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Protein

Alcohol dehydrogenase 1

Gene

adhA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

In Z.mobilis there are two isozymes of alcohol dehydrogenase.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Enzyme regulationi

Inhibited by ethanol.

Pathwayi: ethanol biosynthesis via fermentation pathway

This protein is involved in the pathway ethanol biosynthesis via fermentation pathway, which is part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the pathway ethanol biosynthesis via fermentation pathway and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Zinc 1; catalyticBy similarity1
Metal bindingi58Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi145Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00778.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I
Short name:
ADH I
Gene namesi
Name:adhA
Ordered Locus Names:ZMO1236
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607501 – 337Alcohol dehydrogenase 1Add BLAST337

Interactioni

Subunit structurei

Multimeric (with different ratios of monomers).

Structurei

3D structure databases

ProteinModelPortaliP20368.
SMRiP20368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685.
KOiK13953.
OMAiYKGLKMT.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P20368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAVITKDH TIEVKDTKLR PLKYGEALLE MEYCGVCHTD LHVKNGDFGD
60 70 80 90 100
ETGRITGHEG IGIVKQVGEG VTSLKVGDRA SVAWFFKGCG HCEYCVSGNE
110 120 130 140 150
TLCRNVENAG YTVDGAMAEE CIVVADYSVK VPDGLDPAVA SSITCAGVTT
160 170 180 190 200
YKAVKVSQIQ PGQWLAIYGL GGLGNLALQY AKNVFNAKVI AIDVNDEQLA
210 220 230 240 250
FAKELGADMV INPKNEDAAK IIQEKVGGAH ATVVTAVAKS AFNSAVEAIR
260 270 280 290 300
AGGRVVAVGL PPEKMDLSIP RLVLDGIEVL GSLVGTREDL KEAFQFAAEG
310 320 330
KVKPKVTKRK VEEINQIFDE MEHGKFTGRM VVDFTHH
Length:337
Mass (Da):36,122
Last modified:February 15, 2005 - v2
Checksum:i98D75C912CE1EBE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17T → I AA sequence (PubMed:2935393).Curated1
Sequence conflicti26E → F AA sequence (PubMed:2935393).Curated1
Sequence conflicti28L → H AA sequence (PubMed:2935393).Curated1
Sequence conflicti30E → P AA sequence (PubMed:2935393).Curated1
Sequence conflicti76V → A in AAA27682 (PubMed:2185223).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32100 Genomic DNA. Translation: AAA27682.1.
AY170008 Genomic DNA. Translation: AAO38758.1.
AE008692 Genomic DNA. Translation: AAV89860.1.
L09650 Genomic DNA. Translation: AAA71935.2.
PIRiA35260.
RefSeqiWP_011241052.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89860; AAV89860; ZMO1236.
KEGGizmo:ZMO1236.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH1_ZYMMO
AccessioniPrimary (citable) accession number: P20368
Secondary accession number(s): Q5NN50, Q6Y8J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 15, 2005
Last modified: June 7, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families