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P20352

- TF_MOUSE

UniProt

P20352 - TF_MOUSE

Protein

Tissue factor

Gene

F3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

    GO - Molecular functioni

    1. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. activation of plasma proteins involved in acute inflammatory response Source: Ensembl
    3. blood coagulation Source: MGI
    4. positive regulation of angiogenesis Source: Ensembl
    5. positive regulation of endothelial cell proliferation Source: Ensembl
    6. positive regulation of platelet-derived growth factor receptor signaling pathway Source: Ensembl
    7. positive regulation of protein kinase B signaling Source: Ensembl

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tissue factor
    Short name:
    TF
    Alternative name(s):
    Coagulation factor III
    CD_antigen: CD142
    Gene namesi
    Name:F3
    Synonyms:Cf-3, Cf3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:88381. F3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular matrix Source: Ensembl
    3. extracellular space Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Add
    BLAST
    Chaini29 – 294266Tissue factorPRO_0000033639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)1 Publication
    Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
    Disulfide bondi75 ↔ 83By similarity
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi218 ↔ 241By similarity
    Lipidationi275 – 2751S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP20352.
    PRIDEiP20352.

    PTM databases

    PhosphoSiteiP20352.

    Expressioni

    Inductioni

    Expression in the liver oscillates in a circadian manner.1 Publication

    Gene expression databases

    BgeeiP20352.
    CleanExiMM_F3.
    GenevestigatoriP20352.

    Interactioni

    Subunit structurei

    Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.By similarity

    Protein-protein interaction databases

    IntActiP20352. 1 interaction.
    MINTiMINT-4137612.

    Structurei

    3D structure databases

    ProteinModelPortaliP20352.
    SMRiP20352. Positions 35-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 251223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini275 – 29420CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei252 – 27423HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi245 – 2473WKS motif

    Sequence similaritiesi

    Belongs to the tissue factor family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43483.
    GeneTreeiENSGT00390000012668.
    HOGENOMiHOG000043076.
    HOVERGENiHBG005051.
    InParanoidiP20352.
    KOiK03901.
    OrthoDBiEOG7C2R28.
    PhylomeDBiP20352.
    TreeFamiTF352627.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    IPR016354. Tissue_fac/coagulation_fac-3.
    IPR001187. Tissue_factor.
    [Graphical view]
    PfamiPF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002498. Tissue_factor_3. 1 hit.
    PRINTSiPR00346. TISSUEFACTOR.
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS00621. TISSUE_FACTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20352-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAILVRPRLL AALAPTFLGC LLLQVIAGAG IPEKAFNLTW ISTDFKTILE    50
    WQPKPTNYTY TVQISDRSRN WKNKCFSTTD TECDLTDEIV KDVTWAYEAK 100
    VLSVPRRNSV HGDGDQLVIH GEEPPFTNAP KFLPYRDTNL GQPVIQQFEQ 150
    DGRKLNVVVK DSLTLVRKNG TFLTLRQVFG KDLGYIITYR KGSSTGKKTN 200
    ITNTNEFSID VEEGVSYCFF VQAMIFSRKT NQNSPGSSTV CTEQWKSFLG 250
    ETLIIVGAVV LLATIFIILL SISLCKRRKN RAGQKGKNTP SRLA 294
    Length:294
    Mass (Da):32,935
    Last modified:August 1, 1991 - v2
    Checksum:iA306101293C31FA0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261I → T in AAA40414. (PubMed:2761539)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57896 mRNA. Translation: AAA63400.1.
    M26071 mRNA. Translation: AAA40414.1.
    BC016397 mRNA. Translation: AAH16397.1.
    CCDSiCCDS17805.1.
    PIRiA32318. KFMS3.
    RefSeqiNP_034301.3. NM_010171.3.
    UniGeneiMm.273188.

    Genome annotation databases

    EnsembliENSMUST00000029771; ENSMUSP00000029771; ENSMUSG00000028128.
    GeneIDi14066.
    KEGGimmu:14066.
    UCSCiuc008ree.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57896 mRNA. Translation: AAA63400.1 .
    M26071 mRNA. Translation: AAA40414.1 .
    BC016397 mRNA. Translation: AAH16397.1 .
    CCDSi CCDS17805.1.
    PIRi A32318. KFMS3.
    RefSeqi NP_034301.3. NM_010171.3.
    UniGenei Mm.273188.

    3D structure databases

    ProteinModelPortali P20352.
    SMRi P20352. Positions 35-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P20352. 1 interaction.
    MINTi MINT-4137612.

    Chemistry

    ChEMBLi CHEMBL5787.

    PTM databases

    PhosphoSitei P20352.

    Proteomic databases

    PaxDbi P20352.
    PRIDEi P20352.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029771 ; ENSMUSP00000029771 ; ENSMUSG00000028128 .
    GeneIDi 14066.
    KEGGi mmu:14066.
    UCSCi uc008ree.2. mouse.

    Organism-specific databases

    CTDi 2152.
    MGIi MGI:88381. F3.

    Phylogenomic databases

    eggNOGi NOG43483.
    GeneTreei ENSGT00390000012668.
    HOGENOMi HOG000043076.
    HOVERGENi HBG005051.
    InParanoidi P20352.
    KOi K03901.
    OrthoDBi EOG7C2R28.
    PhylomeDBi P20352.
    TreeFami TF352627.

    Miscellaneous databases

    NextBioi 285048.
    PROi P20352.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20352.
    CleanExi MM_F3.
    Genevestigatori P20352.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    IPR016354. Tissue_fac/coagulation_fac-3.
    IPR001187. Tissue_factor.
    [Graphical view ]
    Pfami PF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002498. Tissue_factor_3. 1 hit.
    PRINTSi PR00346. TISSUEFACTOR.
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS00621. TISSUE_FACTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta 1."
      Ranganathan G., Blatti S.P., Subramaniam M., Fass D.N., Maihle N.J., Getz M.J.
      J. Biol. Chem. 266:496-501(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor."
      Hartzell S., Ryder K., Lanahan A., Lau L.F., Nathans D.
      Mol. Cell. Biol. 9:2567-2573(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37 AND ASN-57.
      Tissue: Myoblast.
    5. "The molecular clock regulates circadian transcription of tissue factor gene."
      Oishi K., Koyanagi S., Ohkura N.
      Biochem. Biophys. Res. Commun. 431:332-335(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiTF_MOUSE
    AccessioniPrimary (citable) accession number: P20352
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3