3HOV X-ray 3.50 F 1-155 [» ]
    3HOW X-ray 3.60 F 1-155 [» ]
    3HOX X-ray 3.65 F 1-155 [» ]
    3HOY X-ray 3.40 F 1-155 [» ]
    3HOZ X-ray 3.65 F 1-155 [» ]
    3I4M X-ray 3.70 F 1-155 [» ]
    3I4N X-ray 3.90 F 1-155 [» ]
    3J0K electron microscopy 36.00 F 72-155 [» ]
    3J1N electron microscopy 16.00 F 72-155 [» ]
    3K1F X-ray 4.30 F 1-155 [» ]
    3K7A X-ray 3.80 F 1-155 [» ]
    3M3Y X-ray 3.18 F 1-155 [» ]
    3M4O X-ray 3.57 F 1-155 [» ]
    3PO2 X-ray 3.30 F 1-155 [» ]
    3PO3 X-ray 3.30 F 1-155 [» ]
    3QT1 X-ray 4.30 F 1-155 [» ]
    3RZD X-ray 3.30 F 1-155 [» ]
    3RZO X-ray 3.00 F 1-155 [» ]
    3S14 X-ray 2.85 F 1-155 [» ]
    3S15 X-ray 3.30 F 1-155 [» ]
    3S16 X-ray 3.24 F 1-155 [» ]
    3S17 X-ray 3.20 F 1-155 [» ]
    3S1M X-ray 3.13 F 1-155 [» ]
    3S1N X-ray 3.10 F 1-155 [» ]
    3S1Q X-ray 3.30 F 1-155 [» ]
    3S1R X-ray 3.20 F 1-155 [» ]
    3S2D X-ray 3.20 F 1-155 [» ]
    3S2H X-ray 3.30 F 1-155 [» ]
    4A3B X-ray 3.50 F 1-155 [» ]
    4A3C X-ray 3.50 F 1-155 [» ]
    4A3D X-ray 3.40 F 1-155 [» ]
    4A3E X-ray 3.40 F 1-155 [» ]
    4A3F X-ray 3.50 F 1-155 [» ]
    4A3G X-ray 3.50 F 1-155 [» ]
    4A3I X-ray 3.80 F 1-155 [» ]
    4A3J X-ray 3.70 F 1-155 [» ]
    4A3K X-ray 3.50 F 1-155 [» ]
    4A3L X-ray 3.50 F 1-155 [» ]
    4A3M X-ray 3.90 F 1-155 [» ]
    4A93 X-ray 3.40 F 1-155 [» ]
    4BBR X-ray 3.40 F 1-155 [» ]
    4BBS X-ray 3.60 F 1-155 [» ]
    4BXX X-ray 3.28 F 1-155 [» ]
    4BXZ X-ray 4.80 F 1-155 [» ]
    4BY1 X-ray 3.60 F 1-155 [» ]
    4BY7 X-ray 3.15 F 1-155 [» ]
    4C2M X-ray 2.80 F/U 1-155 [» ]
    4C3H X-ray 3.27 F 1-155 [» ]
    4C3I X-ray 3.0 F 1-155 [» ]
    4C3J X-ray 3.35 F 1-155 [» ]
    ProteinModelPortali P20435.
    SMRi P20435. Positions 55-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36359. 97 interactions.
    DIPi DIP-2194N.
    IntActi P20435. 38 interactions.
    MINTi MINT-569579.
    STRINGi 4932.YPR187W.

    Proteomic databases

    MaxQBi P20435.
    PaxDbi P20435.
    PeptideAtlasi P20435.
    PRIDEi P20435.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR187W ; YPR187W ; YPR187W .
    GeneIDi 856317.
    KEGGi sce:YPR187W.

    Organism-specific databases

    CYGDi YPR187w.
    SGDi S000006391. RPO26.

    Phylogenomic databases

    eggNOGi COG1758.
    GeneTreei ENSGT00390000010415.
    HOGENOMi HOG000225272.
    KOi K03014.
    OMAi INGGFGP.
    OrthoDBi EOG7MWH92.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34310-MONOMER.
    Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

    Miscellaneous databases

    EvolutionaryTracei P20435.
    NextBioi 981703.
    PROi P20435.

    Gene expression databases

    Genevestigatori P20435.

    Family and domain databases

    Gene3Di 3.90.940.10. 1 hit.
    HAMAPi MF_00192. RNApol_arch_K.
    InterProi IPR020708. DNA-dir_RNA_polK_14-18kDa_CS.
    IPR006110. Pol_omega/K/RPB6.
    IPR012293. RNAP_RPB6_omega.
    IPR028363. RPB6.
    IPR006111. RpoK/Rpb6.
    [Graphical view ]
    PANTHERi PTHR10773. PTHR10773. 1 hit.
    Pfami PF01192. RNA_pol_Rpb6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500154. RPB6. 1 hit.
    PIRSF000778. RpoK/RPB6. 1 hit.
    SUPFAMi SSF63562. SSF63562. 1 hit.
    PROSITEi PS01111. RNA_POL_K_14KD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Subunits shared by eukaryotic nuclear RNA polymerases."
      Woychik N.A., Liao S.-M., Kolodziej P.A., Young R.A.
      Genes Dev. 4:313-323(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "A suppressor of an RNA polymerase II mutation of Saccharomyces cerevisiae encodes a subunit common to RNA polymerases I, II, and III."
      Archambault J., Schappert K.T., Friesen J.D.
      Mol. Cell. Biol. 10:6123-6131(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Differential roles of phosphorylation in the formation of transcriptional active RNA polymerase I."
      Fath S., Milkereit P., Peyroche G., Riva M., Carles C., Tschochner H.
      Proc. Natl. Acad. Sci. U.S.A. 98:14334-14339(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
    6. "Rpa12p, a conserved RNA polymerase I subunit with two functional domains."
      Van Mullem V., Landrieux E., Vandenhaute J., Thuriaux P.
      Mol. Microbiol. 43:1105-1113(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
    7. "The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits."
      Peyroche G., Levillain E., Siaut M., Callebaut I., Schultz P., Sentenac A., Riva M., Carles C.
      Proc. Natl. Acad. Sci. U.S.A. 99:14670-14675(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX, INTERACTION WITH RPA43.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    10. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
      Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
      Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON THE RNA POL III COMPLEX, PHOSPHORYLATION.
    11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
      Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
      Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
    13. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
      Cramer P., Bushnell D.A., Kornberg R.D.
      Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    14. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
      Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
      Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    15. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
      Bushnell D.A., Cramer P., Kornberg R.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
    16. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
      Kettenberger H., Armache K.J., Cramer P.
      Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
    17. "Architecture of initiation-competent 12-subunit RNA polymerase II."
      Armache K.J., Kettenberger H., Cramer P.
      Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
    18. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
      Bushnell D.A., Kornberg R.D.
      Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    19. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
      Westover K.D., Bushnell D.A., Kornberg R.D.
      Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    20. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
      Kettenberger H., Armache K.J., Cramer P.
      Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
    21. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
      Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
      Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
    22. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
      Armache K.J., Mitterweger S., Meinhart A., Cramer P.
      J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
    23. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
      Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
      Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
    24. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
      Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
      Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
    25. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
      Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
      Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
    26. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
    27. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
    28. "RNA polymerase I structure and transcription regulation."
      Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
      Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiRPAB2_YEAST
    AccessioniPrimary (citable) accession number: P20435
    Secondary accession number(s): D6W4I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 153 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6090 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3