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P20396

- TRH_HUMAN

UniProt

P20396 - TRH_HUMAN

Protein

Pro-thyrotropin-releasing hormone

Gene

TRH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.1 Publication

    GO - Molecular functioni

    1. thyrotropin-releasing hormone activity Source: ProtInc

    GO - Biological processi

    1. adult walking behavior Source: Ensembl
    2. cell-cell signaling Source: ProtInc
    3. eating behavior Source: Ensembl
    4. histamine metabolic process Source: Ensembl
    5. hormone-mediated signaling pathway Source: InterPro
    6. negative regulation of feeding behavior Source: Ensembl
    7. negative regulation of glutamate secretion Source: Ensembl
    8. positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
    9. positive regulation of insulin secretion Source: Ensembl
    10. response to cold Source: Ensembl
    11. response to corticosterone Source: Ensembl
    12. response to ethanol Source: Ensembl
    13. response to glucose Source: Ensembl
    14. response to hypoxia Source: Ensembl
    15. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pro-thyrotropin-releasing hormone
    Short name:
    Pro-TRH
    Alternative name(s):
    Prothyroliberin
    Cleaved into the following chain:
    Alternative name(s):
    Protirelin
    TSH-releasing factor
    Thyroliberin
    Thyrotropin-releasing factor
    Short name:
    TRF
    Gene namesi
    Name:TRH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:12298. TRH.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. nucleus Source: Ensembl
    3. plasma membrane Source: Ensembl
    4. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti238670. Isolated thyrotropin-releasing hormone deficiency.
    PharmGKBiPA36978.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 242218Pro-thyrotropin-releasing hormonePRO_0000022509Add
    BLAST
    Peptidei84 – 863Thyrotropin-releasing hormonePRO_0000022510
    Peptidei114 – 1163Thyrotropin-releasing hormonePRO_0000022511
    Peptidei135 – 1373Thyrotropin-releasing hormonePRO_0000022512
    Peptidei152 – 1543Thyrotropin-releasing hormonePRO_0000022513
    Peptidei186 – 1883Thyrotropin-releasing hormonePRO_0000022514
    Peptidei227 – 2293Thyrotropin-releasing hormonePRO_0000022515

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei86 – 861Proline amideBy similarity
    Modified residuei116 – 1161Proline amideBy similarity
    Modified residuei135 – 1351Pyrrolidone carboxylic acidBy similarity
    Modified residuei137 – 1371Proline amideBy similarity
    Modified residuei152 – 1521Pyrrolidone carboxylic acidBy similarity
    Modified residuei154 – 1541Proline amideBy similarity
    Modified residuei188 – 1881Proline amideBy similarity
    Modified residuei227 – 2271Pyrrolidone carboxylic acidBy similarity
    Modified residuei229 – 2291Proline amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiP20396.
    PRIDEiP20396.

    Expressioni

    Tissue specificityi

    Hypothalamus. Expressed in the hair follicle epithelium (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP20396.
    BgeeiP20396.
    CleanExiHS_TRH.
    GenevestigatoriP20396.

    Organism-specific databases

    HPAiHPA035595.
    HPA035596.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303452.

    Structurei

    3D structure databases

    ProteinModelPortaliP20396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TRH family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG45849.
    HOGENOMiHOG000054194.
    HOVERGENiHBG083494.
    InParanoidiP20396.
    KOiK05253.
    OMAiAVGPHKR.
    OrthoDBiEOG70PBZR.
    PhylomeDBiP20396.
    TreeFamiTF332073.

    Family and domain databases

    InterProiIPR008857. TRH.
    [Graphical view]
    PANTHERiPTHR17530. PTHR17530. 1 hit.
    PfamiPF05438. TRH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001795. TRH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20396-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE    50
    RLLFLRENIQ RLQGDQGEHS ASQIFQSDWL SKRQHPGKRE EEEEEGVEEE 100
    EEEEGGAVGP HKRQHPGRRE DEASWSVDVT QHKRQHPGRR SPWLAYAVPK 150
    RQHPGRRLAD PKAQRSWEEE EEEEEREEDL MPEKRQHPGK RALGGPCGPQ 200
    GAYGQAGLLL GLLDDLSRSQ GAEEKRQHPG RRAAWVREPL EE 242
    Length:242
    Mass (Da):27,404
    Last modified:February 1, 1991 - v1
    Checksum:i8C0F9D915B32F29F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81L → V.
    Corresponds to variant rs5658 [ dbSNP | Ensembl ].
    VAR_014787

