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P20340

- RAB6A_HUMAN

UniProt

P20340 - RAB6A_HUMAN

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Protein

Ras-related protein Rab-6A

Gene
RAB6A, RAB6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289GTP
Nucleotide bindingi68 – 725GTP
Nucleotide bindingi126 – 1294GTP
Nucleotide bindingi156 – 1583GTP

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB
  2. GTP binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. protein domain specific binding Source: BHF-UCL

GO - Biological processi

  1. antigen processing and presentation Source: UniProt
  2. GTP catabolic process Source: GOC
  3. minus-end-directed organelle transport along microtubule Source: BHF-UCL
  4. peptidyl-cysteine methylation Source: MGI
  5. protein localization to Golgi apparatus Source: BHF-UCL
  6. protein targeting to Golgi Source: UniProtKB
  7. retrograde vesicle-mediated transport, Golgi to ER Source: BHF-UCL
  8. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_118798. Pre-NOTCH Processing in Golgi.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6A
Short name:
Rab-6
Gene namesi
Name:RAB6A
Synonyms:RAB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9786. RAB6A.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: BHF-UCL
  2. cytosol Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProt
  4. Golgi apparatus Source: UniProtKB
  5. Golgi membrane Source: UniProtKB-SubCell
  6. membrane Source: BHF-UCL
  7. trans-Golgi network Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi27 – 271T → N: Loss of APBA1-binding. 1 Publication
Mutagenesisi46 – 461I → E: Loss of RAB6IP1-binding. 1 Publication
Mutagenesisi72 – 721Q → L: Loss of GTPase activity. Interacts with APBA1. 4 Publications

Organism-specific databases

PharmGKBiPA34146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 208207Ras-related protein Rab-6APRO_0000121112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine5 Publications
Modified residuei82 – 821O-AMP-tyrosine; by Legionella DrrA
Lipidationi206 – 2061S-geranylgeranyl cysteine By similarity
Modified residuei208 – 2081Cysteine methyl ester By similarity
Lipidationi208 – 2081S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiP20340.
PaxDbiP20340.
PRIDEiP20340.

PTM databases

PhosphoSiteiP20340.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiP20340.
BgeeiP20340.
CleanExiHS_RAB6A.
GenevestigatoriP20340.

Organism-specific databases

HPAiCAB009936.
HPA059131.

Interactioni

Subunit structurei

Interacts with CCDC64; leads to its accumulation in the pericentrosomal region By similarity. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APBA1Q02410-24EBI-8851226,EBI-9247455
GCC2Q8IWJ24EBI-1052826,EBI-1645320
OCRLQ0196811EBI-1052826,EBI-6148898

Protein-protein interaction databases

BioGridi111808. 22 interactions.
DIPiDIP-39668N.
IntActiP20340. 11 interactions.
MINTiMINT-1482056.
STRINGi9606.ENSP00000311449.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 217
Helixi26 – 3510
Beta strandi47 – 5610
Beta strandi61 – 699
Helixi73 – 786
Helixi79 – 835
Beta strandi87 – 948
Helixi98 – 1025
Helixi104 – 11512
Beta strandi118 – 1269
Helixi128 – 1303
Helixi131 – 1333
Helixi138 – 14710
Beta strandi151 – 1544
Turni157 – 1593
Helixi163 – 17311

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YZQX-ray1.78A10-177[»]
2GILX-ray1.82A/B/C/D13-174[»]
3BBPX-ray3.00A/B/C1-206[»]
3CWZX-ray3.20A8-195[»]
4DKXX-ray1.90A/B1-208[»]
ProteinModelPortaliP20340.
SMRiP20340. Positions 13-174.

