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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182Copper ACurated1
Metal bindingi217Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini12 – 38Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 78Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei79 – 101HelicalSequence analysisAdd BLAST23
Topological domaini102 – 247Mitochondrial intermembraneSequence analysisAdd BLAST146

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 11By similarityAdd BLAST11
ChainiPRO_000000603912 – 247Cytochrome c oxidase subunit 2Add BLAST236

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.

Structurei

3D structure databases

ProteinModelPortaliP20387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiP20387.
KOiK02261.
OrthoDBiEOG092C40RV.

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYLLNSIIM NDVPTPYGMY FQDSATPNQE GILELHDNIM FYLFIILGLV
60 70 80 90 100
SWLLFTIVRT YSKNPIAYKY IKHGQTIEII WTIFPAVILL IIAFPSFILL
110 120 130 140 150
YLCDEVISPA MTIKAIGLQW YWKYEYSDFI NDNGETVEFE SYVIPEDLLE
160 170 180 190 200
DGQLRLLDTD TSVVVPVDTH IRFVVTAADV IHDFAVPSLG IKIDAAPGRL
210 220 230 240
NQVSALIQRE GVFYGQCSEI CGQSHSAMPI KIEAVSLPAF LEWLNEQ
Length:247
Mass (Da):28,102
Last modified:October 11, 2004 - v3
Checksum:iAA9261AFC1C138DB
GO

Sequence cautioni

The sequence AAT64953 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86A → D (PubMed:2171241).Curated1
Sequence conflicti86A → D (PubMed:15691736).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15999 Genomic DNA. Translation: CAA34129.2.
AY654900 Genomic DNA. Translation: AAT64953.1. Different initiation.
PIRiS11171. OBVK2M.
RefSeqiYP_054502.1. NC_006077.1.

Genome annotation databases

GeneIDi2914081.
KEGGikla:KllafMp06.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOX2_KLULA
AccessioniPrimary (citable) accession number: P20387
Secondary accession number(s): Q6DN57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 11, 2004
Last modified: May 10, 2017
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families