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P20357

- MTAP2_MOUSE

UniProt

P20357 - MTAP2_MOUSE

Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

    GO - Molecular functioni

    1. cytoskeletal regulatory protein binding Source: MGI
    2. microtubule binding Source: MGI
    3. protein binding Source: IntAct

    GO - Biological processi

    1. axonogenesis Source: MGI
    2. cellular response to organic substance Source: MGI
    3. dendrite development Source: MGI
    4. microtubule bundle formation Source: MGI

    Keywords - Ligandi

    Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microtubule-associated protein 2
    Short name:
    MAP-2
    Gene namesi
    Name:Map2
    Synonyms:Mtap2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:97175. Map2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: MGI
    2. cytoplasm Source: MGI
    3. dendrite Source: MGI
    4. dendritic shaft Source: MGI
    5. intracellular Source: MGI
    6. microtubule Source: UniProtKB-KW
    7. microtubule associated complex Source: MGI
    8. neuronal cell body Source: MGI
    9. neuron projection Source: MGI
    10. nuclear periphery Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18281828Microtubule-associated protein 2PRO_0000072748Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei726 – 7261Phosphoserine1 Publication
    Modified residuei1352 – 13521Phosphoserine2 Publications
    Modified residuei1358 – 13581Phosphothreonine2 Publications
    Modified residuei1606 – 16061Phosphothreonine1 Publication
    Modified residuei1609 – 16091Phosphothreonine2 Publications
    Modified residuei1680 – 16801Phosphoserine; by MARK1By similarity

    Post-translational modificationi

    Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP20357.
    PaxDbiP20357.
    PRIDEiP20357.

    PTM databases

    PhosphoSiteiP20357.

    Expressioni

    Gene expression databases

    ArrayExpressiP20357.
    BgeeiP20357.
    CleanExiMM_MTAP2.
    GenevestigatoriP20357.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kndc1Q0KK559EBI-397863,EBI-8605532

    Protein-protein interaction databases

    IntActiP20357. 17 interactions.
    MINTiMINT-4101182.

    Structurei

    3D structure databases

    ProteinModelPortaliP20357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1662 – 169231Tau/MAP 1Add
    BLAST
    Repeati1693 – 172331Tau/MAP 2Add
    BLAST
    Repeati1724 – 175532Tau/MAP 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1452 – 147221Calmodulin-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Tau/MAP repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG148882.
    GeneTreeiENSGT00530000063491.
    HOGENOMiHOG000113477.
    HOVERGENiHBG006322.
    InParanoidiP20357.
    KOiK10430.
    OMAiKTETYDD.
    OrthoDBiEOG75XGKK.

