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P20386 (COX1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COX1
Encoded onMitochondrion
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534Cytochrome c oxidase subunit 1
PRO_0000183348

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane267 – 28721Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane338 – 35821Helical; Potential
Transmembrane372 – 39221Helical; Potential
Transmembrane412 – 43221Helical; Potential
Transmembrane452 – 47221Helical; Potential

Sites

Metal binding621Iron (heme A axial ligand) Probable
Metal binding2411Copper B Probable
Metal binding2451Copper B Probable
Metal binding2901Copper B Probable
Metal binding2911Copper B Probable
Metal binding3761Iron (heme A3 axial ligand) Probable
Metal binding3781Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Sequence conflict661I → M in CAA40765. Ref.1
Sequence conflict97 – 982RL → KM in CAA40765. Ref.1
Sequence conflict2371W → G in CAA40765. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P20386 [UniParc].

Last modified October 11, 2004. Version 3.
Checksum: 9CBF85E4091BA04D

FASTA53458,798
        10         20         30         40         50         60 
MIERWLYSTN AKDIAVLYFI FAIFCGMAGT AMSLIIRLEL AAPGNQVLSG NHQLFNVLVV 

        70         80         90        100        110        120 
GHAVLIIFFL VMPALIGGFG NYMLPLLIGA SDMSFARLNN ISFWCLPPAL VCLVTSTLVE 

       130        140        150        160        170        180 
SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA LHLTSISSLL GAINFIVTTL NMRTNGMTMH 

       190        200        210        220        230        240 
RLPLFVWSIF ITAFLLLLSL PVLSAGVTML LLDRNFNTSF FEVAGGGDPV LYQHLFWFFG 

       250        260        270        280        290        300 
HPEVYILIIP GFGIISHIVS TYSKKPVFGE VSMVYAMASI GLLGFLVWSH HMYIVGLDAD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLAVPMLY AIAFLFLFTI GGLTGVALAN 

       370        380        390        400        410        420 
ASLDVAFHDT YYVVGHFHYV LSMGAIFSLF AGYYYWSPQI LGLYYNEKLA QIQFWLIFVG 

       430        440        450        460        470        480 
ANVIFLPMHF LGVNGMPRRI PDYPDAFAGW NYVASIGSII AVFSLFLFIY ILYDQLVNGL 

       490        500        510        520        530 
ENKVNNKSVI YNKGPDFVES NQIFATNKIK SSSIEFLLTS PPAVHTFNTP AVQS 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the COX1 gene in Kluyveromyces lactis mitochondrial DNA: evidence for recent horizontal transfer of a group II intron."
Hardy C.M., Clark-Walker G.D.
Curr. Genet. 20:99-114(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 90735 / K8.
[2]"Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces lactis."
Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.
FEMS Yeast Res. 5:315-322(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
[3]"Nucleotide sequence of the cytochrome oxidase subunit 2 and val-tRNA genes and surrounding sequences from Kluyveromyces lactis K8 mitochondrial DNA."
Hardy C.M., Clark-Walker G.D.
Yeast 6:403-410(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29.
Strain: ATCC 90735 / K8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57546 Genomic DNA. Translation: CAA40765.1.
AY654900 Genomic DNA. Translation: AAT64956.1.
X15999 Genomic DNA. Translation: CAA34130.1.
PIRS17993.
RefSeqYP_054500.1. NC_006077.1.

3D structure databases

ProteinModelPortalP20386.
SMRP20386. Positions 2-532.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.P20386.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2914076.
KEGGkla:KllafMp05.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.
KOK02256.
OrthoDBEOG72C58S.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_KLULA
AccessionPrimary (citable) accession number: P20386
Secondary accession number(s): Q6DN59
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways