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Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

GO - Molecular functioni

  • cytoskeletal regulatory protein binding Source: MGI
  • dystroglycan binding Source: MGI
  • microtubule binding Source: MGI

GO - Biological processi

  • axonogenesis Source: MGI
  • cellular response to organic substance Source: MGI
  • central nervous system neuron development Source: InterPro
  • dendrite development Source: MGI
  • establishment of cell polarity Source: MGI
  • microtubule bundle formation Source: MGI
  • regulation of axonogenesis Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
Gene namesi
Name:Map2
Synonyms:Mtap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97175. Map2.

Subcellular locationi

GO - Cellular componenti

  • CA3 pyramidal cell dendrite Source: MGI
  • cell body Source: MGI
  • cytoplasm Source: MGI
  • dendrite Source: MGI
  • dendritic shaft Source: MGI
  • intracellular Source: MGI
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: MGI
  • neuronal cell body Source: MGI
  • neuron projection Source: MGI
  • nuclear periphery Source: MGI
  • nucleolus Source: MGI
  • postsynaptic density Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000727481 – 1828Microtubule-associated protein 2Add BLAST1828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei476PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei520PhosphoserineBy similarity1
Modified residuei550PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei626PhosphoserineBy similarity1
Modified residuei726PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei734PhosphothreonineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Modified residuei746PhosphotyrosineCombined sources1
Modified residuei823PhosphoserineCombined sources1
Modified residuei883PhosphoserineBy similarity1
Modified residuei892PhosphoserineBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei1050PhosphoserineBy similarity1
Modified residuei1139PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1160PhosphothreonineBy similarity1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1352PhosphoserineCombined sources1
Modified residuei1358PhosphothreonineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1560PhosphoserineCombined sources1
Modified residuei1592PhosphoserineCombined sources1
Modified residuei1606PhosphothreonineCombined sources1
Modified residuei1609PhosphothreonineCombined sources1
Modified residuei1620PhosphothreonineCombined sources1
Modified residuei1623PhosphothreonineCombined sources1
Modified residuei1650PhosphothreonineCombined sources1
Modified residuei1654PhosphoserineBy similarity1
Modified residuei1680Phosphoserine; by MARK1By similarity1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1788PhosphoserineCombined sources1
Modified residuei1791PhosphoserineCombined sources1
Modified residuei1796PhosphoserineBy similarity1
Modified residuei1809PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP20357.
PaxDbiP20357.
PeptideAtlasiP20357.
PRIDEiP20357.

PTM databases

iPTMnetiP20357.
PhosphoSitePlusiP20357.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015222.
CleanExiMM_MTAP2.
ExpressionAtlasiP20357. baseline and differential.
GenevisibleiP20357. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Kndc1Q0KK559EBI-397863,EBI-8605532

GO - Molecular functioni

  • cytoskeletal regulatory protein binding Source: MGI
  • dystroglycan binding Source: MGI
  • microtubule binding Source: MGI

Protein-protein interaction databases

BioGridi201585. 8 interactors.
IntActiP20357. 20 interactors.
MINTiMINT-4101182.
STRINGi10090.ENSMUSP00000109650.

Structurei

3D structure databases

ProteinModelPortaliP20357.
SMRiP20357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1662 – 1692Tau/MAP 1Add BLAST31
Repeati1693 – 1723Tau/MAP 2Add BLAST31
Repeati1724 – 1755Tau/MAP 3Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1452 – 1472Calmodulin-bindingSequence analysisAdd BLAST21

Sequence similaritiesi

Contains 3 Tau/MAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2418. Eukaryota.
ENOG4111J07. LUCA.
GeneTreeiENSGT00530000063491.
HOGENOMiHOG000113477.
HOVERGENiHBG006322.
InParanoidiP20357.
KOiK10430.
OMAiPFKTGRG.
OrthoDBiEOG091G00IT.

