Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P20375 (COX2_APILI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismApis mellifera ligustica (Common honeybee) (Italian honeybee)
Taxonomic identifier7469 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Cytochrome c oxidase subunit 2
PRO_0000183499

Regions

Topological domain1 – 2525Mitochondrial intermembrane Potential
Transmembrane26 – 4722Helical; Potential
Topological domain48 – 6215Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 225143Mitochondrial intermembrane Potential

Sites

Metal binding1591Copper A Probable
Metal binding1941Copper A Probable
Metal binding1981Copper A Probable
Metal binding2021Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P20375 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 2AFCA78E25B3109B

FASTA22526,664
        10         20         30         40         50         60 
MSTWFMFMFQ ESNSYYADNL ISFHNMVMMI IIMISTLTVY IILDLFMNKF SNLFLLKNHN 

        70         80         90        100        110        120 
IEIIWTIIPI IILLIICFPS LKILYLIDEI VNPFFSIKSI GHQWYWSYEY PEFNNIEFDS 

       130        140        150        160        170        180 
YMLNYNNLNQ FRLLETDNRM VIPMKIPLRL ITTSTDVIHS WTVPSLGIKV DAVPGRINQL 

       190        200        210        220 
NLISKRPGIF FGQCSEICGM NHSFMPIMIE STSFQYFLNW VNKQI 

« Hide

References

[1]"The CO-I and CO-II region of honeybee mitochondrial DNA: evidence for variation in insect mitochondrial evolutionary rates."
Crozier R.H., Crozier Y.C., Mackinlay A.G.
Mol. Biol. Evol. 6:399-411(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Thorax.
[2]"The mitochondrial genome of the honeybee Apis mellifera: complete sequence and genome organization."
Crozier R.H., Crozier Y.C.
Genetics 133:97-117(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Thorax.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M23409 Genomic DNA. Translation: AAA18477.1.
L06178 Genomic DNA. Translation: AAB96800.1.
PIRB32431.
RefSeqNP_008084.1. NC_001566.1.

3D structure databases

ProteinModelPortalP20375.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP20375.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID807700.

Organism-specific databases

CTD4513.

Phylogenomic databases

eggNOGCOG1622.
InParanoidP20375.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_APILI
AccessionPrimary (citable) accession number: P20375
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families