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P20375

- COX2_APILI

UniProt

P20375 - COX2_APILI

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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Apis mellifera ligustica (Common honeybee) (Italian honeybee)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi159 – 1591Copper ACurated
Metal bindingi194 – 1941Copper ACurated
Metal bindingi198 – 1981Copper ACurated
Metal bindingi202 – 2021Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiApis mellifera ligustica (Common honeybee) (Italian honeybee)
Taxonomic identifieri7469 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei26 – 4722HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 6215Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 225143Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Cytochrome c oxidase subunit 2PRO_0000183499Add
BLAST

Proteomic databases

PaxDbiP20375.

Structurei

3D structure databases

ProteinModelPortaliP20375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20375-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTWFMFMFQ ESNSYYADNL ISFHNMVMMI IIMISTLTVY IILDLFMNKF
60 70 80 90 100
SNLFLLKNHN IEIIWTIIPI IILLIICFPS LKILYLIDEI VNPFFSIKSI
110 120 130 140 150
GHQWYWSYEY PEFNNIEFDS YMLNYNNLNQ FRLLETDNRM VIPMKIPLRL
160 170 180 190 200
ITTSTDVIHS WTVPSLGIKV DAVPGRINQL NLISKRPGIF FGQCSEICGM
210 220
NHSFMPIMIE STSFQYFLNW VNKQI
Length:225
Mass (Da):26,664
Last modified:February 1, 1991 - v1
Checksum:i2AFCA78E25B3109B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23409 Genomic DNA. Translation: AAA18477.1.
L06178 Genomic DNA. Translation: AAB96800.1.
PIRiB32431.
RefSeqiNP_008084.1. NC_001566.1.

Genome annotation databases

GeneIDi807700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23409 Genomic DNA. Translation: AAA18477.1 .
L06178 Genomic DNA. Translation: AAB96800.1 .
PIRi B32431.
RefSeqi NP_008084.1. NC_001566.1.

3D structure databases

ProteinModelPortali P20375.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P20375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807700.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

eggNOGi COG1622.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The CO-I and CO-II region of honeybee mitochondrial DNA: evidence for variation in insect mitochondrial evolutionary rates."
    Crozier R.H., Crozier Y.C., Mackinlay A.G.
    Mol. Biol. Evol. 6:399-411(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Thorax.
  2. "The mitochondrial genome of the honeybee Apis mellifera: complete sequence and genome organization."
    Crozier R.H., Crozier Y.C.
    Genetics 133:97-117(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Thorax.

Entry informationi

Entry nameiCOX2_APILI
AccessioniPrimary (citable) accession number: P20375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3