Family and domain databases

InterProiIPR030797. MAP2.
IPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 1 hit.
PTHR11501:SF15. PTHR11501:SF15. 1 hit.
PfamiPF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 3 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 2 hits.
PS51491. TAU_MAP_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGAGEG LSRNANGFPY
60 70 80 90 100
REEEEGAFGE HRSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET ANLPPSPPPS PASEQTATVE
160 170 180 190 200
EDLLTASKME FPEQEKFPSS FAEPLDKGEM EFKMPSKPGE DFEHAALVPD
210 220 230 240 250
TSKTPQDKKD LQGMEGEKLP PVPFAQTFGT NLEDRKQSTE PSIVMPSIGL
260 270 280 290 300
SAEPPAPKEP KDWFIEMPTE SKKDEWGLAA PISPGPLTPM REKDVLEDIP
310 320 330 340 350
RWEGKQFDSP MPSPFHGGSF TLPLDTMKNE RVSEGPRPFA PVFFQSDDKV
360 370 380 390 400
SLQDPSALAT SKESSKDEEP LKDKADKVAD VSISEVTTLL GNVHSPVVEG
410 420 430 440 450
YVGENISGEV KVTTDQEKKE TSAPSVQEPT LTETEPQTKL DEKSTVSIEE
460 470 480 490 500
AVAKKEESFK LRDDKTGVIQ TSTEQSFSKE DQKGQEHTID ELKQDSFPIS
510 520 530 540 550
LEQAVTDAAM TSKTLGKVTS EPEAVSERRE IQGLFEEKTA DKNKLEGAGS
560 570 580 590 600
ATIAEVEMPF YEDKSGMSKY FETSALKEDM TRSTELGSDY YELSDSRGSA
610 620 630 640 650
QESLDTISPK NQHDEKELQA KASQPSPPAQ EAGYSTLAQS YTPDHPSELP
660 670 680 690 700
EEPSSPQERM FTIDPKVYGE KRDLHSKNKD DLTLSRSLGL GGRSAIEQRS
710 720 730 740 750
MSINLPMSCL DSIALGFNFG RGHDLSPLAS DILTNTSGSM DEGDDYLPPT
760 770 780 790 800
TPAVEKMPCF PIESKEEEDK AEQAKVTGGQ TIQVETSSES PFPAKEYYKN
810 820 830 840 850
GTVMAPDLPE MLDLAGTRSR LASVSADAEV ARRKSVPSEA MLAESSTSLP
860 870 880 890 900
PVADESPVTV KPDSQLEDMG YCVFNKYTVP LPSPVQDSEN LSGESGSFYE
910 920 930 940 950
GTDDKVRRDL ATDLSLIEVK LAAAGRVKDE FTAEKEASPP TSADKSRLSR
960 970 980 990 1000
EFDHDRKAND KLDTVLEKSE EHIDSKEHAK ESEEMGGKVE LFGLGITYDQ
1010 1020 1030 1040 1050
ASTKELITTK DTSPEKTEKG LSSVPEVAEV EPTTKADQGL DFAATKAEPS
1060 1070 1080 1090 1100
QLDIKVSDFG QMASGMNVDA GKAIELKFEV AQELTLSSEA PQEADSFMGV
1110 1120 1130 1140 1150
ESGHIKEGGK VNETEVKEKV TKPDLVHQEA VDKEESYESS GEHESLTMES
1160 1170 1180 1190 1200
LKPDEGKKET SPETSLIQDE VALKLSVEIP CPPPVSEADL STDEKGEVQM
1210 1220 1230 1240 1250
EFIQLPKEES TETPDIPAIP SDVTQPQPEA IVSEPAEVPS EEEEIEAGGE
1260 1270 1280 1290 1300
YDKLLFRSDT LQISDLLVSE SREEFVETCP GELKGVVESV VTIEDDFITV
1310 1320 1330 1340 1350
VQTTTDEGES GSHSVRFAAP AQPEEERRPR PHDEELEIEM AAEAQAEPKD
1360 1370 1380 1390 1400
GSPDAPATPE KEEVAFSEYK TETYDDYKDE TTIDDSIMDA DSLWVDTQDD
1410 1420 1430 1440 1450
DRSILTEQLE TIPKEERAEK DARRPSLEKH RKEKPFKTGR GRISTPERKV
1460 1470 1480 1490 1500
AKKEPSTVSR DEVRRKKAVY KKAELAKKSE VQAHSPSRKL ILKPAIKYTR
1510 1520 1530 1540 1550
PTHLSCVKRK TTAASGDLAQ APGAFKQAKD KVTDGISKSP EKRSSLPRPS
1560 1570 1580 1590 1600
SILPPRRGVS GDREENSFSL NSSISSARRT TRSEPIRRAG KSGTSTPTTP
1610 1620 1630 1640 1650
GSTAITPGTP PSYSSRTPGT PGTPSYPRTP GTPKSGILVP SEKKVAIIRT
1660 1670 1680 1690 1700
PPKSPATPKQ LRLINQPLPD LKNVKSKIGS TDNIKYQPKG GQVQIVTKKI
1710 1720 1730 1740 1750
DLSHVTSKCG SLKNIRHRPG GGRVKIESVK LDFKEKAQAK VGSLDNAHHV
1760 1770 1780 1790 1800
PGGGNVKIDS QKLNFREHAK ARVDHGAEII TQSPSRSSVA SPRRLSNVSS
1810 1820
SGSINLLESP QLATLAEDVT AALAKQGL
Length:1,828
Mass (Da):199,132
Last modified:July 27, 2011 - v2
Checksum:iE8FA7621C45D5A0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116H → Y no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti116H → Y in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti455K → E no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti455K → E in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti459F → L no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti459F → L in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti644D → G no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti644D → G in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti938S → T no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti938S → T in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti947R → G no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti947R → G in AAA39490 (PubMed:3142041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21041 mRNA. Translation: AAA39490.1.
AC091465 Genomic DNA. No translation available.
PIRiA40115.
RefSeqiNP_001297563.1. NM_001310634.1.
XP_006495817.1. XM_006495754.2.
UniGeneiMm.256966.
Mm.436793.

