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P20382

- MCH_HUMAN

UniProt

P20382 - MCH_HUMAN

Protein

Pro-MCH

Gene

PMCH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. feeding behavior Source: UniProtKB
    3. multicellular organismal development Source: UniProtKB-KW
    4. neuropeptide signaling pathway Source: UniProtKB-KW
    5. spermatogenesis Source: UniProtKB-KW
    6. synaptic transmission Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, Hormone, Neuropeptide

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pro-MCH
    Cleaved into the following 3 chains:
    Neuropeptide-glycine-glutamic acid
    Short name:
    NGE
    Short name:
    Neuropeptide G-E
    Neuropeptide-glutamic acid-isoleucine
    Short name:
    NEI
    Short name:
    Neuropeptide E-I
    Gene namesi
    Name:PMCH
    Synonyms:MCH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9109. PMCH.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33435.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 165144Pro-MCHPRO_0000019104Add
    BLAST
    Peptidei110 – 12819Neuropeptide-glycine-glutamic acidSequence AnalysisPRO_0000019105Add
    BLAST
    Peptidei131 – 14313Neuropeptide-glutamic acid-isoleucinePRO_0000019106Add
    BLAST
    Peptidei147 – 16519Melanin-concentrating hormonePRO_0000019107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei143 – 1431Isoleucine amideBy similarity
    Disulfide bondi153 ↔ 162By similarity

    Post-translational modificationi

    Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP20382.
    PRIDEiP20382.

    Miscellaneous databases

    PMAP-CutDBQ8WVG0.

    Expressioni

    Tissue specificityi

    Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.1 Publication

    Gene expression databases

    BgeeiP20382.
    CleanExiHS_PMCH.
    GenevestigatoriP20382.

    Organism-specific databases

    HPAiHPA046055.

    Interactioni

    Protein-protein interaction databases

    BioGridi111380. 1 interaction.
    STRINGi9606.ENSP00000332225.

    Structurei

    3D structure databases

    ProteinModelPortaliP20382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42445.
    HOGENOMiHOG000230520.
    HOVERGENiHBG052429.
    InParanoidiP20382.
    KOiK05229.
    OMAiNLAIKPY.
    OrthoDBiEOG7X6M1T.
    PhylomeDBiP20382.
    TreeFamiTF330944.

    Family and domain databases

    InterProiIPR005456. Prepro-melanin_conc_hormone.
    [Graphical view]
    PANTHERiPTHR12091. PTHR12091. 1 hit.
    PfamiPF05824. Pro-MCH. 1 hit.
    [Graphical view]
    PRINTSiPR01641. PROMCHFAMILY.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20382-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK    50
    EDTAEKSVIA PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL 100
    AIKPYLALKG SVAFPAENGV QNTESTQEKR EIGDEENSAK FPIGRRDFDM 150
    LRCMLGRVYR PCWQV 165
    Length:165
    Mass (Da):18,679
    Last modified:May 5, 2009 - v3
    Checksum:i2339E8938EBEC499
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421F → S in AAB27493. (PubMed:8326825)Curated
    Sequence conflicti104 – 1063PYL → GYQ in AAA63214. (PubMed:2149166)Curated
    Sequence conflicti113 – 1131A → D in AAA63214. (PubMed:2149166)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57703 mRNA. Translation: AAA63214.1.
    S63697 Genomic DNA. Translation: AAB27493.1.
    CH471054 Genomic DNA. Translation: EAW97693.1.
    BC018048 mRNA. Translation: AAH18048.1.
    CCDSiCCDS31885.1.
    PIRiI52634.
    RefSeqiNP_002665.2. NM_002674.2.
    UniGeneiHs.707990.

    Genome annotation databases

    EnsembliENST00000329406; ENSP00000332225; ENSG00000183395.
    GeneIDi5367.
    KEGGihsa:5367.
    UCSCiuc001tjl.3. human.

    Polymorphism databases

    DMDMi229462960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57703 mRNA. Translation: AAA63214.1 .
    S63697 Genomic DNA. Translation: AAB27493.1 .
    CH471054 Genomic DNA. Translation: EAW97693.1 .
    BC018048 mRNA. Translation: AAH18048.1 .
    CCDSi CCDS31885.1.
    PIRi I52634.
    RefSeqi NP_002665.2. NM_002674.2.
    UniGenei Hs.707990.

    3D structure databases

    ProteinModelPortali P20382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111380. 1 interaction.
    STRINGi 9606.ENSP00000332225.

    Polymorphism databases

    DMDMi 229462960.

    Proteomic databases

    PaxDbi P20382.
    PRIDEi P20382.

    Protocols and materials databases

    DNASUi 5367.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329406 ; ENSP00000332225 ; ENSG00000183395 .
    GeneIDi 5367.
    KEGGi hsa:5367.
    UCSCi uc001tjl.3. human.

    Organism-specific databases

    CTDi 5367.
    GeneCardsi GC12M102590.
    HGNCi HGNC:9109. PMCH.
    HPAi HPA046055.
    MIMi 176795. gene.
    neXtProti NX_P20382.
    PharmGKBi PA33435.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42445.
    HOGENOMi HOG000230520.
    HOVERGENi HBG052429.
    InParanoidi P20382.
    KOi K05229.
    OMAi NLAIKPY.
    OrthoDBi EOG7X6M1T.
    PhylomeDBi P20382.
    TreeFami TF330944.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 5367.
    NextBioi 20804.
    PMAP-CutDB Q8WVG0.
    PROi P20382.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20382.
    CleanExi HS_PMCH.
    Genevestigatori P20382.

    Family and domain databases

    InterProi IPR005456. Prepro-melanin_conc_hormone.
    [Graphical view ]
    PANTHERi PTHR12091. PTHR12091. 1 hit.
    Pfami PF05824. Pro-MCH. 1 hit.
    [Graphical view ]
    PRINTSi PR01641. PROMCHFAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the human melanin concentrating hormone mRNA."
      Presse F., Nahon J.-L., Fischer W.H., Vale W.
      Mol. Endocrinol. 4:632-637(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.
    2. "Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene."
      Breton C., Schorpp M., Nahon J.-L.
      Brain Res. Mol. Brain Res. 18:297-310(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Mammary cancer.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals."
      Viale A., Ortola C., Hervieu G., Furuta M., Barbero P., Steiner D.F., Seidah N.G., Nahon J.-L.
      J. Biol. Chem. 274:6536-6545(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    6. "The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression."
      Viale A., Zhixing Y., Breton C., Pedeutour F., Coquerel A., Jordan D., Nahon J.-L.
      Brain Res. Mol. Brain Res. 46:243-255(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiMCH_HUMAN
    AccessioniPrimary (citable) accession number: P20382
    Secondary accession number(s): Q16044, Q8WVG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3