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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Iron (heme A axial ligand)Curated1
Metal bindingi241Copper BCurated1
Metal bindingi245Copper BCurated1
Metal bindingi290Copper BCurated1
Metal bindingi291Copper BCurated1
Metal bindingi376Iron (heme A3 axial ligand)Curated1
Metal bindingi378Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833481 – 534Cytochrome c oxidase subunit 1Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP20386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiP20386.
KOiK02256.
OrthoDBiEOG092C2KU4.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIERWLYSTN AKDIAVLYFI FAIFCGMAGT AMSLIIRLEL AAPGNQVLSG
60 70 80 90 100
NHQLFNVLVV GHAVLIIFFL VMPALIGGFG NYMLPLLIGA SDMSFARLNN
110 120 130 140 150
ISFWCLPPAL VCLVTSTLVE SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA
160 170 180 190 200
LHLTSISSLL GAINFIVTTL NMRTNGMTMH RLPLFVWSIF ITAFLLLLSL
210 220 230 240 250
PVLSAGVTML LLDRNFNTSF FEVAGGGDPV LYQHLFWFFG HPEVYILIIP
260 270 280 290 300
GFGIISHIVS TYSKKPVFGE VSMVYAMASI GLLGFLVWSH HMYIVGLDAD
310 320 330 340 350
TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLAVPMLY AIAFLFLFTI
360 370 380 390 400
GGLTGVALAN ASLDVAFHDT YYVVGHFHYV LSMGAIFSLF AGYYYWSPQI
410 420 430 440 450
LGLYYNEKLA QIQFWLIFVG ANVIFLPMHF LGVNGMPRRI PDYPDAFAGW
460 470 480 490 500
NYVASIGSII AVFSLFLFIY ILYDQLVNGL ENKVNNKSVI YNKGPDFVES
510 520 530
NQIFATNKIK SSSIEFLLTS PPAVHTFNTP AVQS
Length:534
Mass (Da):58,798
Last modified:October 11, 2004 - v3
Checksum:i9CBF85E4091BA04D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66I → M in CAA40765 (PubMed:1657415).Curated1
Sequence conflicti97 – 98RL → KM in CAA40765 (PubMed:1657415).Curated2
Sequence conflicti237W → G in CAA40765 (PubMed:1657415).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57546 Genomic DNA. Translation: CAA40765.1.
AY654900 Genomic DNA. Translation: AAT64956.1.
X15999 Genomic DNA. Translation: CAA34130.1.
PIRiS17993.
RefSeqiYP_054500.1. NC_006077.1.

Genome annotation databases

GeneIDi2914076.
KEGGikla:KllafMp05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57546 Genomic DNA. Translation: CAA40765.1.
AY654900 Genomic DNA. Translation: AAT64956.1.
X15999 Genomic DNA. Translation: CAA34130.1.
PIRiS17993.
RefSeqiYP_054500.1. NC_006077.1.

3D structure databases

ProteinModelPortaliP20386.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2914076.
KEGGikla:KllafMp05.

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiP20386.
KOiK02256.
OrthoDBiEOG092C2KU4.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_KLULA
AccessioniPrimary (citable) accession number: P20386
Secondary accession number(s): Q6DN59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.