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Protein

Ras-related protein Rab-3B

Gene

RAB3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPCombined sources9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPCombined sources4
Nucleotide bindingi165 – 167GTPCombined sources3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • myosin V binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation Source: UniProtKB
  • peptidyl-cysteine methylation Source: Ensembl
  • positive regulation of dopamine uptake involved in synaptic transmission Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of exocytosis Source: Ensembl
  • regulation of vesicle size Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3B
Gene namesi
Name:RAB3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9778. RAB3B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • secretory granule Source: Ensembl
  • synaptic vesicle Source: Ensembl
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5865.
OpenTargetsiENSG00000169213.
PharmGKBiPA34133.

Polymorphism and mutation databases

BioMutaiRAB3B.
DMDMi38258903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210811 – 219Ras-related protein Rab-3BAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineCombined sources1
Lipidationi217S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterBy similarity1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP20337.
MaxQBiP20337.
PaxDbiP20337.
PeptideAtlasiP20337.
PRIDEiP20337.

PTM databases

iPTMnetiP20337.
PhosphoSitePlusiP20337.
SwissPalmiP20337.

Expressioni

Gene expression databases

BgeeiENSG00000169213.
CleanExiHS_RAB3B.
GenevisibleiP20337. HS.

Organism-specific databases

HPAiCAB023293.
HPA003159.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.By similarity

GO - Molecular functioni

  • myosin V binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111803. 23 interactors.
STRINGi9606.ENSP00000360718.

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 21Combined sources4
Beta strandi23 – 30Combined sources8
Helixi35 – 45Combined sources11
Beta strandi51 – 55Combined sources5
Turni56 – 58Combined sources3
Beta strandi59 – 66Combined sources8
Turni67 – 70Combined sources4
Beta strandi71 – 76Combined sources6
Helixi78 – 83Combined sources6
Helixi85 – 92Combined sources8
Beta strandi97 – 103Combined sources7
Helixi107 – 111Combined sources5
Helixi113 – 123Combined sources11
Beta strandi129 – 135Combined sources7
Helixi140 – 142Combined sources3
Helixi147 – 157Combined sources11
Beta strandi160 – 163Combined sources4
Turni166 – 169Combined sources4
Helixi172 – 186Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DZ8X-ray1.90A18-190[»]
ProteinModelPortaliP20337.
SMRiP20337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20337.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP20337.
KOiK06108.
OMAiDKMSDSM.
OrthoDBiEOG091G0J64.
PhylomeDBiP20337.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTDGKTG VKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVVPTEKG
160 170 180 190 200
QLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS LDTDPSMLGS
210
SKNTRLSDTP PLLQQNCSC
Length:219
Mass (Da):24,758
Last modified:October 31, 2003 - v2
Checksum:iB73A014B4295A60D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9T → H in AAA60243 (PubMed:2501306).Curated1
Sequence conflicti40F → L in AAA60243 (PubMed:2501306).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28214 mRNA. Translation: AAA60243.1.
AF498932 mRNA. Translation: AAM21080.1.
AL589663, AL445685 Genomic DNA. Translation: CAH74098.1.
AL445685, AL589663 Genomic DNA. Translation: CAI17027.1.
BC005035 mRNA. Translation: AAH05035.1.
CCDSiCCDS560.1.
PIRiD34323.
RefSeqiNP_002858.2. NM_002867.3.
XP_016857447.1. XM_017001958.1.
UniGeneiHs.123072.

Genome annotation databases

EnsembliENST00000371655; ENSP00000360718; ENSG00000169213.
GeneIDi5865.
KEGGihsa:5865.
UCSCiuc001cth.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28214 mRNA. Translation: AAA60243.1.
AF498932 mRNA. Translation: AAM21080.1.
AL589663, AL445685 Genomic DNA. Translation: CAH74098.1.
AL445685, AL589663 Genomic DNA. Translation: CAI17027.1.
BC005035 mRNA. Translation: AAH05035.1.
CCDSiCCDS560.1.
PIRiD34323.
RefSeqiNP_002858.2. NM_002867.3.
XP_016857447.1. XM_017001958.1.
UniGeneiHs.123072.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DZ8X-ray1.90A18-190[»]
ProteinModelPortaliP20337.
SMRiP20337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111803. 23 interactors.
STRINGi9606.ENSP00000360718.

PTM databases

iPTMnetiP20337.
PhosphoSitePlusiP20337.
SwissPalmiP20337.

Polymorphism and mutation databases

BioMutaiRAB3B.
DMDMi38258903.

Proteomic databases

EPDiP20337.
MaxQBiP20337.
PaxDbiP20337.
PeptideAtlasiP20337.
PRIDEiP20337.

Protocols and materials databases

DNASUi5865.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371655; ENSP00000360718; ENSG00000169213.
GeneIDi5865.
KEGGihsa:5865.
UCSCiuc001cth.3. human.

Organism-specific databases

CTDi5865.
DisGeNETi5865.
GeneCardsiRAB3B.
HGNCiHGNC:9778. RAB3B.
HPAiCAB023293.
HPA003159.
MIMi179510. gene.
neXtProtiNX_P20337.
OpenTargetsiENSG00000169213.
PharmGKBiPA34133.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP20337.
KOiK06108.
OMAiDKMSDSM.
OrthoDBiEOG091G0J64.
PhylomeDBiP20337.
TreeFamiTF313199.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169213-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP20337.
GeneWikiiRAB3B.
GenomeRNAii5865.
PROiP20337.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169213.
CleanExiHS_RAB3B.
GenevisibleiP20337. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3B_HUMAN
AccessioniPrimary (citable) accession number: P20337
Secondary accession number(s): Q5VUL2, Q9BSI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 31, 2003
Last modified: November 30, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.