Tissue factor precursor - Mus musculus (Mouse)

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P20352 (TF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tissue factor
Short name=TF

Alternative name(s):
Coagulation factor III
CD_antigen=CD142

Gene names

Name:	F3
Synonyms:	Cf-3, Cf3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subunit structure	Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the tissue factor family.

Ontologies

Keywords
Biological process	Blood coagulation Hemostasis
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara activation of plasma proteins involved in acute inflammatory response Inferred from electronic annotation. Source: Compara blood coagulation Traceable author statement PubMed 11511099. Source: MGI positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of platelet-derived growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cell surface binding Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

Chain

29 – 294

266

Tissue factor

PRO_0000033639

Regions

Topological domain

29 – 251

223

Extracellular Potential

Transmembrane

252 – 274

Helical; Potential

Topological domain

275 – 294

Cytoplasmic Potential

Motif

245 – 247

WKS motif

Amino acid modifications

Lipidation

275

S-palmitoyl cysteine By similarity

Glycosylation

N-linked (GlcNAc...) Ref.4

Glycosylation

N-linked (GlcNAc...) Ref.4

Glycosylation

169

N-linked (GlcNAc...) Potential

Glycosylation

200

N-linked (GlcNAc...) Potential

Disulfide bond

75 ↔ 83

By similarity

Disulfide bond

218 ↔ 241

By similarity

Experimental info

Sequence conflict

I → T in AAA40414. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P20352 [UniParc].

Last modified August 1, 1991. Version 2.
Checksum: A306101293C31FA0
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FASTA

294

32,935

        10         20         30         40         50         60 
MAILVRPRLL AALAPTFLGC LLLQVIAGAG IPEKAFNLTW ISTDFKTILE WQPKPTNYTY 

        70         80         90        100        110        120 
TVQISDRSRN WKNKCFSTTD TECDLTDEIV KDVTWAYEAK VLSVPRRNSV HGDGDQLVIH 

       130        140        150        160        170        180 
GEEPPFTNAP KFLPYRDTNL GQPVIQQFEQ DGRKLNVVVK DSLTLVRKNG TFLTLRQVFG 

       190        200        210        220        230        240 
KDLGYIITYR KGSSTGKKTN ITNTNEFSID VEEGVSYCFF VQAMIFSRKT NQNSPGSSTV 

       250        260        270        280        290 
CTEQWKSFLG ETLIIVGAVV LLATIFIILL SISLCKRRKN RAGQKGKNTP SRLA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta 1." Ranganathan G., Blatti S.P., Subramaniam M., Fass D.N., Maihle N.J., Getz M.J. J. Biol. Chem. 266:496-501(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor." Hartzell S., Ryder K., Lanahan A., Lau L.F., Nathans D. Mol. Cell. Biol. 9:2567-2573(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
[4]	"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation." Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B. Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37 AND ASN-57, MASS SPECTROMETRY. Tissue: Myoblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M57896 mRNA. Translation: AAA63400.1. M26071 mRNA. Translation: AAA40414.1. BC016397 mRNA. Translation: AAH16397.1.
IPI	IPI00118069.
PIR	KFMS3. A32318.
RefSeq	NP_034301.3. NM_010171.3.
UniGene	Mm.273188.
3D structure databases
ProteinModelPortal	P20352.
SMR	P20352. Positions 35-244.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4137612.
PTM databases
PhosphoSite	P20352.
Proteomic databases
PaxDb	P20352.
PRIDE	P20352.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029771; ENSMUSP00000029771; ENSMUSG00000028128.
GeneID	14066.
KEGG	mmu:14066.
UCSC	uc008ree.2. mouse.
Organism-specific databases
CTD	2152.
MGI	MGI:88381. F3.
Phylogenomic databases
eggNOG	NOG43483.
GeneTree	ENSGT00390000012668.
HOGENOM	HOG000043076.
HOVERGEN	HBG005051.
InParanoid	P20352.
KO	K03901.
Gene expression databases
Bgee	P20352.
CleanEx	MM_F3.
Genevestigator	P20352.
GermOnline	ENSMUSG00000028128. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR015373. Interferon_alpha/beta_rcpt_bsu. IPR016354. Tissue_fac/coagulation_fac-3. IPR001187. Tissue_factor. [Graphical view]
Pfam	PF09294. Interfer-bind. 1 hit. [Graphical view]
PIRSF	PIRSF002498. Tissue_factor_3. 1 hit.
PRINTS	PR00346. TISSUEFACTOR.
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS00621. TISSUE_FACTOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL5787.
NextBio	285048.
SOURCE	Search...

Entry information

Entry name

TF_MOUSE

Accession

Primary (citable) accession number: P20352

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 29, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents