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P20382 (MCH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-MCH

Cleaved into the following 3 chains:

  1. Neuropeptide-glycine-glutamic acid
    Short name=NGE
    Short name=Neuropeptide G-E
  2. Neuropeptide-glutamic acid-isoleucine
    Short name=NEI
    Short name=Neuropeptide E-I
  3. Melanin-concentrating hormone
    Short name=MCH
Gene names
Name:PMCH
Synonyms:MCH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.

Subcellular location

Secreted.

Tissue specificity

Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. Ref.6

Post-translational modification

Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.

Sequence similarities

Belongs to the melanin-concentrating hormone family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 165144Pro-MCH
PRO_0000019104
Peptide110 – 12819Neuropeptide-glycine-glutamic acid Potential
PRO_0000019105
Peptide131 – 14313Neuropeptide-glutamic acid-isoleucine
PRO_0000019106
Peptide147 – 16519Melanin-concentrating hormone
PRO_0000019107

Amino acid modifications

Modified residue1431Isoleucine amide By similarity
Disulfide bond153 ↔ 162 By similarity

Experimental info

Sequence conflict421F → S in AAB27493. Ref.2
Sequence conflict104 – 1063PYL → GYQ in AAA63214. Ref.1
Sequence conflict1131A → D in AAA63214. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P20382 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: 2339E8938EBEC499

FASTA16518,679
        10         20         30         40         50         60 
MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK EDTAEKSVIA 

        70         80         90        100        110        120 
PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL AIKPYLALKG SVAFPAENGV 

       130        140        150        160 
QNTESTQEKR EIGDEENSAK FPIGRRDFDM LRCMLGRVYR PCWQV 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the human melanin concentrating hormone mRNA."
Presse F., Nahon J.-L., Fischer W.H., Vale W.
Mol. Endocrinol. 4:632-637(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hypothalamus.
[2]"Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene."
Breton C., Schorpp M., Nahon J.-L.
Brain Res. Mol. Brain Res. 18:297-310(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Mammary cancer.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals."
Viale A., Ortola C., Hervieu G., Furuta M., Barbero P., Steiner D.F., Seidah N.G., Nahon J.-L.
J. Biol. Chem. 274:6536-6545(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING.
[6]"The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression."
Viale A., Zhixing Y., Breton C., Pedeutour F., Coquerel A., Jordan D., Nahon J.-L.
Brain Res. Mol. Brain Res. 46:243-255(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57703 mRNA. Translation: AAA63214.1.
S63697 Genomic DNA. Translation: AAB27493.1.
CH471054 Genomic DNA. Translation: EAW97693.1.
BC018048 mRNA. Translation: AAH18048.1.
CCDSCCDS31885.1.
PIRI52634.
RefSeqNP_002665.2. NM_002674.2.
UniGeneHs.707990.

3D structure databases

ProteinModelPortalP20382.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111380. 1 interaction.
STRING9606.ENSP00000332225.

Polymorphism databases

DMDM229462960.

Proteomic databases

PaxDbP20382.
PRIDEP20382.

Protocols and materials databases

DNASU5367.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329406; ENSP00000332225; ENSG00000183395.
GeneID5367.
KEGGhsa:5367.
UCSCuc001tjl.3. human.

Organism-specific databases

CTD5367.
GeneCardsGC12M102590.
HGNCHGNC:9109. PMCH.
HPAHPA046055.
MIM176795. gene.
neXtProtNX_P20382.
PharmGKBPA33435.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42445.
HOGENOMHOG000230520.
HOVERGENHBG052429.
InParanoidP20382.
KOK05229.
OMANLAIKPY.
OrthoDBEOG7X6M1T.
PhylomeDBP20382.
TreeFamTF330944.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP20382.
CleanExHS_PMCH.
GenevestigatorP20382.

Family and domain databases

InterProIPR005456. Prepro-melanin_conc_hormone.
[Graphical view]
PANTHERPTHR12091. PTHR12091. 1 hit.
PfamPF05824. Pro-MCH. 1 hit.
[Graphical view]
PRINTSPR01641. PROMCHFAMILY.
ProtoNetSearch...

Other

GenomeRNAi5367.
NextBio20804.
PMAP-CutDBQ8WVG0.
PROP20382.
SOURCESearch...

Entry information

Entry nameMCH_HUMAN
AccessionPrimary (citable) accession number: P20382
Secondary accession number(s): Q16044, Q8WVG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM