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P20434

- RPAB1_YEAST

UniProt

P20434 - RPAB1_YEAST

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Protein
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Gene
RPB5, RPA7, RPC9, YBR154C, YBR1204
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerase complexes are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.3 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase I activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
  2. tRNA transcription from RNA polymerase III promoter Source: SGD
  3. transcription from RNA polymerase I promoter Source: UniProtKB
  4. transcription from RNA polymerase II promoter Source: SGD
  5. transcription from RNA polymerase III promoter Source: SGD
  6. transcription, RNA-templated Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29104-MONOMER.
ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Short name:
RNA polymerases I, II, and III subunit ABC1
Alternative name(s):
ABC27
DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide
Gene namesi
Name:RPB5
Synonyms:RPA7, RPC9
Ordered Locus Names:YBR154C
ORF Names:YBR1204
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR154c.
SGDiS000000358. RPB5.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. DNA-directed RNA polymerase I complex Source: UniProtKB
  2. DNA-directed RNA polymerase II, core complex Source: SGD
  3. DNA-directed RNA polymerase III complex Source: SGD
  4. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215DNA-directed RNA polymerases I, II, and III subunit RPABC1UniRule annotation
PRO_0000146086Add
BLAST

Proteomic databases

MaxQBiP20434.
PaxDbiP20434.
PeptideAtlasiP20434.

Expressioni

Gene expression databases

GenevestigatoriP20434.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits: RPO21, RPB2, RPB3, RPB4, RPB5, RPO26, RPB7, RPB8, RPB9, RPB10 and RPC10. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RPB2P085188EBI-15781,EBI-15767

Protein-protein interaction databases

BioGridi32853. 89 interactions.
DIPiDIP-71N.
IntActiP20434. 49 interactions.
MINTiMINT-530046.
STRINGi4932.YBR154C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni3 – 53
Helixi7 – 2519
Helixi32 – 354
Helixi39 – 468
Beta strandi49 – 513
Helixi55 – 573
Beta strandi60 – 623
Helixi66 – 716
Beta strandi72 – 743
Beta strandi78 – 825
Beta strandi84 – 885
Helixi90 – 10213
Beta strandi106 – 11611
Helixi118 – 1214
Turni122 – 1254
Beta strandi127 – 1293
Beta strandi131 – 1366
Helixi137 – 1404
Helixi144 – 1463
Beta strandi147 – 1493
Beta strandi152 – 1554
Helixi158 – 16710
Helixi172 – 1743
Beta strandi177 – 1793
Beta strandi180 – 1823
Helixi183 – 1886
Beta strandi195 – 1995
Beta strandi204 – 2063
Beta strandi210 – 2145

