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P20387

- COX2_KLULA

UniProt

P20387 - COX2_KLULA

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi182 – 1821Copper ACurated
    Metal bindingi217 – 2171Copper ACurated
    Metal bindingi221 – 2211Copper ACurated
    Metal bindingi225 – 2251Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Encoded oniMitochondrion
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1111By similarityAdd
    BLAST
    Chaini12 – 247236Cytochrome c oxidase subunit 2PRO_0000006039Add
    BLAST

    Post-translational modificationi

    The signal sequence of COX2 is processed by IMP1.

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.P20387.

    Structurei

    3D structure databases

    ProteinModelPortaliP20387.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini12 – 3827Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini60 – 7819Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini102 – 247146Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 10123HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000264988.
    KOiK02261.
    OrthoDBiEOG7WDNDC.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20387-1 [UniParc]FASTAAdd to Basket

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    MFYLLNSIIM NDVPTPYGMY FQDSATPNQE GILELHDNIM FYLFIILGLV    50
    SWLLFTIVRT YSKNPIAYKY IKHGQTIEII WTIFPAVILL IIAFPSFILL 100
    YLCDEVISPA MTIKAIGLQW YWKYEYSDFI NDNGETVEFE SYVIPEDLLE 150
    DGQLRLLDTD TSVVVPVDTH IRFVVTAADV IHDFAVPSLG IKIDAAPGRL 200
    NQVSALIQRE GVFYGQCSEI CGQSHSAMPI KIEAVSLPAF LEWLNEQ 247
    Length:247
    Mass (Da):28,102
    Last modified:October 11, 2004 - v3
    Checksum:iAA9261AFC1C138DB
    GO

    Sequence cautioni

    The sequence AAT64953.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 861A → D(PubMed:2171241)Curated
    Sequence conflicti86 – 861A → D(PubMed:15691736)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15999 Genomic DNA. Translation: CAA34129.2.
    AY654900 Genomic DNA. Translation: AAT64953.1. Different initiation.
    PIRiS11171. OBVK2M.
    RefSeqiYP_054502.1. NC_006077.1.

    Genome annotation databases

    GeneIDi2914081.
    KEGGikla:KllafMp06.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15999 Genomic DNA. Translation: CAA34129.2 .
    AY654900 Genomic DNA. Translation: AAT64953.1 . Different initiation.
    PIRi S11171. OBVK2M.
    RefSeqi YP_054502.1. NC_006077.1.

    3D structure databases

    ProteinModelPortali P20387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.P20387.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2914081.
    KEGGi kla:KllafMp06.

    Phylogenomic databases

    HOGENOMi HOG000264988.
    KOi K02261.
    OrthoDBi EOG7WDNDC.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the cytochrome oxidase subunit 2 and val-tRNA genes and surrounding sequences from Kluyveromyces lactis K8 mitochondrial DNA."
      Hardy C.M., Clark-Walker G.D.
      Yeast 6:403-410(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 90735 / K8.
    2. Hardy C.M.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 81-82.
    3. "Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces lactis."
      Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.
      FEMS Yeast Res. 5:315-322(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.

    Entry informationi

    Entry nameiCOX2_KLULA
    AccessioniPrimary (citable) accession number: P20387
    Secondary accession number(s): Q6DN57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3