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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

Fcer1g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-2454202. Fc epsilon receptor (FCERI) signaling.
R-RNO-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-RNO-2871796. FCERI mediated MAPK activation.
R-RNO-2871809. FCERI mediated Ca+2 mobilization.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-75892. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:Fcer1g
Synonyms:Fce1g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2599. Fcer1g.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 235ExtracellularSequence analysis
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Topological domaini45 – 8642CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 8668High affinity immunoglobulin epsilon receptor subunit gammaPRO_0000016505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 – 25InterchainBy similarity
Modified residuei65 – 651PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei76 – 761PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei78 – 781PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP20411.
PRIDEiP20411.

PTM databases

iPTMnetiP20411.

Expressioni

Tissue specificityi

Expressed in leukocytes and pinealocytes. Expression in the pineal gland does not undergo circadian variations.1 Publication

Gene expression databases

ExpressionAtlasiP20411. baseline and differential.
GenevisibleiP20411. RN.

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A (By similarity). Associated with CLEC6A (By similarity). Interacts with CLEC4E (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity).By similarity

Protein-protein interaction databases

BioGridi247476. 2 interactions.
IntActiP20411. 1 interaction.
MINTiMINT-8019886.
STRINGi10116.ENSRNOP00000036716.

Structurei

3D structure databases

ProteinModelPortaliP20411.
SMRiP20411. Positions 21-54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 8229ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP20411.
KOiK07983.
OMAiLYCRLKL.
OrthoDBiEOG747PMP.
PhylomeDBiP20411.
TreeFamiTF330937.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPAVILFLL LLVEEAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV
60 70 80
RKADIASREK SDAVYTGLNT RNQETYETLK HEKPPQ
Length:86
Mass (Da):9,765
Last modified:February 1, 1991 - v1
Checksum:iBD7B12E804311687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04306 Genomic RNA. No translation available.
PIRiS02118.
RefSeqiNP_001124473.1. NM_001131001.1.
UniGeneiRn.201810.

Genome annotation databases

EnsembliENSRNOT00000029179; ENSRNOP00000036716; ENSRNOG00000024159.
GeneIDi25441.
KEGGirno:25441.
UCSCiRGD:2599. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04306 Genomic RNA. No translation available.
PIRiS02118.
RefSeqiNP_001124473.1. NM_001131001.1.
UniGeneiRn.201810.

3D structure databases

ProteinModelPortaliP20411.
SMRiP20411. Positions 21-54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247476. 2 interactions.
IntActiP20411. 1 interaction.
MINTiMINT-8019886.
STRINGi10116.ENSRNOP00000036716.

PTM databases

iPTMnetiP20411.

Proteomic databases

PaxDbiP20411.
PRIDEiP20411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029179; ENSRNOP00000036716; ENSRNOG00000024159.
GeneIDi25441.
KEGGirno:25441.
UCSCiRGD:2599. rat.

Organism-specific databases

CTDi2207.
RGDi2599. Fcer1g.

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiP20411.
KOiK07983.
OMAiLYCRLKL.
OrthoDBiEOG747PMP.
PhylomeDBiP20411.
TreeFamiTF330937.

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-2454202. Fc epsilon receptor (FCERI) signaling.
R-RNO-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-RNO-2871796. FCERI mediated MAPK activation.
R-RNO-2871809. FCERI mediated Ca+2 mobilization.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-75892. Platelet Adhesion to exposed collagen.

Miscellaneous databases

PROiP20411.

Gene expression databases

ExpressionAtlasiP20411. baseline and differential.
GenevisibleiP20411. RN.

Family and domain databases

InterProiIPR021663. CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete structure and expression in transfected cells of high affinity IgE receptor."
    Blank U., Ra C., Miller L., White K., Metzger H., Kinet J.-P.
    Nature 337:187-189(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PARTIAL PROTEIN SEQUENCE.
  2. "Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?"
    Ganguly S., Grodzki C., Sugden D., Moller M., Odom S., Gaildrat P., Gery I., Siraganian R.P., Rivera J., Klein D.C.
    J. Biol. Chem. 282:32758-32764(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFCERG_RAT
AccessioniPrimary (citable) accession number: P20411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.