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Protein

Protachykinin-1

Gene

TAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006128-MONOMER.
ReactomeiR-HSA-380095. Tachykinin receptors bind tachykinins.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP20366.

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
Gene namesi
Name:TAC1
Synonyms:NKA, NKNA, TAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11517. TAC1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6863.
OpenTargetsiENSG00000006128.
PharmGKBiPA36297.

Polymorphism and mutation databases

BioMutaiTAC1.
DMDMi135886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003352920 – 56Sequence analysisAdd BLAST37
PeptideiPRO_000003353058 – 68Substance PAdd BLAST11
PeptideiPRO_000003353172 – 107Neuropeptide KAdd BLAST36
PeptideiPRO_000003353272 – 73Neuropeptide gamma, 1st part2
PeptideiPRO_000003353389 – 107Neuropeptide gamma, 2nd partAdd BLAST19
PeptideiPRO_000003353498 – 107Neurokinin A10
PeptideiPRO_0000033535111 – 126C-terminal-flanking peptideAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68Methionine amide1 Publication1
Modified residuei107Methionine amide2 Publications1

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP20366.
PeptideAtlasiP20366.
PRIDEiP20366.

PTM databases

PhosphoSitePlusiP20366.

Miscellaneous databases

PMAP-CutDBP20366.

Expressioni

Gene expression databases

BgeeiENSG00000006128.
CleanExiHS_TAC1.
GenevisibleiP20366. HS.

Organism-specific databases

HPAiCAB004588.
HPA014429.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TACR1P251032EBI-6655360,EBI-6655287
TACR2P214522EBI-6655449,EBI-6655413

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112727. 6 interactors.
IntActiP20366. 9 interactors.
MINTiMINT-1409908.
STRINGi9606.ENSP00000321106.

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni59 – 62Combined sources4
Turni64 – 66Combined sources3
Helixi73 – 80Combined sources8
Helixi81 – 88Combined sources8
Helixi89 – 91Combined sources3
Helixi92 – 95Combined sources4
Helixi98 – 101Combined sources4
Helixi102 – 106Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B19NMR-A72-107[»]
2KS9NMR-B58-68[»]
2KSANMR-B58-68[»]
2KSBNMR-B58-68[»]
4HOMX-ray1.90B58-68[»]
ProteinModelPortaliP20366.
SMRiP20366.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20366.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZZ. Eukaryota.
ENOG4112BW1. LUCA.
GeneTreeiENSGT00390000002457.
HOVERGENiHBG000127.
InParanoidiP20366.
KOiK05239.
OMAiEMGANDD.
OrthoDBiEOG091G0Y2V.
PhylomeDBiP20366.
TreeFamiTF333405.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P20366-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVALAVF FLVSTQLFAE EIGANDDLNY WSDWYDSDQI KEELPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT
110 120
DSFVGLMGKR ALNSVAYERS AMQNYERRR
Length:129
Mass (Da):15,003
Last modified:February 1, 1991 - v1
Checksum:i51412C1692368DE4
GO
Isoform Alpha (identifier: P20366-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-114: Missing.
     115-115: V → M

Show »
Length:111
Mass (Da):13,036
Checksum:i28E051E5ACC42C47
GO
Isoform Gamma (identifier: P20366-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:114
Mass (Da):13,343
Checksum:i499EECB627AECDE6
GO
Isoform Delta (identifier: P20366-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.
     97-114: Missing.
     115-115: V → M

Show »
Length:96
Mass (Da):11,376
Checksum:iAE50A94DF2437361
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → P in BAD96677 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00637574 – 88Missing in isoform Gamma and isoform Delta. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_00637697 – 114Missing in isoform Alpha and isoform Delta. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_006377115V → M in isoform Alpha and isoform Delta. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54469 mRNA. Translation: CAA38351.1.
U37529 mRNA. Translation: AAA79195.1.
CR407602 mRNA. Translation: CAG28529.1.
CR541730 mRNA. Translation: CAG46531.1.
AK222957 mRNA. Translation: BAD96677.1.
AC004140 Genomic DNA. Translation: AAQ96888.1.
AC004140 Genomic DNA. Translation: AAQ96889.1.
AC004140 Genomic DNA. Translation: AAQ96890.1.
AC004140 Genomic DNA. Translation: AAQ96891.1.
CH236949 Genomic DNA. Translation: EAL24116.1.
CH236949 Genomic DNA. Translation: EAL24117.1.
CH236949 Genomic DNA. Translation: EAL24118.1.
CH236949 Genomic DNA. Translation: EAL24119.1.
CH471091 Genomic DNA. Translation: EAW76734.1.
CH471091 Genomic DNA. Translation: EAW76735.1.
CH471091 Genomic DNA. Translation: EAW76736.1.
CH471091 Genomic DNA. Translation: EAW76737.1.
BC018047 mRNA. Translation: AAH18047.1.
M68906 mRNA. Translation: AAA60159.1.
M68907 mRNA. Translation: AAA60160.1.
AF050655 mRNA. Translation: AAC15701.1.
AF050656 mRNA. Translation: AAC15702.1.
AF050658 mRNA. Translation: AAC15704.1.
CCDSiCCDS5649.1. [P20366-1]
CCDS5650.1. [P20366-2]
CCDS5651.1. [P20366-3]
PIRiA24805. SPHUB.
RefSeqiNP_003173.1. NM_003182.2. [P20366-1]
NP_054702.1. NM_013996.2. [P20366-2]
NP_054703.1. NM_013997.2. [P20366-3]
NP_054704.1. NM_013998.2. [P20366-4]
UniGeneiHs.2563.

