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P20433

- RPB4_YEAST

UniProt

P20433 - RPB4_YEAST

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Protein
DNA-directed RNA polymerase II subunit RPB4
Gene
RPB4, YJL140W, J0654
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. The RPB4-RPB7 subcomplex is necessary for promoter-directed transcription initiation but is not required for recruitment of Pol II to active preinitiation complexes and seems to be dispensable for transcription elongation and termination. The RPB4-RPB7 subcomplex recruits FCP1 to Pol II. Involved in DNA repair of damage in the transcribed strand. RPB4 is dispensable under optimal growth conditions, but becomes essential during heat or cold shock and under nutrient depletion. Suppresses the RBP9-mediated transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER) but facilitates the RAD26-mediated TCR subpathway. Under stress conditions only, involved in mRNA export to the cytoplasm. Involved in mRNA decay. Promotes or enhances the deadenylation process of specific mRNAs and may recruit PAT1 and the LSM1-7 complex to these mRNAs, thus stimulating their decapping and further decay.7 Publications

GO - Molecular functioni

  1. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. protein binding Source: IntAct
  4. translation initiation factor binding Source: SGD

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. mRNA export from nucleus in response to heat stress Source: SGD
  3. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: SGD
  4. positive regulation of translational initiation Source: SGD
  5. recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex Source: SGD
  6. transcription from RNA polymerase II promoter Source: SGD
  7. transcription initiation from RNA polymerase II promoter Source: SGD
  8. transcription, RNA-templated Source: GOC
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, mRNA processing, Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-31585-MONOMER.
ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB4
Short name:
RNA polymerase II subunit B4
Alternative name(s):
B32
DNA-directed RNA polymerase II 32 kDa polypeptide
Gene namesi
Name:RPB4
Ordered Locus Names:YJL140W
ORF Names:J0654
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL140w.
SGDiS000003676. RPB4.

Subcellular locationi

Nucleus. Cytoplasm. CytoplasmP-body
Note: Seems to shuttle between nucleus and cytoplasm in a complex with RPB7.2 Publications

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, core complex Source: SGD
  2. cytoplasm Source: SGD
  3. cytoplasmic mRNA processing body Source: SGD
  4. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221DNA-directed RNA polymerase II subunit RPB4
PRO_0000073984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei91 – 911Phosphothreonine1 Publication
Modified residuei92 – 921Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP20433.
PaxDbiP20433.
PeptideAtlasiP20433.

Expressioni

Gene expression databases

GenevestigatoriP20433.

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a dissociable subcomplex associated with the 10-subunit Pol II core complex. In exponentially proliferating cells, only approximative 20 % of the Pol II complexes contain the RPB4-RPB7 subcomplex. In starving cells, that enter stationary phase, RPB4-RPB7 is associated with Pol II in a stoechiometric manner. The RPB4-RPB7 subcomplex probably associates with TFG1. Interacts with LSM2 and PAT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NIP1P324975EBI-15777,EBI-8965
RPB7P340874EBI-15777,EBI-15790

Protein-protein interaction databases

BioGridi33617. 119 interactions.
DIPiDIP-55N.
IntActiP20433. 20 interactions.
MINTiMINT-538215.
STRINGi4932.YJL140W.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83
Helixi17 – 193
Beta strandi24 – 274
Helixi31 – 333
Beta strandi35 – 384
Turni40 – 423
Beta strandi44 – 463
Beta strandi47 – 504
Helixi52 – 7120
Turni73 – 753
Helixi119 – 13315
Helixi139 – 15113
Helixi157 – 16812
Turni169 – 1713
Helixi174 – 1829
Helixi188 – 1947
Helixi196 – 1983
Turni199 – 2013
Helixi204 – 21714

