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P20366

- TKN1_HUMAN

UniProt

P20366 - TKN1_HUMAN

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Protein

Protachykinin-1

Gene

TAC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei59 – 602Cleavage; by FAP1 Publication

GO - Biological processi

  1. associative learning Source: Ensembl
  2. cell-cell signaling Source: ProtInc
  3. detection of abiotic stimulus Source: ProtInc
  4. inflammatory response Source: Ensembl
  5. insemination Source: ProtInc
  6. long-term memory Source: Ensembl
  7. negative regulation of heart rate Source: Ensembl
  8. neuropeptide signaling pathway Source: UniProtKB-KW
  9. positive regulation of action potential Source: Ensembl
  10. positive regulation of acute inflammatory response Source: Ensembl
  11. positive regulation of corticosterone secretion Source: Ensembl
  12. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  13. positive regulation of epithelial cell migration Source: Ensembl
  14. positive regulation of lymphocyte proliferation Source: Ensembl
  15. positive regulation of ossification Source: Ensembl
  16. positive regulation of renal sodium excretion Source: Ensembl
  17. positive regulation of saliva secretion Source: Ensembl
  18. positive regulation of stress fiber assembly Source: Ensembl
  19. positive regulation of synaptic transmission, cholinergic Source: Ensembl
  20. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  21. regulation of blood pressure Source: Ensembl
  22. response to hormone Source: Ensembl
  23. response to lipopolysaccharide Source: Ensembl
  24. response to morphine Source: Ensembl
  25. response to pain Source: Ensembl
  26. sensory perception of pain Source: Ensembl
  27. synaptic transmission Source: UniProtKB-KW
  28. tachykinin receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Enzyme and pathway databases

ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
Gene namesi
Name:TAC1
Synonyms:NKA, NKNA, TAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:11517. TAC1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: ProtInc
  4. neuronal cell body Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 5637Sequence AnalysisPRO_0000033529Add
BLAST
Peptidei58 – 6811Substance PPRO_0000033530Add
BLAST
Peptidei72 – 10736Neuropeptide KPRO_0000033531Add
BLAST
Peptidei72 – 732Neuropeptide gamma, 1st partPRO_0000033532
Peptidei89 – 10719Neuropeptide gamma, 2nd partPRO_0000033533Add
BLAST
Peptidei98 – 10710Neurokinin APRO_0000033534
Peptidei111 – 12616C-terminal-flanking peptidePRO_0000033535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681Methionine amide1 Publication
Modified residuei107 – 1071Methionine amide2 Publications

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP20366.
PRIDEiP20366.

PTM databases

PhosphoSiteiP20366.

Miscellaneous databases

PMAP-CutDBP20366.

Expressioni

Gene expression databases

BgeeiP20366.
CleanExiHS_TAC1.
ExpressionAtlasiP20366. baseline and differential.
GenevestigatoriP20366.

Organism-specific databases

HPAiCAB004588.
HPA014429.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TACR1P251032EBI-6655360,EBI-6655287
TACR2P214522EBI-6655449,EBI-6655413

Protein-protein interaction databases

BioGridi112727. 8 interactions.
IntActiP20366. 9 interactions.
MINTiMINT-1409908.
STRINGi9606.ENSP00000321106.

Structurei

Secondary structure

1
129
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni59 – 624
Turni64 – 663
Helixi73 – 808
Helixi81 – 888
Helixi89 – 913
Helixi92 – 954
Helixi98 – 1014
Helixi102 – 1065

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B19NMR-A72-107[»]
2KS9NMR-B58-68[»]
2KSANMR-B58-68[»]
2KSBNMR-B58-68[»]
4HOMX-ray1.90B58-68[»]
ProteinModelPortaliP20366.
SMRiP20366. Positions 72-107.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20366.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40889.
GeneTreeiENSGT00390000002457.
HOVERGENiHBG000127.
InParanoidiP20366.
KOiK05239.
OMAiAYERNAM.
OrthoDBiEOG7C2R3N.
PhylomeDBiP20366.
TreeFamiTF333405.

Family and domain databases

InterProiIPR008216. Protachykinin.
IPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform Beta (identifier: P20366-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVALAVF FLVSTQLFAE EIGANDDLNY WSDWYDSDQI KEELPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT
110 120
DSFVGLMGKR ALNSVAYERS AMQNYERRR
Length:129
Mass (Da):15,003
Last modified:February 1, 1991 - v1
Checksum:i51412C1692368DE4
GO
Isoform Alpha (identifier: P20366-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-114: Missing.
     115-115: V → M

Show »
Length:111
Mass (Da):13,036
Checksum:i28E051E5ACC42C47
GO
Isoform Gamma (identifier: P20366-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:114
Mass (Da):13,343
Checksum:i499EECB627AECDE6
GO
Isoform Delta (identifier: P20366-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.
     97-114: Missing.
     115-115: V → M

