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P20337

- RAB3B_HUMAN

UniProt

P20337 - RAB3B_HUMAN

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Protein
Ras-related protein Rab-3B
Gene
RAB3B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379GTP
Nucleotide bindingi48 – 547GTP By similarity
Nucleotide bindingi77 – 815GTP By similarity
Nucleotide bindingi135 – 1384GTP
Nucleotide bindingi165 – 1673GTP

GO - Molecular functioni

  1. GDP binding Source: UniProt
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. antigen processing and presentation Source: UniProt
  2. peptidyl-cysteine methylation Source: Ensembl
  3. positive regulation of dopamine uptake involved in synaptic transmission Source: UniProt
  4. protein transport Source: UniProtKB-KW
  5. regulation of exocytosis Source: Ensembl
  6. regulation of vesicle size Source: UniProt
  7. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3B
Gene namesi
Name:RAB3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:9778. RAB3B.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProt
  2. cytosol Source: Ensembl
  3. extracellular vesicular exosome Source: UniProt
  4. perinuclear region of cytoplasm Source: UniProt
  5. plasma membrane Source: UniProtKB-SubCell
  6. secretory granule Source: Ensembl
  7. synaptic vesicle Source: Ensembl
  8. vesicle Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Ras-related protein Rab-3B
PRO_0000121081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei190 – 1901Phosphoserine1 Publication
Lipidationi217 – 2171S-geranylgeranyl cysteine By similarity
Modified residuei219 – 2191Cysteine methyl ester By similarity
Lipidationi219 – 2191S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiP20337.
PaxDbiP20337.
PeptideAtlasiP20337.
PRIDEiP20337.

PTM databases

PhosphoSiteiP20337.

Expressioni

Gene expression databases

BgeeiP20337.
CleanExiHS_RAB3B.
GenevestigatoriP20337.

Organism-specific databases

HPAiCAB023293.
HPA003159.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL By similarity.

Protein-protein interaction databases

BioGridi111803. 7 interactions.
STRINGi9606.ENSP00000360718.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi18 – 214
Beta strandi23 – 308
Helixi35 – 4511
Beta strandi51 – 555
Turni56 – 583
Beta strandi59 – 668
Turni67 – 704
Beta strandi71 – 766
Helixi78 – 836
Helixi85 – 928
Beta strandi97 – 1037
Helixi107 – 1115
Helixi113 – 12311
Beta strandi129 – 1357
Helixi140 – 1423
Helixi147 – 15711
Beta strandi160 – 1634
Turni166 – 1694
Helixi172 – 18615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DZ8X-ray1.90A18-190[»]
ProteinModelPortaliP20337.
SMRiP20337. Positions 18-187.

Miscellaneous databases

EvolutionaryTraceiP20337.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 599Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP20337.
KOiK06108.
OMAiWFDFFEA.
OrthoDBiEOG7JQBPC.
PhylomeDBiP20337.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20337-1 [UniParc]FASTAAdd to Basket

« Hide

MASVTDGKTG VKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA    50
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL 100
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVVPTEKG 150
QLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS LDTDPSMLGS 200
SKNTRLSDTP PLLQQNCSC 219
Length:219
Mass (Da):24,758
Last modified:October 31, 2003 - v2
Checksum:iB73A014B4295A60D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91T → H in AAA60243. 1 Publication
Sequence conflicti40 – 401F → L in AAA60243. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28214 mRNA. Translation: AAA60243.1.
AF498932 mRNA. Translation: AAM21080.1.
AL589663, AL445685 Genomic DNA. Translation: CAH74098.1.
AL445685, AL589663 Genomic DNA. Translation: CAI17027.1.
BC005035 mRNA. Translation: AAH05035.1.
CCDSiCCDS560.1.
PIRiD34323.
RefSeqiNP_002858.2. NM_002867.3.
UniGeneiHs.123072.

Genome annotation databases

EnsembliENST00000371655; ENSP00000360718; ENSG00000169213.
GeneIDi5865.
KEGGihsa:5865.
UCSCiuc001cth.3. human.

Polymorphism databases

DMDMi38258903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28214 mRNA. Translation: AAA60243.1 .
AF498932 mRNA. Translation: AAM21080.1 .
AL589663 , AL445685 Genomic DNA. Translation: CAH74098.1 .
AL445685 , AL589663 Genomic DNA. Translation: CAI17027.1 .
BC005035 mRNA. Translation: AAH05035.1 .
CCDSi CCDS560.1.
PIRi D34323.
RefSeqi NP_002858.2. NM_002867.3.
UniGenei Hs.123072.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DZ8 X-ray 1.90 A 18-190 [» ]
ProteinModelPortali P20337.
SMRi P20337. Positions 18-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111803. 7 interactions.
STRINGi 9606.ENSP00000360718.

PTM databases

PhosphoSitei P20337.

Polymorphism databases

DMDMi 38258903.

Proteomic databases

MaxQBi P20337.
PaxDbi P20337.
PeptideAtlasi P20337.
PRIDEi P20337.

Protocols and materials databases

DNASUi 5865.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371655 ; ENSP00000360718 ; ENSG00000169213 .
GeneIDi 5865.
KEGGi hsa:5865.
UCSCi uc001cth.3. human.

Organism-specific databases

CTDi 5865.
GeneCardsi GC01M052373.
HGNCi HGNC:9778. RAB3B.
HPAi CAB023293.
HPA003159.
MIMi 179510. gene.
neXtProti NX_P20337.
PharmGKBi PA34133.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P20337.
KOi K06108.
OMAi WFDFFEA.
OrthoDBi EOG7JQBPC.
PhylomeDBi P20337.
TreeFami TF313199.

Miscellaneous databases

EvolutionaryTracei P20337.
GeneWikii RAB3B.
GenomeRNAii 5865.
NextBioi 22778.
PROi P20337.
SOURCEi Search...

Gene expression databases

Bgeei P20337.
CleanExi HS_RAB3B.
Genevestigatori P20337.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."
    Zahraoui A., Touchot N., Chardin P., Tavitian A.
    J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Crystal structure of human RAB3B GTPase bound with GDP."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 18-190 IN COMPLEX WITH GDP.

Entry informationi

Entry nameiRAB3B_HUMAN
AccessioniPrimary (citable) accession number: P20337
Secondary accession number(s): Q5VUL2, Q9BSI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 31, 2003
Last modified: July 9, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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