Miscellaneous databases

EvolutionaryTraceiP20340.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP20340.
KOiK07893.
OMAiSACAANC.
OrthoDBiEOG77DJ7M.
PhylomeDBiP20340.
TreeFamiTF300803.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20340-1) [UniParc]FASTAAdd to Basket

Also known as: Rab-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF    50
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS 100
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 150
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 200
VSEGGCSC 208
Length:208
Mass (Da):23,593
Last modified:January 23, 2007 - v3
Checksum:iC9A3C2DDBF6C3E9E
GO
Isoform 2 (identifier: P20340-2) [UniParc]FASTAAdd to Basket

Also known as: Rab-6a', Rab-6C, Rab6C

The sequence of this isoform differs from the canonical sequence as follows:
     62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

Show »
Length:208
Mass (Da):23,549
Checksum:iDF4B42559600F98B
GO
Isoform 3 (identifier: P20340-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-165: Missing.

Show »
Length:104
Mass (Da):11,715
Checksum:i47907D182528BE16
GO
Isoform 4 (identifier: P20340-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

Show »
Length:175
Mass (Da):19,935
Checksum:i1667A3BFAE94F873
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3333Missing in isoform 4. VSP_046967Add
BLAST
Alternative sequencei62 – 165104Missing in isoform 3. VSP_045302Add
BLAST
Alternative sequencei62 – 8827VRLQL…RDSTV → IRLQLWDTAGQERFRSLIPS YIRDSAA in isoform 2 and isoform 4. VSP_005527Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891I → T in BAH13508. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28212 mRNA. Translation: AAA60246.1.
AF130986 mRNA. Translation: AAD25535.1.
AF119836 mRNA. Translation: AAF23593.1.
AF198616 mRNA. Translation: AAF73841.1.
AF130122 mRNA. Translation: AAD27707.1.
DQ437503 mRNA. Translation: ABD93919.1.
AK057157 mRNA. Translation: BAB71371.1.
AK289748 mRNA. Translation: BAF82437.1.
AK290132 mRNA. Translation: BAF82821.1.
AK301534 mRNA. Translation: BAH13508.1.
AF498939 mRNA. Translation: AAM21087.1.
AF498941 mRNA. Translation: AAM21089.1.
BT019698 mRNA. Translation: AAV38504.1.
AP002770 Genomic DNA. No translation available.
AP002993 Genomic DNA. No translation available.
BC003617 mRNA. Translation: AAH03617.1.
BC068486 mRNA. Translation: AAH68486.1.
BC096818 mRNA. Translation: AAH96818.1.
CCDSiCCDS58155.1. [P20340-4]
CCDS58156.1. [P20340-3]
CCDS8223.1. [P20340-2]
CCDS8224.1. [P20340-1]
PIRiG34323.
RefSeqiNP_001230647.1. NM_001243718.1. [P20340-3]
NP_001230648.1. NM_001243719.1. [P20340-4]
NP_002860.2. NM_002869.4. [P20340-2]
NP_942599.1. NM_198896.1. [P20340-1]
UniGeneiHs.503222.
Hs.591552.

Genome annotation databases

EnsembliENST00000310653; ENSP00000311449; ENSG00000175582. [P20340-2]
ENST00000336083; ENSP00000336850; ENSG00000175582. [P20340-1]
ENST00000536566; ENSP00000437863; ENSG00000175582. [P20340-4]
ENST00000541588; ENSP00000445350; ENSG00000175582. [P20340-3]
GeneIDi5870.
KEGGihsa:5870.
UCSCiuc001oue.3. human. [P20340-2]
uc001ouf.3. human. [P20340-1]
uc009yts.3. human.

