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P20366

- TKN1_HUMAN

UniProt

P20366 - TKN1_HUMAN

Protein

Protachykinin-1

Gene

TAC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. associative learning Source: Ensembl
    2. cell-cell signaling Source: ProtInc
    3. detection of abiotic stimulus Source: ProtInc
    4. inflammatory response Source: Ensembl
    5. insemination Source: ProtInc
    6. long-term memory Source: Ensembl
    7. negative regulation of heart rate Source: Ensembl
    8. neuropeptide signaling pathway Source: UniProtKB-KW
    9. positive regulation of action potential Source: Ensembl
    10. positive regulation of acute inflammatory response Source: Ensembl
    11. positive regulation of corticosterone secretion Source: Ensembl
    12. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    13. positive regulation of epithelial cell migration Source: Ensembl
    14. positive regulation of lymphocyte proliferation Source: Ensembl
    15. positive regulation of ossification Source: Ensembl
    16. positive regulation of renal sodium excretion Source: Ensembl
    17. positive regulation of saliva secretion Source: Ensembl
    18. positive regulation of stress fiber assembly Source: Ensembl
    19. positive regulation of synaptic transmission, cholinergic Source: Ensembl
    20. positive regulation of synaptic transmission, GABAergic Source: Ensembl
    21. regulation of blood pressure Source: Ensembl
    22. response to hormone Source: Ensembl
    23. response to lipopolysaccharide Source: Ensembl
    24. response to morphine Source: Ensembl
    25. response to pain Source: Ensembl
    26. sensory perception of pain Source: Ensembl
    27. synaptic transmission Source: UniProtKB-KW
    28. tachykinin receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter

    Enzyme and pathway databases

    ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protachykinin-1
    Alternative name(s):
    PPT
    Cleaved into the following 5 chains:
    Neurokinin A
    Short name:
    NKA
    Alternative name(s):
    Neuromedin L
    Substance K
    Neuropeptide K
    Short name:
    NPK
    Gene namesi
    Name:TAC1
    Synonyms:NKA, NKNA, TAC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:11517. TAC1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: ProtInc
    4. neuronal cell body Source: Ensembl
    5. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36297.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 5637Sequence AnalysisPRO_0000033529Add
    BLAST
    Peptidei58 – 6811Substance PPRO_0000033530Add
    BLAST
    Peptidei72 – 10736Neuropeptide KPRO_0000033531Add
    BLAST
    Peptidei72 – 732Neuropeptide gamma, 1st partPRO_0000033532
    Peptidei89 – 10719Neuropeptide gamma, 2nd partPRO_0000033533Add
    BLAST
    Peptidei98 – 10710Neurokinin APRO_0000033534
    Peptidei111 – 12616C-terminal-flanking peptidePRO_0000033535Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei68 – 681Methionine amide1 Publication
    Modified residuei107 – 1071Methionine amide2 Publications

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP20366.
    PRIDEiP20366.

    PTM databases

    PhosphoSiteiP20366.

    Miscellaneous databases

    PMAP-CutDBP20366.

    Expressioni

    Gene expression databases

    ArrayExpressiP20366.
    BgeeiP20366.
    CleanExiHS_TAC1.
    GenevestigatoriP20366.

    Organism-specific databases

    HPAiCAB004588.
    HPA014429.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TACR1P251032EBI-6655360,EBI-6655287
    TACR2P214522EBI-6655449,EBI-6655413

    Protein-protein interaction databases

    BioGridi112727. 8 interactions.
    IntActiP20366. 9 interactions.
    MINTiMINT-1409908.
    STRINGi9606.ENSP00000321106.