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NT9X-ray4.20D1-221[»]
1PQVX-ray3.80D1-85[»]
D115-221[»]
1WCMX-ray3.80D4-221[»]
1Y14X-ray2.30A/C35-221[»]
1Y1VX-ray3.80D1-221[»]
1Y1WX-ray4.00D1-221[»]
1Y1YX-ray4.00D1-221[»]
1Y77X-ray4.50D1-221[»]
2B63X-ray3.80D1-221[»]
2B8KX-ray4.15D1-221[»]
2JA5X-ray3.80D1-221[»]
2JA6X-ray4.00D1-221[»]
2JA7X-ray3.80D/P1-221[»]
2JA8X-ray3.80D1-221[»]
2R7ZX-ray3.80D1-221[»]
2R92X-ray3.80D1-221[»]
2R93X-ray4.00D1-221[»]
2VUMX-ray3.40D1-221[»]
3FKIX-ray3.88D1-221[»]
3H3VX-ray4.00E1-221[»]
3HOUX-ray3.20D/P1-221[»]
3HOVX-ray3.50D1-221[»]
3HOWX-ray3.60D1-221[»]
3HOXX-ray3.65D1-221[»]
3HOYX-ray3.40D1-221[»]
3HOZX-ray3.65D1-221[»]
3I4MX-ray3.70D1-221[»]
3I4NX-ray3.90D1-221[»]
3J0Kelectron microscopy36.00D1-221[»]
3J1Nelectron microscopy16.00D4-221[»]
3K1FX-ray4.30D1-221[»]
3PO2X-ray3.30D1-221[»]
3PO3X-ray3.30D1-221[»]
3QT1X-ray4.30D3-221[»]
4A3BX-ray3.50D1-221[»]
4A3CX-ray3.50D1-221[»]
4A3DX-ray3.40D1-221[»]
4A3EX-ray3.40D1-221[»]
4A3FX-ray3.50D1-221[»]
4A3GX-ray3.50D1-221[»]
4A3IX-ray3.80D1-221[»]
4A3JX-ray3.70D1-221[»]
4A3KX-ray3.50D1-221[»]
4A3LX-ray3.50D1-221[»]
4A3MX-ray3.90D1-221[»]
4A93X-ray3.40D1-221[»]
4BBRX-ray3.40D1-221[»]
4BBSX-ray3.60D1-221[»]
4BXXX-ray3.28D1-221[»]
4BXZX-ray4.80D1-221[»]
4BY1X-ray3.60D1-221[»]
4BY7X-ray3.15D1-221[»]
ProteinModelPortaliP20433.
SMRiP20433. Positions 1-221.

Miscellaneous databases

EvolutionaryTraceiP20433.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5250.
GeneTreeiENSGT00390000004912.
HOGENOMiHOG000195281.
KOiK03012.
OMAiGTLECED.
OrthoDBiEOG7NW6NW.

Family and domain databases

InterProiIPR010997. HRDC-like.
IPR005574. RNA_pol_II_Rpb4.
IPR006590. RNA_pol_II_Rpb4_core.
[Graphical view]
PfamiPF03874. RNA_pol_Rpb4. 1 hit.
[Graphical view]
SMARTiSM00657. RPOL4c. 1 hit.
[Graphical view]
SUPFAMiSSF47819. SSF47819. 1 hit.

Sequencei

Sequence statusi: Complete.

P20433-1 [UniParc]FASTAAdd to Basket

« Hide

MNVSTSTFQT RRRRLKKVEE EENAATLQLG QEFQLKQINH QGEEEELIAL    50
NLSEARLVIK EALVERRRAF KRSQKKHKKK HLKHENANDE TTAVEDEDDD 100
LDEDDVNADD DDFMHSETRE KELESIDVLL EQTTGGNNKD LKNTMQYLTN 150
FSRFRDQETV GAVIQLLKST GLHPFEVAQL GSLACDTADE AKTLIPSLNN 200
KISDDELERI LKELSNLETL Y 221
Length:221
Mass (Da):25,414
Last modified:February 1, 1991 - v1
Checksum:i72A8A26871B87775
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27253 Genomic DNA. Translation: AAA34996.1.
X58099 Genomic DNA. Translation: CAA41112.1.
X87371 Genomic DNA. Translation: CAA60815.1.
Z49415 Genomic DNA. Translation: CAA89435.1.
AY557856 Genomic DNA. Translation: AAS56182.1.
BK006943 Genomic DNA. Translation: DAA08660.1.
PIRiA32490.
RefSeqiNP_012395.1. NM_001181573.1.

