UniProtKB - P20411 (FCERG_RAT)
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Protein
High affinity immunoglobulin epsilon receptor subunit gamma
Gene
Fcer1g
Organism
Rattus norvegicus (Rat)
Status
Functioni
Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin (By similarity).By similarity
GO - Molecular functioni
- IgE binding Source: RGD
- IgE receptor activity Source: RGD
- IgG binding Source: RGD
- protein homodimerization activity Source: RGD
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class I Source: RGD
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: RGD
- cell surface receptor signaling pathway Source: RGD
- cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
- defense response to bacterium Source: RGD
- Fc-epsilon receptor signaling pathway Source: RGD
- Fc-gamma receptor signaling pathway Source: RGD
- Fc receptor mediated stimulatory signaling pathway Source: RGD
- immunoglobulin mediated immune response Source: RGD
- innate immune response Source: RGD
- integrin-mediated signaling pathway Source: RGD
- mast cell activation Source: RGD
- negative regulation of mast cell apoptotic process Source: RGD
- neutrophil activation involved in immune response Source: RGD
- neutrophil chemotaxis Source: RGD
- phagocytosis, engulfment Source: RGD
- positive regulation of immune response Source: RGD
- positive regulation of interleukin-10 production Source: RGD
- positive regulation of interleukin-6 production Source: RGD
- positive regulation of mast cell cytokine production Source: RGD
- positive regulation of mast cell degranulation Source: RGD
- positive regulation of phagocytosis Source: RGD
- positive regulation of tumor necrosis factor production Source: RGD
- positive regulation of type I hypersensitivity Source: RGD
- positive regulation of type IIa hypersensitivity Source: RGD
- positive regulation of type III hypersensitivity Source: RGD
- protein homooligomerization Source: RGD
- protein localization to plasma membrane Source: RGD
- receptor internalization Source: UniProtKB
- regulation of immune response Source: RGD
- regulation of platelet activation Source: RGD
- serotonin secretion by platelet Source: RGD
- signal transduction Source: RGD
- T cell differentiation involved in immune response Source: RGD
Keywordsi
Molecular function | IgE-binding protein, Receptor |
Enzyme and pathway databases
Reactomei | R-RNO-114604 GPVI-mediated activation cascade R-RNO-202733 Cell surface interactions at the vascular wall R-RNO-2454202 Fc epsilon receptor (FCERI) signaling R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-RNO-2871796 FCERI mediated MAPK activation R-RNO-2871809 FCERI mediated Ca+2 mobilization R-RNO-2871837 FCERI mediated NF-kB activation R-RNO-6798695 Neutrophil degranulation R-RNO-75892 Platelet Adhesion to exposed collagen |
Names & Taxonomyi
Protein namesi | Recommended name: High affinity immunoglobulin epsilon receptor subunit gammaAlternative name(s): Fc receptor gamma-chain Short name: FcRgamma Fc-epsilon RI-gamma IgE Fc receptor subunit gamma Short name: FceRI gamma |
Gene namesi | Name:Fcer1g Synonyms:Fce1g |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2599 Fcer1g |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 23 | ExtracellularSequence analysis | 5 | |
Transmembranei | 24 – 44 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 86 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000016505 | 19 – 86 | High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST | 68 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 | InterchainBy similarity | ||
Modified residuei | 65 | PhosphotyrosinePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 76 | PhosphotyrosinePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 78 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | P20411 |
PRIDEi | P20411 |
PTM databases
iPTMneti | P20411 |
PhosphoSitePlusi | P20411 |
Expressioni
Tissue specificityi
Expressed in leukocytes and pinealocytes. Expression in the pineal gland does not undergo circadian variations.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000024159 |
ExpressionAtlasi | P20411 baseline and differential |
Genevisiblei | P20411 RN |
Interactioni
Subunit structurei
IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages. Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD. Interacts with TARM1.By similarity
GO - Molecular functioni
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
BioGridi | 2474762 interactors. |
IntActi | P20411 1 interactor. |
MINTi | P20411 |
STRINGi | 10116.ENSRNOP00000036716 |
Structurei
3D structure databases
ProteinModelPortali | P20411 |
SMRi | P20411 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 82 | ITAMPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the CD3Z/FCER1G family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J5TQ Eukaryota ENOG410Z3W0 LUCA |
GeneTreei | ENSGT00390000003894 |
HOGENOMi | HOG000293158 |
HOVERGENi | HBG051601 |
InParanoidi | P20411 |
KOi | K07983 |
OMAi | LYCRLKL |
OrthoDBi | EOG091G15OK |
PhylomeDBi | P20411 |
TreeFami | TF330937 |
Family and domain databases
InterProi | View protein in InterPro IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma IPR003110 Phos_immunorcpt_sig_ITAM |
Pfami | View protein in Pfam PF02189 ITAM, 1 hit PF11628 TCR_zetazeta, 1 hit |
SMARTi | View protein in SMART SM00077 ITAM, 1 hit |
PROSITEi | View protein in PROSITE PS51055 ITAM_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P20411-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIPAVILFLL LLVEEAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV
60 70 80
RKADIASREK SDAVYTGLNT RNQETYETLK HEKPPQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04306 Genomic RNA No translation available. |
PIRi | S02118 |
RefSeqi | NP_001124473.1, NM_001131001.1 |
UniGenei | Rn.201810 |
Genome annotation databases
Ensembli | ENSRNOT00000029179; ENSRNOP00000036716; ENSRNOG00000024159 |
GeneIDi | 25441 |
KEGGi | rno:25441 |
UCSCi | RGD:2599 rat |
Similar proteinsi
Entry informationi
Entry namei | FCERG_RAT | |
Accessioni | P20411Primary (citable) accession number: P20411 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | February 28, 2018 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |