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P20374

- COX1_APILI

UniProt

P20374 - COX1_APILI

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Apis mellifera ligustica (Common honeybee) (Italian honeybee)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron (heme A axial ligand)Curated
    Metal bindingi238 – 2381Copper BCurated
    Metal bindingi242 – 2421Copper BCurated
    Metal bindingi288 – 2881Copper BCurated
    Metal bindingi289 – 2891Copper BCurated
    Metal bindingi374 – 3741Iron (heme A3 axial ligand)Curated
    Metal bindingi376 – 3761Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiApis mellifera ligustica (Common honeybee) (Italian honeybee)
    Taxonomic identifieri7469 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome c oxidase subunit 1PRO_0000183284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP20374.
    SMRiP20374. Positions 3-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei383 – 40321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 47121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    InParanoidiP20374.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20374-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKWFMSTNH KNIGILYIIL ALWSGMLGSS MSLIIRMELS SPGSWISNDQ    50
    IYNTIVTSHA FLMIFFMVMP FLIGGFGNWL IPLMLGSPDM AFPRMNNISF 100
    WLLPPSLFML LLSNLFYPSP GTGWTVYPPL SAYLYHSSPS VDFAIFSLHM 150
    SGISSIMGSL NLMVTIMMMK NFSMNYDQIS LFPWSVFITA ILLIMSLPVL 200
    AGAITMLLFD RNFNTSFFDP MGGGDPILYQ HLFWFFGHPE VYILILPGFG 250
    LISHIVMNES GKKEIFGNLS MIYAMLGIGF LGFIVWAHHM FTVGLDVDTR 300
    AYFTSATMII AVPTGIKVFS WLATYHGSKL KLNISILWSL GFIMLFTIGG 350
    LTGIMLSNSS IDIILHDTYY VVGHFHYVLS MGAVFAIISS FIHWYPLITG 400
    LLLNIKWLKI QFIMMFIGVN LTFFPQHFLG LMSMPRRYSD YPDSYYCWNS 450
    ISSMGSMISL NSMIFLIFII LESLISKRML LFKFNQSSLE WLNFLPPLDH 500
    SHLEIPLLIK NLNLKSILIK F 521
    Length:521
    Mass (Da):59,294
    Last modified:February 1, 1991 - v1
    Checksum:i2149417AC981CE64
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081F → L in strain: Isolate ligus8.
    Natural varianti270 – 2701S → G in strain: Isolate ligus8.
    Natural varianti271 – 2711M → I in strain: Isolate ligus2.
    Natural varianti437 – 4371R → P in strain: Isolate ligus7.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23409 Genomic DNA. Translation: AAA18476.1.
    L06178 Genomic DNA. Translation: AAB96799.1.
    AY114452 Genomic DNA. Translation: AAM76437.1.
    AY114453 Genomic DNA. Translation: AAM76438.1.
    AY114454 Genomic DNA. Translation: AAM76439.1.
    AY114455 Genomic DNA. Translation: AAM76440.1.
    AY114456 Genomic DNA. Translation: AAM76441.1.
    AY114457 Genomic DNA. Translation: AAM76442.1.
    AY114458 Genomic DNA. Translation: AAM76443.1.
    AY114460 Genomic DNA. Translation: AAM76445.1.
    PIRiA32431.
    RefSeqiNP_008083.1. NC_001566.1.

    Genome annotation databases

    GeneIDi807695.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23409 Genomic DNA. Translation: AAA18476.1 .
    L06178 Genomic DNA. Translation: AAB96799.1 .
    AY114452 Genomic DNA. Translation: AAM76437.1 .
    AY114453 Genomic DNA. Translation: AAM76438.1 .
    AY114454 Genomic DNA. Translation: AAM76439.1 .
    AY114455 Genomic DNA. Translation: AAM76440.1 .
    AY114456 Genomic DNA. Translation: AAM76441.1 .
    AY114457 Genomic DNA. Translation: AAM76442.1 .
    AY114458 Genomic DNA. Translation: AAM76443.1 .
    AY114460 Genomic DNA. Translation: AAM76445.1 .
    PIRi A32431.
    RefSeqi NP_008083.1. NC_001566.1.

    3D structure databases

    ProteinModelPortali P20374.
    SMRi P20374. Positions 3-504.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 807695.

    Organism-specific databases

    CTDi 4512.

    Phylogenomic databases

    InParanoidi P20374.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The CO-I and CO-II region of honeybee mitochondrial DNA: evidence for variation in insect mitochondrial evolutionary rates."
      Crozier R.H., Crozier Y.C., Mackinlay A.G.
      Mol. Biol. Evol. 6:399-411(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Thorax.
    2. "The mitochondrial genome of the honeybee Apis mellifera: complete sequence and genome organization."
      Crozier R.H., Crozier Y.C.
      Genetics 133:97-117(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Thorax.
    3. "ND2 and CO1 mitochondrial genes in Apis mellifera L.: a molecular approach to Mediterranean populations monitoring."
      Marino A., Mantovani B., Carpana E., Sabatini A.G., Lodesani M.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 93-507.
      Strain: Isolate ligus2, Isolate ligus3, Isolate ligus4, Isolate ligus5, Isolate ligus6, Isolate ligus7, Isolate ligus8 and Isolate ligus9.
    4. "Putative origin and function of the intergenic region between COI and COII of Apis mellifera L. mitochondrial DNA."
      Cornuet J.-M., Garnery L., Solignac M.
      Genetics 128:393-403(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 338-521.

    Entry informationi

    Entry nameiCOX1_APILI
    AccessioniPrimary (citable) accession number: P20374
    Secondary accession number(s): Q8LUG0
    , Q8LXP4, Q8LXP6, Q8LXP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3