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P20340

- RAB6A_HUMAN

UniProt

P20340 - RAB6A_HUMAN

Protein

Ras-related protein Rab-6A

Gene

RAB6A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 171 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289GTP3 Publications
    Nucleotide bindingi68 – 725GTP3 Publications
    Nucleotide bindingi126 – 1294GTP3 Publications
    Nucleotide bindingi156 – 1583GTP3 Publications

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein domain specific binding Source: BHF-UCL

    GO - Biological processi

    1. antigen processing and presentation Source: UniProt
    2. GTP catabolic process Source: GOC
    3. minus-end-directed organelle transport along microtubule Source: BHF-UCL
    4. peptidyl-cysteine methylation Source: MGI
    5. protein localization to Golgi apparatus Source: BHF-UCL
    6. protein targeting to Golgi Source: UniProtKB
    7. retrograde vesicle-mediated transport, Golgi to ER Source: BHF-UCL
    8. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_118798. Pre-NOTCH Processing in Golgi.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-6A
    Short name:
    Rab-6
    Gene namesi
    Name:RAB6A
    Synonyms:RAB6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9786. RAB6A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: BHF-UCL
    2. cytosol Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: UniProtKB
    5. Golgi membrane Source: UniProtKB-SubCell
    6. membrane Source: BHF-UCL
    7. trans-Golgi network Source: BHF-UCL

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi27 – 271T → N: Loss of APBA1-binding. 1 Publication
    Mutagenesisi46 – 461I → E: Loss of RAB6IP1-binding. 1 Publication
    Mutagenesisi72 – 721Q → L: Loss of GTPase activity. Interacts with APBA1. 4 Publications

    Organism-specific databases

    PharmGKBiPA34146.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed5 Publications
    Chaini2 – 208207Ras-related protein Rab-6APRO_0000121112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine5 Publications
    Modified residuei82 – 821O-AMP-tyrosine; by Legionella DrrA1 Publication
    Lipidationi206 – 2061S-geranylgeranyl cysteineBy similarity
    Modified residuei208 – 2081Cysteine methyl esterBy similarity
    Lipidationi208 – 2081S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiP20340.
    PaxDbiP20340.
    PRIDEiP20340.

    PTM databases

    PhosphoSiteiP20340.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiP20340.
    BgeeiP20340.
    CleanExiHS_RAB6A.
    GenevestigatoriP20340.

    Organism-specific databases

    HPAiCAB009936.
    HPA059131.

    Interactioni

    Subunit structurei

    Interacts with CCDC64; leads to its accumulation in the pericentrosomal region By similarity. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.By similarity13 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APBA1Q02410-24EBI-8851226,EBI-9247455
    GCC2Q8IWJ24EBI-1052826,EBI-1645320
    OCRLQ0196811EBI-1052826,EBI-6148898

    Protein-protein interaction databases

    BioGridi111808. 22 interactions.
    DIPiDIP-39668N.
    IntActiP20340. 11 interactions.
    MINTiMINT-1482056.
    STRINGi9606.ENSP00000311449.

    Structurei

    Secondary structure

    1
    208
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi15 – 217
    Helixi26 – 3510
    Beta strandi47 – 5610
    Beta strandi61 – 699
    Helixi73 – 786
    Helixi79 – 835
    Beta strandi87 – 948
    Helixi98 – 1025
    Helixi104 – 11512
    Beta strandi118 – 1269
    Helixi128 – 1303
    Helixi131 – 1333
    Helixi138 – 14710
    Beta strandi151 – 1544
    Turni157 – 1593
    Helixi163 – 17311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YZQX-ray1.78A10-177[»]
    2GILX-ray1.82A/B/C/D13-174[»]
    3BBPX-ray3.00A/B/C1-206[»]
    3CWZX-ray3.20A8-195[»]
    4DKXX-ray1.90A/B1-208[»]
    ProteinModelPortaliP20340.
    SMRiP20340. Positions 13-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20340.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 509Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP20340.
    KOiK07893.
    OMAiSACAANC.
    OrthoDBiEOG77DJ7M.
    PhylomeDBiP20340.
    TreeFamiTF300803.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P20340-1) [UniParc]FASTAAdd to Basket