    Structurei

    Secondary structure

    1
    129
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni59 – 624
    Turni64 – 663
    Helixi73 – 808
    Helixi81 – 888
    Helixi89 – 913
    Helixi92 – 954
    Helixi98 – 1014
    Helixi102 – 1065

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B19NMR-A72-107[»]
    2KS9NMR-B58-68[»]
    2KSANMR-B58-68[»]
    2KSBNMR-B58-68[»]
    4HOMX-ray1.90B58-68[»]
    ProteinModelPortaliP20366.
    SMRiP20366. Positions 72-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20366.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tachykinin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40889.
    HOVERGENiHBG000127.
    InParanoidiP20366.
    KOiK05239.
    OMAiAYERNAM.
    OrthoDBiEOG7C2R3N.
    PhylomeDBiP20366.
    TreeFamiTF333405.

    Family and domain databases

    InterProiIPR008216. Protachykinin.
    IPR013055. Tachy_Neuro_lke_CS.
    IPR008215. Tachykinin.
    [Graphical view]
    PANTHERiPTHR11250. PTHR11250. 1 hit.
    PRINTSiPR01829. PROTACHYKNIN.
    SMARTiSM00203. TK. 2 hits.
    [Graphical view]
    PROSITEiPS00267. TACHYKININ. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Beta (identifier: P20366-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKILVALAVF FLVSTQLFAE EIGANDDLNY WSDWYDSDQI KEELPEPFEH    50
    LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT 100
    DSFVGLMGKR ALNSVAYERS AMQNYERRR 129
    Length:129
    Mass (Da):15,003
    Last modified:February 1, 1991 - v1
    Checksum:i51412C1692368DE4
    GO
    Isoform Alpha (identifier: P20366-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         97-114: Missing.
         115-115: V → M

    Show »
    Length:111
    Mass (Da):13,036
    Checksum:i28E051E5ACC42C47
    GO
    Isoform Gamma (identifier: P20366-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-88: Missing.

    Show »
    Length:114
    Mass (Da):13,343
    Checksum:i499EECB627AECDE6
    GO
    Isoform Delta (identifier: P20366-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-88: Missing.
         97-114: Missing.
         115-115: V → M

    Show »
    Length:96
    Mass (Da):11,376
    Checksum:iAE50A94DF2437361
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321S → P in BAD96677. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei74 – 8815Missing in isoform Gamma and isoform Delta. 2 PublicationsVSP_006375Add
    BLAST
    Alternative sequencei97 – 11418Missing in isoform Alpha and isoform Delta. 1 PublicationVSP_006376Add
    BLAST
    Alternative sequencei115 – 1151V → M in isoform Alpha and isoform Delta. 1 PublicationVSP_006377

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54469 mRNA. Translation: CAA38351.1.
    U37529 mRNA. Translation: AAA79195.1.
    CR407602 mRNA. Translation: CAG28529.1.
    CR541730 mRNA. Translation: CAG46531.1.
    AK222957 mRNA. Translation: BAD96677.1.
    AC004140 Genomic DNA. Translation: AAQ96888.1.
    AC004140 Genomic DNA. Translation: AAQ96889.1.
    AC004140 Genomic DNA. Translation: AAQ96890.1.
    AC004140 Genomic DNA. Translation: AAQ96891.1.
    CH236949 Genomic DNA. Translation: EAL24116.1.
    CH236949 Genomic DNA. Translation: EAL24117.1.
    CH236949 Genomic DNA. Translation: EAL24118.1.
    CH236949 Genomic DNA. Translation: EAL24119.1.
    CH471091 Genomic DNA. Translation: EAW76734.1.
    CH471091 Genomic DNA. Translation: EAW76735.1.
    CH471091 Genomic DNA. Translation: EAW76736.1.
    CH471091 Genomic DNA. Translation: EAW76737.1.
    BC018047 mRNA. Translation: AAH18047.1.
    M68906 mRNA. Translation: AAA60159.1.
    M68907 mRNA. Translation: AAA60160.1.
    AF050655 mRNA. Translation: AAC15701.1.
    AF050656 mRNA. Translation: AAC15702.1.
    AF050658 mRNA. Translation: AAC15704.1.
    CCDSiCCDS5649.1. [P20366-1]
    CCDS5650.1. [P20366-2]
    CCDS5651.1. [P20366-3]
    PIRiA24805. SPHUB.
    RefSeqiNP_003173.1. NM_003182.2. [P20366-1]
    NP_054702.1. NM_013996.2. [P20366-2]
    NP_054703.1. NM_013997.2. [P20366-3]
    NP_054704.1. NM_013998.2. [P20366-4]
    UniGeneiHs.2563.

