P20337 (RAB3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 120.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ras-related protein Rab-3B | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 219 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Protein transport. Probably involved in vesicular traffic By similarity. |
| Subunit structure | Binds RIMS1 and RIMS2 By similarity. |
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side Potential. |
| Sequence similarities | Belongs to the small GTPase superfamily. Rab family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Cell membrane Membrane |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Methylation Phosphoprotein Prenylation |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activityTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 219 | 219 | Ras-related protein Rab-3B | PRO_0000121081 | |||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 29 – 37 | 9 | GTP | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 77 – 81 | 5 | GTP By similarity | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 135 – 138 | 4 | GTP | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 165 – 167 | 3 | GTP | ||||||||||||||||||||||||||||||||||||
| Motif | 51 – 59 | 9 | Effector region By similarity | ||||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||||
| Modified residue | 188 | 1 | Phosphoserine By similarity | ||||||||||||||||||||||||||||||||||||
| Modified residue | 219 | 1 | Cysteine methyl ester By similarity | ||||||||||||||||||||||||||||||||||||
| Lipidation | 217 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||||
| Lipidation | 219 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 9 | 1 | T → H in AAA60243. Ref.1 | ||||||||||||||||||||||||||||||||||||
| Sequence conflict | 40 | 1 | F → L in AAA60243. Ref.1 | ||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 19 – 21 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 23 – 28 | 6 | |||||||||||||||||||||||||||||||||||||
| Helix | 36 – 45 | 10 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 51 – 55 | 5 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 59 – 66 | 8 | |||||||||||||||||||||||||||||||||||||
| Turn | 67 – 70 | 4 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 71 – 76 | 6 | |||||||||||||||||||||||||||||||||||||
| Helix | 85 – 92 | 8 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 99 – 101 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 107 – 111 | 5 | |||||||||||||||||||||||||||||||||||||
| Helix | 113 – 123 | 11 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 131 – 133 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 140 – 142 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 152 – 156 | 5 | |||||||||||||||||||||||||||||||||||||
| Turn | 166 – 169 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 172 – 186 | 15 | |||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion." Zahraoui A., Touchot N., Chardin P., Tavitian A. J. Biol. Chem. 264:12394-12401(1989) [PubMed: 2501306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [5] | "Crystal structure of human RAB3B GTPase bound with GDP." Structural genomics consortium (SGC) Submitted (FEB-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 18-190 IN COMPLEX WITH GDP. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M28214 mRNA. Translation: AAA60243.1. AF498932 mRNA. Translation: AAM21080.1. AL589663, AL445685 Genomic DNA. Translation: CAH74098.1. AL445685, AL589663 Genomic DNA. Translation: CAI17027.1. BC005035 mRNA. Translation: AAH05035.1. | ||||||||||||
| IPI | IPI00300562. | ||||||||||||
| PIR | D34323. | ||||||||||||
| RefSeq | NP_002858.2. NM_002867.3. | ||||||||||||
| UniGene | Hs.123072. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | P20337. | ||||||||||||
| SMR | P20337. Positions 18-187. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | P20337. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P20337. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 38258903. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P20337. | ||||||||||||
| PRIDE | P20337. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000371655; ENSP00000360718; ENSG00000169213. | ||||||||||||
| GeneID | 5865. | ||||||||||||
| KEGG | hsa:5865. | ||||||||||||
| UCSC | uc001cth.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 5865. | ||||||||||||
| GeneCards | GC01M052373. | ||||||||||||
| H-InvDB | HIX0199885. | ||||||||||||
| HGNC | HGNC:9778. RAB3B. | ||||||||||||
| HPA | CAB023293. HPA003159. | ||||||||||||
| MIM | 179510. gene. | ||||||||||||
| neXtProt | NX_P20337. | ||||||||||||
| PharmGKB | PA34133. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG19658. | ||||||||||||
| GeneTree | ENSGT00600000084147. | ||||||||||||
| HOGENOM | HBG745225. | ||||||||||||
| HOVERGEN | HBG009351. | ||||||||||||
| InParanoid | P20337. | ||||||||||||
| OMA | GKDASDQ. | ||||||||||||
| OrthoDB | EOG4TB4C6. | ||||||||||||
| PhylomeDB | P20337. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P20337. | ||||||||||||
| Bgee | P20337. | ||||||||||||
| CleanEx | HS_RAB3B. | ||||||||||||
| Genevestigator | P20337. | ||||||||||||
| GermOnline | ENSG00000169213. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view] | ||||||||||||
| KO | K06108. | ||||||||||||
| Pfam | PF00071. Ras. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00449. RASTRNSFRMNG. | ||||||||||||
| SMART | SM00175. RAB. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00231. Small_GTP. 1 hit. | ||||||||||||
| PROSITE | PS51419. RAB. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 22778. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | RAB3B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P20337 Secondary accession number(s): Q5VUL2, Q9BSI1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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