SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P20375

- COX2_APILI

UniProt

P20375 - COX2_APILI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 2
Gene
COII
Organism
Apis mellifera ligustica (Common honeybee) (Italian honeybee)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi159 – 1591Copper A Inferred
Metal bindingi194 – 1941Copper A Inferred
Metal bindingi198 – 1981Copper A Inferred
Metal bindingi202 – 2021Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiApis mellifera ligustica (Common honeybee) (Italian honeybee)
Taxonomic identifieri7469 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei26 – 4722Helical; Reviewed prediction
Add
BLAST
Topological domaini48 – 6215Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei63 – 8220Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 225143Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Cytochrome c oxidase subunit 2
PRO_0000183499Add
BLAST

Proteomic databases

PaxDbiP20375.

Structurei

3D structure databases

ProteinModelPortaliP20375.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
InParanoidiP20375.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20375-1 [UniParc]FASTAAdd to Basket

« Hide

MSTWFMFMFQ ESNSYYADNL ISFHNMVMMI IIMISTLTVY IILDLFMNKF    50
SNLFLLKNHN IEIIWTIIPI IILLIICFPS LKILYLIDEI VNPFFSIKSI 100
GHQWYWSYEY PEFNNIEFDS YMLNYNNLNQ FRLLETDNRM VIPMKIPLRL 150
ITTSTDVIHS WTVPSLGIKV DAVPGRINQL NLISKRPGIF FGQCSEICGM 200
NHSFMPIMIE STSFQYFLNW VNKQI 225
Length:225
Mass (Da):26,664
Last modified:February 1, 1991 - v1
Checksum:i2AFCA78E25B3109B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23409 Genomic DNA. Translation: AAA18477.1.
L06178 Genomic DNA. Translation: AAB96800.1.
PIRiB32431.
RefSeqiNP_008084.1. NC_001566.1.

Genome annotation databases

GeneIDi807700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23409 Genomic DNA. Translation: AAA18477.1 .
L06178 Genomic DNA. Translation: AAB96800.1 .
PIRi B32431.
RefSeqi NP_008084.1. NC_001566.1.

3D structure databases

ProteinModelPortali P20375.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P20375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807700.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

eggNOGi COG1622.
InParanoidi P20375.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The CO-I and CO-II region of honeybee mitochondrial DNA: evidence for variation in insect mitochondrial evolutionary rates."
    Crozier R.H., Crozier Y.C., Mackinlay A.G.
    Mol. Biol. Evol. 6:399-411(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Thorax.
  2. "The mitochondrial genome of the honeybee Apis mellifera: complete sequence and genome organization."
    Crozier R.H., Crozier Y.C.
    Genetics 133:97-117(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Thorax.

Entry informationi

Entry nameiCOX2_APILI
AccessioniPrimary (citable) accession number: P20375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi