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P20357

- MTAP2_MOUSE

UniProt

P20357 - MTAP2_MOUSE

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Protein

Microtubule-associated protein 2

Gene
Map2, Mtap2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

GO - Molecular functioni

  1. cytoskeletal regulatory protein binding Source: MGI
  2. microtubule binding Source: MGI
  3. protein binding Source: IntAct

GO - Biological processi

  1. axonogenesis Source: MGI
  2. cellular response to organic substance Source: MGI
  3. dendrite development Source: MGI
  4. microtubule bundle formation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
Gene namesi
Name:Map2
Synonyms:Mtap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:97175. Map2.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cell body Source: MGI
  2. cytoplasm Source: MGI
  3. dendrite Source: MGI
  4. dendritic shaft Source: MGI
  5. intracellular Source: MGI
  6. microtubule Source: UniProtKB-KW
  7. microtubule associated complex Source: MGI
  8. neuronal cell body Source: MGI
  9. neuron projection Source: MGI
  10. nuclear periphery Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18281828Microtubule-associated protein 2PRO_0000072748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261Phosphoserine1 Publication
Modified residuei1352 – 13521Phosphoserine2 Publications
Modified residuei1358 – 13581Phosphothreonine2 Publications
Modified residuei1606 – 16061Phosphothreonine1 Publication
Modified residuei1609 – 16091Phosphothreonine2 Publications
Modified residuei1680 – 16801Phosphoserine; by MARK1 By similarity

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP20357.
PaxDbiP20357.
PRIDEiP20357.

PTM databases

PhosphoSiteiP20357.

Expressioni

Gene expression databases

ArrayExpressiP20357.
BgeeiP20357.
CleanExiMM_MTAP2.
GenevestigatoriP20357.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Kndc1Q0KK559EBI-397863,EBI-8605532

Protein-protein interaction databases

IntActiP20357. 17 interactions.
MINTiMINT-4101182.

Structurei

3D structure databases

ProteinModelPortaliP20357.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1662 – 169231Tau/MAP 1Add
BLAST
Repeati1693 – 172331Tau/MAP 2Add
BLAST
Repeati1724 – 175532Tau/MAP 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1452 – 147221Calmodulin-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 3 Tau/MAP repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG148882.
GeneTreeiENSGT00530000063491.
HOGENOMiHOG000113477.
HOVERGENiHBG006322.
InParanoidiP20357.
KOiK10430.
OMAiKTETYDD.
OrthoDBiEOG75XGKK.

Family and domain databases

InterProiIPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 1 hit.
PfamiPF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 3 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 2 hits.
PS51491. TAU_MAP_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20357-1 [UniParc]FASTAAdd to Basket