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DZFX-ray1.90A1-215[»]
1I3QX-ray3.10E1-215[»]
1I50X-ray2.80E1-215[»]
1I6HX-ray3.30E1-215[»]
1K83X-ray2.80E1-215[»]
1NIKX-ray4.10E1-215[»]
1NT9X-ray4.20E1-215[»]
1PQVX-ray3.80E1-215[»]
1R5UX-ray4.50E1-215[»]
1R9SX-ray4.25E1-215[»]
1R9TX-ray3.50E1-215[»]
1SFOX-ray3.61E1-215[»]
1TWAX-ray3.20E1-215[»]
1TWCX-ray3.00E1-215[»]
1TWFX-ray2.30E1-215[»]
1TWGX-ray3.30E1-215[»]
1TWHX-ray3.40E1-215[»]
1WCMX-ray3.80E1-215[»]
1Y1VX-ray3.80E1-215[»]
1Y1WX-ray4.00E1-215[»]
1Y1YX-ray4.00E1-215[»]
1Y77X-ray4.50E1-215[»]
2B63X-ray3.80E1-215[»]
2B8KX-ray4.15E1-215[»]
2E2HX-ray3.95E1-215[»]
2E2IX-ray3.41E1-215[»]
2E2JX-ray3.50E1-215[»]
2JA5X-ray3.80E1-215[»]
2JA6X-ray4.00E1-215[»]
2JA7X-ray3.80E/Q1-215[»]
2JA8X-ray3.80E1-215[»]
2NVQX-ray2.90E1-215[»]
2NVTX-ray3.36E1-215[»]
2NVXX-ray3.60E1-215[»]
2NVYX-ray3.40E1-215[»]
2NVZX-ray4.30E1-215[»]
2R7ZX-ray3.80E1-215[»]
2R92X-ray3.80E1-215[»]
2R93X-ray4.00E1-215[»]
2VUMX-ray3.40E1-215[»]
2YU9X-ray3.40E1-215[»]
3CQZX-ray2.80E1-215[»]
3FKIX-ray3.88E1-215[»]
3GTGX-ray3.78E1-215[»]
3GTJX-ray3.42E1-215[»]
3GTKX-ray3.80E1-215[»]
3GTLX-ray3.38E1-215[»]
3GTMX-ray3.80E1-215[»]
3GTOX-ray4.00E1-215[»]
3GTPX-ray3.90E1-215[»]
3GTQX-ray3.80E1-215[»]
3H3VX-ray4.00F1-215[»]
3HOUX-ray3.20E/Q1-215[»]
3HOVX-ray3.50E1-215[»]
3HOWX-ray3.60E1-215[»]
3HOXX-ray3.65E1-215[»]
3HOYX-ray3.40E1-215[»]
3HOZX-ray3.65E1-215[»]
3I4MX-ray3.70E1-215[»]
3I4NX-ray3.90E1-215[»]
3J0Kelectron microscopy36.00E1-215[»]
3J1Nelectron microscopy16.00E1-215[»]
3K1FX-ray4.30E1-215[»]
3K7AX-ray3.80E1-215[»]
3M3YX-ray3.18E1-215[»]
3M4OX-ray3.57E1-215[»]
3PO2X-ray3.30E1-215[»]
3PO3X-ray3.30E1-215[»]
3QT1X-ray4.30E1-215[»]
3RZDX-ray3.30E1-215[»]
3RZOX-ray3.00E1-215[»]
3S14X-ray2.85E1-215[»]
3S15X-ray3.30E1-215[»]
3S16X-ray3.24E1-215[»]
3S17X-ray3.20E1-215[»]
3S1MX-ray3.13E1-215[»]
3S1NX-ray3.10E1-215[»]
3S1QX-ray3.30E1-215[»]
3S1RX-ray3.20E1-215[»]
3S2DX-ray3.20E1-215[»]
3S2HX-ray3.30E1-215[»]
4A3BX-ray3.50E1-215[»]
4A3CX-ray3.50E1-215[»]
4A3DX-ray3.40E1-215[»]
4A3EX-ray3.40E1-215[»]
4A3FX-ray3.50E1-215[»]
4A3GX-ray3.50E1-215[»]
4A3IX-ray3.80E1-215[»]
4A3JX-ray3.70E1-215[»]
4A3KX-ray3.50E1-215[»]
4A3LX-ray3.50E1-215[»]
4A3MX-ray3.90E1-215[»]
4A93X-ray3.40E1-215[»]
4BBRX-ray3.40E1-215[»]
4BBSX-ray3.60E1-215[»]
4BXXX-ray3.28E1-215[»]
4BXZX-ray4.80E1-215[»]
4BY1X-ray3.60E1-215[»]
4BY7X-ray3.15E1-215[»]
4C2MX-ray2.80E/T1-215[»]
4C3HX-ray3.27E1-215[»]
4C3IX-ray3.0E1-215[»]
4C3JX-ray3.35E1-215[»]
ProteinModelPortaliP20434.
SMRiP20434. Positions 1-215.

Miscellaneous databases

EvolutionaryTraceiP20434.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2012.
GeneTreeiENSGT00390000013841.
HOGENOMiHOG000205213.
KOiK03013.
OMAiDEAETYK.
OrthoDBiEOG7XPZJ6.

Family and domain databases

Gene3Di3.40.1340.10. 1 hit.
3.90.940.20. 1 hit.
HAMAPiMF_00025. RNApol_RpoH_RPB5.
InterProiIPR014381. DNA_RNA_pol_RPB5_euk/virus.
IPR005571. RNA_pol_Rpb5_N.
IPR000783. RNA_pol_subH/Rpb5_C.
IPR020608. RNA_pol_subH/Rpb5_CS.
IPR020609. RpoH/RPB5.
[Graphical view]
PfamiPF01191. RNA_pol_Rpb5_C. 1 hit.
PF03871. RNA_pol_Rpb5_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000747. RPB5. 1 hit.
ProDomiPD005155. RNA_pol_subH/Rpb5_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53036. SSF53036. 1 hit.
SSF55287. SSF55287. 1 hit.
PROSITEiPS01110. RNA_POL_H_23KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20434-1 [UniParc]FASTAAdd to Basket

