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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalytic1
Metal bindingi69Zinc 1; catalytic1
Metal bindingi100Zinc 21
Metal bindingi103Zinc 21
Metal bindingi106Zinc 21
Metal bindingi114Zinc 21
Metal bindingi156Zinc 1; catalytic1
Binding sitei204NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I
Gene namesi
Name:ADH1
Ordered Locus Names:KLLA0F21010g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607221 – 350Alcohol dehydrogenase 1Add BLAST350

Proteomic databases

PRIDEiP20369.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi284590.XP_456023.1.

Structurei

3D structure databases

ProteinModelPortaliP20369.
SMRiP20369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP20369.
KOiK13953.
OMAiESNCPEA.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P20369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASIPETQK GVIFYENGGE LQYKDIPVPK PKANELLINV KYSGVCHTDL
60 70 80 90 100
HAWKGDWPLP TKLPLVGGHE GAGVVVAMGE NVKGWKIGDF AGIKWLNGSC
110 120 130 140 150
MSCEYCELSN ESNCPEADLS GYTHDGSFQQ YATADAVQAA KIPVGTDLAE
160 170 180 190 200
VAPVLCAGVT VYKALKSANL KAGDWVAISG AAGGLGSLAV QYAKAMGYRV
210 220 230 240 250
LGIDAGEEKA KLFKDLGGEY FIDFTKSKNI PEEVIEATKG GAHGVINVSV
260 270 280 290 300
SEFAIEQSTN YVRSNGTVVL VGLPRDAKCK SDVFNQVVKS ISIVGSYVGN
310 320 330 340 350
RADTREAIDF FSRGLVKAPI HVVGLSELPS IYEKMEKGAI VGRYVVDTSK
Length:350
Mass (Da):37,261
Last modified:February 1, 1991 - v1
Checksum:i3D71BE2D5CC86119
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98731.1.
PIRiS09475.
RefSeqiXP_456023.1. XM_456023.1.

Genome annotation databases

EnsemblFungiiCAG98731; CAG98731; KLLA0_F21010g.
GeneIDi2895056.
KEGGikla:KLLA0F21010g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98731.1.
PIRiS09475.
RefSeqiXP_456023.1. XM_456023.1.

3D structure databases

ProteinModelPortaliP20369.
SMRiP20369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_456023.1.

Proteomic databases

PRIDEiP20369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG98731; CAG98731; KLLA0_F21010g.
GeneIDi2895056.
KEGGikla:KLLA0F21010g.

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP20369.
KOiK13953.
OMAiESNCPEA.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_KLULA
AccessioniPrimary (citable) accession number: P20369
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 15, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.