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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Apis mellifera ligustica (Common honeybee) (Italian honeybee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme A axial ligand)Curated1
Metal bindingi238Copper BCurated1
Metal bindingi242Copper BCurated1
Metal bindingi288Copper BCurated1
Metal bindingi289Copper BCurated1
Metal bindingi374Iron (heme A3 axial ligand)Curated1
Metal bindingi376Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiApis mellifera ligustica (Common honeybee) (Italian honeybee)
Taxonomic identifieri7469 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832841 – 521Cytochrome c oxidase subunit 1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP20374
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

P20374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKWFMSTNH KNIGILYIIL ALWSGMLGSS MSLIIRMELS SPGSWISNDQ
60 70 80 90 100
IYNTIVTSHA FLMIFFMVMP FLIGGFGNWL IPLMLGSPDM AFPRMNNISF
110 120 130 140 150
WLLPPSLFML LLSNLFYPSP GTGWTVYPPL SAYLYHSSPS VDFAIFSLHM
160 170 180 190 200
SGISSIMGSL NLMVTIMMMK NFSMNYDQIS LFPWSVFITA ILLIMSLPVL
210 220 230 240 250
AGAITMLLFD RNFNTSFFDP MGGGDPILYQ HLFWFFGHPE VYILILPGFG
260 270 280 290 300
LISHIVMNES GKKEIFGNLS MIYAMLGIGF LGFIVWAHHM FTVGLDVDTR
310 320 330 340 350
AYFTSATMII AVPTGIKVFS WLATYHGSKL KLNISILWSL GFIMLFTIGG
360 370 380 390 400
LTGIMLSNSS IDIILHDTYY VVGHFHYVLS MGAVFAIISS FIHWYPLITG
410 420 430 440 450
LLLNIKWLKI QFIMMFIGVN LTFFPQHFLG LMSMPRRYSD YPDSYYCWNS
460 470 480 490 500
ISSMGSMISL NSMIFLIFII LESLISKRML LFKFNQSSLE WLNFLPPLDH
510 520
SHLEIPLLIK NLNLKSILIK F
Length:521
Mass (Da):59,294
Last modified:February 1, 1991 - v1
Checksum:i2149417AC981CE64
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti108F → L in strain: Isolate ligus8. 1
Natural varianti270S → G in strain: Isolate ligus8. 1
Natural varianti271M → I in strain: Isolate ligus2. 1
Natural varianti437R → P in strain: Isolate ligus7. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23409 Genomic DNA Translation: AAA18476.1
L06178 Genomic DNA Translation: AAB96799.1
AY114452 Genomic DNA Translation: AAM76437.1
AY114453 Genomic DNA Translation: AAM76438.1
AY114454 Genomic DNA Translation: AAM76439.1
AY114455 Genomic DNA Translation: AAM76440.1
AY114456 Genomic DNA Translation: AAM76441.1
AY114457 Genomic DNA Translation: AAM76442.1
AY114458 Genomic DNA Translation: AAM76443.1
AY114460 Genomic DNA Translation: AAM76445.1
PIRiA32431
RefSeqiNP_008083.1, NC_001566.1

Genome annotation databases

GeneIDi807695

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOX1_APILI
AccessioniPrimary (citable) accession number: P20374
Secondary accession number(s): Q8LUG0
, Q8LXP4, Q8LXP6, Q8LXP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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