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63582, M63581 Genomic DNA. Translation: AAA36480.1.
    AK313473 mRNA. Translation: BAG36258.1.
    CH471052 Genomic DNA. Translation: EAW79229.1.
    BC069375 mRNA. Translation: AAH69375.1.
    BC074888 mRNA. Translation: AAH74888.1.
    BC074889 mRNA. Translation: AAH74889.1.
    BC110515 mRNA. Translation: AAI10516.1.
    BC110516 mRNA. Translation: AAI10517.1.
    CCDSiCCDS3066.1.
    PIRiA34550. RHHUT.
    RefSeqiNP_009048.1. NM_007117.4.
    UniGeneiHs.182231.
    Hs.732877.

    Genome annotation databases

    EnsembliENST00000302649; ENSP00000303452; ENSG00000170893.
    GeneIDi7200.
    KEGGihsa:7200.
    UCSCiuc003enc.4. human.

    Polymorphism databases

    DMDMi135841.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Thyrotropin-releasing hormone entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63582 , M63581 Genomic DNA. Translation: AAA36480.1 .
    AK313473 mRNA. Translation: BAG36258.1 .
    CH471052 Genomic DNA. Translation: EAW79229.1 .
    BC069375 mRNA. Translation: AAH69375.1 .
    BC074888 mRNA. Translation: AAH74888.1 .
    BC074889 mRNA. Translation: AAH74889.1 .
    BC110515 mRNA. Translation: AAI10516.1 .
    BC110516 mRNA. Translation: AAI10517.1 .
    CCDSi CCDS3066.1.
    PIRi A34550. RHHUT.
    RefSeqi NP_009048.1. NM_007117.4.
    UniGenei Hs.182231.
    Hs.732877.

    3D structure databases

    ProteinModelPortali P20396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303452.

    Chemistry

    BindingDBi P20396.

    Polymorphism databases

    DMDMi 135841.

    Proteomic databases

    PaxDbi P20396.
    PRIDEi P20396.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302649 ; ENSP00000303452 ; ENSG00000170893 .
    GeneIDi 7200.
    KEGGi hsa:7200.
    UCSCi uc003enc.4. human.

    Organism-specific databases

    CTDi 7200.
    GeneCardsi GC03P129693.
    HGNCi HGNC:12298. TRH.
    HPAi HPA035595.
    HPA035596.
    MIMi 613879. gene.
    neXtProti NX_P20396.
    Orphaneti 238670. Isolated thyrotropin-releasing hormone deficiency.
    PharmGKBi PA36978.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45849.
    HOGENOMi HOG000054194.
    HOVERGENi HBG083494.
    InParanoidi P20396.
    KOi K05253.
    OMAi AVGPHKR.
    OrthoDBi EOG70PBZR.
    PhylomeDBi P20396.
    TreeFami TF332073.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GenomeRNAii 7200.
    NextBioi 28216.
    PROi P20396.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20396.
    Bgeei P20396.
    CleanExi HS_TRH.
    Genevestigatori P20396.

    Family and domain databases

    InterProi IPR008857. TRH.
    [Graphical view ]
    PANTHERi PTHR17530. PTHR17530. 1 hit.
    Pfami PF05438. TRH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001795. TRH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone."
      Yamada M., Radovick S., Wondisford F.E., Nakayama Y., Weintraub B.D., Wilber J.F.
      Mol. Endocrinol. 4:551-556(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Subthalamic nucleus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Thyrotropin releasing hormone (TRH): a new player in human hair-growth control."
      Gaspar E., Hardenbicker C., Bodo E., Wenzel B., Ramot Y., Funk W., Kromminga A., Paus R.
      FASEB J. 24:393-403(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTRH_HUMAN
    AccessioniPrimary (citable) accession number: P20396
    Secondary accession number(s): B2R8R1, Q2TB83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3