Polymorphism databases

DMDMi131796.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28212 mRNA. Translation: AAA60246.1 .
AF130986 mRNA. Translation: AAD25535.1 .
AF119836 mRNA. Translation: AAF23593.1 .
AF198616 mRNA. Translation: AAF73841.1 .
AF130122 mRNA. Translation: AAD27707.1 .
DQ437503 mRNA. Translation: ABD93919.1 .
AK057157 mRNA. Translation: BAB71371.1 .
AK289748 mRNA. Translation: BAF82437.1 .
AK290132 mRNA. Translation: BAF82821.1 .
AK301534 mRNA. Translation: BAH13508.1 .
AF498939 mRNA. Translation: AAM21087.1 .
AF498941 mRNA. Translation: AAM21089.1 .
BT019698 mRNA. Translation: AAV38504.1 .
AP002770 Genomic DNA. No translation available.
AP002993 Genomic DNA. No translation available.
BC003617 mRNA. Translation: AAH03617.1 .
BC068486 mRNA. Translation: AAH68486.1 .
BC096818 mRNA. Translation: AAH96818.1 .
CCDSi CCDS58155.1. [P20340-4 ]
CCDS58156.1. [P20340-3 ]
CCDS8223.1. [P20340-2 ]
CCDS8224.1. [P20340-1 ]
PIRi G34323.
RefSeqi NP_001230647.1. NM_001243718.1. [P20340-3 ]
NP_001230648.1. NM_001243719.1. [P20340-4 ]
NP_002860.2. NM_002869.4. [P20340-2 ]
NP_942599.1. NM_198896.1. [P20340-1 ]
UniGenei Hs.503222.
Hs.591552.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YZQ X-ray 1.78 A 10-177 [» ]
2GIL X-ray 1.82 A/B/C/D 13-174 [» ]
3BBP X-ray 3.00 A/B/C 1-206 [» ]
3CWZ X-ray 3.20 A 8-195 [» ]
4DKX X-ray 1.90 A/B 1-208 [» ]
ProteinModelPortali P20340.
SMRi P20340. Positions 13-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111808. 22 interactions.
DIPi DIP-39668N.
IntActi P20340. 11 interactions.
MINTi MINT-1482056.
STRINGi 9606.ENSP00000311449.

PTM databases

PhosphoSitei P20340.

Polymorphism databases

DMDMi 131796.

Proteomic databases

MaxQBi P20340.
PaxDbi P20340.
PRIDEi P20340.

Protocols and materials databases

DNASUi 5870.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310653 ; ENSP00000311449 ; ENSG00000175582 . [P20340-2 ]
ENST00000336083 ; ENSP00000336850 ; ENSG00000175582 . [P20340-1 ]
ENST00000536566 ; ENSP00000437863 ; ENSG00000175582 . [P20340-4 ]
ENST00000541588 ; ENSP00000445350 ; ENSG00000175582 . [P20340-3 ]
GeneIDi 5870.
KEGGi hsa:5870.
UCSCi uc001oue.3. human. [P20340-2 ]
uc001ouf.3. human. [P20340-1 ]
uc009yts.3. human.

Organism-specific databases

CTDi 5870.
GeneCardsi GC11M073386.
HGNCi HGNC:9786. RAB6A.
HPAi CAB009936.
HPA059131.
MIMi 179513. gene.
neXtProti NX_P20340.
PharmGKBi PA34146.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P20340.
KOi K07893.
OMAi SACAANC.
OrthoDBi EOG77DJ7M.
PhylomeDBi P20340.
TreeFami TF300803.

Enzyme and pathway databases

Reactomei REACT_118798. Pre-NOTCH Processing in Golgi.