    Family and domain databases

    InterProiIPR027324. MAP2/MAP4/Tau.
    IPR013588. MAP2_projctn.
    IPR001084. MAP_tubulin-bd_rpt.
    [Graphical view]
    PANTHERiPTHR11501. PTHR11501. 1 hit.
    PfamiPF08377. MAP2_projctn. 1 hit.
    PF00418. Tubulin-binding. 3 hits.
    [Graphical view]
    PROSITEiPS00229. TAU_MAP_1. 2 hits.
    PS51491. TAU_MAP_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20357-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGAGEG LSRNANGFPY     50
    REEEEGAFGE HRSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA 100
    EAVAVLKGEQ EKEAQHKDQP AALPLAAEET ANLPPSPPPS PASEQTATVE 150
    EDLLTASKME FPEQEKFPSS FAEPLDKGEM EFKMPSKPGE DFEHAALVPD 200
    TSKTPQDKKD LQGMEGEKLP PVPFAQTFGT NLEDRKQSTE PSIVMPSIGL 250
    SAEPPAPKEP KDWFIEMPTE SKKDEWGLAA PISPGPLTPM REKDVLEDIP 300
    RWEGKQFDSP MPSPFHGGSF TLPLDTMKNE RVSEGPRPFA PVFFQSDDKV 350
    SLQDPSALAT SKESSKDEEP LKDKADKVAD VSISEVTTLL GNVHSPVVEG 400
    YVGENISGEV KVTTDQEKKE TSAPSVQEPT LTETEPQTKL DEKSTVSIEE 450
    AVAKKEESFK LRDDKTGVIQ TSTEQSFSKE DQKGQEHTID ELKQDSFPIS 500
    LEQAVTDAAM TSKTLGKVTS EPEAVSERRE IQGLFEEKTA DKNKLEGAGS 550
    ATIAEVEMPF YEDKSGMSKY FETSALKEDM TRSTELGSDY YELSDSRGSA 600
    QESLDTISPK NQHDEKELQA KASQPSPPAQ EAGYSTLAQS YTPDHPSELP 650
    EEPSSPQERM FTIDPKVYGE KRDLHSKNKD DLTLSRSLGL GGRSAIEQRS 700
    MSINLPMSCL DSIALGFNFG RGHDLSPLAS DILTNTSGSM DEGDDYLPPT 750
    TPAVEKMPCF PIESKEEEDK AEQAKVTGGQ TIQVETSSES PFPAKEYYKN 800
    GTVMAPDLPE MLDLAGTRSR LASVSADAEV ARRKSVPSEA MLAESSTSLP 850
    PVADESPVTV KPDSQLEDMG YCVFNKYTVP LPSPVQDSEN LSGESGSFYE 900
    GTDDKVRRDL ATDLSLIEVK LAAAGRVKDE FTAEKEASPP TSADKSRLSR 950
    EFDHDRKAND KLDTVLEKSE EHIDSKEHAK ESEEMGGKVE LFGLGITYDQ 1000
    ASTKELITTK DTSPEKTEKG LSSVPEVAEV EPTTKADQGL DFAATKAEPS 1050
    QLDIKVSDFG QMASGMNVDA GKAIELKFEV AQELTLSSEA PQEADSFMGV 1100
    ESGHIKEGGK VNETEVKEKV TKPDLVHQEA VDKEESYESS GEHESLTMES 1150
    LKPDEGKKET SPETSLIQDE VALKLSVEIP CPPPVSEADL STDEKGEVQM 1200
    EFIQLPKEES TETPDIPAIP SDVTQPQPEA IVSEPAEVPS EEEEIEAGGE 1250
    YDKLLFRSDT LQISDLLVSE SREEFVETCP GELKGVVESV VTIEDDFITV 1300
    VQTTTDEGES GSHSVRFAAP AQPEEERRPR PHDEELEIEM AAEAQAEPKD 1350
    GSPDAPATPE KEEVAFSEYK TETYDDYKDE TTIDDSIMDA DSLWVDTQDD 1400
    DRSILTEQLE TIPKEERAEK DARRPSLEKH RKEKPFKTGR GRISTPERKV 1450
    AKKEPSTVSR DEVRRKKAVY KKAELAKKSE VQAHSPSRKL ILKPAIKYTR 1500
    PTHLSCVKRK TTAASGDLAQ APGAFKQAKD KVTDGISKSP EKRSSLPRPS 1550
    SILPPRRGVS GDREENSFSL NSSISSARRT TRSEPIRRAG KSGTSTPTTP 1600
    GSTAITPGTP PSYSSRTPGT PGTPSYPRTP GTPKSGILVP SEKKVAIIRT 1650
    PPKSPATPKQ LRLINQPLPD LKNVKSKIGS TDNIKYQPKG GQVQIVTKKI 1700
    DLSHVTSKCG SLKNIRHRPG GGRVKIESVK LDFKEKAQAK VGSLDNAHHV 1750
    PGGGNVKIDS QKLNFREHAK ARVDHGAEII TQSPSRSSVA SPRRLSNVSS 1800
    SGSINLLESP QLATLAEDVT AALAKQGL 1828
    Length:1,828
    Mass (Da):199,132
    Last modified:July 27, 2011 - v2
    Checksum:iE8FA7621C45D5A0D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161H → Y no nucleotide entry (PubMed:3205744)Curated
    Sequence conflicti116 – 1161H → Y in AAA39490. (PubMed:3142041)Curated
    Sequence conflicti455 – 4551K → E no nucleotide entry (PubMed:3205744)Curated
    Sequence conflicti455 – 4551K → E in AAA39490. (PubMed:3142041)Curated
    Sequence conflicti459 – 4591F → L no nucleotide entry (PubMed:3205744)Curated
    Sequence conflicti459 – 4591F → L in AAA39490. (PubMed:3142041)Curated
    Sequence conflicti644 – 6441D → G no nucleotide entry (PubMed:3205744)Curated
    Sequence conflicti644 – 6441D → G in AAA39490. (PubMed:3142041)Curated
    Sequence conflicti938 – 9381S → T no nucleotide entry (PubMed:3205744)Curated
    Sequence conflicti938 – 9381S → T in AAA39490. (PubMed:3142041)Curated
    Sequence conflicti947 – 9471R → G no nucleotide entry (PubMed:3205744)Curated
    Sequence conflicti947 – 9471R → G in AAA39490. (PubMed:3142041)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21041 mRNA. Translation: AAA39490.1.
    AC091465 Genomic DNA. No translation available.
    PIRiA40115.
    RefSeqiXP_006495817.1. XM_006495754.1.
    XP_006495818.1. XM_006495755.1.
    UniGeneiMm.256966.