    Also known as: Rab-6a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF    50
    LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS 100
    FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 150
    MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 200
    VSEGGCSC 208
    Length:208
    Mass (Da):23,593
    Last modified:January 23, 2007 - v3
    Checksum:iC9A3C2DDBF6C3E9E
    GO
    Isoform 2 (identifier: P20340-2) [UniParc]FASTAAdd to Basket

    Also known as: Rab-6a', Rab-6C, Rab6C

    The sequence of this isoform differs from the canonical sequence as follows:
         62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

    Show »
    Length:208
    Mass (Da):23,549
    Checksum:iDF4B42559600F98B
    GO
    Isoform 3 (identifier: P20340-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         62-165: Missing.

    Show »
    Length:104
    Mass (Da):11,715
    Checksum:i47907D182528BE16
    GO
    Isoform 4 (identifier: P20340-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.
         62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

    Show »
    Length:175
    Mass (Da):19,935
    Checksum:i1667A3BFAE94F873
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti189 – 1891I → T in BAH13508. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3333Missing in isoform 4. 1 PublicationVSP_046967Add
    BLAST
    Alternative sequencei62 – 165104Missing in isoform 3. 1 PublicationVSP_045302Add
    BLAST
    Alternative sequencei62 – 8827VRLQL…RDSTV → IRLQLWDTAGQERFRSLIPS YIRDSAA in isoform 2 and isoform 4. 6 PublicationsVSP_005527Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28212 mRNA. Translation: AAA60246.1.
    AF130986 mRNA. Translation: AAD25535.1.
    AF119836 mRNA. Translation: AAF23593.1.
    AF198616 mRNA. Translation: AAF73841.1.
    AF130122 mRNA. Translation: AAD27707.1.
    DQ437503 mRNA. Translation: ABD93919.1.
    AK057157 mRNA. Translation: BAB71371.1.
    AK289748 mRNA. Translation: BAF82437.1.
    AK290132 mRNA. Translation: BAF82821.1.
    AK301534 mRNA. Translation: BAH13508.1.
    AF498939 mRNA. Translation: AAM21087.1.
    AF498941 mRNA. Translation: AAM21089.1.
    BT019698 mRNA. Translation: AAV38504.1.
    AP002770 Genomic DNA. No translation available.
    AP002993 Genomic DNA. No translation available.
    BC003617 mRNA. Translation: AAH03617.1.
    BC068486 mRNA. Translation: AAH68486.1.
    BC096818 mRNA. Translation: AAH96818.1.
    CCDSiCCDS58155.1. [P20340-4]
    CCDS58156.1. [P20340-3]
    CCDS8223.1. [P20340-2]
    CCDS8224.1. [P20340-1]
    PIRiG34323.
    RefSeqiNP_001230647.1. NM_001243718.1. [P20340-3]
    NP_001230648.1. NM_001243719.1. [P20340-4]
    NP_002860.2. NM_002869.4. [P20340-2]
    NP_942599.1. NM_198896.1. [P20340-1]
    UniGeneiHs.503222.
    Hs.591552.

    Genome annotation databases

    EnsembliENST00000310653; ENSP00000311449; ENSG00000175582. [P20340-2]
    ENST00000336083; ENSP00000336850; ENSG00000175582. [P20340-1]
    ENST00000536566; ENSP00000437863; ENSG00000175582. [P20340-4]
    ENST00000541588; ENSP00000445350; ENSG00000175582. [P20340-3]
    GeneIDi5870.
    KEGGihsa:5870.
    UCSCiuc001oue.3. human. [P20340-2]
    uc001ouf.3. human. [P20340-1]
    uc009yts.3. human.