« Hide

MDQENERNIS RLWRAFRTVK EMVKDRGYFI TQEEVELPLE DFKAKYCDSM    50
GRPQRKMMSF QANPTEESIS KFPDMGSLWV EFCDEPSVGV KTMKTFVIHI 100
QEKNFQTGIF VYQNNITPSA MKLVPSIPPA TIETFNEAAL VVNITHHELV 150
PKHIRLSSDE KRELLKRYRL KESQLPRIQR ADPVALYLGL KRGEVVKIIR 200
KSETSGRYAS YRICM 215
Length:215
Mass (Da):25,079
Last modified:February 1, 1991 - v1
Checksum:i2A15F7114D69D829
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371L → W in AAC60556. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53287 Genomic DNA. Translation: CAA37381.1.
X71329 Genomic DNA. Translation: CAA50472.1.
S59774 Genomic DNA. Translation: AAC60556.1.
Z36023 Genomic DNA. Translation: CAA85113.1.
BK006936 Genomic DNA. Translation: DAA07269.1.
PIRiA34588.
RefSeqiNP_009712.1. NM_001178502.1.

Genome annotation databases

EnsemblFungiiYBR154C; YBR154C; YBR154C.
GeneIDi852451.
KEGGisce:YBR154C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53287 Genomic DNA. Translation: CAA37381.1 .
X71329 Genomic DNA. Translation: CAA50472.1 .
S59774 Genomic DNA. Translation: AAC60556.1 .
Z36023 Genomic DNA. Translation: CAA85113.1 .
BK006936 Genomic DNA. Translation: DAA07269.1 .
PIRi A34588.
RefSeqi NP_009712.1. NM_001178502.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DZF X-ray 1.90 A 1-215 [» ]
1I3Q X-ray 3.10 E 1-215 [» ]
1I50 X-ray 2.80 E 1-215 [» ]
1I6H X-ray 3.30 E 1-215 [» ]
1K83 X-ray 2.80 E 1-215 [» ]
1NIK X-ray 4.10 E 1-215 [» ]
1NT9 X-ray 4.20 E 1-215 [» ]
1PQV X-ray 3.80 E 1-215 [» ]
1R5U X-ray 4.50 E 1-215 [» ]
1R9S X-ray 4.25 E 1-215 [» ]
1R9T X-ray 3.50 E 1-215 [» ]
1SFO X-ray 3.61 E 1-215 [» ]
1TWA X-ray 3.20 E 1-215 [» ]
1TWC X-ray 3.00 E 1-215 [» ]
1TWF X-ray 2.30 E 1-215 [» ]
1TWG X-ray 3.30 E 1-215 [» ]
1TWH X-ray 3.40 E 1-215 [» ]
1WCM X-ray 3.80 E 1-215 [» ]
1Y1V X-ray 3.80 E 1-215 [» ]
1Y1W X-ray 4.00 E 1-215 [» ]
1Y1Y X-ray 4.00 E 1-215 [» ]
1Y77 X-ray 4.50 E 1-215 [» ]
2B63 X-ray 3.80 E 1-215 [» ]
2B8K X-ray 4.15 E 1-215 [» ]
2E2H X-ray 3.95 E 1-215 [» ]
2E2I X-ray 3.41 E 1-215 [» ]
2E2J X-ray 3.50 E 1-215 [» ]
2JA5 X-ray 3.80 E 1-215 [» ]
2JA6 X-ray 4.00 E 1-215 [» ]
2JA7 X-ray 3.80 E/Q 1-215 [» ]
2JA8 X-ray 3.80 E 1-215 [» ]
2NVQ X-ray 2.90 E 1-215 [» ]
2NVT X-ray 3.36 E 1-215 [» ]
2NVX X-ray 3.60 E 1-215 [» ]
2NVY X-ray 3.40 E 1-215 [» ]
2NVZ X-ray 4.30 E 1-215 [» ]
2R7Z X-ray 3.80 E 1-215 [» ]
2R92 X-ray 3.80 E 1-215 [» ]
2R93 X-ray 4.00 E 1-215 [» ]
