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Protein

Chorion transcription factor Cf2

Gene

Cf2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator; binds to the promoter region of Cp15. Also binds to its own promoter, thus having a probable autoregulatory role.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14824C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50824C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • adult somatic muscle development Source: FlyBase
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP20385.

Names & Taxonomyi

Protein namesi
Recommended name:
Chorion transcription factor Cf2
Gene namesi
Name:Cf2
ORF Names:CG11924
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000286. Cf2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Chorion transcription factor Cf2PRO_0000046914Add
BLAST

Proteomic databases

PaxDbiP20385.

Expressioni

Tissue specificityi

Isoform I is found in embryos, pupae and adult somatic tissue; isoform II occurs in embryos, pupae, ovaries, testis and to a lesser extent in adult somatic tissue.1 Publication

Gene expression databases

BgeeiP20385.
ExpressionAtlasiP20385. differential.
GenevisibleiP20385. DM.

Interactioni

Protein-protein interaction databases

BioGridi59880. 4 interactions.
MINTiMINT-1629839.
STRINGi7227.FBpp0088592.

Structurei

3D structure databases

ProteinModelPortaliP20385.
SMRiP20385. Positions 72-101, 116-148, 366-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 288Poly-Pro
Compositional biasi193 – 28492Gln-richAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14824C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50824C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
InParanoidiP20385.
KOiK02215.
OMAiAPRDMRL.
OrthoDBiEOG7MPRDS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform I (identifier: P20385-1) [UniParc]FASTAAdd to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKSTTNPQE QRLPRPEDQS PAPPPPPPSS ATTSTAAPAT PTHQVATVIA
60 70 80 90 100
NMDTLKTAFL PNLSMDPNVH VSPHYCPMCH QQFERPQHVA DHMQLCHGIT
110 120 130 140 150
LNAQGAIATL DGGHPQAQQH PKLSHPCFNC DEKFGNAVDL DEHHRLAHQT
160 170 180 190 200
PAFLSRCLMC SIYGIHSATQ QPNEYKCTQC GSICTTAMLA AGQQGFMEQQ
210 220 230 240 250
EAAVTPDDQL PAMAPRDMRL TPEEQHHQQQ LQAEHHHQQQ HQQQQQQQQQ
260 270 280 290 300
QQELLEQQQR EMQEQAQQQQ VHHHQQDQDL AGDQVALKVP PLTVKLNKNA
310 320 330 340 350
NGGAIVSHPQ VIIKEEPLSL SDSGDVVNSV PVYAIQANPG VPAPASSGVL
360 370 380 390 400
VGTQTVPADL AHKIRHKCPD CPKTFKTPGT LAMHRKIHTG EADATPKERP
410 420 430 440 450
YTCSYCGKSF TQSNTLKQHT RIHTGEKPFR CGYCGRAFTV KDYLNKHLTT
460 470 480 490 500
HTGEKPFHCG YCEKSFSVKD YLTKHIRTHT GEKPYTCPYC DKRFTQRSAL
510
TVHTTKLHPL
Length:510
Mass (Da):56,750
Last modified:September 27, 2005 - v3
Checksum:i4C692B85157DE0AB
GO
Isoform II (identifier: P20385-2) [UniParc]FASTAAdd to basket

Also known as: B, C, III

The sequence of this isoform differs from the canonical sequence as follows:
     430-457: Missing.