    Genome annotation databases

    EnsembliENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222.
    GeneIDi17756.
    KEGGimmu:17756.
    UCSCiuc007bhz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21041 mRNA. Translation: AAA39490.1 .
    AC091465 Genomic DNA. No translation available.
    PIRi A40115.
    RefSeqi XP_006495817.1. XM_006495754.1.
    XP_006495818.1. XM_006495755.1.
    UniGenei Mm.256966.

    3D structure databases

    ProteinModelPortali P20357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P20357. 17 interactions.
    MINTi MINT-4101182.

    PTM databases

    PhosphoSitei P20357.

    Proteomic databases

    MaxQBi P20357.
    PaxDbi P20357.
    PRIDEi P20357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114013 ; ENSMUSP00000109646 ; ENSMUSG00000015222 .
    GeneIDi 17756.
    KEGGi mmu:17756.
    UCSCi uc007bhz.1. mouse.

    Organism-specific databases

    CTDi 4133.
    MGIi MGI:97175. Map2.

    Phylogenomic databases

    eggNOGi NOG148882.
    GeneTreei ENSGT00530000063491.
    HOGENOMi HOG000113477.
    HOVERGENi HBG006322.
    InParanoidi P20357.
    KOi K10430.
    OMAi KTETYDD.
    OrthoDBi EOG75XGKK.

    Miscellaneous databases

    PROi P20357.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20357.
    Bgeei P20357.
    CleanExi MM_MTAP2.
    Genevestigatori P20357.

    Family and domain databases

    InterProi IPR027324. MAP2/MAP4/Tau.
    IPR013588. MAP2_projctn.
    IPR001084. MAP_tubulin-bd_rpt.
    [Graphical view ]
    PANTHERi PTHR11501. PTHR11501. 1 hit.
    Pfami PF08377. MAP2_projctn. 1 hit.
    PF00418. Tubulin-binding. 3 hits.
    [Graphical view ]
    PROSITEi PS00229. TAU_MAP_1. 2 hits.
    PS51491. TAU_MAP_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of a cDNA encoding mouse MAP2."
      Wang D., Lewis S.A., Cowan N.J.
      Nucleic Acids Res. 16:11369-11370(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein."
      Lewis S.A., Wang D., Cowan N.J.
      Science 242:936-939(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 94-107; 583-597; 909-920; 989-1004; 1159-1174; 1403-1414 AND 1511-1538, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-726; SER-1352; THR-1358; THR-1606 AND THR-1609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1352; THR-1358 AND THR-1609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    7. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiMTAP2_MOUSE
    AccessioniPrimary (citable) accession number: P20357
    Secondary accession number(s): E9QLE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3