Genome annotation databases

EnsembliENST00000319273; ENSP00000321106; ENSG00000006128. [P20366-1]
ENST00000346867; ENSP00000289574; ENSG00000006128. [P20366-3]
ENST00000350485; ENSP00000289576; ENSG00000006128. [P20366-2]
GeneIDi6863.
KEGGihsa:6863.
UCSCiuc003uop.5. human. [P20366-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Neurokinin-1 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54469 mRNA. Translation: CAA38351.1.
U37529 mRNA. Translation: AAA79195.1.
CR407602 mRNA. Translation: CAG28529.1.
CR541730 mRNA. Translation: CAG46531.1.
AK222957 mRNA. Translation: BAD96677.1.
AC004140 Genomic DNA. Translation: AAQ96888.1.
AC004140 Genomic DNA. Translation: AAQ96889.1.
AC004140 Genomic DNA. Translation: AAQ96890.1.
AC004140 Genomic DNA. Translation: AAQ96891.1.
CH236949 Genomic DNA. Translation: EAL24116.1.
CH236949 Genomic DNA. Translation: EAL24117.1.
CH236949 Genomic DNA. Translation: EAL24118.1.
CH236949 Genomic DNA. Translation: EAL24119.1.
CH471091 Genomic DNA. Translation: EAW76734.1.
CH471091 Genomic DNA. Translation: EAW76735.1.
CH471091 Genomic DNA. Translation: EAW76736.1.
CH471091 Genomic DNA. Translation: EAW76737.1.
BC018047 mRNA. Translation: AAH18047.1.
M68906 mRNA. Translation: AAA60159.1.
M68907 mRNA. Translation: AAA60160.1.
AF050655 mRNA. Translation: AAC15701.1.
AF050656 mRNA. Translation: AAC15702.1.
AF050658 mRNA. Translation: AAC15704.1.
CCDSiCCDS5649.1. [P20366-1]
CCDS5650.1. [P20366-2]
CCDS5651.1. [P20366-3]
PIRiA24805. SPHUB.
RefSeqiNP_003173.1. NM_003182.2. [P20366-1]
NP_054702.1. NM_013996.2. [P20366-2]
NP_054703.1. NM_013997.2. [P20366-3]
NP_054704.1. NM_013998.2. [P20366-4]
UniGeneiHs.2563.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B19NMR-A72-107[»]
2KS9NMR-B58-68[»]
2KSANMR-B58-68[»]
2KSBNMR-B58-68[»]
4HOMX-ray1.90B58-68[»]
ProteinModelPortaliP20366.
SMRiP20366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112727. 6 interactors.
IntActiP20366. 9 interactors.
MINTiMINT-1409908.
STRINGi9606.ENSP00000321106.

PTM databases

PhosphoSitePlusiP20366.

Polymorphism and mutation databases

BioMutaiTAC1.
DMDMi135886.

Proteomic databases

PaxDbiP20366.
PeptideAtlasiP20366.
PRIDEiP20366.

Protocols and materials databases

DNASUi6863.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319273; ENSP00000321106; ENSG00000006128. [P20366-1]
ENST00000346867; ENSP00000289574; ENSG00000006128. [P20366-3]
ENST00000350485; ENSP00000289576; ENSG00000006128. [P20366-2]
GeneIDi6863.
KEGGihsa:6863.
UCSCiuc003uop.5. human. [P20366-1]

Organism-specific databases

CTDi6863.
DisGeNETi6863.
GeneCardsiTAC1.
HGNCiHGNC:11517. TAC1.
HPAiCAB004588.
HPA014429.
MIMi162320. gene.
neXtProtiNX_P20366.
OpenTargetsiENSG00000006128.
PharmGKBiPA36297.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWZZ. Eukaryota.
ENOG4112BW1. LUCA.
GeneTreeiENSGT00390000002457.
HOVERGENiHBG000127.
InParanoidiP20366.
KOiK05239.
OMAiEMGANDD.
OrthoDBiEOG091G0Y2V.
PhylomeDBiP20366.
TreeFamiTF333405.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006128-MONOMER.
ReactomeiR-HSA-380095. Tachykinin receptors bind tachykinins.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP20366.

Miscellaneous databases

EvolutionaryTraceiP20366.
GeneWikiiTAC1.
GenomeRNAii6863.
PMAP-CutDBP20366.
PROiP20366.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006128.
CleanExiHS_TAC1.
GenevisibleiP20366. HS.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTKN1_HUMAN
AccessioniPrimary (citable) accession number: P20366
Secondary accession number(s): O60600
, O60601, Q00072, Q53GH4, Q549V0, Q549V1, Q549V2, Q6FHM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 170 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.