2VUM X-ray 3.40 E 1-215 [» ]
2YU9 X-ray 3.40 E 1-215 [» ]
3CQZ X-ray 2.80 E 1-215 [» ]
3FKI X-ray 3.88 E 1-215 [» ]
3GTG X-ray 3.78 E 1-215 [» ]
3GTJ X-ray 3.42 E 1-215 [» ]
3GTK X-ray 3.80 E 1-215 [» ]
3GTL X-ray 3.38 E 1-215 [» ]
3GTM X-ray 3.80 E 1-215 [» ]
3GTO X-ray 4.00 E 1-215 [» ]
3GTP X-ray 3.90 E 1-215 [» ]
3GTQ X-ray 3.80 E 1-215 [» ]
3H3V X-ray 4.00 F 1-215 [» ]
3HOU X-ray 3.20 E/Q 1-215 [» ]
3HOV X-ray 3.50 E 1-215 [» ]
3HOW X-ray 3.60 E 1-215 [» ]
3HOX X-ray 3.65 E 1-215 [» ]
3HOY X-ray 3.40 E 1-215 [» ]
3HOZ X-ray 3.65 E 1-215 [» ]
3I4M X-ray 3.70 E 1-215 [» ]
3I4N X-ray 3.90 E 1-215 [» ]
3J0K electron microscopy 36.00 E 1-215 [» ]
3J1N electron microscopy 16.00 E 1-215 [» ]
3K1F X-ray 4.30 E 1-215 [» ]
3K7A X-ray 3.80 E 1-215 [» ]
3M3Y X-ray 3.18 E 1-215 [» ]
3M4O X-ray 3.57 E 1-215 [» ]
3PO2 X-ray 3.30 E 1-215 [» ]
3PO3 X-ray 3.30 E 1-215 [» ]
3QT1 X-ray 4.30 E 1-215 [» ]
3RZD X-ray 3.30 E 1-215 [» ]
3RZO X-ray 3.00 E 1-215 [» ]
3S14 X-ray 2.85 E 1-215 [» ]
3S15 X-ray 3.30 E 1-215 [» ]
3S16 X-ray 3.24 E 1-215 [» ]
3S17 X-ray 3.20 E 1-215 [» ]
3S1M X-ray 3.13 E 1-215 [» ]
3S1N X-ray 3.10 E 1-215 [» ]
3S1Q X-ray 3.30 E 1-215 [» ]
3S1R X-ray 3.20 E 1-215 [» ]
3S2D X-ray 3.20 E 1-215 [» ]
3S2H X-ray 3.30 E 1-215 [» ]
4A3B X-ray 3.50 E 1-215 [» ]
4A3C X-ray 3.50 E 1-215 [» ]
4A3D X-ray 3.40 E 1-215 [» ]
4A3E X-ray 3.40 E 1-215 [» ]
4A3F X-ray 3.50 E 1-215 [» ]
4A3G X-ray 3.50 E 1-215 [» ]
4A3I X-ray 3.80 E 1-215 [» ]
4A3J X-ray 3.70 E 1-215 [» ]
4A3K X-ray 3.50 E 1-215 [» ]
4A3L X-ray 3.50 E 1-215 [» ]
4A3M X-ray 3.90 E 1-215 [» ]
4A93 X-ray 3.40 E 1-215 [» ]
4BBR X-ray 3.40 E 1-215 [» ]
4BBS X-ray 3.60 E 1-215 [» ]
4BXX X-ray 3.28 E 1-215 [» ]
4BXZ X-ray 4.80 E 1-215 [» ]
4BY1 X-ray 3.60 E 1-215 [» ]
4BY7 X-ray 3.15 E 1-215 [» ]
4C2M X-ray 2.80 E/T 1-215 [» ]
4C3H X-ray 3.27 E 1-215 [» ]
4C3I X-ray 3.0 E 1-215 [» ]
4C3J X-ray 3.35 E 1-215 [» ]
ProteinModelPortali P20434.
SMRi P20434. Positions 1-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32853. 89 interactions.
DIPi DIP-71N.
IntActi P20434. 49 interactions.
MINTi MINT-530046.
STRINGi 4932.YBR154C.

Proteomic databases

MaxQBi P20434.
PaxDbi P20434.
PeptideAtlasi P20434.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR154C ; YBR154C ; YBR154C .
GeneIDi 852451.
KEGGi sce:YBR154C.

Organism-specific databases

CYGDi YBR154c.
SGDi S000000358. RPB5.