    Genome annotation databases

    EnsembliENST00000319273; ENSP00000321106; ENSG00000006128. [P20366-1]
    ENST00000346867; ENSP00000289574; ENSG00000006128. [P20366-3]
    ENST00000350485; ENSP00000289576; ENSG00000006128. [P20366-2]
    GeneIDi6863.
    KEGGihsa:6863.
    UCSCiuc003uop.4. human. [P20366-1]
    uc003uoq.4. human. [P20366-2]
    uc003uor.4. human. [P20366-3]
    uc003uos.4. human. [P20366-4]

    Polymorphism databases

    DMDMi135886.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Neurokinin-1 entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54469 mRNA. Translation: CAA38351.1 .
    U37529 mRNA. Translation: AAA79195.1 .
    CR407602 mRNA. Translation: CAG28529.1 .
    CR541730 mRNA. Translation: CAG46531.1 .
    AK222957 mRNA. Translation: BAD96677.1 .
    AC004140 Genomic DNA. Translation: AAQ96888.1 .
    AC004140 Genomic DNA. Translation: AAQ96889.1 .
    AC004140 Genomic DNA. Translation: AAQ96890.1 .
    AC004140 Genomic DNA. Translation: AAQ96891.1 .
    CH236949 Genomic DNA. Translation: EAL24116.1 .
    CH236949 Genomic DNA. Translation: EAL24117.1 .
    CH236949 Genomic DNA. Translation: EAL24118.1 .
    CH236949 Genomic DNA. Translation: EAL24119.1 .
    CH471091 Genomic DNA. Translation: EAW76734.1 .
    CH471091 Genomic DNA. Translation: EAW76735.1 .
    CH471091 Genomic DNA. Translation: EAW76736.1 .
    CH471091 Genomic DNA. Translation: EAW76737.1 .
    BC018047 mRNA. Translation: AAH18047.1 .
    M68906 mRNA. Translation: AAA60159.1 .
    M68907 mRNA. Translation: AAA60160.1 .
    AF050655 mRNA. Translation: AAC15701.1 .
    AF050656 mRNA. Translation: AAC15702.1 .
    AF050658 mRNA. Translation: AAC15704.1 .
    CCDSi CCDS5649.1. [P20366-1 ]
    CCDS5650.1. [P20366-2 ]
    CCDS5651.1. [P20366-3 ]
    PIRi A24805. SPHUB.
    RefSeqi NP_003173.1. NM_003182.2. [P20366-1 ]
    NP_054702.1. NM_013996.2. [P20366-2 ]
    NP_054703.1. NM_013997.2. [P20366-3 ]
    NP_054704.1. NM_013998.2. [P20366-4 ]
    UniGenei Hs.2563.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B19 NMR - A 72-107 [» ]
    2KS9 NMR - B 58-68 [» ]
    2KSA NMR - B 58-68 [» ]
    2KSB NMR - B 58-68 [» ]
    4HOM X-ray 1.90 B 58-68 [» ]
    ProteinModelPortali P20366.
    SMRi P20366. Positions 72-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112727. 8 interactions.
    IntActi P20366. 9 interactions.
    MINTi MINT-1409908.
    STRINGi 9606.ENSP00000321106.

    Chemistry

    BindingDBi P20366.
    DrugBanki DB00626. Bacitracin.

    PTM databases

    PhosphoSitei P20366.

    Polymorphism databases

    DMDMi 135886.