Miscellaneous databases

ChiTaRSi RAB6A. human.
EvolutionaryTracei P20340.
GeneWikii RAB6A.
GenomeRNAii 5870.
NextBioi 22798.
PROi P20340.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20340.
Bgeei P20340.
CleanExi HS_RAB6A.
Genevestigatori P20340.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."
    Zahraoui A., Touchot N., Chardin P., Tavitian A.
    J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells."
    Caillol N., Pasqualini E., Lloubes R., Lombardo D.
    J. Cell. Biochem. 79:628-647(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreatic tumor.
  3. "Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells."
    Shan J., Mason J.M., Yuan L., Barcia M., Porti D., Calabro A., Budman D., Vinciguerra V., Xu H.-P.
    Gene 257:67-75(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms."
    Echard A., Opdam F.J.M., de Leeuw H.J.P.C., Jollivet F., Savelkoul P., Hendriks W., Voorberg J., Goud B., Fransen J.A.M.
    Mol. Biol. Cell 11:3819-3833(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, CHARACTERIZATION.
  5. "A second form of RAB6 in humans."
    Barr F.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  6. Delisle B.P., Foell J.D., Slind J.K., Kilby J.A., Balijepalli R.C., Kamp T.J., January C.T.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Heart.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Brain, Spleen and Thalamus.
  8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney, Placenta and Testis.
  12. Bienvenut W.V., Claeys D.
    Submitted (NOV-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13; 64-74; 77-84 AND 116-143, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Platelet.
  13. "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome."
    Cuif M.-H., Possmayer F., Zander H., Bordes N., Jollivet F., Couedel-Courteille A., Janoueix-Lerosey I., Langsley G., Bornens M., Goud B.
    EMBO J. 18:1772-1782(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RABGAP1.
  14. "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex."
    Matanis T., Akhmanova A., Wulf P., Del Nery E., Weide T., Stepanova T., Galjart N., Grosveld F., Goud B., De Zeeuw C.I., Barnekow A., Hoogenraad C.C.
    Nat. Cell Biol. 4:986-992(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BICD1 AND BICD2.
  15. Cited for: INTERACTION WITH VSP52.
  16. "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic."
    Yamane J., Kubo A., Nakayama K., Yuba-Kubo A., Katsuno T., Tsukita S., Tsukita S.
    Exp. Cell Res. 313:3472-3485(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TMF1.
  17. "Rab6 family proteins interact with the dynein light chain protein DYNLRB1."
    Wanschers B.F.J., van de Vorstenbosch R., Wijers M., Wieringa B., King S.M., Fransen J.
    Cell Motil. Cytoskeleton 65:183-196(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYNLRB1.
  18. Cited for: INTERACTION WITH SCYL1BP1.
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. Cited for: INTERACTION WITH PIFO.
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. "Modulation of Rab GTPase function by a protein phosphocholine transferase."
    Mukherjee S., Liu X., Arasaki K., McDonough J., Galan J.E., Roy C.R.
    Nature 477:103-106(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: AMPYLATION AT TYR-82.
  24. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  26. "Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance."
    Peeters K., Litvinenko I., Asselbergh B., Almeida-Souza L., Chamova T., Geuens T., Ydens E., Zimon M., Irobi J., De Vriendt E., De Winter V., Ooms T., Timmerman V., Tournev I., Jordanova A.
    Am. J. Hum. Genet. 92:955-964(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BICD2.
  27. Cited for: INTERACTION WITH APBA1, MUTAGENESIS OF THR-27 AND GLN-72.
  28. "Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution."
    Bergbrede T., Pylypenko O., Rak A., Alexandrov K.
    J. Struct. Biol. 152:235-238(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 13-174 IN COMPLEX WITH GTP, MUTAGENESIS OF GLN-72.
  29. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."
    Eathiraj S., Pan X., Ritacco C., Lambright D.G.
    Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 10-177 IN COMPLEX WITH GTP ANALOG.
  30. "Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185."
    Burguete A.S., Fenn T.D., Brunger A.T., Pfeffer S.R.
    Cell 132:286-298(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 1-206 IN COMPLEX WITH GTP, INTERACTION WITH GCC2, MUTAGENESIS OF GLN-72.
  31. "Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain."
    Recacha R., Boulet A., Jollivet F., Monier S., Houdusse A., Goud B., Khan A.R.
    Structure 17:21-30(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 8-195 IN COMPLEX WITH GTP AND RAB6IP1, MUTAGENESIS OF ILE-46 AND GLN-72.

Entry informationi

Entry nameiRAB6A_HUMAN
AccessioniPrimary (citable) accession number: P20340
Secondary accession number(s): A8K133
, B7Z772, F5H668, Q1W5D8, Q5U0A8, Q9UBE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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