Genome annotation databases

EnsemblFungiiYJL140W; YJL140W; YJL140W.
GeneIDi853301.
KEGGisce:YJL140W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27253 Genomic DNA. Translation: AAA34996.1 .
X58099 Genomic DNA. Translation: CAA41112.1 .
X87371 Genomic DNA. Translation: CAA60815.1 .
Z49415 Genomic DNA. Translation: CAA89435.1 .
AY557856 Genomic DNA. Translation: AAS56182.1 .
BK006943 Genomic DNA. Translation: DAA08660.1 .
PIRi A32490.
RefSeqi NP_012395.1. NM_001181573.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NT9 X-ray 4.20 D 1-221 [» ]
1PQV X-ray 3.80 D 1-85 [» ]
D 115-221 [» ]
1WCM X-ray 3.80 D 4-221 [» ]
1Y14 X-ray 2.30 A/C 35-221 [» ]
1Y1V X-ray 3.80 D 1-221 [» ]
1Y1W X-ray 4.00 D 1-221 [» ]
1Y1Y X-ray 4.00 D 1-221 [» ]
1Y77 X-ray 4.50 D 1-221 [» ]
2B63 X-ray 3.80 D 1-221 [» ]
2B8K X-ray 4.15 D 1-221 [» ]
2JA5 X-ray 3.80 D 1-221 [» ]
2JA6 X-ray 4.00 D 1-221 [» ]
2JA7 X-ray 3.80 D/P 1-221 [» ]
2JA8 X-ray 3.80 D 1-221 [» ]
2R7Z X-ray 3.80 D 1-221 [» ]
2R92 X-ray 3.80 D 1-221 [» ]
2R93 X-ray 4.00 D 1-221 [» ]
2VUM X-ray 3.40 D 1-221 [» ]
3FKI X-ray 3.88 D 1-221 [» ]
3H3V X-ray 4.00 E 1-221 [» ]
3HOU X-ray 3.20 D/P 1-221 [» ]
3HOV X-ray 3.50 D 1-221 [» ]
3HOW X-ray 3.60 D 1-221 [» ]
3HOX X-ray 3.65 D 1-221 [» ]
3HOY X-ray 3.40 D 1-221 [» ]
3HOZ X-ray 3.65 D 1-221 [» ]
3I4M X-ray 3.70 D 1-221 [» ]
3I4N X-ray 3.90 D 1-221 [» ]
3J0K electron microscopy 36.00 D 1-221 [» ]
3J1N electron microscopy 16.00 D 4-221 [» ]
3K1F X-ray 4.30 D 1-221 [» ]
3PO2 X-ray 3.30 D 1-221 [» ]
3PO3 X-ray 3.30 D 1-221 [» ]
3QT1 X-ray 4.30 D 3-221 [» ]
4A3B X-ray 3.50 D 1-221 [» ]
4A3C X-ray 3.50 D 1-221 [» ]
4A3D X-ray 3.40 D 1-221 [» ]
4A3E X-ray 3.40 D 1-221 [» ]
4A3F X-ray 3.50 D 1-221 [» ]
4A3G X-ray 3.50 D 1-221 [» ]
4A3I X-ray 3.80 D 1-221 [» ]
4A3J X-ray 3.70 D 1-221 [» ]
4A3K X-ray 3.50 D 1-221 [» ]
4A3L X-ray 3.50 D 1-221 [» ]
4A3M X-ray 3.90 D 1-221 [» ]
4A93 X-ray 3.40 D 1-221 [» ]
4BBR X-ray 3.40 D 1-221 [» ]
4BBS X-ray 3.60 D 1-221 [» ]
4BXX X-ray 3.28 D 1-221 [» ]
4BXZ X-ray 4.80 D 1-221 [» ]
4BY1 X-ray 3.60 D 1-221 [» ]
4BY7 X-ray 3.15 D 1-221 [» ]
ProteinModelPortali P20433.
SMRi P20433. Positions 1-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33617. 119 interactions.
DIPi DIP-55N.
IntActi P20433. 20 interactions.
MINTi MINT-538215.
STRINGi 4932.YJL140W.

Proteomic databases

MaxQBi P20433.
PaxDbi P20433.
PeptideAtlasi P20433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL140W ; YJL140W ; YJL140W .
GeneIDi 853301.
KEGGi sce:YJL140W.

Organism-specific databases

CYGDi YJL140w.
SGDi S000003676. RPB4.

Phylogenomic databases

eggNOGi COG5250.
GeneTreei ENSGT00390000004912.
HOGENOMi HOG000195281.
KOi K03012.
OMAi GTLECED.
OrthoDBi EOG7NW6NW.

Enzyme and pathway databases

BioCyci YEAST:G3O-31585-MONOMER.
Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

Miscellaneous databases

EvolutionaryTracei P20433.
NextBioi 973621.
PROi P20433.

Gene expression databases

Genevestigatori P20433.

