Fcer1g

Functionⁱ

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin (By similarity).By similarity

GO - Molecular functionⁱ

IgE binding
Source: RGD
Inferred from sequence orthologyⁱ
- 2527850
IgE receptor activity
Source: RGD
Inferred from sequence orthologyⁱ
- 14764707
IgG binding
Source: RGD
Inferred from sequence orthologyⁱ
- 14643301
protein homodimerization activity
Source: RGD
Inferred from sequence orthologyⁱ
- 14967045

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	IgE-binding protein, Receptor

Molecular function

IgE-binding protein, Receptor

Enzyme and pathway databases

Reactomeⁱ	R-RNO-114604 GPVI-mediated activation cascade R-RNO-202733 Cell surface interactions at the vascular wall R-RNO-2454202 Fc epsilon receptor (FCERI) signaling R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-RNO-2871796 FCERI mediated MAPK activation R-RNO-2871809 FCERI mediated Ca+2 mobilization R-RNO-2871837 FCERI mediated NF-kB activation R-RNO-6798695 Neutrophil degranulation R-RNO-75892 Platelet Adhesion to exposed collagen

Reactomeⁱ

R-RNO-114604 GPVI-mediated activation cascade
R-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-2454202 Fc epsilon receptor (FCERI) signaling
R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-RNO-2871796 FCERI mediated MAPK activation
R-RNO-2871809 FCERI mediated Ca+2 mobilization
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-6798695 Neutrophil degranulation
R-RNO-75892 Platelet Adhesion to exposed collagen

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: High affinity immunoglobulin epsilon receptor subunit gamma Alternative name(s): Fc receptor gamma-chain Short name: FcRgamma Fc-epsilon RI-gamma IgE Fc receptor subunit gamma Short name: FceRI gamma
Gene namesⁱ	Name:Fcer1g Synonyms:Fce1g
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 13

Organism-specific databases

Rat genome database More...RGDⁱ	2599 Fcer1g

RGDⁱ

2599 Fcer1g

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 23	ExtracellularSequence analysis	5
Transmembraneⁱ	24 – 44	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	45 – 86	CytoplasmicSequence analysisAdd BLAST	42

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000016505	19 – 86	High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST		68

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	25	InterchainBy similarity
Modified residueⁱ	65	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	76	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	78	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbⁱ	P20411
PRIDEⁱ	P20411

PTM databases

iPTMnetⁱ	P20411
PhosphoSitePlusⁱ	P20411

Expressionⁱ

Tissue specificityⁱ

Expressed in leukocytes and pinealocytes. Expression in the pineal gland does not undergo circadian variations.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000024159
ExpressionAtlasⁱ	P20411 baseline and differential
Genevisibleⁱ	P20411 RN

Interactionⁱ

Subunit structureⁱ

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages. Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD. Interacts with TARM1.By similarity

GO - Molecular functionⁱ

protein homodimerization activity
Source: RGD
Inferred from sequence orthologyⁱ
- 14967045

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	2474762 interactors.
IntActⁱ	P20411 1 interactor.
Molecular INTeraction database More...MINTⁱ	P20411
STRINGⁱ	10116.ENSRNOP00000036716

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P20411
SMRⁱ	P20411
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	54 – 82	ITAMPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the CD3Z/FCER1G family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J5TQ Eukaryota ENOG410Z3W0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003894
HOGENOMⁱ	HOG000293158
HOVERGENⁱ	HBG051601
InParanoidⁱ	P20411
KEGG Orthology (KO) More...KOⁱ	K07983
OMAⁱ	LYCRLKL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15OK
PhylomeDBⁱ	P20411
TreeFamⁱ	TF330937

Family and domain databases

InterProⁱ	View protein in InterPro IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma IPR003110 Phos_immunorcpt_sig_ITAM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02189 ITAM, 1 hit PF11628 TCR_zetazeta, 1 hit
SMARTⁱ	View protein in SMART SM00077 ITAM, 1 hit
PROSITEⁱ	View protein in PROSITE PS51055 ITAM_1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P20411-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIPAVILFLL LLVEEAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV 
        60         70         80 
RKADIASREK SDAVYTGLNT RNQETYETLK HEKPPQ

Length:86

Mass (Da):9,765

Last modified:February 1, 1991 - v1

Checksum:ⁱBD7B12E804311687

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L04306 Genomic RNA No translation available.
PIRⁱ	S02118
NCBI Reference Sequences More...RefSeqⁱ	NP_001124473.1, NM_001131001.1
UniGeneⁱ	Rn.201810