    Proteomic databases

    PaxDbi P20366.
    PRIDEi P20366.

    Protocols and materials databases

    DNASUi 6863.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319273 ; ENSP00000321106 ; ENSG00000006128 . [P20366-1 ]
    ENST00000346867 ; ENSP00000289574 ; ENSG00000006128 . [P20366-3 ]
    ENST00000350485 ; ENSP00000289576 ; ENSG00000006128 . [P20366-2 ]
    GeneIDi 6863.
    KEGGi hsa:6863.
    UCSCi uc003uop.4. human. [P20366-1 ]
    uc003uoq.4. human. [P20366-2 ]
    uc003uor.4. human. [P20366-3 ]
    uc003uos.4. human. [P20366-4 ]

    Organism-specific databases

    CTDi 6863.
    GeneCardsi GC07P097361.
    HGNCi HGNC:11517. TAC1.
    HPAi CAB004588.
    HPA014429.
    MIMi 162320. gene.
    neXtProti NX_P20366.
    PharmGKBi PA36297.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40889.
    HOVERGENi HBG000127.
    InParanoidi P20366.
    KOi K05239.
    OMAi AYERNAM.
    OrthoDBi EOG7C2R3N.
    PhylomeDBi P20366.
    TreeFami TF333405.

    Enzyme and pathway databases

    Reactomei REACT_16963. Tachykinin receptors bind tachykinins.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P20366.
    GeneWikii TAC1.
    GenomeRNAii 6863.
    NextBioi 26783.
    PMAP-CutDB P20366.
    PROi P20366.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20366.
    Bgeei P20366.
    CleanExi HS_TAC1.
    Genevestigatori P20366.

    Family and domain databases

    InterProi IPR008216. Protachykinin.
    IPR013055. Tachy_Neuro_lke_CS.
    IPR008215. Tachykinin.
    [Graphical view ]
    PANTHERi PTHR11250. PTHR11250. 1 hit.
    PRINTSi PR01829. PROTACHYKNIN.
    SMARTi SM00203. TK. 2 hits.
    [Graphical view ]
    PROSITEi PS00267. TACHYKININ. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A."
      Harmar A.J., Armstrong A., Pascall J.C., Chapman K., Rosie R., Curtis A., Going J., Edwards C.R.W., Fink G.
      FEBS Lett. 208:67-72(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), AMIDATION AT MET-68 AND MET-107.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
    3. Tan A., Too H.P.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
      Tissue: Brain.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
      Tissue: Small intestine.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
      Tissue: Brain.
    9. "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis."
      Chiwakata C., Brackmann B., Hunt N., Davidoff M., Schulze W., Ivell R.
      Endocrinology 128:2441-2448(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-122 (ISOFORMS BETA AND GAMMA).
      Tissue: Testis.
    10. "Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour."
      Theodorsson-Norheim E., Joernvall H., Andersson M., Norheim I., Oeberg K., Jacobsson G.
      Eur. J. Biochem. 166:693-697(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 98-107, AMIDATION AT MET-107.
    11. "Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes."
      Lai J.P., Douglas S.D., Rappaport E., Wu J.M., Ho W.Z.
      J. Neuroimmunol. 91:121-128(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-122 (ISOFORMS ALPHA; BETA AND DELTA).
      Tissue: Blood and Brain.
    12. "Characterization of the C-terminal flanking peptide of human beta-preprotachykinin."
      McGregor G.P., Conlon J.M.
      Peptides 11:907-910(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 111-126.
      Tissue: Adrenal medulla.
    13. "Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles."
      Dike A., Cowsik S.M.
      Biochemistry 45:2994-3004(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 72-107.

    Entry informationi

    Entry nameiTKN1_HUMAN
    AccessioniPrimary (citable) accession number: P20366
    Secondary accession number(s): O60600
    , O60601, Q00072, Q53GH4, Q549V0, Q549V1, Q549V2, Q6FHM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 153 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3