Show »
Length:96
Mass (Da):11,376
Checksum:iAE50A94DF2437361
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321S → P in BAD96677. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 8815Missing in isoform Gamma and isoform Delta. 2 PublicationsVSP_006375Add
BLAST
Alternative sequencei97 – 11418Missing in isoform Alpha and isoform Delta. 1 PublicationVSP_006376Add
BLAST
Alternative sequencei115 – 1151V → M in isoform Alpha and isoform Delta. 1 PublicationVSP_006377

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54469 mRNA. Translation: CAA38351.1.
U37529 mRNA. Translation: AAA79195.1.
CR407602 mRNA. Translation: CAG28529.1.
CR541730 mRNA. Translation: CAG46531.1.
AK222957 mRNA. Translation: BAD96677.1.
AC004140 Genomic DNA. Translation: AAQ96888.1.
AC004140 Genomic DNA. Translation: AAQ96889.1.
AC004140 Genomic DNA. Translation: AAQ96890.1.
AC004140 Genomic DNA. Translation: AAQ96891.1.
CH236949 Genomic DNA. Translation: EAL24116.1.
CH236949 Genomic DNA. Translation: EAL24117.1.
CH236949 Genomic DNA. Translation: EAL24118.1.
CH236949 Genomic DNA. Translation: EAL24119.1.
CH471091 Genomic DNA. Translation: EAW76734.1.
CH471091 Genomic DNA. Translation: EAW76735.1.
CH471091 Genomic DNA. Translation: EAW76736.1.
CH471091 Genomic DNA. Translation: EAW76737.1.
BC018047 mRNA. Translation: AAH18047.1.
M68906 mRNA. Translation: AAA60159.1.
M68907 mRNA. Translation: AAA60160.1.
AF050655 mRNA. Translation: AAC15701.1.
AF050656 mRNA. Translation: AAC15702.1.
AF050658 mRNA. Translation: AAC15704.1.
CCDSiCCDS5649.1. [P20366-1]
CCDS5650.1. [P20366-2]
CCDS5651.1. [P20366-3]
PIRiA24805. SPHUB.
RefSeqiNP_003173.1. NM_003182.2. [P20366-1]
NP_054702.1. NM_013996.2. [P20366-2]
NP_054703.1. NM_013997.2. [P20366-3]
NP_054704.1. NM_013998.2. [P20366-4]
UniGeneiHs.2563.

Genome annotation databases

EnsembliENST00000319273; ENSP00000321106; ENSG00000006128. [P20366-1]
ENST00000346867; ENSP00000289574; ENSG00000006128. [P20366-3]
ENST00000350485; ENSP00000289576; ENSG00000006128. [P20366-2]
GeneIDi6863.
KEGGihsa:6863.
UCSCiuc003uop.4. human. [P20366-1]
uc003uoq.4. human. [P20366-2]
uc003uor.4. human. [P20366-3]
uc003uos.4. human. [P20366-4]

Polymorphism databases

DMDMi135886.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Neurokinin-1 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54469 mRNA. Translation: CAA38351.1 .
U37529 mRNA. Translation: AAA79195.1 .
CR407602 mRNA. Translation: CAG28529.1 .
CR541730 mRNA. Translation: CAG46531.1 .
AK222957 mRNA. Translation: BAD96677.1 .
AC004140 Genomic DNA. Translation: AAQ96888.1 .
AC004140 Genomic DNA. Translation: AAQ96889.1 .
AC004140 Genomic DNA. Translation: AAQ96890.1 .
AC004140 Genomic DNA. Translation: AAQ96891.1 .
CH236949 Genomic DNA. Translation: EAL24116.1 .
CH236949 Genomic DNA. Translation: EAL24117.1 .
CH236949 Genomic DNA. Translation: EAL24118.1 .
CH236949 Genomic DNA. Translation: EAL24119.1 .
CH471091 Genomic DNA. Translation: EAW76734.1 .
CH471091 Genomic DNA. Translation: EAW76735.1 .
CH471091 Genomic DNA. Translation: EAW76736.1 .
CH471091 Genomic DNA. Translation: EAW76737.1 .
BC018047 mRNA. Translation: AAH18047.1 .
M68906 mRNA. Translation: AAA60159.1 .
M68907 mRNA. Translation: AAA60160.1 .
AF050655 mRNA. Translation: AAC15701.1 .
AF050656 mRNA. Translation: AAC15702.1 .
AF050658 mRNA. Translation: AAC15704.1 .
CCDSi CCDS5649.1. [P20366-1 ]
CCDS5650.1. [P20366-2 ]
CCDS5651.1. [P20366-3 ]
PIRi A24805. SPHUB.
RefSeqi NP_003173.1. NM_003182.2. [P20366-1 ]
NP_054702.1. NM_013996.2. [P20366-2 ]
NP_054703.1. NM_013997.2. [P20366-3 ]
NP_054704.1. NM_013998.2. [P20366-4 ]
UniGenei Hs.2563.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B19 NMR - A 72-107 [» ]
2KS9 NMR - B 58-68 [» ]
2KSA NMR - B 58-68 [» ]
2KSB NMR - B 58-68 [» ]
4HOM X-ray 1.90 B 58-68 [» ]
ProteinModelPortali P20366.
SMRi P20366. Positions 72-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112727. 8 interactions.
IntActi P20366. 9 interactions.
MINTi MINT-1409908.
STRINGi 9606.ENSP00000321106.

