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Protein

Tissue factor

Gene

F3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor
Short name:
TF
Alternative name(s):
Coagulation factor III
CD_antigen: CD142
Gene namesi
Name:F3
Synonyms:Cf-3, Cf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88381. F3.

Subcellular locationi

  • Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 251ExtracellularSequence analysisAdd BLAST223
Transmembranei252 – 274HelicalSequence analysisAdd BLAST23
Topological domaini275 – 294CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000003363929 – 294Tissue factorAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi57N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi75 ↔ 83By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 241By similarity
Lipidationi275S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP20352.
PaxDbiP20352.
PeptideAtlasiP20352.
PRIDEiP20352.

PTM databases

iPTMnetiP20352.
PhosphoSitePlusiP20352.
SwissPalmiP20352.

Expressioni

Inductioni

Expression in the liver oscillates in a circadian manner.1 Publication

Gene expression databases

BgeeiENSMUSG00000028128.
CleanExiMM_F3.

Interactioni

Subunit structurei

Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20352. 1 interactor.
MINTiMINT-4137612.
STRINGi10090.ENSMUSP00000029771.

Structurei

3D structure databases

ProteinModelPortaliP20352.
SMRiP20352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi245 – 247WKS motif3

Sequence similaritiesi

Belongs to the tissue factor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYA1. Eukaryota.
ENOG4111MW4. LUCA.
HOGENOMiHOG000043076.
HOVERGENiHBG005051.
InParanoidiP20352.
KOiK03901.
PhylomeDBiP20352.
TreeFamiTF352627.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
IPR001187. Tissue_factor.
IPR030472. Tissue_Factor_CS.
PANTHERiPTHR20859:SF72. PTHR20859:SF72. 1 hit.
PfamiView protein in Pfam
PF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
PIRSFiPIRSF002498. Tissue_factor_3. 1 hit.
PRINTSiPR00346. TISSUEFACTOR.
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiView protein in PROSITE
PS00621. TISSUE_FACTOR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILVRPRLL AALAPTFLGC LLLQVIAGAG IPEKAFNLTW ISTDFKTILE
60 70 80 90 100
WQPKPTNYTY TVQISDRSRN WKNKCFSTTD TECDLTDEIV KDVTWAYEAK
110 120 130 140 150
VLSVPRRNSV HGDGDQLVIH GEEPPFTNAP KFLPYRDTNL GQPVIQQFEQ
160 170 180 190 200
DGRKLNVVVK DSLTLVRKNG TFLTLRQVFG KDLGYIITYR KGSSTGKKTN
210 220 230 240 250
ITNTNEFSID VEEGVSYCFF VQAMIFSRKT NQNSPGSSTV CTEQWKSFLG
260 270 280 290
ETLIIVGAVV LLATIFIILL SISLCKRRKN RAGQKGKNTP SRLA
Length:294
Mass (Da):32,935
Last modified:August 1, 1991 - v2
Checksum:iA306101293C31FA0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26I → T in AAA40414 (PubMed:2761539).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57896 mRNA. Translation: AAA63400.1.
M26071 mRNA. Translation: AAA40414.1.
BC016397 mRNA. Translation: AAH16397.1.
CCDSiCCDS17805.1.
PIRiA32318. KFMS3.
RefSeqiNP_034301.3. NM_010171.3.
UniGeneiMm.273188.

Genome annotation databases

GeneIDi14066.
KEGGimmu:14066.
UCSCiuc008ree.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTF_MOUSE
AccessioniPrimary (citable) accession number: P20352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 1, 1991
Last modified: May 10, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families