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Protein

Pro-MCH

Gene

PMCH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hormone, Neuropeptide

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

BioCyciZFISH:G66-32233-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP20382.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-MCH
Cleaved into the following 3 chains:
Neuropeptide-glycine-glutamic acid
Short name:
NGE
Short name:
Neuropeptide G-E
Neuropeptide-glutamic acid-isoleucine
Short name:
NEI
Short name:
Neuropeptide E-I
Gene namesi
Name:PMCH
Synonyms:MCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9109. PMCH.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5367.
OpenTargetsiENSG00000183395.
PharmGKBiPA33435.

Polymorphism and mutation databases

BioMutaiPMCH.
DMDMi229462960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001910422 – 165Pro-MCHAdd BLAST144
PeptideiPRO_0000019105110 – 128Neuropeptide-glycine-glutamic acidSequence analysisAdd BLAST19
PeptideiPRO_0000019106131 – 143Neuropeptide-glutamic acid-isoleucineAdd BLAST13
PeptideiPRO_0000019107147 – 165Melanin-concentrating hormoneAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143Isoleucine amideBy similarity1
Disulfide bondi153 ↔ 162By similarity

Post-translational modificationi

Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP20382.
PeptideAtlasiP20382.
PRIDEiP20382.

Miscellaneous databases

PMAP-CutDBQ8WVG0.

Expressioni

Tissue specificityi

Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.1 Publication

Gene expression databases

BgeeiENSG00000183395.
CleanExiHS_PMCH.
GenevisibleiP20382. HS.

Organism-specific databases

HPAiHPA046055.

Interactioni

Protein-protein interaction databases

BioGridi111380. 1 interactor.
STRINGi9606.ENSP00000332225.

Structurei

3D structure databases

ProteinModelPortaliP20382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW1Y. Eukaryota.
ENOG410XWB7. LUCA.
GeneTreeiENSGT00390000004984.
HOGENOMiHOG000230520.
HOVERGENiHBG052429.
InParanoidiP20382.
KOiK05229.
OMAiFMNDEEN.
OrthoDBiEOG091G0R53.
PhylomeDBiP20382.
TreeFamiTF330944.

Family and domain databases

InterProiIPR005456. Prepro-melanin_conc_hormone.
[Graphical view]
PANTHERiPTHR12091. PTHR12091. 1 hit.
PfamiPF05824. Pro-MCH. 1 hit.
[Graphical view]
PRINTSiPR01641. PROMCHFAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK
60 70 80 90 100
EDTAEKSVIA PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL
110 120 130 140 150
AIKPYLALKG SVAFPAENGV QNTESTQEKR EIGDEENSAK FPIGRRDFDM
160
LRCMLGRVYR PCWQV
Length:165
Mass (Da):18,679
Last modified:May 5, 2009 - v3
Checksum:i2339E8938EBEC499
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42F → S in AAB27493 (PubMed:8326825).Curated1
Sequence conflicti104 – 106PYL → GYQ in AAA63214 (PubMed:2149166).Curated3
Sequence conflicti113A → D in AAA63214 (PubMed:2149166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57703 mRNA. Translation: AAA63214.1.
S63697 Genomic DNA. Translation: AAB27493.1.
CH471054 Genomic DNA. Translation: EAW97693.1.
BC018048 mRNA. Translation: AAH18048.1.
CCDSiCCDS31885.1.
PIRiI52634.
RefSeqiNP_002665.2. NM_002674.3.
UniGeneiHs.707990.

Genome annotation databases

EnsembliENST00000329406; ENSP00000332225; ENSG00000183395.
GeneIDi5367.
KEGGihsa:5367.
UCSCiuc001tjl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57703 mRNA. Translation: AAA63214.1.
S63697 Genomic DNA. Translation: AAB27493.1.
CH471054 Genomic DNA. Translation: EAW97693.1.
BC018048 mRNA. Translation: AAH18048.1.
CCDSiCCDS31885.1.
PIRiI52634.
RefSeqiNP_002665.2. NM_002674.3.
UniGeneiHs.707990.

3D structure databases

ProteinModelPortaliP20382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111380. 1 interactor.
STRINGi9606.ENSP00000332225.

Polymorphism and mutation databases

BioMutaiPMCH.
DMDMi229462960.

Proteomic databases

PaxDbiP20382.
PeptideAtlasiP20382.
PRIDEiP20382.

Protocols and materials databases

DNASUi5367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329406; ENSP00000332225; ENSG00000183395.
GeneIDi5367.
KEGGihsa:5367.
UCSCiuc001tjl.4. human.

Organism-specific databases

CTDi5367.
DisGeNETi5367.
GeneCardsiPMCH.
HGNCiHGNC:9109. PMCH.
HPAiHPA046055.
MIMi176795. gene.
neXtProtiNX_P20382.
OpenTargetsiENSG00000183395.
PharmGKBiPA33435.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW1Y. Eukaryota.
ENOG410XWB7. LUCA.
GeneTreeiENSGT00390000004984.
HOGENOMiHOG000230520.
HOVERGENiHBG052429.
InParanoidiP20382.
KOiK05229.
OMAiFMNDEEN.
OrthoDBiEOG091G0R53.
PhylomeDBiP20382.
TreeFamiTF330944.

Enzyme and pathway databases

BioCyciZFISH:G66-32233-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP20382.

Miscellaneous databases

GenomeRNAii5367.
PMAP-CutDBQ8WVG0.
PROiP20382.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183395.
CleanExiHS_PMCH.
GenevisibleiP20382. HS.

Family and domain databases

InterProiIPR005456. Prepro-melanin_conc_hormone.
[Graphical view]
PANTHERiPTHR12091. PTHR12091. 1 hit.
PfamiPF05824. Pro-MCH. 1 hit.
[Graphical view]
PRINTSiPR01641. PROMCHFAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiMCH_HUMAN
AccessioniPrimary (citable) accession number: P20382
Secondary accession number(s): Q16044, Q8WVG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.