Chemistry

BindingDBi P20366.

PTM databases

PhosphoSitei P20366.

Polymorphism databases

DMDMi 135886.

Proteomic databases

PaxDbi P20366.
PRIDEi P20366.

Protocols and materials databases

DNASUi 6863.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319273 ; ENSP00000321106 ; ENSG00000006128 . [P20366-1 ]
ENST00000346867 ; ENSP00000289574 ; ENSG00000006128 . [P20366-3 ]
ENST00000350485 ; ENSP00000289576 ; ENSG00000006128 . [P20366-2 ]
GeneIDi 6863.
KEGGi hsa:6863.
UCSCi uc003uop.4. human. [P20366-1 ]
uc003uoq.4. human. [P20366-2 ]
uc003uor.4. human. [P20366-3 ]
uc003uos.4. human. [P20366-4 ]

Organism-specific databases

CTDi 6863.
GeneCardsi GC07P097361.
HGNCi HGNC:11517. TAC1.
HPAi CAB004588.
HPA014429.
MIMi 162320. gene.
neXtProti NX_P20366.
PharmGKBi PA36297.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40889.
GeneTreei ENSGT00390000002457.
HOVERGENi HBG000127.
InParanoidi P20366.
KOi K05239.
OMAi AYERNAM.
OrthoDBi EOG7C2R3N.
PhylomeDBi P20366.
TreeFami TF333405.

Enzyme and pathway databases

Reactomei REACT_16963. Tachykinin receptors bind tachykinins.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P20366.
GeneWikii TAC1.
GenomeRNAii 6863.
NextBioi 26783.
PMAP-CutDB P20366.
PROi P20366.
SOURCEi Search...

Gene expression databases

Bgeei P20366.
CleanExi HS_TAC1.
ExpressionAtlasi P20366. baseline and differential.
Genevestigatori P20366.

Family and domain databases

InterProi IPR008216. Protachykinin.
IPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin.
[Graphical view ]
PANTHERi PTHR11250. PTHR11250. 1 hit.
PRINTSi PR01829. PROTACHYKNIN.
SMARTi SM00203. TK. 2 hits.
[Graphical view ]
PROSITEi PS00267. TACHYKININ. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A."
    Harmar A.J., Armstrong A., Pascall J.C., Chapman K., Rosie R., Curtis A., Going J., Edwards C.R.W., Fink G.
    FEBS Lett. 208:67-72(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), AMIDATION AT MET-68 AND MET-107.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
  3. Tan A., Too H.P.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
    Tissue: Brain.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
    Tissue: Small intestine.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
    Tissue: Brain.
  9. "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis."
    Chiwakata C., Brackmann B., Hunt N., Davidoff M., Schulze W., Ivell R.
    Endocrinology 128:2441-2448(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-122 (ISOFORMS BETA AND GAMMA).
    Tissue: Testis.
  10. "Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour."
    Theodorsson-Norheim E., Joernvall H., Andersson M., Norheim I., Oeberg K., Jacobsson G.
    Eur. J. Biochem. 166:693-697(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 98-107, AMIDATION AT MET-107.
  11. "Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes."
    Lai J.P., Douglas S.D., Rappaport E., Wu J.M., Ho W.Z.
    J. Neuroimmunol. 91:121-128(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-122 (ISOFORMS ALPHA; BETA AND DELTA).
    Tissue: Blood and Brain.
  12. "Characterization of the C-terminal flanking peptide of human beta-preprotachykinin."
    McGregor G.P., Conlon J.M.
    Peptides 11:907-910(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 111-126.
    Tissue: Adrenal medulla.
  13. "Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."
    Keane F.M., Nadvi N.A., Yao T.W., Gorrell M.D.
    FEBS J. 278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY FAP, CLEAVAGE SITE.
  14. "Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles."
    Dike A., Cowsik S.M.
    Biochemistry 45:2994-3004(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 72-107.

Entry informationi

Entry nameiTKN1_HUMAN
AccessioniPrimary (citable) accession number: P20366
Secondary accession number(s): O60600
, O60601, Q00072, Q53GH4, Q549V0, Q549V1, Q549V2, Q6FHM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3