    Polymorphism databases

    DMDMi131796.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28212 mRNA. Translation: AAA60246.1 .
    AF130986 mRNA. Translation: AAD25535.1 .
    AF119836 mRNA. Translation: AAF23593.1 .
    AF198616 mRNA. Translation: AAF73841.1 .
    AF130122 mRNA. Translation: AAD27707.1 .
    DQ437503 mRNA. Translation: ABD93919.1 .
    AK057157 mRNA. Translation: BAB71371.1 .
    AK289748 mRNA. Translation: BAF82437.1 .
    AK290132 mRNA. Translation: BAF82821.1 .
    AK301534 mRNA. Translation: BAH13508.1 .
    AF498939 mRNA. Translation: AAM21087.1 .
    AF498941 mRNA. Translation: AAM21089.1 .
    BT019698 mRNA. Translation: AAV38504.1 .
    AP002770 Genomic DNA. No translation available.
    AP002993 Genomic DNA. No translation available.
    BC003617 mRNA. Translation: AAH03617.1 .
    BC068486 mRNA. Translation: AAH68486.1 .
    BC096818 mRNA. Translation: AAH96818.1 .
    CCDSi CCDS58155.1. [P20340-4 ]
    CCDS58156.1. [P20340-3 ]
    CCDS8223.1. [P20340-2 ]
    CCDS8224.1. [P20340-1 ]
    PIRi G34323.
    RefSeqi NP_001230647.1. NM_001243718.1. [P20340-3 ]
    NP_001230648.1. NM_001243719.1. [P20340-4 ]
    NP_002860.2. NM_002869.4. [P20340-2 ]
    NP_942599.1. NM_198896.1. [P20340-1 ]
    UniGenei Hs.503222.
    Hs.591552.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YZQ X-ray 1.78 A 10-177 [» ]
    2GIL X-ray 1.82 A/B/C/D 13-174 [» ]
    3BBP X-ray 3.00 A/B/C 1-206 [» ]
    3CWZ X-ray 3.20 A 8-195 [» ]
    4DKX X-ray 1.90 A/B 1-208 [» ]
    ProteinModelPortali P20340.
    SMRi P20340. Positions 13-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111808. 22 interactions.
    DIPi DIP-39668N.
    IntActi P20340. 11 interactions.
    MINTi MINT-1482056.
    STRINGi 9606.ENSP00000311449.

    PTM databases

    PhosphoSitei P20340.

    Polymorphism databases

    DMDMi 131796.

    Proteomic databases

    MaxQBi P20340.
    PaxDbi P20340.
    PRIDEi P20340.

    Protocols and materials databases

    DNASUi 5870.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310653 ; ENSP00000311449 ; ENSG00000175582 . [P20340-2 ]
    ENST00000336083 ; ENSP00000336850 ; ENSG00000175582 . [P20340-1 ]
    ENST00000536566 ; ENSP00000437863 ; ENSG00000175582 . [P20340-4 ]
    ENST00000541588 ; ENSP00000445350 ; ENSG00000175582 . [P20340-3 ]
    GeneIDi 5870.
    KEGGi hsa:5870.
    UCSCi uc001oue.3. human. [P20340-2 ]
    uc001ouf.3. human. [P20340-1 ]
    uc009yts.3. human.

    Organism-specific databases

    CTDi 5870.
    GeneCardsi GC11M073386.
    HGNCi HGNC:9786. RAB6A.
    HPAi CAB009936.
    HPA059131.
    MIMi 179513. gene.
    neXtProti NX_P20340.
    PharmGKBi PA34146.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P20340.
    KOi K07893.
    OMAi SACAANC.
    OrthoDBi EOG77DJ7M.
    PhylomeDBi P20340.
    TreeFami TF300803.

    Enzyme and pathway databases

    Reactomei REACT_118798. Pre-NOTCH Processing in Golgi.