Family and domain databases

InterProi IPR010997. HRDC-like.
IPR005574. RNA_pol_II_Rpb4.
IPR006590. RNA_pol_II_Rpb4_core.
[Graphical view ]
Pfami PF03874. RNA_pol_Rpb4. 1 hit.
[Graphical view ]
SMARTi SM00657. RPOL4c. 1 hit.
[Graphical view ]
SUPFAMi SSF47819. SSF47819. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RNA polymerase II subunit RPB4 is essential for high- and low-temperature yeast cell growth."
    Woychik N.A., Young R.A.
    Mol. Cell. Biol. 9:2854-2859(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The Saccharomyces cerevisiae RPB4 gene is tightly linked to the TIF2 gene."
    Foreman P.K., Davis R.W., Sachs A.B.
    Nucleic Acids Res. 19:2781-2781(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
    Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
    Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  4. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. "Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro."
    Edwards A.M., Kane C.M., Young R.A., Kornberg R.D.
    J. Biol. Chem. 266:71-75(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPB4-RPB7 COMPLEX.
  8. "Dissociable Rpb4-Rpb7 subassembly of RNA polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation."
    Orlicky S.M., Tran P.T., Sayre M.H., Edwards A.M.
    J. Biol. Chem. 276:10097-10102(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPB4-RPB7 COMPLEX.
  9. "Rpb4, a non-essential subunit of core RNA polymerase II of Saccharomyces cerevisiae is important for activated transcription of a subset of genes."
    Pillai B., Sampath V., Sharma N., Sadhale P.
    J. Biol. Chem. 276:30641-30647(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Rpb4 and Rpb9 mediate subpathways of transcription-coupled DNA repair in Saccharomyces cerevisiae."
    Li S., Smerdon M.J.
    EMBO J. 21:5921-5929(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN DNA REPAIR.
  11. "Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress."
    Farago M., Nahari T., Hammel C., Cole C.N., Choder M.
    Mol. Biol. Cell 14:2744-2755(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MRNA EXPORT.
  12. "Structure and mechanism of RNA polymerase II CTD phosphatases."
    Kamenski T., Heilmeier S., Meinhart A., Cramer P.
    Mol. Cell 15:399-407(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPB4-RPB7 COMPLEX.
  13. "The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs."
    Lotan R., Bar-On V.G., Harel-Sharvit L., Duek L., Melamed D., Choder M.
    Genes Dev. 19:3004-3016(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MRNA DECAY, SUBCELLULAR LOCATION, INTERACTION WITH PAT1 AND LSM2.
  14. "Nucleocytoplasmic shuttling of the Rpb4p and Rpb7p subunits of Saccharomyces cerevisiae RNA polymerase II by two pathways."
    Selitrennik M., Duek L., Lotan R., Choder M.
    Eukaryot. Cell 5:2092-2103(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  15. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91 AND THR-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "RNA polymerase II/TFIIF structure and conserved organization of the initiation complex."
    Chung W.H., Craighead J.L., Chang W.H., Ezeokonkwo C., Bareket-Samish A., Kornberg R.D., Asturias F.J.
    Mol. Cell 12:1003-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE RNA POL II/TFIIF COMPLEX, INTERACTION WITH TFG1.
  18. "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage."
    Kettenberger H., Armache K.J., Cramer P.
    Cell 114:347-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH DST1.
  19. "Architecture of initiation-competent 12-subunit RNA polymerase II."
    Armache K.J., Kettenberger H., Cramer P.
    Proc. Natl. Acad. Sci. U.S.A. 100:6964-6968(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.2 ANGSTROMS) OF THE RNA POL II COMPLEX.
  20. "Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS."
    Kettenberger H., Armache K.J., Cramer P.
    Mol. Cell 16:955-965(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.5 ANGSTROMS) OF THE RNA POL II COMPLEX.
  21. "Structures of complete RNA polymerase II and its subcomplex, Rpb4/7."
    Armache K.J., Mitterweger S., Meinhart A., Cramer P.
    J. Biol. Chem. 280:7131-7134(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX.
  22. "Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs."
    Kettenberger H., Eisenfuhr A., Brueckner F., Theis M., Famulok M., Cramer P.
    Nat. Struct. Mol. Biol. 13:44-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) OF THE RNA POL II COMPLEX IN COMPLEX WITH INHIBITING NON-CODING RNA.
  23. "Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model."
    Meyer P.A., Ye P., Zhang M., Suh M.H., Fu J.
    Structure 14:973-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.15 ANGSTROMS) OF THE RNA POL II COMPLEX.

Entry informationi

Entry nameiRPB4_YEAST
AccessioniPrimary (citable) accession number: P20433
Secondary accession number(s): D6VW44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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