Phylogenomic databases

eggNOGi COG2012.
GeneTreei ENSGT00390000013841.
HOGENOMi HOG000205213.
KOi K03013.
OMAi DEAETYK.
OrthoDBi EOG7XPZJ6.

Enzyme and pathway databases

BioCyci YEAST:G3O-29104-MONOMER.
Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

Miscellaneous databases

EvolutionaryTracei P20434.
NextBioi 971369.
PROi P20434.

Gene expression databases

Genevestigatori P20434.

Family and domain databases

Gene3Di 3.40.1340.10. 1 hit.
3.90.940.20. 1 hit.
HAMAPi MF_00025. RNApol_RpoH_RPB5.
InterProi IPR014381. DNA_RNA_pol_RPB5_euk/virus.
IPR005571. RNA_pol_Rpb5_N.
IPR000783. RNA_pol_subH/Rpb5_C.
IPR020608. RNA_pol_subH/Rpb5_CS.
IPR020609. RpoH/RPB5.
[Graphical view ]
Pfami PF01191. RNA_pol_Rpb5_C. 1 hit.
PF03871. RNA_pol_Rpb5_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000747. RPB5. 1 hit.
ProDomi PD005155. RNA_pol_subH/Rpb5_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF53036. SSF53036. 1 hit.
SSF55287. SSF55287. 1 hit.
PROSITEi PS01110. RNA_POL_H_23KD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subunits shared by eukaryotic nuclear RNA polymerases."
    Woychik N.A., Liao S.-M., Kolodziej P.A., Young R.A.
    Genes Dev. 4:313-323(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of a 4.8 kb fragment of Saccharomyces cerevisiae chromosome II including three essential open reading frames."
    Baur A., Schaaff-Gerstenschlaeger I., Boles E., Miosga T., Rose M., Zimmermann F.K.
    Yeast 9:289-293(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
    Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
    Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE RNA POL III COMPLEX.
  6. "Differential roles of phosphorylation in the formation of transcriptional active RNA polymerase I."
    Fath S., Milkereit P., Peyroche G., Riva M., Carles C., Tschochner H.
    Proc. Natl. Acad. Sci. U.S.A. 98:14334-14339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
  7. "Rpa12p, a conserved RNA polymerase I subunit with two functional domains."
    Van Mullem V., Landrieux E., Vandenhaute J., Thuriaux P.
    Mol. Microbiol. 43:1105-1113(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
  8. "The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits."
    Peyroche G., Levillain E., Siaut M., Callebaut I., Schultz P., Sentenac A., Riva M., Carles C.
    Proc. Natl. Acad. Sci. U.S.A. 99:14670-14675(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POL I COMPLEX.
  9. "Crystal structure of RPB5, a universal eukaryotic RNA polymerase subunit and transcription factor interaction target."
    Todone F., Weinzierl R.O.J., Brick P., Onesti S.
    Proc. Natl. Acad. Sci. U.S.A. 97:6306-6310(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  10. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX.
  11. "Structural basis of transcription: RNA polymerase II at 2.8 A resolution."
    Cramer P., Bushnell D.A., Kornberg R.D.
    Science 292:1863-1876(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  12. "Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution."
    Gnatt A.L., Cramer P., Fu J., Bushnell D.A., Kornberg R.D.
    Science 292:1876-1882(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  13. "Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution."
    Bushnell D.A., Cramer P., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:1218-1222(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE RNA POL II CORE COMPLEX IN COMPLEX WITH ALPHA-AMANITIN.
  14. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  15. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  16. "Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription."
    Bushnell D.A., Kornberg R.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:6969-6973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  17. "Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center."
    Westover K.D., Bushnell D.A., Kornberg R.D.
    Cell 119:481-489(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  18. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS).
  19. "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms."
    Bushnell D.A., Westover K.D., Davis R.E., Kornberg R.D.
    Science 303:983-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II CORE COMPLEX.
  20. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  21. "Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model."
    Jasiak A.J., Armache K.J., Martens B., Jansen R.P., Cramer P.
    Mol. Cell 23:71-81(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE POL III CORE COMPLEX.
  22. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  23. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.
  24. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.00 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  25. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.
  26. "RNA polymerase I structure and transcription regulation."
    Engel C., Sainsbury S., Cheung A.C., Kostrewa D., Cramer P.
    Nature 502:650-655(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE POL I COMPLEX, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiRPAB1_YEAST
AccessioniPrimary (citable) accession number: P20434
Secondary accession number(s): D6VQE9, Q02121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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