Show »
Length:482
Mass (Da):53,524
Checksum:i665DAB55A5B75A4C
GO

Sequence cautioni

The sequence AAA28394.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA28394.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAV37010.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541L → S in AAA28394 (PubMed:1411512).Curated
Sequence conflicti254 – 2541L → S in AAA28395 (PubMed:1411512).Curated
Sequence conflicti254 – 2541L → S in AAA28396 (PubMed:1411512).Curated
Sequence conflicti254 – 2541L → S in CAA37460 (PubMed:2120114).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei430 – 45728Missing in isoform II. 2 PublicationsVSP_006824Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97196 Genomic DNA. Translation: AAA28394.1. Sequence problems.
M97196 Genomic DNA. Translation: AAA28395.1.
M97196 Genomic DNA. Translation: AAA28396.1.
AE014134 Genomic DNA. Translation: AAF50966.2.
AE014134 Genomic DNA. Translation: AAO41152.1.
AE014134 Genomic DNA. Translation: AAO41153.1.
BT028816 mRNA. Translation: ABI34197.1.
BT016125 mRNA. Translation: AAV37010.1. Sequence problems.
X53380 mRNA. Translation: CAA37460.1.
PIRiA36901.
B36901.
C36901.
RefSeqiNP_523474.1. NM_078750.4. [P20385-1]
NP_787977.2. NM_175963.3. [P20385-2]
NP_787978.1. NM_175964.2. [P20385-2]
NP_787979.1. NM_175965.2. [P20385-2]
UniGeneiDm.21408.

Genome annotation databases

EnsemblMetazoaiFBtr0089649; FBpp0088592; FBgn0000286. [P20385-1]
GeneIDi33692.
KEGGidme:Dmel_CG11924.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97196 Genomic DNA. Translation: AAA28394.1. Sequence problems.
M97196 Genomic DNA. Translation: AAA28395.1.
M97196 Genomic DNA. Translation: AAA28396.1.
AE014134 Genomic DNA. Translation: AAF50966.2.
AE014134 Genomic DNA. Translation: AAO41152.1.
AE014134 Genomic DNA. Translation: AAO41153.1.
BT028816 mRNA. Translation: ABI34197.1.
BT016125 mRNA. Translation: AAV37010.1. Sequence problems.
X53380 mRNA. Translation: CAA37460.1.
PIRiA36901.
B36901.
C36901.
RefSeqiNP_523474.1. NM_078750.4. [P20385-1]
NP_787977.2. NM_175963.3. [P20385-2]
NP_787978.1. NM_175964.2. [P20385-2]
NP_787979.1. NM_175965.2. [P20385-2]
UniGeneiDm.21408.

3D structure databases

ProteinModelPortaliP20385.
SMRiP20385. Positions 72-101, 116-148, 366-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59880. 4 interactions.
MINTiMINT-1629839.
STRINGi7227.FBpp0088592.

Proteomic databases

PaxDbiP20385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089649; FBpp0088592; FBgn0000286. [P20385-1]
GeneIDi33692.
KEGGidme:Dmel_CG11924.

Organism-specific databases

CTDi33692.
FlyBaseiFBgn0000286. Cf2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
InParanoidiP20385.
KOiK02215.
OMAiAPRDMRL.
OrthoDBiEOG7MPRDS.

Enzyme and pathway databases

SignaLinkiP20385.

Miscellaneous databases

GenomeRNAii33692.
PROiP20385.

Gene expression databases

BgeeiP20385.
ExpressionAtlasiP20385. differential.
GenevisibleiP20385. DM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene."
    Hsu T., Gogos J.A., Kirsh S.A., Kafatos F.C.
    Science 257:1946-1950(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: Oregon-R.
    Tissue: Embryo and Ovary.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM II), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-455 (ISOFORM I).
    Strain: Berkeley.
    Tissue: Ovary and Testis.
  5. "Proteins that bind to Drosophila chorion cis-regulatory elements: a new C2H2 zinc finger protein and a C2C2 steroid receptor-like component."
    Shea M.J., King D.L., Conboy M.J., Mariani B.D., Kafatos F.C.
    Genes Dev. 4:1128-1140(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 248-510 (ISOFORM II), FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Embryo.

Entry informationi

Entry nameiCF2_DROME
AccessioniPrimary (citable) accession number: P20385
Secondary accession number(s): Q01522
, Q0IGV4, Q24263, Q5U0W7, Q86BN0, Q86BN1, Q9VR41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: September 27, 2005
Last modified: July 6, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.