« Hide

MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGAGEG LSRNANGFPY     50
REEEEGAFGE HRSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA 100
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET ANLPPSPPPS PASEQTATVE 150
EDLLTASKME FPEQEKFPSS FAEPLDKGEM EFKMPSKPGE DFEHAALVPD 200
TSKTPQDKKD LQGMEGEKLP PVPFAQTFGT NLEDRKQSTE PSIVMPSIGL 250
SAEPPAPKEP KDWFIEMPTE SKKDEWGLAA PISPGPLTPM REKDVLEDIP 300
RWEGKQFDSP MPSPFHGGSF TLPLDTMKNE RVSEGPRPFA PVFFQSDDKV 350
SLQDPSALAT SKESSKDEEP LKDKADKVAD VSISEVTTLL GNVHSPVVEG 400
YVGENISGEV KVTTDQEKKE TSAPSVQEPT LTETEPQTKL DEKSTVSIEE 450
AVAKKEESFK LRDDKTGVIQ TSTEQSFSKE DQKGQEHTID ELKQDSFPIS 500
LEQAVTDAAM TSKTLGKVTS EPEAVSERRE IQGLFEEKTA DKNKLEGAGS 550
ATIAEVEMPF YEDKSGMSKY FETSALKEDM TRSTELGSDY YELSDSRGSA 600
QESLDTISPK NQHDEKELQA KASQPSPPAQ EAGYSTLAQS YTPDHPSELP 650
EEPSSPQERM FTIDPKVYGE KRDLHSKNKD DLTLSRSLGL GGRSAIEQRS 700
MSINLPMSCL DSIALGFNFG RGHDLSPLAS DILTNTSGSM DEGDDYLPPT 750
TPAVEKMPCF PIESKEEEDK AEQAKVTGGQ TIQVETSSES PFPAKEYYKN 800
GTVMAPDLPE MLDLAGTRSR LASVSADAEV ARRKSVPSEA MLAESSTSLP 850
PVADESPVTV KPDSQLEDMG YCVFNKYTVP LPSPVQDSEN LSGESGSFYE 900
GTDDKVRRDL ATDLSLIEVK LAAAGRVKDE FTAEKEASPP TSADKSRLSR 950
EFDHDRKAND KLDTVLEKSE EHIDSKEHAK ESEEMGGKVE LFGLGITYDQ 1000
ASTKELITTK DTSPEKTEKG LSSVPEVAEV EPTTKADQGL DFAATKAEPS 1050
QLDIKVSDFG QMASGMNVDA GKAIELKFEV AQELTLSSEA PQEADSFMGV 1100
ESGHIKEGGK VNETEVKEKV TKPDLVHQEA VDKEESYESS GEHESLTMES 1150
LKPDEGKKET SPETSLIQDE VALKLSVEIP CPPPVSEADL STDEKGEVQM 1200
EFIQLPKEES TETPDIPAIP SDVTQPQPEA IVSEPAEVPS EEEEIEAGGE 1250
YDKLLFRSDT LQISDLLVSE SREEFVETCP GELKGVVESV VTIEDDFITV 1300
VQTTTDEGES GSHSVRFAAP AQPEEERRPR PHDEELEIEM AAEAQAEPKD 1350
GSPDAPATPE KEEVAFSEYK TETYDDYKDE TTIDDSIMDA DSLWVDTQDD 1400
DRSILTEQLE TIPKEERAEK DARRPSLEKH RKEKPFKTGR GRISTPERKV 1450
AKKEPSTVSR DEVRRKKAVY KKAELAKKSE VQAHSPSRKL ILKPAIKYTR 1500
PTHLSCVKRK TTAASGDLAQ APGAFKQAKD KVTDGISKSP EKRSSLPRPS 1550
SILPPRRGVS GDREENSFSL NSSISSARRT TRSEPIRRAG KSGTSTPTTP 1600
GSTAITPGTP PSYSSRTPGT PGTPSYPRTP GTPKSGILVP SEKKVAIIRT 1650
PPKSPATPKQ LRLINQPLPD LKNVKSKIGS TDNIKYQPKG GQVQIVTKKI 1700
DLSHVTSKCG SLKNIRHRPG GGRVKIESVK LDFKEKAQAK VGSLDNAHHV 1750
PGGGNVKIDS QKLNFREHAK ARVDHGAEII TQSPSRSSVA SPRRLSNVSS 1800
SGSINLLESP QLATLAEDVT AALAKQGL 1828
Length:1,828
Mass (Da):199,132
Last modified:July 27, 2011 - v2
Checksum:iE8FA7621C45D5A0D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161H → Y no nucleotide entry 1 Publication
Sequence conflicti116 – 1161H → Y in AAA39490. 1 Publication
Sequence conflicti455 – 4551K → E no nucleotide entry 1 Publication
Sequence conflicti455 – 4551K → E in AAA39490. 1 Publication
Sequence conflicti459 – 4591F → L no nucleotide entry 1 Publication
Sequence conflicti459 – 4591F → L in AAA39490. 1 Publication
Sequence conflicti644 – 6441D → G no nucleotide entry 1 Publication
Sequence conflicti644 – 6441D → G in AAA39490. 1 Publication
Sequence conflicti938 – 9381S → T no nucleotide entry 1 Publication
Sequence conflicti938 – 9381S → T in AAA39490. 1 Publication
Sequence conflicti947 – 9471R → G no nucleotide entry 1 Publication
Sequence conflicti947 – 9471R → G in AAA39490. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21041 mRNA. Translation: AAA39490.1.
AC091465 Genomic DNA. No translation available.
PIRiA40115.
RefSeqiXP_006495817.1. XM_006495754.1.
XP_006495818.1. XM_006495755.1.
UniGeneiMm.256966.

Genome annotation databases

EnsembliENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222.
GeneIDi17756.
KEGGimmu:17756.
UCSCiuc007bhz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21041 mRNA. Translation: AAA39490.1 .
AC091465 Genomic DNA. No translation available.
PIRi A40115.
RefSeqi XP_006495817.1. XM_006495754.1.
XP_006495818.1. XM_006495755.1.
UniGenei Mm.256966.

3D structure databases

ProteinModelPortali P20357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P20357. 17 interactions.
MINTi MINT-4101182.

PTM databases

PhosphoSitei P20357.

Proteomic databases

MaxQBi P20357.
PaxDbi P20357.
PRIDEi P20357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114013 ; ENSMUSP00000109646 ; ENSMUSG00000015222 .
GeneIDi 17756.
KEGGi mmu:17756.
UCSCi uc007bhz.1. mouse.

Organism-specific databases

CTDi 4133.
MGIi MGI:97175. Map2.

Phylogenomic databases

eggNOGi NOG148882.
GeneTreei ENSGT00530000063491.
HOGENOMi HOG000113477.
HOVERGENi HBG006322.
InParanoidi P20357.
KOi K10430.
OMAi KTETYDD.
OrthoDBi EOG75XGKK.

Miscellaneous databases

PROi P20357.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20357.
Bgeei P20357.
CleanExi MM_MTAP2.
Genevestigatori P20357.

Family and domain databases

InterProi IPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view ]
PANTHERi PTHR11501. PTHR11501. 1 hit.
Pfami PF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 3 hits.
[Graphical view ]
PROSITEi PS00229. TAU_MAP_1. 2 hits.
PS51491. TAU_MAP_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of a cDNA encoding mouse MAP2."
    Wang D., Lewis S.A., Cowan N.J.
    Nucleic Acids Res. 16:11369-11370(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein."
    Lewis S.A., Wang D., Cowan N.J.
    Science 242:936-939(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 94-107; 583-597; 909-920; 989-1004; 1159-1174; 1403-1414 AND 1511-1538, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-726; SER-1352; THR-1358; THR-1606 AND THR-1609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1352; THR-1358 AND THR-1609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiMTAP2_MOUSE
AccessioniPrimary (citable) accession number: P20357
Secondary accession number(s): E9QLE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi