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Protein

Pro-thyrotropin-releasing hormone

Gene

TRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-thyrotropin-releasing hormone
Short name:
Pro-TRH
Alternative name(s):
Prothyroliberin
Cleaved into the following chain:
Alternative name(s):
Protirelin
TSH-releasing factor
Thyroliberin
Thyrotropin-releasing factor
Short name:
TRF
Gene namesi
Name:TRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000170893.3.
HGNCiHGNC:12298. TRH.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7200.
MalaCardsiTRH.
OpenTargetsiENSG00000170893.
Orphaneti238670. Isolated thyrotropin-releasing hormone deficiency.
PharmGKBiPA36978.

Polymorphism and mutation databases

DMDMi135841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002250925 – 242Pro-thyrotropin-releasing hormoneAdd BLAST218
PeptideiPRO_000002251084 – 86Thyrotropin-releasing hormone3
PeptideiPRO_0000022511114 – 116Thyrotropin-releasing hormone3
PeptideiPRO_0000022512135 – 137Thyrotropin-releasing hormone3
PeptideiPRO_0000022513152 – 154Thyrotropin-releasing hormone3
PeptideiPRO_0000022514186 – 188Thyrotropin-releasing hormone3
PeptideiPRO_0000022515227 – 229Thyrotropin-releasing hormone3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86Proline amideBy similarity1
Modified residuei116Proline amideBy similarity1
Modified residuei135Pyrrolidone carboxylic acidBy similarity1
Modified residuei137Proline amideBy similarity1
Modified residuei152Pyrrolidone carboxylic acidBy similarity1
Modified residuei154Proline amideBy similarity1
Modified residuei188Proline amideBy similarity1
Modified residuei227Pyrrolidone carboxylic acidBy similarity1
Modified residuei229Proline amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP20396.
PeptideAtlasiP20396.
PRIDEiP20396.

PTM databases

iPTMnetiP20396.
PhosphoSitePlusiP20396.

Expressioni

Tissue specificityi

Hypothalamus. Expressed in the hair follicle epithelium (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000170893.
CleanExiHS_TRH.
ExpressionAtlasiP20396. baseline and differential.
GenevisibleiP20396. HS.

Organism-specific databases

HPAiHPA035595.
HPA035596.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20396. 2 interactors.
STRINGi9606.ENSP00000303452.

Chemistry databases

BindingDBiP20396.

Structurei

3D structure databases

ProteinModelPortaliP20396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRH family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IXZK. Eukaryota.
ENOG4111JXZ. LUCA.
GeneTreeiENSGT00390000016951.
HOGENOMiHOG000054194.
HOVERGENiHBG083494.
InParanoidiP20396.
KOiK05253.
OMAiQHPGRRE.
OrthoDBiEOG091G0M01.
PhylomeDBiP20396.
TreeFamiTF332073.

Family and domain databases

InterProiView protein in InterPro
IPR008857. TRH.
PANTHERiPTHR17530. PTHR17530. 1 hit.
PfamiView protein in Pfam
PF05438. TRH. 1 hit.
PIRSFiPIRSF001795. TRH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE
60 70 80 90 100
RLLFLRENIQ RLQGDQGEHS ASQIFQSDWL SKRQHPGKRE EEEEEGVEEE
110 120 130 140 150
EEEEGGAVGP HKRQHPGRRE DEASWSVDVT QHKRQHPGRR SPWLAYAVPK
160 170 180 190 200
RQHPGRRLAD PKAQRSWEEE EEEEEREEDL MPEKRQHPGK RALGGPCGPQ
210 220 230 240
GAYGQAGLLL GLLDDLSRSQ GAEEKRQHPG RRAAWVREPL EE
Length:242
Mass (Da):27,404
Last modified:February 1, 1991 - v1
Checksum:i8C0F9D915B32F29F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0147878L → V. Corresponds to variant dbSNP:rs5658Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63582, M63581 Genomic DNA. Translation: AAA36480.1.
AK313473 mRNA. Translation: BAG36258.1.
CH471052 Genomic DNA. Translation: EAW79229.1.
BC069375 mRNA. Translation: AAH69375.1.
BC074888 mRNA. Translation: AAH74888.1.
BC074889 mRNA. Translation: AAH74889.1.
BC110515 mRNA. Translation: AAI10516.1.
BC110516 mRNA. Translation: AAI10517.1.
CCDSiCCDS3066.1.
PIRiA34550. RHHUT.
RefSeqiNP_009048.1. NM_007117.4.
UniGeneiHs.182231.
Hs.732877.

Genome annotation databases

EnsembliENST00000302649; ENSP00000303452; ENSG00000170893.
GeneIDi7200.
KEGGihsa:7200.
UCSCiuc003enc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRH_HUMAN
AccessioniPrimary (citable) accession number: P20396
Secondary accession number(s): B2R8R1, Q2TB83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 25, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families