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P20382

- MCH_HUMAN

UniProt

P20382 - MCH_HUMAN

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Protein
Pro-MCH
Gene
PMCH, MCH
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. feeding behavior Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB-KW
  4. neuropeptide signaling pathway Source: UniProtKB-KW
  5. spermatogenesis Source: UniProtKB-KW
  6. synaptic transmission Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hormone, Neuropeptide

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-MCH
Cleaved into the following 3 chains:
Neuropeptide-glycine-glutamic acid
Short name:
NGE
Short name:
Neuropeptide G-E
Neuropeptide-glutamic acid-isoleucine
Short name:
NEI
Short name:
Neuropeptide E-I
Gene namesi
Name:PMCH
Synonyms:MCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9109. PMCH.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 165144Pro-MCH
PRO_0000019104Add
BLAST
Peptidei110 – 12819Neuropeptide-glycine-glutamic acid Reviewed prediction
PRO_0000019105Add
BLAST
Peptidei131 – 14313Neuropeptide-glutamic acid-isoleucine
PRO_0000019106Add
BLAST
Peptidei147 – 16519Melanin-concentrating hormone
PRO_0000019107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431Isoleucine amide By similarity
Disulfide bondi153 ↔ 162 By similarity

Post-translational modificationi

Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP20382.
PRIDEiP20382.

Miscellaneous databases

PMAP-CutDBQ8WVG0.

Expressioni

Tissue specificityi

Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.1 Publication

Gene expression databases

BgeeiP20382.
CleanExiHS_PMCH.
GenevestigatoriP20382.

Organism-specific databases

HPAiHPA046055.

Interactioni

Protein-protein interaction databases

BioGridi111380. 1 interaction.
STRINGi9606.ENSP00000332225.

Structurei

3D structure databases

ProteinModelPortaliP20382.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42445.
HOGENOMiHOG000230520.
HOVERGENiHBG052429.
InParanoidiP20382.
KOiK05229.
OMAiNLAIKPY.
OrthoDBiEOG7X6M1T.
PhylomeDBiP20382.
TreeFamiTF330944.

Family and domain databases

InterProiIPR005456. Prepro-melanin_conc_hormone.
[Graphical view]
PANTHERiPTHR12091. PTHR12091. 1 hit.
PfamiPF05824. Pro-MCH. 1 hit.
[Graphical view]
PRINTSiPR01641. PROMCHFAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20382-1 [UniParc]FASTAAdd to Basket

« Hide

MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK    50
EDTAEKSVIA PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL 100
AIKPYLALKG SVAFPAENGV QNTESTQEKR EIGDEENSAK FPIGRRDFDM 150
LRCMLGRVYR PCWQV 165
Length:165
Mass (Da):18,679
Last modified:May 5, 2009 - v3
Checksum:i2339E8938EBEC499
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421F → S in AAB27493. 1 Publication
Sequence conflicti104 – 1063PYL → GYQ in AAA63214. 1 Publication
Sequence conflicti113 – 1131A → D in AAA63214. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57703 mRNA. Translation: AAA63214.1.
S63697 Genomic DNA. Translation: AAB27493.1.
CH471054 Genomic DNA. Translation: EAW97693.1.
BC018048 mRNA. Translation: AAH18048.1.
CCDSiCCDS31885.1.
PIRiI52634.
RefSeqiNP_002665.2. NM_002674.2.
UniGeneiHs.707990.

Genome annotation databases

EnsembliENST00000329406; ENSP00000332225; ENSG00000183395.
GeneIDi5367.
KEGGihsa:5367.
UCSCiuc001tjl.3. human.

Polymorphism databases

DMDMi229462960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57703 mRNA. Translation: AAA63214.1 .
S63697 Genomic DNA. Translation: AAB27493.1 .
CH471054 Genomic DNA. Translation: EAW97693.1 .
BC018048 mRNA. Translation: AAH18048.1 .
CCDSi CCDS31885.1.
PIRi I52634.
RefSeqi NP_002665.2. NM_002674.2.
UniGenei Hs.707990.

3D structure databases

ProteinModelPortali P20382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111380. 1 interaction.
STRINGi 9606.ENSP00000332225.

Polymorphism databases

DMDMi 229462960.

Proteomic databases

PaxDbi P20382.
PRIDEi P20382.

Protocols and materials databases

DNASUi 5367.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329406 ; ENSP00000332225 ; ENSG00000183395 .
GeneIDi 5367.
KEGGi hsa:5367.
UCSCi uc001tjl.3. human.

Organism-specific databases

CTDi 5367.
GeneCardsi GC12M102590.
HGNCi HGNC:9109. PMCH.
HPAi HPA046055.
MIMi 176795. gene.
neXtProti NX_P20382.
PharmGKBi PA33435.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42445.
HOGENOMi HOG000230520.
HOVERGENi HBG052429.
InParanoidi P20382.
KOi K05229.
OMAi NLAIKPY.
OrthoDBi EOG7X6M1T.
PhylomeDBi P20382.
TreeFami TF330944.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 5367.
NextBioi 20804.
PMAP-CutDB Q8WVG0.
PROi P20382.
SOURCEi Search...

Gene expression databases

Bgeei P20382.
CleanExi HS_PMCH.
Genevestigatori P20382.

Family and domain databases

InterProi IPR005456. Prepro-melanin_conc_hormone.
[Graphical view ]
PANTHERi PTHR12091. PTHR12091. 1 hit.
Pfami PF05824. Pro-MCH. 1 hit.
[Graphical view ]
PRINTSi PR01641. PROMCHFAMILY.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the human melanin concentrating hormone mRNA."
    Presse F., Nahon J.-L., Fischer W.H., Vale W.
    Mol. Endocrinol. 4:632-637(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  2. "Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene."
    Breton C., Schorpp M., Nahon J.-L.
    Brain Res. Mol. Brain Res. 18:297-310(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Mammary cancer.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals."
    Viale A., Ortola C., Hervieu G., Furuta M., Barbero P., Steiner D.F., Seidah N.G., Nahon J.-L.
    J. Biol. Chem. 274:6536-6545(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  6. "The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression."
    Viale A., Zhixing Y., Breton C., Pedeutour F., Coquerel A., Jordan D., Nahon J.-L.
    Brain Res. Mol. Brain Res. 46:243-255(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiMCH_HUMAN
AccessioniPrimary (citable) accession number: P20382
Secondary accession number(s): Q16044, Q8WVG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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