Genome annotation databases

Ensemblⁱ	ENSRNOT00000029179; ENSRNOP00000036716; ENSRNOG00000024159
GeneIDⁱ	25441
KEGGⁱ	rno:25441
UCSC genome browser More...UCSCⁱ	RGD:2599 rat

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P20411	B1H251	Rattus norvegicus (Rat)	86	UniRef100_P20411	Cluster: High affinity immunoglobulin epsilon receptor subunit gamma	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P20411	P20491 B1H251 UPI000A3120E4	Mus musculus (Mouse) Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari)	86	UniRef90_P20491	Cluster: High affinity immunoglobulin epsilon receptor subunit gamma	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P20411	P20491 B1H251 UPI000A3120E4 UPI00048F9E07 UPI00032B28CE UPI00042BE977 UPI000C81405C UPI0002234FFA UPI00033190AC A0A1A6HWC6 +33	Mus musculus (Mouse) Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Oryctolagus cuniculus (Rabbit) Ochotona princeps (Southern American pika) Chelonia mydas (Green sea-turtle) (Chelonia agassizi) Loxodonta africana (African elephant) Sorex araneus (Eurasian common shrew) (European shrew) Neotoma lepida (Desert woodrat) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) And more	86	UniRef50_P20491	Cluster: High affinity immunoglobulin epsilon receptor subunit gamma	44

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L04306 Genomic RNA No translation available.
PIRⁱ	S02118
NCBI Reference Sequences More...RefSeqⁱ	NP_001124473.1, NM_001131001.1
UniGeneⁱ	Rn.201810

3D structure databases

ProteinModelPortalⁱ	P20411
SMRⁱ	P20411
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	2474762 interactors.
IntActⁱ	P20411 1 interactor.
Molecular INTeraction database More...MINTⁱ	P20411
STRINGⁱ	10116.ENSRNOP00000036716

PTM databases

iPTMnetⁱ	P20411
PhosphoSitePlusⁱ	P20411

Proteomic databases

PaxDbⁱ	P20411
PRIDEⁱ	P20411

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000029179; ENSRNOP00000036716; ENSRNOG00000024159
GeneIDⁱ	25441
KEGGⁱ	rno:25441
UCSC genome browser More...UCSCⁱ	RGD:2599 rat

Organism-specific databases

CTDⁱ	2207
Rat genome database More...RGDⁱ	2599 Fcer1g

Phylogenomic databases

eggNOGⁱ	ENOG410J5TQ Eukaryota ENOG410Z3W0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003894
HOGENOMⁱ	HOG000293158
HOVERGENⁱ	HBG051601
InParanoidⁱ	P20411
KEGG Orthology (KO) More...KOⁱ	K07983
OMAⁱ	LYCRLKL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15OK
PhylomeDBⁱ	P20411
TreeFamⁱ	TF330937

Enzyme and pathway databases

Reactomeⁱ	R-RNO-114604 GPVI-mediated activation cascade R-RNO-202733 Cell surface interactions at the vascular wall R-RNO-2454202 Fc epsilon receptor (FCERI) signaling R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-RNO-2871796 FCERI mediated MAPK activation R-RNO-2871809 FCERI mediated Ca+2 mobilization R-RNO-2871837 FCERI mediated NF-kB activation R-RNO-6798695 Neutrophil degranulation R-RNO-75892 Platelet Adhesion to exposed collagen

Reactomeⁱ

R-RNO-114604 GPVI-mediated activation cascade
R-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-2454202 Fc epsilon receptor (FCERI) signaling
R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-RNO-2871796 FCERI mediated MAPK activation
R-RNO-2871809 FCERI mediated Ca+2 mobilization
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-6798695 Neutrophil degranulation
R-RNO-75892 Platelet Adhesion to exposed collagen

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P20411

PROⁱ

PR:P20411

Gene expression databases

Bgeeⁱ	ENSRNOG00000024159
ExpressionAtlasⁱ	P20411 baseline and differential
Genevisibleⁱ	P20411 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma IPR003110 Phos_immunorcpt_sig_ITAM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02189 ITAM, 1 hit PF11628 TCR_zetazeta, 1 hit
SMARTⁱ	View protein in SMART SM00077 ITAM, 1 hit
PROSITEⁱ	View protein in PROSITE PS51055 ITAM_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FCERG_RAT
Accessionⁱ	P20411Primary (citable) accession number: P20411
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	February 1, 1991
	Last modified:	February 28, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P20411 (FCERG_RAT)

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High affinity immunoglobulin epsilon receptor subunit gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