    Miscellaneous databases

    ChiTaRSi RAB6A. human.
    EvolutionaryTracei P20340.
    GeneWikii RAB6A.
    GenomeRNAii 5870.
    NextBioi 22798.
    PROi P20340.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20340.
    Bgeei P20340.
    CleanExi HS_RAB6A.
    Genevestigatori P20340.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."
      Zahraoui A., Touchot N., Chardin P., Tavitian A.
      J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells."
      Caillol N., Pasqualini E., Lloubes R., Lombardo D.
      J. Cell. Biochem. 79:628-647(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pancreatic tumor.
    3. "Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells."
      Shan J., Mason J.M., Yuan L., Barcia M., Porti D., Calabro A., Budman D., Vinciguerra V., Xu H.-P.
      Gene 257:67-75(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms."
      Echard A., Opdam F.J.M., de Leeuw H.J.P.C., Jollivet F., Savelkoul P., Hendriks W., Voorberg J., Goud B., Fransen J.A.M.
      Mol. Biol. Cell 11:3819-3833(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, CHARACTERIZATION.
    5. "A second form of RAB6 in humans."
      Barr F.A.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    6. Delisle B.P., Foell J.D., Slind J.K., Kilby J.A., Balijepalli R.C., Kamp T.J., January C.T.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Heart.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
      Tissue: Brain, Spleen and Thalamus.
    8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney, Placenta and Testis.
    12. Bienvenut W.V., Claeys D.
      Submitted (NOV-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 64-74; 77-84 AND 116-143, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Platelet.
    13. "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome."
      Cuif M.-H., Possmayer F., Zander H., Bordes N., Jollivet F., Couedel-Courteille A., Janoueix-Lerosey I., Langsley G., Bornens M., Goud B.
      EMBO J. 18:1772-1782(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RABGAP1.
    14. "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex."
      Matanis T., Akhmanova A., Wulf P., Del Nery E., Weide T., Stepanova T., Galjart N., Grosveld F., Goud B., De Zeeuw C.I., Barnekow A., Hoogenraad C.C.
      Nat. Cell Biol. 4:986-992(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BICD1 AND BICD2.
    15. Cited for: INTERACTION WITH VSP52.
    16. "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic."
      Yamane J., Kubo A., Nakayama K., Yuba-Kubo A., Katsuno T., Tsukita S., Tsukita S.
      Exp. Cell Res. 313:3472-3485(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TMF1.
    17. "Rab6 family proteins interact with the dynein light chain protein DYNLRB1."
      Wanschers B.F.J., van de Vorstenbosch R., Wijers M., Wieringa B., King S.M., Fransen J.
      Cell Motil. Cytoskeleton 65:183-196(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYNLRB1.
    18. Cited for: INTERACTION WITH SCYL1BP1.
    19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. Cited for: INTERACTION WITH PIFO.
    21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "Modulation of Rab GTPase function by a protein phosphocholine transferase."
      Mukherjee S., Liu X., Arasaki K., McDonough J., Galan J.E., Roy C.R.
      Nature 477:103-106(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: AMPYLATION AT TYR-82.
    24. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    25. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    26. "Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance."
      Peeters K., Litvinenko I., Asselbergh B., Almeida-Souza L., Chamova T., Geuens T., Ydens E., Zimon M., Irobi J., De Vriendt E., De Winter V., Ooms T., Timmerman V., Tournev I., Jordanova A.
      Am. J. Hum. Genet. 92:955-964(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BICD2.
    27. Cited for: INTERACTION WITH APBA1, MUTAGENESIS OF THR-27 AND GLN-72.
    28. "Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution."
      Bergbrede T., Pylypenko O., Rak A., Alexandrov K.
      J. Struct. Biol. 152:235-238(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 13-174 IN COMPLEX WITH GTP, MUTAGENESIS OF GLN-72.
    29. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."
      Eathiraj S., Pan X., Ritacco C., Lambright D.G.
      Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 10-177 IN COMPLEX WITH GTP ANALOG.
    30. "Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185."
      Burguete A.S., Fenn T.D., Brunger A.T., Pfeffer S.R.
      Cell 132:286-298(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 1-206 IN COMPLEX WITH GTP, INTERACTION WITH GCC2, MUTAGENESIS OF GLN-72.
    31. "Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain."
      Recacha R., Boulet A., Jollivet F., Monier S., Houdusse A., Goud B., Khan A.R.
      Structure 17:21-30(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 8-195 IN COMPLEX WITH GTP AND RAB6IP1, MUTAGENESIS OF ILE-46 AND GLN-72.

    Entry informationi

    Entry nameiRAB6A_HUMAN
    AccessioniPrimary (citable) accession number: P20340
    Secondary accession number(s): A8K133
    , B7Z772, F5H668, Q1W5D8, Q5U0A8, Q9UBE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 171 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3