Genome annotation databases

EnsembliENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222.
GeneIDi17756.
KEGGimmu:17756.
UCSCiuc007bhz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21041 mRNA. Translation: AAA39490.1.
AC091465 Genomic DNA. No translation available.
PIRiA40115.
RefSeqiNP_001297563.1. NM_001310634.1.
XP_006495817.1. XM_006495754.2.
UniGeneiMm.256966.
Mm.436793.

3D structure databases

ProteinModelPortaliP20357.
SMRiP20357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201585. 8 interactors.
IntActiP20357. 20 interactors.
MINTiMINT-4101182.
STRINGi10090.ENSMUSP00000109650.

PTM databases

iPTMnetiP20357.
PhosphoSitePlusiP20357.

Proteomic databases

MaxQBiP20357.
PaxDbiP20357.
PeptideAtlasiP20357.
PRIDEiP20357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222.
GeneIDi17756.
KEGGimmu:17756.
UCSCiuc007bhz.1. mouse.

Organism-specific databases

CTDi4133.
MGIiMGI:97175. Map2.

Phylogenomic databases

eggNOGiKOG2418. Eukaryota.
ENOG4111J07. LUCA.
GeneTreeiENSGT00530000063491.
HOGENOMiHOG000113477.
HOVERGENiHBG006322.
InParanoidiP20357.
KOiK10430.
OMAiPFKTGRG.
OrthoDBiEOG091G00IT.

Miscellaneous databases

PROiP20357.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015222.
CleanExiMM_MTAP2.
ExpressionAtlasiP20357. baseline and differential.
GenevisibleiP20357. MM.

Family and domain databases

InterProiIPR030797. MAP2.
IPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 1 hit.
PTHR11501:SF15. PTHR11501:SF15. 1 hit.
PfamiPF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 3 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 2 hits.
PS51491. TAU_MAP_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTAP2_MOUSE
AccessioniPrimary (citable) accession number: P20357
Secondary accession number(s): E9QLE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.