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P20387 (COX2_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence caution

The sequence AAT64953.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1111 By similarity
Chain12 – 247236Cytochrome c oxidase subunit 2
PRO_0000006039

Regions

Topological domain12 – 3827Mitochondrial intermembrane Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 7819Mitochondrial matrix Potential
Transmembrane79 – 10123Helical; Potential
Topological domain102 – 247146Mitochondrial intermembrane Potential

Sites

Metal binding1821Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable

Experimental info

Sequence conflict861A → D Ref.1
Sequence conflict861A → D Ref.3

Sequences

Sequence LengthMass (Da)Tools
P20387 [UniParc].

Last modified October 11, 2004. Version 3.
Checksum: AA9261AFC1C138DB

FASTA24728,102
        10         20         30         40         50         60 
MFYLLNSIIM NDVPTPYGMY FQDSATPNQE GILELHDNIM FYLFIILGLV SWLLFTIVRT 

        70         80         90        100        110        120 
YSKNPIAYKY IKHGQTIEII WTIFPAVILL IIAFPSFILL YLCDEVISPA MTIKAIGLQW 

       130        140        150        160        170        180 
YWKYEYSDFI NDNGETVEFE SYVIPEDLLE DGQLRLLDTD TSVVVPVDTH IRFVVTAADV 

       190        200        210        220        230        240 
IHDFAVPSLG IKIDAAPGRL NQVSALIQRE GVFYGQCSEI CGQSHSAMPI KIEAVSLPAF 


LEWLNEQ 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the cytochrome oxidase subunit 2 and val-tRNA genes and surrounding sequences from Kluyveromyces lactis K8 mitochondrial DNA."
Hardy C.M., Clark-Walker G.D.
Yeast 6:403-410(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 90735 / K8.
[2]Hardy C.M.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 81-82.
[3]"Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces lactis."
Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.
FEMS Yeast Res. 5:315-322(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15999 Genomic DNA. Translation: CAA34129.2.
AY654900 Genomic DNA. Translation: AAT64953.1. Different initiation.
PIROBVK2M. S11171.
RefSeqYP_054502.1. NC_006077.1.

3D structure databases

ProteinModelPortalP20387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.P20387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2914081.
KEGGkla:KllafMp06.

Phylogenomic databases

HOGENOMHOG000264988.
KOK02261.
OrthoDBEOG7WDNDC.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_KLULA
AccessionPrimary (citable) accession number: P20387
Secondary accession number(s): Q6DN57
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families